HUBUNGAN MASA KERJA DENGAN KEJADIAN CARPAL TUNNEL SYNDROME PADA PENJAHIT SEKTOR INFORMAL DI KELURAHAN SOLOR KOTA KUPANG

Carpal Tunnel Syndrome (CTS) merupakan salah satu gangguan muskuloskeletal yang paling cepat menimbulkan gejala pada pekerja. Penelitian pada pekerjaan dengan risiko tinggi di pergelangan tangan dan tangan menunjukkan prevalensi CTS sebesar 5,6%-14,8%. Salah satu pekerjaan yang banyak melakukan aktivitas statis dengan gerakan berulang yang lama adalah penjahit. Masa kerja merupakan salah satu faktor yang dapat menyebabkan CTS pada penjahit. Gerakan berulang yang dilakukan dalam jangka waktu yang lama dapat meningkatkan risiko terjadinya CTS. Penjahit sektor informal merupakan pekerja yang seringkali luput dari perhatian pemerintah, sehingga sangat rentan mengalami CTS. Hal ini terjadi karena kurangnya pengetahuan mereka akan cara kerja yang baik dan benar sehingga mereka cenderung bekerja dengan posisi yang salah secara berulang-ulang.Tujuan penelitian ini untuk menganalisis hubungan masa kerja dengan kejadian CTS pada penjahit sektor informal di Kelurahan Solor Kota Kupang. Metodologi penelitian ini metode analisis observasional dengan rancangan cross sectional. Sampel pada penelitian ini berjumlah 41 orang dengan cara total sampling. Hasil pada penelitian ini diperoleh hasil p=0,025(p <0,05) untuk penilaian menggunakan uji Fisher's Exact Test. Kesimpulan pada penelitian ini teradapat hubungan signifikan antara masa kerja dengan kejadian Carpal Tunnel Syndrome pada penjahit sektor informal di Kelurahan Solor Kota Kupan

Should there be a future for Tablet PCs in schools?

Tablet PCs are a relatively new format of computer, which seem to offer features which may be beneficial to schools. The uptake of Tablet PCs by schools has been somewhat limited, not least due to their greater cost than laptops of a 'similar' specification. This paper explores the key question of the extent to which schools should be investing in Tablet PCs, if at all, in preference to other formats of fully functional PCs, drawing on evidence from a Becta funded evaluation of the use of Tablet PCs in schools in England conducted in 2004-2005. The Computer Practice Framework was used to develop a set of questions which helped structure a meta-analysis of the data from 12 case studies that formed part of this evaluation. The methodology used and some limitations of the evaluation are outlined, and the key findings are described. The paper concludes that Tablet PCs do appear to offer significant potential to schools, though this potential was not being fully realised in most of the case study schools. A number of specific circumstances in which Tablet PCs do appear to be the most cost effective option are also identified

HUBUNGAN ANTARA PENGETAHUAN IBU TENTANG MP-ASI DENGAN STATUS GIZI BALITA DI WILAYAH KERJA PUSKESMAS NAIBONAT

Prevalensi balita penderita gizi buruk dan gizi kurang di NTT adalah yang tertinggi di Indonesia dengan daerah tertinggi ketiga yaitu Kabupaten Kupang dengan persentase 37,6%. Terjadinya kasus gizi buruk dan gizi kurang dipengaruhi oleh beberapa faktor, salah satunya yaitu pemberian asupan gizi yang kurang baik yang disebabkan oleh banyak faktor, termasuk pengetahuan ibu tentang jenis dan cara pemberian asupan gizi pada anak. Tujuan penelitian  ini bertujuan untuk mengetahui apakah ada hubungan antara pengetahuan ibu tentang MP-ASI dengan status gizi balita di wilayah kerja Puskesmas Naibonat. Metode penelitian bersifat analitik observasional dengan pendekatan cross-sectional. Sampel penelitian adalah ibu dengan anak berusia balita berjumlah 91 orang. Metode analisis yang digunakan adalah chi square. Instrumen penelitian yang digunakan adalah kuesioner dengan 14 pertanyaan. Hasil dari penelitian ini berdasarkan skor pengetahuan ibu tentang MP-ASI, 64,83%(59 orang) adalah ibu dengan skor pengetahuan kurang, sedangkan berdasarkan status gizi balita, 58,24%(53 orang) memiliki status gizi baik. Nilai ρ= 0.695 yang didapatkan setelah penelitian, menunjukkan bahwa tidak ada korelasi yang signifikan antara pengetahuan ibu tentang MP-ASI dengan status gizi balita. Kesimpulan tidak terdapat hubungan antara pengetahuan ibu tentang MP-ASI dengan status gizi balita di wilayah kerja Puskesmas Naibonat

Medium-term Outcomes of Myocarditis and Pericarditis following BNT162b2 Vaccination among Adolescents in Hong Kong

In this study, we examined the clinical and electrophysiological outcomes of adolescents in Hong Kong who developed myocarditis or pericarditis following BNT162b2 vaccination for COVID-19, and followed-up for 60 to 180 days after their initial diagnosis. Clinical assessments included electrocardiogram (ECG) and echocardiogram at the initial admission and follow-up were compared. Treadmill testing was also performed in some cases. Between 14 June 2021 and 16 February 2022, 53 subjects were approached to participate in this follow-up study, of which 28 patients were followed up for >60 days with a median follow-up period of 100 days (range, 61-178 days) and were included in this study. On admission, 23 patients had ECG abnormalities but no high-grade atrioventricular block. Six patients had echocardiogram abnormalities, including reduced contractility, small rim pericardial effusions, and hyperechoic ventricular walls. All patients achieved complete recovery on follow-up. After discharge, 10 patients (35.7%) reported symptoms, including occasional chest pain, shortness of breath, reduced exercise tolerance, and recurrent vasovagal near-syncope. At follow-up, assessments, including ECGs, were almost all normal. Among the three patients with possible ECG abnormalities, all their echocardiograms or treadmill testings were normal. Sixteen patients (57.1%) underwent treadmill testing at a median of 117 days post-admission, which were also normal. However, at follow-up, there was a significant mean bodyweight increase of 1.81kg (95%CI 0.47-3.1 kg, p=0.01), possibly due to exercise restriction. In conclusion, most adolescents experiencing myocarditis and pericarditis following BNT162b2 vaccination achieved complete recovery. Some patients developed non-specific persistent symptoms, and bodyweight changes shall be monitored

Alzheimer\u27s Therapeutics Targeting Amyloid Beta 1-42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors is Displaced by Drug Candidates That Improve Cognitive Deficits

Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer\u27s disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression that is the basis for inhibition of electrophysiological measures of synaptic plasticity and thus learning and memory. We have utilized phenotypic screens in mature, in vitro cultures of rat brain cells to identify small molecules which block or prevent the binding and effects of Abeta oligomers. Synthetic Abeta oligomers bind saturably to a single site on neuronal synapses and induce deficits in membrane trafficking in neuronal cultures with an EC50 that corresponds to its binding affinity. The therapeutic lead compounds we have found are pharmacological antagonists of Abeta oligomers, reducing the binding of Abeta oligomers to neurons in vitro, preventing spine loss in neurons and preventing and treating oligomer-induced deficits in membrane trafficking. These molecules are highly brain penetrant and prevent and restore cognitive deficits in mouse models of Alzheimer\u27s disease. Counter-screening these compounds against a broad panel of potential CNS targets revealed they are highly potent and specific ligands of the sigma-2/PGRMC1 receptor. Brain concentrations of the compounds corresponding to greater than 80% receptor occupancy at the sigma-2/PGRMC1 receptor restore cognitive function in transgenic hAPP Swe/Ldn mice. These studies demonstrate that synthetic and human-derived Abeta oligomers act as pharmacologically-behaved ligands at neuronal receptors--i.e. they exhibit saturable binding to a target, they exert a functional effect related to their binding and their displacement by small molecule antagonists blocks their functional effect. The first-in-class small molecule receptor antagonists described here restore memory to normal in multiple AD models and sustain improvement long-term, representing a novel mechanism of action for disease-modifying Alzheimer\u27s therapeutics

High HIV Incidence and Sexual Behavior Change among Pregnant Women in Lilongwe, Malawi: Implications for the Risk of HIV Acquisition

HIV incidence is higher among pregnant women than their non-pregnant counterparts in some sub-Saharan African settings. Our aims were (1) to estimate HIV incidence during pregnancy and (2) to compare sexual activity between pregnant, postpartum, and non-pregnant women.We examined a retrospective cohort of 1087 women to identify seroconverters using antenatal and labor ward HIV test results. We also conducted a cross-sectional survey, including a quantitative questionnaire (n = 200) and in-depth interviews (n = 20) among women in early pregnancy, late pregnancy, postpartum, and non-pregnancy. Outcomes included measures of sexual activity, reported spouse's risky behavior, and beliefs about abstinence.11 of 1087 women seroconverted during pregnancy yielding a 1% seroconversion risk and an incidence rate of 4.0/100 person years (95% CI 2.2-7.2). The reported sexual activity of the early pregnancy and non-pregnancy groups was similar, but significantly higher than the late pregnancy and postpartum groups (p<0.001). During pregnancy, sex acts decreased as gestation increased (p = 0.001). There was no reported difference in the spouse's risky behavior. Most women believed that sex should cease between the 6(th) and 8(th) month of pregnancy and should not resume until 6 months postpartum. Some talked about conflict between their cultural obligation to abstain and fear of HIV infection if their spouses find other partners.HIV incidence is high among pregnant women in Malawi, and sexual activity decreases during pregnancy and postpartum. Pregnant women need to be informed of their increased risk for HIV and the importance of using condoms throughout pregnancy and the postpartum period

Consensus guidelines for the use and interpretation of angiogenesis assays

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference

25th Annual Computational Neuroscience Meeting: CNS-2016

Abstracts of the 25th Annual Computational Neuroscience Meeting: CNS-2016 Seogwipo City, Jeju-do, South Korea. 2–7 July 201