Advanced Positioning and Location based services in 4G Mobile-IP Radio Access Networks

2004 IEEE 15TH IEEE International Symposium on personal, indoor and mobile radio communications (PIMRC 2004), Barcelona, Spain, 5-8 september 2004.This paper proposes an evolved architecture from 3G networks to provide basic and advanced positioning methods for location based services in mobile IPv6-based radio access networks. We start analyzing current status of location-based services (i.e. LBS or LCS) and architectures in 3G networks as well as state-of-the-art research on LBS and mobile Internet. Next we set the requirements the solution should fulfill. We continue proposing the evolved architecture for support of basic and advanced positioning methods, using MIPv6 and HMIPv6 as mobility scenario for the mobile IPv6 based RAN, describing element's functions and changes from current approaches as well as description of the dynamic behavior. We complete the proposal with a bandwidth analysis of the signaling, identifying issues when planning implementation of LCS services in the network

Prototipo brazo robótico.

La Inteligencia Artificial (IA) es la rama de las ciencias de la computación que se ocupa de construir sistemas que permitan exhibir un comportamiento cada vez más inteligente. Un brazo robótico es un tipo de brazo mecánico, normalmente programable, con funciones parecidas a las de un brazo humano; este puede ser la suma total del mecanismo o puede ser parte de un robot más complejo. Las partes de estos manipuladores o brazos son interconectadas a través de articulaciones que permiten, tanto un movimiento rotacional, como un movimiento transnacional o desplazamiento lineal. El efector final, o mano robótica, se puede diseñar para realizar cualquier tarea que se desee como puede ser soldar, sujetar, girar, etc., dependiendo de la aplicación. En algunas circunstancias, lo que se busca es una simulación de la mano humana, como en los robots usados en tareas de desactivación de explosivo

The Impact of Sleep Quality on Mood Status and Quality of Life in Patients with Alopecia Areata: A Comparative Study

Alopecia Areata (AA) is a chronic condition which has been associated with poor quality of life and mood status disturbances. The aim of this study is to compare the sleep quality between AA patients and controls, and to analyze the impact of poor sleep quality on patients with AA regarding mood status disturbances, quality of life and sexuality. A cross-sectional study including patients suffering from mild-to-severe AA and sex- and age-matched healthy controls was performed. Socio-demographic and clinical variables, sleep quality, quality of life, sexual disfunction, anxiety, depression and personality were collected using validated questionnaires. A total of 120 participants (60 patients and 60 controls) were included. Patients with AA showed worse sleep scores than controls (p = 0.003), as well as higher rates of anxiety and depression (p < 0.05). After a multivariate analysis, a worse sleep quality was found to be linked to anxiety, depression, a poorer quality of life and a type D personality score independently of the disease severity. In light of the results, patients with AA have a worse sleep quality than healthy controls. A poor sleep quality is associated with anxiety, depression and a worse quality of life, therefore being a general marker of a poor quality of life. Screening for sleep disturbances in specialized units could be useful to detect patients who could benefit from additional psychological support

An Updated in the Management of Alopecia Areata

Alopecia areata (AA) is the most frequent type of non-scarring alopecia after androgenetic alopecia. The lifetime risk of developing AA is approximately 1.7–2.1%, and its incidence is increasing over time. Clinically, it is characterized by circumscribed and smooth patches of alopecia with black dots. Several treatments have been used in AA including topical an oral minoxidil and corticosteroids. Although new treatment options are being developed and advances have been made in recent years, there is currently no preventive or curative treatment for AA and classical treatments produce variable results. The design of a treatment strategy for alopecia areata should be based on consensual decision-making with the patient, taking into account his or her preferences and the risk and benefit of each treatment. In this chapter, we review the treatment of AA

Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome.

Substance use disorders are more prevalent in schizophrenia, but the causal links between both conditions remain unclear. Maternal immune activation (MIA) is associated with schizophrenia which may be triggered by stressful experiences during adolescence. Therefore, we used a double-hit rat model, combining MIA and peripubertal stress (PUS), to study cocaine addiction and the underlying neurobehavioural alterations. We injected lipopolysaccharide or saline on gestational days 15 and 16 to Sprague-Dawley dams. Their male offspring underwent five episodes of unpredictable stress every other day from postnatal day 28 to 38. When animals reached adulthood, we studied cocaine addiction-like behaviour, impulsivity, Pavlovian and instrumental conditioning, and several aspects of brain structure and function by MRI, PET and RNAseq. MIA facilitated the acquisition of cocaine self-administration and increased the motivation for the drug; however, PUS reduced cocaine intake, an effect that was reversed in MIA + PUS rats. We found concomitant brain alterations: MIA + PUS altered the structure and function of the dorsal striatum, increasing its volume and interfering with glutamatergic dynamics (PUS decreased the levels of NAA + NAAG but only in LPS animals) and modulated specific genes that could account for the restoration of cocaine intake such as the pentraxin family. On its own, PUS reduced hippocampal volume and hyperactivated the dorsal subiculum, also having a profound effect on the dorsal striatal transcriptome. However, these effects were obliterated when PUS occurred in animals with MIA experience. Our results describe an unprecedented interplay between MIA and stress on neurodevelopment and the susceptibility to cocaine addiction.This work has been funded by the Spanish Ministry of Economy and Competitiveness (Project no.: PSI2016-80541-P to EA and AH-M); Ministry of Science (PID2019- 104523RB-I00 to A-HM and PID2019-111594RB-100 to EA), Spanish Ministry of Health, Social Services and Equality (Network of Addictive Disorders - Project no.: RTA-RD16/ 020/0022 of the Institute of Health Carlos III and National Plan on Drugs, Project no.: 2016I073 to EA and 2017I042 to A H-M); The BBVA Foundation (Leonardo Grants) to AH-M; The European Union (Project no.: JUST- 2017- AG- DRUG-806996-JUSTSO) to EA; and the UNED (Plan for the Promotion of Research) to EA and AH-M. MLS-M was supported by the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (project PI17/01766), co-financed by the European Regional Development Fund (ERDF), ‘A way to make Europe’; project PID2021-128862OB-I00 funded by MCIN/AEI/ 10.13039/501100011033/FEDER, UE, CIBER de Salud Mental - Instituto de Salud Carlos III (project number CB07/09/0031); Delegación del Gobierno para el Plan Nacional sobre Drogas (project number 2017/085, 2022/008917); and Fundación Alicia Koplowitz. Fundación Tatiana Pérez de Guzmán el Bueno supported MC-V. MD’s work was supported by Ministerio de Ciencia e Innovación (MCIN) and Instituto de Salud Carlos III (PT20/00044). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S

Perceptions of medical students toward teledermatology as an educational tool: a cross-sectional study

IntroductionTeledermatology consultations have recently been on the rise, especially due to the SARS-CoV-2 pandemic. The role of teledermatology has been extensively discussed as a mean for the education of dermatology residents. Nevertheless, little has been explored on its use as a pedagogical tool for medical students. The objectives of this study were to assess the level of satisfaction of medical students with teledermatology and to evaluate their opinion about its use as an educational tool.MethodsA cross-sectional study was carried out at the Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada (Spain). Participants were fourth-year medical students. Every student would spend half of their internship in face-to-face consultations and the other half in teledermatology consultations. Data was collected via self-administered questionnaires.ResultsEighty one students were finally surveyed, being 66.67% (73/81) female. A majority of students considered a mixed clinical internship model (face-to-face consultations combined with teledermatology) more suitable for obtaining higher marks in the subject of dermatology and in the Medical Intern Resident exam (p = 0.04). Nevertheless, face-to-face practice was considered more useful for their training as general practitioners (p = 0.04).ConclusionDespite the fact that students highly value doctor-patient relationship, teledermatology is considered a powerful educational tool

Boletín Económico Regional: Eje Cafetero, II trimestre de 2022

Durante el segundo trimestre de 2022, la economía del Eje Cafetero continuó con una buena dinámica en la mayoría de sus sectores, teniendo en cuenta la menor base de comparación del año anterior, afectada por el paro nacional. Se presentaron crecimientos en la industria, el comercio interno y de vehículos, y la ocupación hotelera; así como en la mayoría de las variables de la construcción y el transporte, y en el sector pecuario particularmente en sacrificio de ganado bovino y porcino. También se registró crecimiento en el comercio exterior tanto en exportaciones como en importaciones. Por el contrario, hubo caída en la actividad agrícola en cosecha cafetera de Caldas y en el acopio de leche por parte de la industria. Finalmente, la tasa de desempleo se redujo en las tres capitales de la región, destacándose la de Manizales y su área metropolitana como una de las más bajas del país; al tiempo que la inflación en la región continúo con mayores incrementos

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer. How genomic instability influences the metabolic capacity of cancer cells is nevertheless poorly understood. Here, we show that homologous recombination-defective (HRD) cancers rely on oxidative metabolism to supply NAD+ and ATP for poly(ADP-ribose) polymerase (PARP)-dependent DNA repair mechanisms. Studies in breast and ovarian cancer HRD models depict a metabolic shift that includes enhanced expression of the oxidative phosphorylation (OXPHOS) pathway and its key components and a decline in the glycolytic Warburg phenotype. Hence, HRD cells are more sensitive to metformin and NAD+ concentration changes. On the other hand, shifting from an OXPHOS to a highly glycolytic metabolism interferes with the sensitivity to PARP inhibitors (PARPi) in these HRD cells. This feature is associated with a weak response to PARP inhibition in patient-derived xenografts, emerging as a new mechanism to determine PARPi sensitivity. This study shows a mechanistic link between two major cancer hallmarks, which in turn suggests novel possibilities for specifically treating HRD cancers with OXPHOS inhibitors

Balance de energía, nitrógeno y fósforo en sistemas de ceba bovina en pastoreo

Objective: The aim of this work was to perform balances of energy, nitrogen, and phosphorus in pre-fattening and fattening bovine systems at Turiguanó Livestock Breeding Company, in the province of Ciego de Ávila, Cuba. Materials and methods: The botanical composition of the farms evaluated was determined, and energy, nitrogen, and phosphorus balances were performed. Results: The annual energy, nitrogen, and phosphorus balances were negative on the farms in the study. Conclusions: New strategies are required to enhance energy and nutrient (nitrogen and phosphorus) use to increase beef production during the final stage. Accordingly, improvements in recycling, balance, and efficiency in the use of energy and these minerals are linked to increases in live weight/day, and better final weights for the industry during that stage.Objetivo: Realizar el balance de energía, nitrógeno y fósforo de sistemas de ceba inicial y ceba final bovina en la Empresa Pecuaria Genética Turiguanó en la provincia Ciego de Ávila en Cuba. Materiales y métodos: Se determinó la composición botánica en las unidades evaluadas y se realizaron los balances de energía, nitrógeno y fósforo. Resultados: Las unidades estudiadas presentaron balances negativos anuales en lo energético y en el nitrógeno y fósforo. Conclusiones: Son necesarias estrategias para aumentar el aprovechamiento de energía y los nutrientes como nitrógeno y fósforo e incrementar la producción bovina de carne en su fase final, por lo que las mejoras del reciclaje, el balance y la eficiencia de utilización de la energía y estos minerales, están ligadas a los incrementos en peso vivo/día y a mejores pesos finales a industria en esta fase