Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature

The extraskeletal myxoid chondrosarcoma (CME) is a rare malignant soft tissue tumour described as a distinct clinical, histological, immunohistochemical, genetical and evolutive entity. It represents only 2.5% of soft tissue sarcomas. Its individualization is important because it has a long and indolent clinical course, and tumour-related death often occurs after a long survival period. The diagnostic key is morphological supported by immunohistochemistry and genetics t (9; 22) that allow differentiating it from other tumours with myxoid stroma and from chordoma. This report describes a patient with paravertebral extraskeletal myxoid chondrosrcoma with a high locoregional extension

Two new species of Centroptilum Eaton, 1869 from North Africa (Ephemeroptera, Baetidae).

Based on recently collected larvae from Algeria and Morocco, the species delimitation within the genus Centroptilum Eaton, 1869 in that region is validated. Two new species are described and illustrated, one from north-eastern Algeria, and one from North Morocco, using an integrated approach with morphological and molecular evidence. A table summarising the morphological differences between the new species and Centroptilumluteolum (Müller, 1776) from Central Europe is provided. Further, molecular evidence for additional undescribed species of Centroptilum in other regions of the West Palearctic is provided and discussed

Comparative Study of Chemical Composition and the biological effect of essential oils for two plants; Lavandula Stoechas et Laurus Nobilis.

For both plants, the aerial parts used of Lavandula Stoechas (LS) and Laurus Nobilis (LN) are leaves harvested during the flowering period. They give respectively (0.12%; 0.45%) and (0.326% 0.623%) by hydrodistillation essence. The constituents of the chemical composition have been identified by gas chromatography coupled to mass spectrometry (GC-MS). The essential oils leaves of LN and LN for two areas, "Zinat" and "Hallila" are very rich in oxygenated monoterpenes. Moreover, the biological effect, for essential oils of LS and LN possess an antibacterial activity against a bacteria Bacillus subtilis, except for LN has also the effect against Escherichia coli K12 and other bacteria don’t  have  the effect against Porteus sp, Staphylococcus aureus and Escherichia coli K12 LS of our species

Seismic risk in the city of Al Hoceima (north of Morocco) using the vulnerability index method, applied in Risk-UE project

The final publication is available at Springer via http://dx.doi.org/10.1007/s11069-016-2566-8Al Hoceima is one of the most seismic active regions in north of Morocco. It is demonstrated by the large seismic episodes reported in seismic catalogs and research studies. However, seismic risk is relatively high due to vulnerable buildings that are either old or don’t respect seismic standards. Our aim is to present a study about seismic risk and seismic scenarios for the city of Al Hoceima. The seismic vulnerability of the existing residential buildings was evaluated using the vulnerability index method (Risk-UE). It was chosen to be adapted and applied to the Moroccan constructions for its practicality and simple methodology. A visual inspection of 1102 buildings was carried out to assess the vulnerability factors. As for seismic hazard, it was evaluated in terms of macroseismic intensity for two scenarios (a deterministic and probabilistic scenario). The maps of seismic risk are represented by direct damage on buildings, damage to population and economic cost. According to the results, the main vulnerability index of the city is equal to 0.49 and the seismic risk is estimated as Slight (main damage grade equal to 0.9 for the deterministic scenario and 0.7 for the probabilistic scenario). However, Moderate to heavy damage is expected in areas located in the newer extensions, in both the east and west of the city. Important economic losses and damage to the population are expected in these areas as well. The maps elaborated can be a potential guide to the decision making in the field of seismic risk prevention and mitigation strategies in Al Hoceima.Peer ReviewedPostprint (author's final draft

Place de la radiothérapie adjuvante dans la prise en charge des cancers de l’endomètre : à propos de 60 cas

Objectif : L’objectif principal de ce travail est de rapporter l’expérience du service de radiothérapie du CHU HASSANII de Fès dans la prise en charge du cancer de l’endomètre. Patientes et méthodes : Notre étude était rétrospective, 60 patientes atteintes d’un cancer de l’endomètre ont été prises en charge entre janvier 2016 et décembre 2018 dans notre service par une radiothérapie adjuvante (radiothérapie externe et ou curiethérapie du fond vaginal). Résultats : L’âge moyen était de 59 ans.Toutes nos patients ont été opérées, elles ont toutes bénéficié d’une hystérectomie totale + annexectomie bilatérale. Le curage ganglionnaire a été réalisé chez 29 patientes. Le type histologique le plus fréquent était l’adénocarcinome endométrioïde, présent dans 88,3% des cas. Il s’agit selon la classification internationale de la (FIGO) de 2010 de  25% de cancers de stade IA, 34% de IB , 15% de stade II,  26% de stade III. Une radiothérapie a été délivrée chez toutes les patientes, 41 patientes ont bénéficié d’un traitement associant une radiothérapie externe suivie d’une curiethérapie du fond vaginal. Dix-neuf patientes ont été traitées par curiethérapie du fond vaginal exclusive. neuf patientes ont reçu une chimiothérapie. Avec un recul moyen de 37 mois, 4 patientes  ont présenté une récidive locale et 15 des métastases à distance, la survie globale était de 86,6%. Conclusion : Le traitement du cancer de l'endomètre repose sur la chirurgie. La radiothérapie est le traitement adjuvant principal. A travers cette étude nous avons rapporté l'expérience de notre service dans le traitement de cette tumeur.

Evidence of collaborative opportunities to ensure long-term sustainability in African farming

Farmers face the challenge of increasing production to feed a growing population and support livelihoods, whilst also improving the sustainability and resilience of cropping systems. Understanding the key factors that influence farming management practices is crucial for determining farmers’ adaptive capacity and willingness to engage in cooperative strategies. To that end, we investigated management practices that farmers adopt and the factors underlying farmers’ decision-making. We also aimed to identify the constraints that impede the adoption of strategies perceived to increase farming resilience and to explore how the acceleration of technology adoption through cooperation could ensure the long-term sustainability of farming. Surveys were distributed to farming stakeholders and professionals who worked across the contrasting environments of Morocco. We used descriptive statistics and analysis by log-linear modelling to predict the importance of factors influencing farmers’ decision- making. The results show that influencing factors tended to cluster around environmental pressures, crop characteristics and water availability with social drivers playing a lesser role. Subsidies were also found to be an important factor in decision-making. Farming stakeholders generally believed that collaborative networks are likely to facilitate the adoption of sustainable agricultural practices. We conclude that farmers need both eco- nomic incentives and technical support to enhance their adaptive capacity as this can lessen the socioeconomic vulnerability inherent in arid and semi-arid regions

Calorimetric and transport investigations of CePd_{2+x}Ge_{2-x} (x=0 and 0.02) up to 22 GPa

The influence of pressure on the magnetically ordered CePd_{2.02}Ge_{1.98} has been investigated by a combined measurement of electrical resistivity, $\rho(T)$, and ac-calorimetry, C(T), for temperatures in the range 0.3 K<T<10 K and pressures, p, up to 22 GPa. Simultaneously CePd_2Ge_2 has been examined by $\rho(T)$ down to 40 mK. In CePd_{2.02}Ge_{1.98} and CePd_2Ge_2 the magnetic order is suppressed at a critical pressure p_c=11.0 GPa and p_c=13.8 GPa, respectively. In the case of CePd_{2.02}Ge_{1.98} not only the temperature coefficient of $\rho(T)$, A, indicates the loss of magnetic order but also the ac-signal $1/V_{ac}\propto C/T$ recorded at low temperature. The residual resistivity is extremely pressure sensitive and passes through a maximum and then a minimum in the vicinity of p_c. The (T,p) phase diagram and the A(p)-dependence of both compounds can be qualitatively understood in terms of a pressure-tuned competition between magnetic order and the Kondo effect according to the Doniach picture. The temperature-volume (T,V) phase diagram of CePd_2Ge_2 combined with that of CePd_2Si_2 shows that in stoichiometric compounds mainly the change of interatomic distances influences the exchange interaction. It will be argued that in contrast to this the much lower p_c-value of CePd_{2.02}Ge_{1.98} is caused by an enhanced hybridization between 4f and conduction electrons.Comment: 9 pages, 7 figure

Patients' and Practitioners' Views of Knee Osteoarthritis and Its Management: A Qualitative Interview Study

PURPOSE: To identify the views of patients and care providers regarding the management of knee osteoarthritis (OA) and to reveal potential obstacles to improving health care strategies. METHODS: We performed a qualitative study based on semi-structured interviews of a stratified sample of 81 patients (59 women) and 29 practitioners (8 women, 11 general practitioners [GPs], 6 rheumatologists, 4 orthopedic surgeons, and 8 [4 GPs] delivering alternative medicine). RESULTS: Two main domains of patient views were identified: one about the patient-physician relationship and the other about treatments. Patients feel that their complaints are not taken seriously. They also feel that practitioners act as technicians, paying more attention to the knee than to the individual, and they consider that not enough time is spent on information and counseling. They have negative perceptions of drugs and a feeling of medical uncertainty about OA, which leads to less compliance with treatment and a switch to alternative medicine. Patients believe that knee OA is an inevitable illness associated with age, that not much can be done to modify its evolution, that treatments are of little help, and that practitioners have not much to propose. They express unrealistic fears about the impact of knee OA on daily and social life. Practitioners' views differ from those of patients. Physicians emphasize the difficulty in elaborating treatment strategies and the need for a tool to help in treatment choice. CONCLUSIONS: This qualitative study suggests several ways to improve the patient-practitioner relationship and the efficacy of treatment strategies, by increasing their acceptability and compliance. Providing adapted and formalized information to patients, adopting more global assessment and therapeutic approaches, and dealing more accurately with patients' paradoxal representation of drug therapy are main factors of improvement that should be addressed

Why don’t patients take their analgesics? A meta-ethnography assessing the perceptions of medication adherence in patients with osteoarthritis

Introduction/objectives: Whilst analgesics and medications have demonstrated efficacy for people with osteoarthritis, their effectiveness is dependent on adherence. This has previously been reported as particularly low in this population. The purpose of this meta-ethnography was to explore possible perceptions for this. Method: A systematic review of published and unpublished literature was undertaken. All qualitative studies assessing the attitudes or perceptions of people with osteoarthritis towards medication adherence were eligible. Study quality was assessed using the Critical Appraisal Skills Programme Qualitative tool. Analysis was undertaken using a meta-ethnography approach, distilling to a third order construct and developing a line of argument. Results: From 881 citations, five studies met the eligibility criteria. The meta-ethnography generated a model where medication adherence for people with osteoarthritis is perceived as a balance between the willingness or preference to take medications with the alterative being toleration of symptoms. Motivators to influence this ‘balance’ may fluctuate and change over time but include: severity of symptoms, education and understanding of osteoarthritis and current medications, or general health which may raise issues for poly-pharmacy as other medications are added or substituted into the patient’s formulary. Conclusions: Medicine adherence in people with osteoarthritis is complex, involving motivators which will fluctuate in impact on individuals at different points along the disease progression. Awareness of each motivator may better inform clinicians as to what education, support or change in prescription practice should be adopted to ensure that medicine adherence is individualised to better promote long-term behaviour change