142 research outputs found

    Comparison between the satisfaction degree of physical education teachers with initial training and labour integration

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    La evaluación de la satisfacción de los docentes con la carrera realizada es uno de los parámetros que permiten medir la calidad de la enseñanza y mejorar el acceso a la función docente. El presente estudio trata de analizar cuál es la satisfacción del profesorado de Educación Física con la carrera realizada atendiendo a tres factores que son decisivos para el diagnóstico: la valoración de la formación inicial recibida, el acceso al mundo laboral y las experiencias profesionales. Desde estos ejes evaluamos —con una metodología mixta— las diferencias que existen entre la satisfacción de hombres y mujeres y aquellas que nacen de las opiniones de egresados de Magisterio de Educación Física y titulados de Ciencias de la Actividad Física y el Deporte. Los resultados muestran cómo la variable “sexo” nos lleva a concluir que no existen diferencias reveladoras entre la satisfacción de hombres y mujeres con la carrera, a pesar de que las motivaciones y percepciones de cada colectivo presentan variaciones. Estas diferencias son mayores atendiendo a la variable “estudios”. Las competencias prácticas en la formación recibida, los problemas de acceso a la función docente y las sensaciones negativas percibidas en los primeros destinos son algunos de los aspectos que llevan a los maestros a sentirse menos satisfechos con la carrera. El estudio concluye con la necesidad de profundizar en las barreras que hombres y mujeres tienen en la profesión y conocer si las diferencias en la satisfacción en función de los estudios aumentan con los años de experienciaThe assessment of teachers' satisfaction with their careers is one of the parameters that can be used to measure the quality of teaching and improve access to the teaching function. The present study tries to analyze the satisfaction of Physical Education teachers with the career, taking into account three factors are decisive for the diagnosis: the assessment of the initial training received, access to the world life and professional experiences. From these axes we evaluate with mixed methodology the differences that exist between the satisfaction of men and women and those that come from the opinions of Physical Education Teaching degree graduates and graduates of Sciences of Physical Activity and Sport. The results show how the variable "sex" leads us to conclude that there are no significant differences between the satisfaction of men and women with the career, despite the fact that the motivations and perceptions of each group vary. These differences are significant considering the variable "studies". The practical skills in the training received, the problems of access to the teaching function and the negative sensations perceived in the first destinations are some of the aspects that lead teachers to feel less satisfied with the career. The study concludes with the need to delve deeper into the barriers that men and women have in the profession and to know whether the differences in satisfaction according to studies increase with years of experienc

    Network-based telemetry to facilitate the programmable management plane for optical transport infrastructure

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    Large network operator environments are composed of thousands of nodes and devices capable of performing multiple roles. This network infrastructure is multi-layered, multi-vendor and underpinned by a high capacity and complex optical transport network. Managing this network requires millions of lines of configuration files and hundreds of Operational Support Systems. Typically, the management data structure uses a hierarchical namespace containing tens of thousands of object identifiers (OID). Each OID identifies a variable that can be read, modified or set via management protocol. The British Telecom network collects many millions of OIDs every 10 minutes, and executes many thousands of configuration changes per month via many tools, and multiple generations of protocols, data models and software components. Blending Software Defined Network (SDN) model-driven management and Network Functions Virtualisation (NFV), for on-demand (scale-in and scale-out) virtual network functions (Big Data nodes, network heuristics and analytics), provides an exciting opportunity for significant operational savings: reduced outage impact, simplification of management stack, fault correlation and network healing, and network usage trending for efficient resource allocation and scaling. This paper and talk outlines the management plane challenges and use cases for complex tier-1 optical environments. It discusses how we need to rethink network analytics and embrace streaming telemetry for real-time resource adaptation. It outlines a guiding network telemetry framework being developed by leading operators and the enabling community-driven technologies, and how they may be used to facilitate the programmable management plane for optical transport infrastructure

    Aprender a desobedecer, ¿una tarea necesaria para los futuros docentes?

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    In this paper we analyze the concept of Education for disobedience that the trainee-teacher students at the University of Valladolid (UVa), Spain, have when they start their basic training. In this way, we try to approach the perception that future teachers, responsible for the formation of future generations, have regarding this concept. Once they have taken the subject of Education for Peace and Equality in the Education degree, in which students are trained on issues related to Education for disobedience, we have assessed whether there is a change in the conception and attitudes associated with this type of education. To do this, we carried out a case study, during ten academic years, in which we used 1,395 open questionnaires, six group interviews with students, two individual interviews with teachers and non-participant observation records. Once the study, we concluded that there are serious deficiencies in the training of students on Education for disobedience. We underline the importance of carrying out this type of training with future teachers, since it is a way to globalize solidarity, justice and social transformation through education and peaceful acts of disobedience. This is a necessary aspect to train critical people with the capacity to transform the world in the face of inequalities and social injustices.En este trabajo analizamos el concepto de Educación para la desobediencia con el que acceden los estudiantes de Magisterio de la Universidad de Valladolid (UVa), España, a su formación inicial. De esta forma, pretendemos acercarnos a la percepción que tienen sobre el concepto los futuros docentes, encargados de la formación de las generaciones venideras. Una vez cursada la asignatura de Educación para la Paz y la Igualdad en el grado de Educación, en la que se forma a los estudiantes sobre los temas relacionados con la Educación para la desobediencia, valoramos si se produce un cambio en la concepción y actitudes sobre este tipo de educación. Para ello, llevamos a cabo un estudio de caso, durante diez cursos académicos, en el que empleamos 1.395 cuestionarios abiertos, seis entrevistas grupales a estudiantes, dos entrevistas individuales al profesorado y registros de observación no participante. Una vez llevado a cabo el estudio concluimos que existen graves carencias en la formación de los estudiantes sobre Educación para la desobediencia. Remarcamos la importancia de llevar a cabo este tipo de formación con los futuros docentes, ya que es una forma de que la solidaridad, la justicia y la transformación social se puedan globalizar a través de la educación y de actos pacíficos de desobediencia. Éste es un aspecto necesario para formar personas críticas con capacidad para transformar el mundo frente a las desigualdades e injusticias sociales

    Evaluación del trabajo de grupo a través de la participación en proyectos de aprendizaje tutorado. Reflexiones y propuestas

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    Presentamos la puesta en práctica de un Proyecto de Aprendizaje Tutorado Cooperativo (PAT), a través del Puzzle de Aronson y coordinado entre dos de las asignaturas del Título de Grado de Educación Infantil: Educación para la paz y la igualdad y Organización y planificación escolar. Materias que se imparten en el primer año de carrera, con carácter básico y con una carga lectiva de 6 créditos ECTS. Entre los objetivos propuestos destacamos: eliminar el efecto polizón (Slavin, 1999) y conseguir la participación equilibrada de los integrantes del grupo de trabajo, así como mejorar los aprendizajes obtenidos y buscar alternativas para evaluar y calificar los trabajos grupales en el ámbito universitario. La evaluación que se ha llevado a cabo en los PAT nos lleva a que asignar responsabilidades individuales dentro de los PAT, así como llevarlos a la práctica en un contexto real próximo a su futura labor como docentes, parecen dos medidas importantes para que los estudiantes asuman un mayor compromiso con el trabajo grupal

    First experimental demonstration of ABNO-driven in-operation flexgrid network re-optimization

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    The after failure repair optimization problem is used to experimentally validate in-operation planning using the ABNO architecture to control a flexgrid optical network. A back-end PCE is used to solve this computationally-intensive planning problem.Postprint (published version

    Telomere length alterations in microsatellite stable colorectal cancer and association with the immune response

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    Telomeres are repetitive sequences (TTAGGG) located at the end of chromosomes. Telomeres progressively shorten with each cell replication cycle, ultimately leading to chromosomal instability and loss of cell viability. Telomere length anomaly appears to be one of the earliest and most prevalent genetic alterations in malignant transformation. Here we aim to estimate telomere length from whole-exome sequencing data in colon tumors and normal colonic mucosa, and to analyze the potential association of telomere length with clinical factors and gene expression in colon cancer. Reads containing at least five repetitions of the telomere sequence (TTAGGG) were extracted from the raw sequences of 42 adjacent normal-tumor paired samples. The number of reads from the tumor sample was normalized to build the Tumor Telomere Length Ratio (TTLR), considered an estimation of telomere length change in the tumor compared to the paired normal tissue. We evaluated the associations between TTLR and clinical factors, gene expression and copy number (CN) aberrations measured in the same tumor samples. Colon tumors showed significantly shorter telomeres than their paired normal samples. No significant association was observed between TTLR and gender, age, tumor location, prognosis, stromal infiltration or molecular subtypes. The functional gene set enrichment analysis showed pathways related to immune response significantly associated with TLLR. By extracting a relative measure of telomere length from whole-exome sequencing data, we have assessed that colon tumor cells predominantly shorten telomeres, and this alteration is associated with expression changes in genes related to immune response and inflammation in tumor cells

    First experimental assessment of ABNO-driven in-operation flexgrid network re-optimization

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    Traffic affected by link failures can be recovered using path restoration schemes. In dynamically operated networks provided with a control plane, restoration algorithms run in a centralized element, such as the path computation element (PCE). To increase traffic restorability in flexgrid networks, multiple paths, subconnections, can be used to restore every single affected connection. However, the multipath restoration scheme might result in a poor resource utilization entailing a lesser grade of service. In-operation network planning algorithms can be used to mitigate this problem once the failed link is repaired; we propose solving the so-called multipath after failure repair optimization problem (MP-AFRO) to reduce subconnections count by aggregating those belonging to the same original connection and rerouting the resulting connection to release spectral resources. The MP-AFRO problem is modeled using a mixed integer linear program formulation. In view of the complexity of the model and the limited time to solve the problem, we propose a heuristic algorithm that provides a good tradeoff between complexity and optimality. The performance on the MP-AFRO heuristic is firstly validated by simulation. Next, the heuristic algorithm is deployed inside an in-operation planning tool in the form of back-end PCE (bPCE) inside the application-based network operations architecture controlling a network; the bPCE is connected to the centralized active stateful PCE. MP-AFRO is experimentally demonstrated using a distributed field trial test-bed connecting the premises of Telefonica (Madrid), CNIT (Pisa), and UPC (Barcelona).Peer ReviewedPostprint (author’s final draft

    Colon-specific eQTL analysis to inform on functional SNPs

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    BACKGROUND: Genome-wide association studies on colorectal cancer have identified more than 60 susceptibility loci, but for most of them there is no clear knowledge of functionality or the underlying gene responsible for the risk modification. Expression quantitative trail loci (eQTL) may provide functional information for such single nucleotide polymorphisms (SNPs). METHODS: We have performed detailed eQTL analysis specific for colon tissue on a series of 97 colon tumours, their paired adjacent normal mucosa and 47 colon mucosa samples donated by healthy individuals. R package MatrixEQTL was used to search for genome-wide cis-eQTL and trans-eQTL fitting linear models adjusted for age, gender and tissue type to rank transformed expression data. RESULTS: The cis-eQTL analyses has revealed 29,073 SNP-gene associations with permutation-adjusted P-values < 0.01. These correspond to 363 unique genes. The trans-eQTL analysis identified 10,665 significant SNP-gene associations, most of them in the same chromosome, further than 1 Mb of the gene. We provide a web tool to search for specific SNPs or genes. The tool calculates Pearson or Spearman correlation, and allows to select tissue type for analysis. Data and plots can be exported. CONCLUSIONS: This resource should be useful to prioritise SNPs for further functional studies and to identify relevant genes behind identified loci

    NTHL1 biallelic mutations seldom cause colorectal cancer, serrated polyposis or a multi-tumor phenotype, in absence of colorectal adenomas

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    In 2015 Weren et al. described a hereditary cancer syndrome caused by biallelic mutations in the DNA base excision repair gene NTHL1, characterized by attenuated adenomatous polyposis and increased colorectal cancer (CRC) risk, largely resembling the recessive syndrome caused by MUTYH mutations1. To date, 33 homozygous or compound heterozygous NTHL1 mutation carriers have been reported (21 families)1,2,3,4,5,6,7,8. More than 5 colonic adenomas (range: 6 to >50) were identified in 24 of the 28 (85%) mutation carriers who underwent colonoscopy screening, and CRC was diagnosed in 19 (68%) of them. Noteworthy, 17 carriers (57%) were diagnosed with multiple primary malignant tumors in extracolonic locations, being the most recurrently found breast and endometrial tumors, head neck squamous cell carcimomas, meningiomas, and bladder and basal cell carcinomas, suggesting that the NTHL1-associated syndrome is a multi-tumor disease rather than a solely CRC syndrome. On the other hand, the fact that at least ¼ (7/28) of the reported biallelic mutation carriers who underwent colonoscopy screening had ≤10 adenomas, and that ≥5 hyperplastic polyps were detected in five carriers (polyp number range: 5->30), lead us to suspect a possible association of NTHL1 mutations with nonpolyposis CRC and serrated/hyperplastic polyposis. Based on previous evidence and with the aim of refining the phenotypic characteristics of the NTHL1-associated syndrome, here we evaluated the implication of NTHL1 biallelic mutations in the predisposition to personal or familial history of multiple tumor types, familial/early-onset nonpolyposis CRC, and serrated/hyperplastic polyposis
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