PENGARUH PARTISIPASI PENYUSUNAN ANGGARAN, BUDAYA ORGANISASI, DAN KOMITMEN ORGANISASI TERHADAP KINERJA PEGAWAI (Studi kasus pada pegawai bagian Keuangan Dinas Tenaga Kerja Transmigrasi dan Kependudukan Provinsi Jawa Timur)

PENGARUH PARTISIPASI PENYUSUNAN ANGGARAN, BUDAYA ORGANISASI, DAN KOMITMEN ORGANISASI TERHADAP KINERJA PEGAWAI (Studi kasus pada Bagian Keuangan Dinas Tenaga Kerja, Transmigrasi dan Kependudukan Pemerintah Provinsi Jawa Timur) Oleh Alda Ceressa Marta ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh partisipasi penyusunan anggaran, budaya organisasi, dan komitmen organisasi terhadap kinerja pegawai bagian keuangan Dinas Tenaga Kerja, Transmigrasi dan Kependudukan Pemerintah Provinsi Jatim. Sampel penelitian ini sebanyak 30 orang dengan responden yang terlibat dalam penyusunan anggaran Dinas Tenaga Kerja Transmigrasi dan Kependudukan Pemprov Jatim. Pengumpulan data dilakukan dengan melakukan wawancara dan survei dengan pembagian kuesioner kepada responden. Data yang dipergunakan dalam penelitian ini adalah data primer. Sedangkan teknik analisis yang dipergunakan adalah analisis Regresi Linier Berganda. Pengujian statistik ini menggunakan Softwere SPSS 20 for windows. Hasil analisis kemudian di analisis dengan uji asumsi klasik serta uji F. Hasil dari penelitian ini menunjukkan adanya pengaruh positif dan tidak signifikan mengenai partisipasi penyusunan anggaran dan komitmen organisasi terhadap kinerja pegawai. Dan terdapat pengaruh positif dan signifikan mengenai budaya organisasi terhadap kinerja pegawai. Sedangkan, variabel budaya organisasi berpengaruh lebih dominan terhadap peningkatan kinerja pegawai dibandingkan dengan variabel partisipasi penyusunan anggaran dan komitmen organisasi

Azatioprina na doença inflamatória intestinal: fatores preditivos da resposta sustentada a longo prazo

ResumoIntroduçãoA azatioprina (AZA) é uma opção terapêutica de manutenção na doença inflamatória intestinal (DII). Contudo, os fatores que influenciam ou predizem a sua resposta são pouco conhecidos.ObjetivoAvaliar os fatores preditivos de sucesso terapêutico da AZA a longo prazo.MétodosAnálise retrospetiva de todos os doentes com DII seguidos no nosso hospital medicados com AZA (2‐2,5mg/Kg/dia) por doença corticodependente ou corticorrefratária e, na doença de Crohn (DC), por comportamento fistulizante ou após cirurgia. Registámos o tipo de doença (DC/colite ulcerosa [CU]/DII indeterminada), parâmetros clínicos, parâmetros laboratoriais (PL) – leucócitos, PCR, hemoglobina, plaquetas e VGM – antes e aos 3 meses de tratamento, bem como terapêutica concomitante com 5‐ASA e corticoide. O tratamento foi considerado eficaz quando os doentes mantinham o controlo da doença por critérios clínicos/endoscópicos, com manutenção da AZA ou com cessação da mesma após 3 meses de tratamento, e sem necessidade de escalar a terapêutica. Excluímos os doentes com intolerância à AZA nos primeiros 3 meses e os tratados concomitantemente com agentes biológicos.ResultadosSetenta e dois doentes (37 mulheres e 35 homens); idade média de 38,0±13,8 anos; 35 doentes com DC, 34 com CU e 3 com DII indeterminada. Duração média de tratamento com AZA de 35,1±30,6 meses. A AZA foi eficaz em 48 doentes (66,7%). A idade no início da AZA prediz o sucesso terapêutico (R=0,303, p=0,019). O sexo, o tipo de doença e os PL antes do tratamento não tiveram relação com a eficácia. Aos 3 meses de tratamento, os PL mostraram relação com o sucesso terapêutico a longo prazo: leucócitos (r=–0,295, p=0,013), PCR (r=–0,332, p=0,005), hemoglobina (r=0,307, p=0,010), plaquetas (r=–0,360, p=0,003) e VGM (r=0,255, p=0,047); no seu conjunto os PL predizem a eficácia (R=0,517; p=0,005). Existe associação entre a localização da CU (r=–0,381; p=0,026), o tempo de tratamento concomitante com 5‐ASA (r=0,258, p=0,029) e a suspensão de corticoides (r=0,265, p=0,04) com a eficácia do tratamento.ConclusãoO tratamento com a AZA foi eficaz na maioria dos doentes com DII. A idade avançada no início da terapêutica e os PL aos 3 meses foram preditivos de resposta sustentada da AZA.AbstractIntroductionAzathioprine (AZA) is an option for maintenance therapy in Inflammatory Bowel Disease (IBD). However, the factors which influence or predict its response are poorly understood.AimEvaluate the predictive factors for a successful long‐term therapeutic response of AZA.MethodsRetrospective analysis of all patients with IBD followed up in our hospital treated with AZA (2‐2.5mg/Kg/day) due to steroid dependent or resistent disease or, in Crohn disease (CD), due to fistulizing behavior or post‐surgery. We recorded the type of disease (DC/ ulcerative colitis (UC), indeterminate IBD), clinical parameters, laboratory parameters (LP) – WBC, CRP, hemoglobin, platelets and MCV – before and after 3 months of treatment, as well as concomitant usage of 5‐ASA and steroids. The treatment was considered effective when patients maintained control of the disease by clinical/endoscopic criteria, with continued maintainance of AZA or cessation of therapy after 3 months of treatment, and without escalation of therapy. We excluded patients who show intolerance to AZA in the first 3 months and patients treated concomitantly with biological agents.Results72 patients (37 women and 35 men); mean age 38.0±13.8 years; 35 patients with CD, 34 with UC and 3 with indeterminate IBD. The average duration of treatment with AZA was 35.1±30.6 months. AZA was effective in 48 patients (66.7%). The age at onset of AZA predicts therapeutic sucess (R=0.303, p=0.019). The sex, type of disease and LP before treatment did not correlate with efficacy. The LP after 3 months of therapy correlated with therapeutic sucess in the long‐term: WBC (r=–0.295, p=0.013), CRP (r=–0.332, p=0.005), hemoglobin (r=0.307, p=0.010), platelets (r=–0.360, p=0.003) and MCV (r=0.255, p=0.047). In combination, LP predict the efficacy of treatment (R=0.517, p=0.005). There is also an association between the location of UC (r=–0.381, p=0.026), as well as the duration of concurrent treatment with 5‐ASA (r=0.258, p=0.029) and the suspension of steroids (r=0.265, p=0.04) with the efficacy of the treatment.ConclusionAZA proved to be an effective treatment in the majority of patients with IBD. The old age of onset of the therapy and LP at 3 months were predictive of a sustained response of AZA

Rehabilitative practice in Europe: roles and competencies of physiotherapists. Are we learning something new from COVID-19 pandemic?

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Serological diagnosis of canine leishmaniosis: comparison of three commercial ELISA tests (Leiscan®, ID Screen® and Leishmania 96®), a rapid test (Speed Leish K®) and an in-house IFAT

BACKGROUND: Speed Leish K(®) is used as a serological screening test for Leishmania infection prior to vaccination. Limited comparative serological studies with Speed Leish K(®) have been performed. The aim of this study was to evaluate the diagnostic performance of four commercially available serologic tests including ELISAs (Leiscan(®), ID Screen(®) and Leishmania 96(®)), a rapid test (Speed Leish K(®)) and an in-house IFAT for the detection of specific antibodies against Leishmania infantum antigen in dogs in different states of infection. METHODS: Sick infected dogs (n = 36), healthy infected dogs (n = 18), L. infantum seropositive dogs with low to high levels of antibodies (n = 53), dogs seropositive to other pathogens (to evaluate cross reaction) (n = 14) and uninfected dogs from a non-endemic area (n = 50) and from an endemic area (n = 32) were analysed by the serological methods mentioned above. RESULTS: The sensitivity was as follows: ID Screen(®) (0.953), Leiscan(®) and Leishmania 96(®) (0.925), IFAT (0.869) and Speed Leish K(®) (0.636). The maximum specificity (1.000) was attained for all diagnostic tests except the Leishmania 96(®) (0.896) and IFAT (0.917). The accuracy was as follows: ID Screen(®) (0.975), Leiscan(®) (0.961), Leishmania 96(®) (0.911), IFAT (0.892) and Speed Leish K(®) (0.808). In relation to the area under the ROC curve (AUC-ROC), the maximum value was attained with the ID Screen(®) (0.993) closely followed by Leiscan(®) (0.990), then, Leishmania 96(®) (0.962), IFAT (0.926) and Speed Leish K(®) (0.818). For the Kappa index, the best result was obtained by the ID Screen(®) (0.951) followed by Leiscan(®) (0.921), Leishmania 96(®) (0.822), IFAT (0.783) and Speed Leish K(®) (0.622). Statistically significant differences were found between the AUC-ROC of quantitative serological tests and the only qualitative rapid test evaluated. There were also statistically significant differences between AUC-ROC of the ELISAs (ID Screen(®) and Leiscan(®)) and IFAT. CONCLUSIONS: Leiscan(®) and ID Screen(®) had superior diagnostic performance measures than IFAT and all quantitative serological tests were superior when compared to Speed Leish K(®). Thus, Speed Leish K(®) may be considered a less valuable screening test prior to vaccination as it may result in vaccination of seropositive dogs and in some cases seropositive sick dogs

Tectónica y sus efectos sobre la Tierra, desarrollo de una unidad didáctica

Este Trabajo de Fin de Máster se corresponde con el de la modalidad A. En este trabajo se va a presentar una propuesta didáctica que incluirá varias actividades planteadas para la asignatura de Biología y Geología del curso de 4º de ESO. La temática de la unidad didáctica se emplaza en el Bloque 2: La dinámica de la Tierra, del currículo determinado por la Orden ECD/489/2016, de 26 de mayo, por la que se aprueba el currículo de la Educación Secundaria Obligatoria y se autoriza su aplicación en los centros docentes de la Comunidad Autónoma de Aragón. La propuesta didáctica se realizó de forma online, debido a la situación de confinamiento a la estaba sometido el país, por lo que es uso de las TIC adquiere un papel esencial en esta propuesta didáctica. Se han realizado actividades prácticas que conectan con la teoría, para favorecer el aprendizaje significativo. Con el fin de favorecer la motivación de los estudiantes se han planteado actividades gamificadas, para conseguir su interés y que aprendan divirtiéndose. Se han empleado también metodologías prácticas, de método del caso y clases magistrales. La parte teórica de la unidad didáctica se realizó mediante presentaciones o vídeos que fueron colgados parar los alumnos. Las actividades prácticas que se realizaron consistieron en el uso de cuestionarios online, un mapa interactivo o simulador, las herramientas Quizziz y EDpuzzle y la realización de un modelo que fue explicado y recogido por los alumnos con un vídeo.<br /

Diseño de una unidad didáctica basada en cuestiones sociocientíficas a través de las TIC para la formación de alumnado reflexivo y crítico

Este trabajo trata sobre mi actuación en el centro IES Andalán, la propuesta didáctica diseñada y llevada a cabo, con el objetivo de poner en práctica los contenidos y competencias adquiridas durante el trascurso del Máster de Profesorado, especialidad de Biología y Geología en la Universidad de Zaragoza. La unidad didáctica en cuestión es la de “Medio ambiente y ser humano”, de la asignatura de Biología y Geología de 4º de ESO. Su implantación fue llevada a cabo durante el periodo de prácticas, con una duración de 6 semanas, coincidente con la declaración del estado de alarma en España por la COVID-19, y por tanto con la no presencialidad de las clases. Así, el recurso principal utilizado es el uso de las Tecnologías de la Información y la Comunicación (TIC), además de otros como una comunicación fluida entre profesora-alumnado o la proyección de vídeos o imágenes. El principal objetivo fomentar el proceso educativo como un método de construcción de un diálogo crítico y reflexivo que forme ciudadanos activos y participativos en la sociedad. Se produce también, la evaluación del alumnado y de la implantación de la propia unidad didáctica así como la búsqueda de alternativas a las debilidades.<br /

EDUKASI PENDIDIKAN GIZI TERKAIT BAHAYA JAJAN DI LUAR PADA ANAK SEKOLAH DASAR DI PEDESAAN DAN PERKOTAAN

Primary schoolers are children aged 6-12 years, and the school-aged is the final childhood. Snack food consumed by school children occasionally causes problems for their health; they often snack carelessly because not all of the healthy snacks found by primary schoolers contain various ingredients that are good for the body. This study aimed to determine the effect of nutrition education on the dangers of outside snacking on the knowledge and behavior of school children. This activity is a quasi-experiment one group pre-test and post-test design. The collection tool is a questionnaire developed by researchers and indirect communication or online via video calling software and posters. Data analysis was conducted using the paired t-test method. The results of statistical calculations of the knowledge and behavior of the dangers of snacking outside for primary schoolers show that the pre-test and post-test have increased significantly with a p-value &lt; 0.05. This activity concludes that there is an increase in knowledge and behavior of the dangers of outside snacks for primary school students. --- Anak sekolah merupakan anak yang berusia 6-12 tahun, usia sekolah sebagai masa kanak-kanak akhir. Makanan ringan dikonsumsi anak sekolah terkadang menimbulkan masalah bagi kesehatan mereka yang sering jajan sembarangan karena tidak semua jajanan sehat yang ditemukan anak sekolah mengandung beraneka ragam bahan yang baik untuk tubuh. Pengabdian ini bertujuan untuk mengetahui pengaruh pendidikan gizi tentang bahaya jajan di luar terhadap pengetahuan dan perilaku anak sekolah. Kegiatan ini menggunakan kuasi eksperimen dengan desain one group pre-test dan post-test. Alat pengumpulan data menggunakan kuesioner yang dikembangkan oleh peneliti dan menggunakan komunikasi tidak langsung atau daring dengan media video dan poster. Analisis data menggunakan metode uji paired t-test. Hasil perhitungan statistik pengetahuan dan perilaku bahaya jajan di luar pada anak sekolah menunjukkan bahwa pre-test dan post-test mengalami peningkatan yang signifikan dengan p-value &lt; 0.05. Kesimpulan kegiatan ini ada peningkatan pengetahuan dan perilaku terkait bahaya jajan di luar pada anak sekolah dasar

Can the five repetition sit-to-stand test discriminate inpatients and outpatients with acute exacerbations of COPD?

The five repetition sit-to-stand test (5STS) is a simple and validated functional test, suitable to be performed in different settings, that has been related with mortality in chronic obstructive pulmonary disease (COPD). Yet, its relationship with the need for hospitalisation is unknown. This study explored the 5STS ability to discriminate between hospitalised and non-hospitalised patients at the onset of an acute exacerbation of COPD (AECOPD). Patients with AECOPD visiting the urgency ward of 2 hospitals were recruited. Clinicians defined the need for hospitalisation based on their best judgment. The 5STS was completed within 48h of the AECOPD onset. Receiver operating characteristic analysis was performed and the area under the curve (AUC) was calculated. 47 patients (92% male, 69±7yrs, FEV150±20%predicted) participated. Age, gender, FEV1, body mass index and quadriceps muscle strength were not different between inpatients and outpatients. 5STS showed good ability to discriminate between inpatients and outpatients (AUC=0.73; 95%CI 0.59-0.88), with a sensitivity of 75% and specificity of 53% for a cut-off of 13.7s (Fig. 1). 5STS can accurately discriminate between inpatients and outpatients with AECOPD. A cut-off of 13.7s may be used to differentiate these patients. Results also emphasise the need to improve patients’ functionality during hospitalisation. Studies with larger samples are needed.publishe

Influence of the TAS2R38 gene single nucleotide polymorphisms in metabolism and anthropometry in thyroid dysfunction

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The gene TAS2R38 single nucleotide polymorphisms (SNPs-P49A, A262V and V296I) can condition bitter tasting by PAV (proline–alanine–valine) and non-bitter-tasting by AVI (alanine–valine–isoleucine) homozygosity. We evaluated this polymorphisms association with thyroid function, metabolism and anthropometry parameters determined by: Endpoint analysis (SNPs); DXA (fat mass-%, total fat mass—kg, lean mass—kg); Standard methods (lipid metabolism parameters, HbA1c-%, glycemia—mg/dL, insulinemia—µIU/mL, HOMA-IR, uricemia—mg/dL, calcemia—mg/dL and BMI—kg/m2); ELISA (leptinemia—ng/mL); Spectrophotometry (Angiotensin Converting Enzyme activity—UI/L). Statistics: SPSS program; OR [IC95%]; p < 0.05. Sample: 114 hypothyroid, 49 hyperthyroid, and 179 controls. An association between A262V-valine–valine and hypothyroidism/hyperthyroidism was verified (OR = 2.841; IC95% [1.726–4.676]), p < 0.001/OR = 8.915; IC95% [4.286–18.543]), p < 0.001). Protector effect from thyroid dysfunction: A262V-alanine–valine (OR = 0.467; IC95% [0.289–0.757], p = 0.002/OR = 0.132; IC95% [0.056–0.309], p < 0.001) and PAV (OR = 0.456; IC95% [0.282–0.737], p = 0.001/OR = 0.101; IC95% [0.041–0.250], p < 0.001). Higher parameter values associated with genotypes were: fat-mass-% (V296I-valine–isoleucine), lean-mass (P49A-proline–proline; PVI), leptin (AVI), HbA1c (A262V-alanine–valine) and lower values in lean-Mass (AVI; PVV), leptin (A262V-alanine–alanine), HbA1c (PVV), uricemia (V296I-valine–isoleucine), glycemia (A262V-alanine–alanine; AAV) and plasma triglycerides (PVV). In conclusion, TAS2R38 influences thyroid function, body composition and metabolism. Bitter taste perception (PAV) and the genotype A262V-alanine–valine can protect from thyroid dysfunction. AVV, PVV and genotype A262V-valine–valine may confer higher predisposition for thyroid dysfunction, particularly PVV for hyperthyroidism.The writing of the manuscript was also supported by funds from the Foundation for Science and Technology to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020).info:eu-repo/semantics/publishedVersio

Tratamiento psicológico en el trastorno de somatización : eficacia y propuestas de intervención

This review analyze randomized controlled studies carried out both in somatization disorder and in undifferentiated somatoform disorder patients that had been treated using two kind of interventions: 1. A consultation letter referred by a mental health specialist to the patient's family doctor and 2. Using cognitive-behaviour therapy. In these studies some variables such as the setting, the content, the number of sessions, the outcome, the foUow-up, etc. has been assessed. We summarize the main conclusions on psychological interventions developed up to the moment in these patients and we propose new stepped cognitive-behavioural therapies to implement in the future in somatization disorder patients.Este trabajo de revisión analiza los estudios controlados randomizados realizados tanto en pacientes con trastorno de somatización como en pacientes con trastorno somatomorfo indiferenciado que han sido tratados mediante dos tipos de intervenciones: 1. Mediante la remisión de una carta de interconsulta por parte de un especialista de salud mental a atención primaria y 2. mediante terapia cognitivo-conductual. En estos estudios se analizan variables como el entorno, el contenido de la terapia, el formato, el número de sesiones, las variables de resultado, el tiempo de seguimiento, etc. Se resumen las principales conclusiones de las intervenciones psicológicas realizadas hasta el momento en estos pacientes y se realizan propuestas para nuevos terapias cognitivo- conductuales en escalado a realizar en el futuro en pacientes con trastorno de somatización