Cooperative Communications with HARQ in a Wireless Mesh Network Based on 3GPP LTE

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 201

The Osteopontin Level in Liver, Adipose Tissue and Serum Is Correlated with Fibrosis in Patients with Alcoholic Liver Disease

<div><h3>Background</h3><p>Osteopontin (OPN) plays an important role in the progression of chronic liver diseases. We aimed to quantify the liver, adipose tissue and serum levels of OPN in heavy alcohol drinkers and to compare them with the histological severity of hepatic inflammation and fibrosis.</p> <h3>Methodology/Principal Findings</h3><p>OPN was evaluated in the serum of a retrospective and prospective group of 109 and 95 heavy alcohol drinkers, respectively, in the liver of 34 patients from the retrospective group, and in the liver and adipose tissue from an additional group of 38 heavy alcohol drinkers. Serum levels of OPN increased slightly with hepatic inflammation and progressively with the severity of hepatic fibrosis. Hepatic OPN expression correlated with hepatic inflammation, fibrosis, TGFβ expression, neutrophils accumulation and with the serum OPN level. Interestingly, adipose tissue OPN expression also correlated with hepatic fibrosis even after 7 days of alcohol abstinence. The elevated serum OPN level was an independent risk factor in estimating significant (F≥2) fibrosis in a model combining alkaline phosphatase, albumin, hemoglobin, OPN and FibroMeter® levels. OPN had an area under the receiving operator curve that estimated significant fibrosis of 0.89 and 0.88 in the retrospective and prospective groups, respectively. OPN, Hyaluronate (AUROC: 0.88), total Cytokeratin 18 (AUROC: 0.83) and FibroMeter® (AUROC: 0.90) estimated significance to the same extent in the retrospective group. Finally, the serum OPN levels also correlated with hepatic fibrosis and estimated significant (F≥2) fibrosis in 86 patients with chronic hepatitis C, which suggested that its elevated level could be a general response to chronic liver injury.</p> <h3>Conclusion/Significance</h3><p>OPN increased in the liver, adipose tissue and serum with liver fibrosis in alcoholic patients. Further, OPN is a new relevant biomarker for significant liver fibrosis. OPN could thus be an important actor in the pathogenesis of this chronic liver disease.</p> </div

Molecular Mechanisms Generating and Stabilizing Terminal 22q13 Deletions in 44 Subjects with Phelan/McDermid Syndrome

In this study, we used deletions at 22q13, which represent a substantial source of human pathology (Phelan/McDermid syndrome), as a model for investigating the molecular mechanisms of terminal deletions that are currently poorly understood. We characterized at the molecular level the genomic rearrangement in 44 unrelated patients with 22q13 monosomy resulting from simple terminal deletions (72%), ring chromosomes (14%), and unbalanced translocations (7%). We also discovered interstitial deletions between 17–74 kb in 9% of the patients. Haploinsufficiency of the SHANK3 gene, confirmed in all rearrangements, is very likely the cause of the major neurological features associated with PMS. SHANK3 mutations can also result in language and/or social interaction disabilities. We determined the breakpoint junctions in 29 cases, providing a realistic snapshot of the variety of mechanisms driving non-recurrent deletion and repair at chromosome ends. De novo telomere synthesis and telomere capture are used to repair terminal deletions; non-homologous end-joining or microhomology-mediated break-induced replication is probably involved in ring 22 formation and translocations; non-homologous end-joining and fork stalling and template switching prevail in cases with interstitial 22q13.3. For the first time, we also demonstrated that distinct stabilizing events of the same terminal deletion can occur in different early embryonic cells, proving that terminal deletions can be repaired by multistep healing events and supporting the recent hypothesis that rare pathogenic germline rearrangements may have mitotic origin. Finally, the progressive clinical deterioration observed throughout the longitudinal medical history of three subjects over forty years supports the hypothesis of a role for SHANK3 haploinsufficiency in neurological deterioration, in addition to its involvement in the neurobehavioral phenotype of PMS

The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics

To be an artist : (Gérard Gasiorowski, 1964-1986)

Gérard Gasiorowski, artiste français dont l'opus polymorphe, mais essentiellement pictural, s'est déroulé sur deux décennies seulement, a oscillé d'un photoréalisme austère et raffiné à un expressionnisme tourmenté et parfois lyrique. Mais si cette œuvre use indéniablement des moyens de la peinture, elle se veut avant tout, par son dispositif global, une réflexion critique sur la production esthétique de son temps et les différentes instances de l'art. Après une ascension fulgurante de peintre distingué, ayant épuisé les vertus de l'image, cet enfant terrible brise ses jouets pour se retrancher en un long cycle de travaux dit régressifs, avant de revenir à une interprétation grave et majestueuse de son histoire intime de l'art. Si ces trois temps de l'œuvre peuvent être lus comme des phases, ils peuvent être également considérés comme les chapitres d'un récit où l'auteur serait aussi le ou les personnages. Car, et de façon délibérée, c'est sur le registre de la fiction que l'ouvrage pictural s'est élaboré. Dérision et autodérision auront conduit Gasiorowski, pour échapper aux classifications d'usage, aux académismes, à inventer l'artiste qui saurait au mieux servir la peinture sans se servir. Car «Peinture» était pour lui corps et langage, soit une entité complexe et non un simple produit. S'appuyant sur une documentation augmentée et en partie inédite (exhumations des archives et de certaines œuvres) ainsi que sur une enquête portant sur les sources iconographiques utilisées par l'auteur, ce travail a, entre autres, permis d'établir que cette stratégie était présente, à l'œuvre, dès le début.Gérard Gasiorowski was a French artist whose polymorphic, though essentially pictorial work, was developed over two decades only, and oscillated from an austere and sophisticated photorealism to a tormented and occasionally lyrical expressionism. But if his work undeniably uses the painting medium, it claims to be, before everything and as a whole, a critical thought of the aesthetic production of his time and the different art authorities. After a dazzling ascension as a eminent painter, this terrible child, having exhausted all the properties of the image, breaks his toys to take refuge in a long cycle of so-called regressive works, before returning to a serious and majestic interpretation of his persona! history of art. If these three moments can be seen as phases of his work, they can be considered as chapters of a novel as well, in which the author would also be the character(s), for his pictorial work has been based on fiction, in a deliberate way. Mockery and self-mockery finally led Gasiorowski to invent the artist who would know how to serve painting without serving himself, in order to escape usual classifications and academicism. Because « Painting » was a body, a language, i complex entity to him, and not just a product. Based on an extended and partly new documentation (exhumation of archives and some previously unseen works) and a survey on the iconographic sources used by the artist, this dissertation has, among other things, enabled to establish that this strategy was present in Gasiorowski's work since the beginning

Les jours sans fin (présentation de la photographie de Vincent Cordebard, en couverture)

Un regard, une histoire, la beauté du regard, l’horreur de l’histoire : dans les yeux, sur le corps dont on ne peut imaginer ce qu’il a subi, un récit… sans mots. Juste un regard. Deux textes sont présentés ici : celui du peintre Philippe Agostini et celui du photographe Thierry Girard. Après leur lecture, on ne dialoguera plus jamais de la même manière avec cette jeune femme au corps strié par la plume de Vincent Cordebard… Il n’y aura plus de mots pour dire l’émotion. La beauté est-elle fi..

Toxoplasmose chez la femme enceinte et le nouveau-né (diagnostic biologique et traitement)

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF