Selective Harmonic Mitigation Technique for Cascaded H-Bridge Converters With Nonequal DC Link Voltages

Multilevel converters have received increased interest recently as a result of their ability to generate high quality output waveforms with a low switching frequency. This makes them very attractive for high power applications. A Cascaded HBridge converter is a multilevel topology which is formed from the series connection of H-Bridge cells. Optimized pulse width modulation techniques such as Selective Harmonic Elimination (SHE-PWM) or Selective Harmonic Mitigation (SHM-PWM) are capable of pre-programming the harmonic profile of the output waveform over a range of modulation indices. Such modulation methods may however not perform optimally if the DC links of the Cascaded H-Bridge Converter are not balanced. This paper presents a new SHM-PWM control strategy which is capable of meeting grid codes even under non-equal DC link voltages. The method is based on the interpolation of different sets of angles obtained for specific situations of imbalance. Both simulation and experimental results are presented to validate the proposed control method

Higher than present global mean sea level recorded by an Early Pliocene intertidal unit in Patagonia (Argentina)

Reconstructions of global mean sea level from earlier warm periods in Earth?s history can helpconstrain future projections of sea level rise. Here we report on the sedimentology and age ofa geological unit in central Patagonia, Argentina, that we dated to the Early Pliocene(4.69?5.23 Ma, 2σ) with strontium isotope stratigraphy. The unit was interpreted as representativeof an intertidal environment, and its elevation was measured with differential GPS atca. 36m above present-day sea level. Considering modern tidal ranges, it was possible toconstrain paleo relative sea level within ±2.7m (1σ). We use glacial isostatic adjustmentmodels and estimates of vertical land movement to calculate that, when the Camaronesintertidal sequence was deposited, global mean sea level was 28.4 ± 11.7m (1σ) above present.This estimate matches those derived from analogous Early Pliocene sea level proxies inthe Mediterranean Sea and South Africa. Evidence from these three locations indicates thatEarly Pliocene sea level may have exceeded 20m above its present level. Such high globalmean sea level values imply an ice-free Greenland, a significant melting of West Antarctica,and a contribution of marine-based sectors of East Antarctica to global mean sea level.Fil: Rovere, Alessio. Universitat Bremen; AlemaniaFil: Pappalardo, Marta. Universidad de Pisa; ItaliaFil: Richiano, Sebastián Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Geología y Paleontología; ArgentinaFil: Aguirre, Marina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Sandstrom, Michael R.. Columbia University; Estados UnidosFil: Hearty, Paul J.. University of Texas at Austin; Estados UnidosFil: Austermann, Jacqueline. Columbia University; Estados UnidosFil: Castellanos, Ignacio. Universidad Nacional de La Plata; ArgentinaFil: Raymo, Maureen E.. Columbia University; Estados Unido

An Early Pliocene relative sea level record from Patagonia (Argentina)

We report ciao a geological unit surveyed and dated in central Patagonia, Argentina (Camarones town, San Jorge Gulf). The unit was interpreted as representative of an intertidal environment and dated to the Early Pliocene (4.69-5.23 Ma) with strontium isotope stratigraphy. The elevation of this unit was measured with differential GPS at ca. 36 m above present-day sea level. Considering modern tidal ranges, it was possible to constrain paleo relative sea level within ±2.5m (1s). We use glacial isostatic adjustment models and estimates of vertical land movement to calculate that, when the Camarones intertidal sequence was deposited, global mean sea level was 28.4 ± 11.7m above present. This estimate matches those derived from analogous Early Pliocene sea level proxies in the Mediterranean Sea and South Africa. Evidence from these three locations indicates that Early Pliocene sea level may have exceeded 20m above its present level. Such high global mean sea level values imply an ice-free Greenland, a significant melting of West Antarctica, and a contribution of East Antarctica to global mean sea level.Los datos utilizados para este trabajo pueden accederse haciendo clic en "Documentos relacionados".Facultad de Ciencias Naturales y Muse

Mechanistic Studies on the Synthesis of Pyrrolidines and Piperidines via Copper-Catalyzed Intramolecular C–H Amination

We have recently developed a method for the synthesis of pyrrolidines and piperidines via intramolecular C–H amination of N-fluoride amides using [TpxCuL] complexes as precatalysts [Tpx = tris(pyrazolyl)borate ligand and L = THF or CH3CN]. Herein, we report mechanistic studies on this transformation, which includes the isolation and structural characterization of a fluorinated copper(II) complex, [(TpiPr2OH)CuF] [TpiPr = hydrotris(3,5-diisopropylpyrazolyl)borate], pertinent to the mechanistic pathway. The effects of the nature of the Tpx ligand in the copper catalyst as well as of the halide in the N–X amides employed as reactants have been investigated both from experimental and computational perspectives.We thank the Ministerio de Ciencia e Innovación (PID2020- 113797RB-C21, PID2020-112825RB-I00, CTQ2017-88496-R, and CEX2019-000925-S), COST Action CA15106 “C−H Activation in Organic Synthesis (CHAOS)”and Red Intecat (CTQ2016-81923-REDC), and Universidad de Huelva (P.O.Feder 2014-2020 UHU-1254043). We thank Universidad de Huelva/CBUA for funding for open access charge

Inflammatory bone loss associated with MFG‐E8 deficiency is rescued by teriparatide

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154457/1/fsb2fj201701238r-sup-0002.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154457/2/fsb2fj201701238r.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154457/3/fsb2fj201701238r-sup-0001.pd

Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis

ObjectivesTo determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD), characterize structural and tissue‐level features of BRONJ‐like lesions in this model, and examine the specific anti‐resorptive role of ZOL in BRONJ.Materials and MethodsRice rats (n = 228) consumed high sucrose‐casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125 µg/kg IV ZOL/4 weeks encompassing osteoporosis and oncology ZOL doses. Rats from each dose group (n = 9–16) were necropsied after 12, 18, 24 and 30 weeks of treatment. BRONJ‐like lesion prevalence and tissue‐level features were assessed grossly, histopathologically and by MicroCT. ZOL bone turnover effects were assessed by femoral peripheral quantitative computed tomography, serum bone turnover marker ELISAs and osteoclast immunolabelling.ResultsPrevalence of BRONJ‐like lesions was significantly associated with (a) ZOL treatment duration, but plateaued at the lowest oncologic dose, and (b) there was a similar dose‐related plateau in the systemic anti‐resorptive effect of ZOL. ZOL and BRONJ‐like lesions also altered the structural and tissue‐level features of the jaw.ConclusionThe relationship between BRONJ‐like lesion prevalence and ZOL dose and duration varies depending on the co‐ or pre‐existing oral risk factor. At clinically relevant doses of ZOL, BRONJ‐like lesions are associated with anti‐resorptive activity.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149302/1/odi13052.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149302/2/odi13052_am.pd

Definition of a list of fish diseases to aid health management in Spain

Trabajo presentado en la 14th EAFP International Conference (European Association of Fish Pathologists), celebrada en Praga (República Checa), del 14 al 19 de septiembre de 2009An expert working group used a risk ranking technique to compile a list of fish disease hazards (pathogens) of relevance to Spanish aquaculture. It was possible to divide the list into three groups: I-high national risk; II-regional risk; III-low risk. The three groups were as follows: Group I (high risk) Aphanomyces invadans (EUS)**, spring viraemia of carp virus (SVCV), koi herpes virus (KHV)¿ and infectious haematopoietic necrosis virus (IHNV)¿ Group II (regional risk) Enteromyxum spp. (leei and scophthalmi), Aquabirnaviridae (incl. IPNV), viral encephalopathy and retinopathy virus (VERV), Streptococcus iniae, Philasterides dicentrarchi and Aeromonas salmonicida (in the marine environment). Group III (low risk) Sparicotyle chrysophrii/Microcotylidae, Flavobacterium maritimus, Photobacterium piscicida, Togaviridae, Sphaerospora testicularis, Edwardsiella tarda, Birnavirus (no-EVE), Lactococcus garviae, viral haemorrhagic septicaemia virus (VHSV)¿, Tenacibaculum maritimum, epizootic haematopoietic necrosis virus (EHNV)**, Renibacterium salmoninarum (BKD) and Gyrodactylus salaris. The exercise formed part of a project concerning aquaculture health management (Jacumar-GESAC¿) in Spain and is being used to help define sampling plans for disease monitoring using epidemiological and risk-based criteria. **The diseases caused by these pathogens are notifiable and exotic according to Directive 2006/88/EC ¿The diseases caused by these pathogens are notifiable and non-exotic according to Directive 2006/88/EC ¿Plan Nacional de Cultivos Marinos; Gestión sanitaria de la acuicultura: Adaptación a la nueva normativa (GESAC) ¿ financed by the Junta Nacional Asesora de Cultivos Marinos (Jacumar

The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray.

Cross-reactivity of plant foods is an important phenomenon in allergy, with geographical variations with respect to the number and prevalence of the allergens involved in this process, whose complexity requires detailed studies. We have addressed the role of thaumatin-like proteins (TLPs) in cross-reactivity between fruit and pollen allergies. A representative panel of 16 purified TLPs was printed onto an allergen microarray. The proteins selected belonged to the sources most frequently associated with peach allergy in representative regions of Spain. Sera from two groups of well characterized patients, one with allergy to Rosaceae fruit (FAG) and another against pollens but tolerant to food-plant allergens (PAG), were obtained from seven geographical areas with different environmental pollen profiles. Cross-reactivity between members of this family was demonstrated by inhibition assays. Only 6 out of 16 purified TLPs showed noticeable allergenic activity in the studied populations. Pru p 2.0201, the peach TLP (41%), chestnut TLP (24%) and plane pollen TLP (22%) proved to be allergens of probable relevance to fruit allergy, being mainly associated with pollen sensitization, and strongly linked to specific geographical areas such as Barcelona, Bilbao, the Canary Islands and Madrid. The patients exhibited mayor que50% positive response to Pru p 2.0201 and to chestnut TLP in these specific areas. Therefore, their recognition patterns were associated with the geographical area, suggesting a role for pollen in the sensitization of these allergens. Finally, the co-sensitizations of patients considering pairs of TLP allergens were analyzed by using the co-sensitization graph associated with an allergen microarray immunoassay. Our data indicate that TLPs are significant allergens in plant food allergy and should be considered when diagnosing and treating pollen-food allergy

Prevalence and genetic diversity of Avipoxvirus in house sparrows in Spain

Avipoxvirus (APV) is a fairly common virus affecting birds that causes morbidity and mortality in wild and captive birds. We studied the prevalence of pox-like lesions and genetic diversity of APV in house sparrows (Passer domesticus) in natural, agricultural and urban areas in southern Spain in 2013 and 2014 and in central Spain for 8 months (2012±2013). Overall, 3.2% of 2,341 house sparrows visually examined in southern Spain had cutaneous lesions consistent with avian pox. A similar prevalence (3%) was found in 338 birds from central Spain. Prevalence was higher in hatch-year birds than in adults. We did not detect any clear spatial or temporal patterns of APV distribution. Molecular analyses of poxvirus-like lesions revealed that 63% of the samples were positive. Molecular and phylogenetic analyses of 29 DNA sequences from the fpv167 gene, detected two strains belonging to the canarypox clade (subclades B1 and B2) previously found in Spain. One of them appears predominant in Iberia and North Africa and shares 70% similarity to fowlpox and canarypox virus. This APV strain has been identified in a limited number of species in the Iberian Peninsula, Morocco and Hungary. The second one has a global distribution and has been found in numerous wild bird species around the world. To our knowledge, this represents the largest study of avian poxvirus disease in the broadly distributed house sparrow and strongly supports the findings that Avipox prevalence in this species in South and central Spain is moderate and the genetic diversity low.This study was funded by the Spanish Ministry of Science and Innovation (Project CGL2010-15734/BOS), the Spanish Ministry of Economy and Competitiveness (Project CGL2013-41642-P/BOS) and the Innovation and Development Agency of Andalusia (Spain) (P11-RNM-7038). Grants were awarded to JMP (Juan de la Cierva- JCI-2012-11868) and MAJM (FPIBES-2011-047609), Spanish Ministry of Economy and Competitiveness; RAJW (CEI-PICATA2012), CEI Campus of International Excellence; MM (FPU12/0568), Spanish Ministry of Education, Culture and Sports. RAJW was supported by the Craaford Foundation (grant 20160971) during the writing of this publication. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript