Effect of Styrene Butadiene Rubber Latex on Mechanical Properties of Eco Concrete: Limestone Powder Concrete

To make concrete a truly green material, viable cement substitutes are available. This experimental investigation is performed to study the effect of using limestone powder (LSP) and styrene butadiene rubber (SBR) latex in the concrete mix. In this work, a concrete with 1:1.8:3 cementitious material:sand:gravel and water/cement ratio w/c of 0.5 is produced. First, LSP is used with 0, 5, 10, 15, and 20% replacements by weight of cements. The fineness of the LSP is measured using sieve No. 200 and showed about 30% pass. Second, and to improve the matrix of concrete due to the dilution effect, four ratios of SBR latex (0, 5, 10, and 15%) are added by weight of cements to the mix for each LSP ratio. Compressive strength at ages of 3, 7, 14, 28, and 90 days is tested for the concrete specimens mixed with LSP only to examine its effect on concrete strength’s development with time, whereas strengths are recorded at the age of 28 days for the other concretes. Three prisms were cast for each ratio and tested at 28 days. The results show general improvements in terms of compressive and flexural strengths

Seismic Fragility Curves for Reinforced Concrete Dual System Buildings

A seismic fragility curve is a visual representation that illustrates the likelihood of a structure surpassing a particular damage or performance limit state caused by an earthquake with a specific intensity or ground motion level. This curve is typically generated using probabilistic seismic hazard analysis and structural reliability analysis methods. It is based on statistical models that rely on past earthquake data and simulations of future earthquake scenarios to predict the structure or system’s behavior under seismic forces. In this study, the seismic performance of 30 stories of 95 m height dual system reinforced concrete buildings located in Erbil is evaluated by analyzing three distinct ground motions. A non-linear platform is used to simulate and analyze data, followed by the generation of seismic inter-story drift fragility curves using Incremental Dynamic Analysis. The buildings’ seismic structural performance is assessed based on five different performance levels, including operational phase, immediate occupancy, damage control, life safety, and collapse prevention (CP). Each level is associated with different levels of damage and corresponding degrees of functionality and safety. The fragility curves show that the building has a 50% chance of achieving or exceeding the (CP) level with highly intense ground vibrations with peak ground acceleration = 1.6 g. In addition, these curves can be beneficial in creating future local design codes and provide significant support in evaluating the seismic performance of existing buildings

Oxidant/antioxidant status in serum of breast cancer women treated by surgical interference and chemotherapy

Objectives: The study was designed to assess lipid peroxidation and oxidative defense system in patients with breast cancer, following them from the time of diagnosis through surgery and treatment. . Patients and Methods: The study was conducted in Al-Jammhori Hospital, Mosul, Iraq. Twenty three women with breast cancer types III and IV and 22 apparently healthy women as a control group were included in this study. Blood samples (5 ml) were taken from patients and controls and analysed for serum malondialdehyde (MDA) and total antioxidant status (TAS) concentration. Blood samples were taken from patients one week before and after the operation and other blood samples were taken two weeks after the first dose of infusion with a combination therapy of cyclophosphamide, 5-fluorouracil and doxorubicin. The therapy was started two weeks after the surgery every 6 weeks for 6 cycles. Results: In breast cancer women, serum MDA was significantly higher (

Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus

Saudi Arabian flora have a history of use as folklore remedies, although such properties have yet to be explored rigorously, and the safety of such remedies should be assessed. This study determined the anti-proliferative, cytotoxic, and antioxidant properties of extracts of the following five plants indigenous to Saudi Arabia: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta, and Tribulus macropterus. The aerial parts of the five plants were collected from various locations of the western and northern regions of Saudi Arabia and used to prepare methanolic extracts. Three approaches were used to determine the proliferation and cytotoxicity effects using HaCaT cells: MTT, FACS, and confocal microscopy. Meanwhile, two approaches were used to study the antioxidant potential: DPPH (acellular) and RosGlo (cellular, using HaCaT cells). C. colocynthis possessed anti-proliferative activity against HaCaT cells, showing a significant decrease in cell proliferation from 24 h onwards, while R. stricta showed significant inhibition of cell growth at 120 and 168 h. The IC50 values were determined for both plant extracts for C. colocynthis, with 17.32 and 16.91 µg/mL after five and seven days of treatment, respectively, and for R. stricta, with 175 and 105.3 µg/mL after five and seven days of treatment. R. stricta and M. crassifolia exhibited the highest capacities for scavenging the DPPH radical with IC50 values of 335 and 448 µg/mL, respectively. The subsequent ROS-Glo H2O2 assay confirmed these findings. The R. stricta and M. crassifolia extracts showed potent antioxidant activity in both acellular and cellular models. The C. colocynthis extract also demonstrated significant anti-proliferation and cytotoxic activity, as did the R. stricta extract. These properties support their usage in folk medicine and also indicate a further potential for development for holistic medicinal use or as sources of new active compounds

Optimisation of arsenic adsorption from water by carbon nanofibres grown on powdered activated carbon impregnated with nickel

Contamination of water due to arsenic (As) is increasing in many parts of the world. The removal of As from aqueous solution by using impregnated carbon nanofibres (CNFs) as the adsorbent is reported in this paper. The effects of pH, CNFs dosage, contact time and initial concentration of arsenic were studied at room temperature (±25°C). The interactions among the parameters were also investigated. The data obtained from the adsorption experiment were analysed using statistical software in order to develop a regression equation to represent the optimum operating conditions. The interactions of each parameters were considered during this analysis and the result indicated that the highest removal (97.25%) of As can be attained at pH 6, initial concentration of arsenic of 0.08 mg L-1, contact time of 60 min and CNF dosage of 200 mg L-1. Comparison between impregnated CNF and Powdered Activated Carbon (PAC) were also done and it is determined that impregnated CNF has better removal compared to PAC alone. The final concentration of As after the treatment using CNFs was about 8 ~ 10 times less than that of using PAC. Therefore, it can be concluded that CNFs are highly potential for the adsorption of As from water

Access and utilisation of primary health care services comparing urban and rural areas of Riyadh Providence, Kingdom of Saudi Arabia

The Kingdom of Saudi Arabia (KSA) has seen an increase in chronic diseases. International evidence suggests that early intervention is the best approach to reduce the burden of chronic disease. However, the limited research available suggests that health care access remains unequal, with rural populations having the poorest access to and utilisation of primary health care centres and, consequently, the poorest health outcomes. This study aimed to examine the factors influencing the access to and utilisation of primary health care centres in urban and rural areas of Riyadh province of the KSA

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Maternal mortality and morbidity burden in the Eastern Mediterranean region : findings from the Global Burden of Disease 2015 study

Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015. We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR countries. The maternal mortality ratio in the EMR decreased 16.3% from 283 (241-328) maternal deaths per 100,000 live births in 1990 to 237 (188-293) in 2015. Maternal mortality ratio was strongly correlated with socio-demographic status, where the lowest-income countries contributed the most to the burden of maternal mortality in the region. Progress in reducing maternal mortality in the EMR has accelerated in the past 15 years, but the burden remains high. Coordinated and rigorous efforts are needed to make sure that adequate and timely services and interventions are available for women at each stage of reproductive life

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations