Interior Design with The Bali Village Nuances At Facility Area in The Ubud Village Resort

Along with the modernization, many works of region cultural were forgotten but improve and innovate the technology especially in the design and buildings construction. Characteristic of Balinese buildings has changes since before and after the influence of Majapahit Hinduism came to Bali. The building character before the influence was mostly built by bamboos. Bamboo building in Bali can be seen in various places such as facilities areas like resort. Departing from the name of the resort is The Ubud Village Resort, the writer will optimize the interior in the resort facility area with the concept of "Kampung Bali". The design is expected to take advantage of innovations in a more modern while still preserving the culture of Bali. The Concept that were presented at this resort is to describe a village in Bali during the traditional era with the natural impression, but more dynamic and add some innovations to the art of Balinese building in order to face a period of modernization.

Desain Interoir Dengan Nuansa Kampung Bali Pada Area Fasilitas The Ubud Village Resort

Indonesia dikenal dengan Negara Maritim karena memiliki wilayah perairan yang luas dan memiliki banyak pulau. Setiap pulau memiliki keeksotisan dari ciri khas masing-masing budaya, contoh yaitu pulau Bali. Seiring dengan modernisasi banyak karya-karya yang melupakan budaya daerahnya namun jauh lebih baik dengan inovasi teknologi khususnya dalam bidang rancang bangun bangunan. Bangunan Bali mengalami perubahan-perubahan karakteristik bangunan. Bangunan bambu di Bali dapat dilihat diberbagai tempat yang bersifat fasilitas seperti resort. The Ubud Village Resort yang berlokasikan di Ubud kabupaten Gianyar, Bali merupakan salah satu akomodasi dibidang pariwisata. Berangkat dari nama resort yaitu The Ubud Village Resort yakni “Kampung Ubud” peneliti akan mengoptimalkan interior pada area fasilitas resort dengan konsep “Kampung Bali”. Dengan konsep tersebut diharapkan dapat memanfaatkan inovasiinovasi yang lebih modern dengan tetap melestarikan kebudayaan Bali. Mengangkat kebudayaan yang lebih inovatif akan berdampak kepada daya tarik pengunjung resort dikarenakan The Ubud Village mampu memberikan keunikan dan identitas pada resort secara visual. Selain ketertarikan secara visual, kenyamanan pengunjung juga perlu diperhatikan guna memertahankan kepercayaan resort sebagai tempat tujuan berelaksasi dan berekreasi. Metodologi desain meliputi pengumpulan data yang dilaksanakan secara langsung maupun tidak langsung. Data primer diperoleh melalui survei lapangan di The Ubud Village Resort untuk mengetahui kondisi eksisting. Selain itu wawancara dan analisa kuesioner bertujuan untuk mengetahui keinginan dan harapan pengunjung. Data sekunder diperoleh melalui berbagai sumber baik buku, majalah, maupun jurnal sebagai data pelengkap Konsep yang dihadirkan pada resort ini adalah menjabarkan suatu pedesaan di Bali pada masa tradisional yang menekankan kesan yang yang natural, lebih dinamis dan menambahkan inovasi seni bangunan Bali guna menghadapi masa moderenisasi ini. ========== Indonesia is known as the Maritime State because it has large waters territorial and has many islands. Each island has a characteristic of each culture, for an example is Bali island. Along with the modernization, many works of region cultural were forgotten but much better in technological innovation, especially in the design and buildings construction. Caracteristic of Balinese building has changes. Bamboo building in Bali can be seen in various places such as facilities areas like resort. The Ubud Village Resort which is located in Ubud Gianyar Bali Departing from the name of the resort is The Ubud Village Resort, the writer will optimize the interior in the resort facility area with the concept of "Kampung Bali". With these concepts are expected to take advantage of innovations in a more modern while still preserving the culture of Bali. Lifting more innovative culture will affect visitor attraction because The Ubud Village Resort is able to provide a unique and visual identity to the resort. In addition to visual interest, the convenience of visitors also need to be considered in order to maintain the loyalty as a destination for relaxation and recreation. Design methodology involves by collecting data that is held directly or indirectly. The primary data obtained surveys at The Ubud Village Resort to determine the existing condition. In addition, interviews and questionnaire analysis aims to determine the wishes and expectations of visitors. Secondary data was collected through various sources, both books, magazines, and journals as compliance data The Concept that were presented at this resort is to describe a village in Bali during the traditional emphasizes with the natural impression, but more dynamic and add some innovations to the art of Balinese building in order to face a period of modernization

Novel Arenavirus, Zambia

To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA–positive rodents (Mastomys natalensis) among 263 captured. Full-genome sequences of the viruses suggested that they were new strains similar to Lassa virus–related arenaviruses. Analyzing samples from additional rodents and other species can elucidate epizootiologic aspects of arenaviruses

Nowcast and forecast of galactic cosmic ray (GCR) and solar energetic particle (SEP) fluxes in magnetosphere and ionosphere – Extension of WASAVIES to Earth orbit

Real-time estimation of cosmic-ray fluxes on satellite orbits is one of the greatest challenges in space weather research. Therefore, we develop a system for nowcasting and forecasting the galactic cosmic ray (GCR) and solar energetic particle (SEP) fluxes at any location in the magnetosphere and ionosphere during ground-level enhancement (GLE) events. It is an extended version of the WArning System for AVIation Exposure to SEP (WASAVIES), which can determine event profiles by using real-time data of the count rates of several neutron monitors (NMs) at the ground level and high-energy proton fluxes observed by Geostationary Operational Environmental Satellites (GOES) satellites. The extended version, called WASAVIES-EO, can calculate the GCR and SEP fluxes outside a satellite based on its two-line element (TLE) data. Moreover, organ absorbed-dose and dose-equivalent rates of astronauts in the International Space Station (ISS) can be estimated using the system, considering its shielding effect. The accuracy of WASAVIES-EO was validated based on the dose rates measured in ISS, as well as based on high-energy proton fluxes observed by POES satellites during large GLEs that have occurred in the 21st century. Agreement between the nowcast and forecast dose rates in ISS, especially in terms of their temporal structures, indicates the usefulness of the developed system for future mission operations

Regulation of PD-L1 expression in non–small cell lung cancer by interleukin-1β

IntroductionProgrammed cell death–ligand 1 (PD-L1) is a biomarker for prediction of the clinical efficacy of immune checkpoint inhibitors in various cancer types. The role of cytokines in regulation of PD-L1 expression in tumor cells has not been fully characterized, however. Here we show that interleukin-1β (IL-1β) plays a key role in regulation of PD-L1 expression in non–small cell lung cancer (NSCLC).MethodsWe performed comprehensive screening of cytokine gene expression in NSCLC tissue using available single-cell RNA-Sequence data. Then we examined the role of IL-1β in vitro to elucidate its induction of PD-L1 on NSCLC cells.ResultsThe IL-1β gene is highly expressed in the tumor microenvironment, particularly in macrophages. The combination of IL-1β and interferon-γ (IFN-γ) induced a synergistic increase in PD-L1 expression in NSCLC cell lines. IL-1β and IFN-γ also cooperatively activated mitogen-activated protein kinase (MAPK) signaling and promoted the binding of downstream transcription factors to the PD-L1 gene promoter. Furthermore, inhibitors of MAPK signaling blocked upregulation of PD-L1 by IL-1β and IFN-γ.DiscussionOur study reports high levels of IL-1β in the tumor microenvironment may cooperate with IFN-γ to induce maximal PD-L1 expression in tumor cells via activation of MAPK signaling, with the IL-1β–MAPK axis being a promising therapeutic target for attenuation of PD-L1–mediated suppression of antitumor immunity

PDZRN3 Negatively Regulates BMP-2–induced Osteoblast Differentiation through Inhibition of Wnt Signaling

PDZRN3, a member of the PDZ domain–containing RING finger family of proteins plays an important role in negative feedback control of BMP-2–induced osteoblast differentiation in C2C12 mouse mesenchymal progenitor cells through inhibition of Wnt–β-catenin signaling

Dynamic Regulation of Myosin Light Chain Phosphorylation by Rho-kinase

Myosin light chain (MLC) phosphorylation plays important roles in various cellular functions such as cellular morphogenesis, motility, and smooth muscle contraction. MLC phosphorylation is determined by the balance between activities of Rho-associated kinase (Rho-kinase) and myosin phosphatase. An impaired balance between Rho-kinase and myosin phosphatase activities induces the abnormal sustained phosphorylation of MLC, which contributes to the pathogenesis of certain vascular diseases, such as vasospasm and hypertension. However, the dynamic principle of the system underlying the regulation of MLC phosphorylation remains to be clarified. Here, to elucidate this dynamic principle whereby Rho-kinase regulates MLC phosphorylation, we developed a mathematical model based on the behavior of thrombin-dependent MLC phosphorylation, which is regulated by the Rho-kinase signaling network. Through analyzing our mathematical model, we predict that MLC phosphorylation and myosin phosphatase activity exhibit bistability, and that a novel signaling pathway leading to the auto-activation of myosin phosphatase is required for the regulatory system of MLC phosphorylation. In addition, on the basis of experimental data, we propose that the auto-activation pathway of myosin phosphatase occurs in vivo. These results indicate that bistability of myosin phosphatase activity is responsible for the bistability of MLC phosphorylation, and the sustained phosphorylation of MLC is attributed to this feature of bistability

Influx of nitrogen-rich material from the outer Solar System indicated by iron nitride in Ryugu samples

Large amounts of nitrogen compounds, such as ammonium salts, may be stored in icy bodies and comets, but the transport of these nitrogen-bearing solids into the near-Earth region is not well understood. Here, we report the discovery of iron nitride on magnetite grains from the surface of the near-Earth C-type carbonaceous asteroid Ryugu, suggesting inorganic nitrogen fixation. Micrometeoroid impacts and solar wind irradiation may have caused the selective loss of volatile species from major iron-bearing minerals to form the metallic iron. Iron nitride is a product of nitridation of the iron metal by impacts of micrometeoroids that have higher nitrogen contents than the CI chondrites. The impactors are probably primitive materials with origins in the nitrogen-rich reservoirs in the outer Solar System. Our observation implies that the amount of nitrogen available for planetary formation and prebiotic reactions in the inner Solar System is greater than previously recognized

Four‐dimensional‐STEM analysis of the phyllosilicate‐rich matrix of Ryugu samples

Ryugu asteroid grains brought back to the Earth by the Hayabusa2 space mission are pristine samples containing hydrated minerals and organic compounds. Here, we investigate the mineralogy of their phyllosilicate-rich matrix with four-dimensional scanning transmission electron microscopy (4D-STEM). We have identified and mapped the mineral phases at the nanometer scale (serpentine, smectite, pyrrhotite), observed the presence of Ni-bearing pyrrhotite, and identified the serpentine polymorph as lizardite, in agreement with the reported aqueous alteration history of Ryugu. Furthermore, we have mapped the d-spacings of smectite and observed a broad distribution of values, ranging from 1 to 2 nm, with an average d-spacing of 1.24 nm, indicating significant heterogeneity within the sample. Such d-spacing variability could be the result of either the presence of organic matter trapped in the interlayers or the influence of various geochemical conditions at the submicrometer scale, suggestive of a range of organic compounds and/or changes in smectite crystal chemistry