2000 Commencement Program

Contains the names of degree recipients and commencement speakers, an order of exercises, and other related information.https://digitalcommons.assumption.edu/commencement-programs/1054/thumbnail.jp

Validation of a capillary zone electrophoresis method for the determination of ciprofloxacin, gatifloxacin, moxifloxacin and ofloxacin in pharmaceutical formulations

An alternative capillary zone electrophoresis (CZE) method for the determination of ciprofloxacin (CPFLX), gatifloxacin (GTFLX), moxifloxacin (MFLX) and ofloxacin (OFLX) through a simple aqueous electrolyte system consisting of 25 mmol L-1 of TRIS/ hydrochloride and 15 mmol L-1 of sodium tetraborate buffer mixture (pH 8.87) using direct UV detection at 282 nm within 3 min was validated. The analytical parameters of validation evaluated were: linearity (r > 0.998), selectivity (comparison between slope of the calibration curve of external standard and calibration curve of standard addition), repeatability in area for sample (RSD%: < 3.94% for CPFLX, < 3.87% for GTFLX, 1.30% for MFLX and < 1.88% for OFLX), intermediate precision in area for sample (RSD%: < 3.59% for CPFLX, < 3.09% for GTFLX, 2.67% for MFLX and < 2.25% for OFLX), accuracy (mean of recovery range: 101.2% for CPFLX, 101.0% for GTFLX, 101.3% for MFLX and 99.9% for OFLX), limit of detection (mg L-1: 2.72 for CPFLX, 1.92 for GTFLX, 0.795 for MFLX and 1.05 for OFLX), limit of quantification (mg L-1: 9.06 for CPFLX, 6.40 for GTFLX, 2.65 for MFLX and 3.50 for OFLX) and robustness. Due to its simplicity, selectivity, precision, accuracy and rapidity, the methodology can be an interesting alternative for quality assurance in the pharmaceutical industry of these drugs

Degradation prediction model for friction in highways

The purpose of this paper is to develop a multiple linear regression model that describes the pavement’s friction behaviour using a degradation evo- lution law that also considers the effects of weather, vertical alignment and traf- fic factors. This study is based on real data obtained from two different highways with an approximate total length of 43 km. These sections present different alignment features (plan/profile), different Annual Average Daily Traffic and are subject- ed to different weather conditions. Nevertheless, both comprise the same type of upper layer. The efficiency of the linear regression model in approaching and explaining da- ta was demonstrated. The most relevant factors involved in the degradation pro- cess of pavements’ friction were identified.Fundação para a Ciência e a Tecnologia (FCT

Prediction of friction degradation in highways with linear mixed models

The development of a linear mixed model to describe the degradation of friction on flexible road pavements to be included in pavement management systems is the aim of this study. It also aims at showing that, at the network level, factors such as temperature, rainfall, hypsometry, type of layer, and geometric alignment features may influence the degradation of friction throughout time. A dataset from six districts of Portugal with 7204 sections was made available by the Ascendi Concession highway network. Linear mixed models with random effects in the intercept were developed for the two-level and three-level datasets involving time, section and district. While the three-level models are region-specific, the two-level models offer the possibility to be adopted to other areas. For both levels, two approaches were made: One integrating into the model only the variables inherent to traffic and climate conditions and the other including also the factors intrinsic to the highway characteristics. The prediction accuracy of the model was improved when the variables hypsometry, geometrical features, and type of layer were considered. Therefore, accurate predictions for friction evolution throughout time are available to assist the network manager to optimize the overall level of road safety.This research was funded by FCT—Fundação para a Ciência e Tecnologia (Foundation for Science and Technology), Grants No. UIDB/04029/2020 and UIDB/00319/2020

Comparison of extraction methods for kahweol and cafestol analysis in roasted coffee

Não InformadoKahweol and cafestol, diterpenes from the unsaponifiable fraction of coffee, present known effects on human health such as anticarcinogenic and hipercholesterolemic activities. There are discrepancies regarding the levels reported for these compounds in roasted coffee, probably due to the extraction processes. Therefore, four sample preparation methods were studied: direct hot saponification (DHS), direct cold saponification (DCS); and Bligh and Dyer (BD) or Soxhlet (SO) extraction followed by saponification. The levels of diterpenes and their dehydro derivatives obtained by high performance liquid chromatography with diode array and mass spectrometry detectors (HPLC-DAD-MS/MS) and the chromatographic profiles of roasted coffee, obtained by these four methods, were compared. DHS was more efficient for extraction, showing better separation of chromatographic peaks and levels of 930.2 (± 36.8), 113.2 (± 4.7), 568.6 (± 16.6) and 87.1 (± 3.7) mg 100 g-1 for kahweol, dehydrokahweol, cafestol and dehydrocafestol, respectively. The DHS extract presented a diterpene content (kahweol and cafestol) 15% superior to that of DCS and up to 88% superior than using SO and BD methods.Kahweol and cafestol, diterpenes from the unsaponifiable fraction of coffee, present known effects on human health such as anticarcinogenic and hipercholesterolemic activities. There are discrepancies regarding the levels reported for these compounds in roasted coffee, probably due to the extraction processes. Therefore, four sample preparation methods were studied: direct hot saponification (DHS), direct cold saponification (DCS)and Bligh and Dyer (BD) or Soxhlet (SO) extraction followed by saponification. The levels of diterpenes and their dehydro derivatives obtained by high performance liquid chromatography with diode array and mass spectrometry detectors (HPLC-DAD-MS/MS) and the chromatographic profiles of roasted coffee, obtained by these four methods, were compared. DHS was more efficient for extraction, showing better separation of chromatographic peaks and levels of 930.2 (± 36.8), 113.2 (± 4.7), 568.6 (± 16.6) and 87.1 (± 3.7) mg 100 g-1 for kahweol, dehydrokahweol, cafestol and dehydrocafestol, respectively. The DHS extract presented a diterpene content (kahweol and cafestol) 15% superior to that of DCS and up to 88% superior than using SO and BD methods.Kahweol and cafestol, diterpenes from the unsaponifiable fraction of coffee, present known effects on human health such as anticarcinogenic and hipercholesterolemic activities. There are discrepancies regarding the levels reported for these compounds in roasted coffee, probably due to the extraction processes. Therefore, four sample preparation methods were studied: direct hot saponification (DHS), direct cold saponification (DCS)and Bligh and Dyer (BD) or Soxhlet (SO) extraction followed by saponification. The levels of diterpenes and their dehydro derivatives obtained by high performance liquid chromatography with diode array and mass spectrometry detectors (HPLC-DAD-MS/MS) and the chromatographic profiles of roasted coffee, obtained by these four methods, were compared. DHS was more efficient for extraction, showing better separation of chromatographic peaks and levels of 930.2 (± 36.8), 113.2 (± 4.7), 568.6 (± 16.6) and 87.1 (± 3.7) mg 100 g-1 for kahweol, dehydrokahweol, cafestol and dehydrocafestol, respectively. The DHS extract presented a diterpene content (kahweol and cafestol) 15% superior to that of DCS and up to 88% superior than using SO and BD methods.243492492499Não InformadoNão InformadoCaveol e cafestol, diterpenos da fração lipídica do café, têm efeitos conhecidos na saúde humana, como atividade anticarcinogênica e hipercolesterolêmica. Existem divergências quanto às concentrações desses compostos reportadas para café torrado, provavelmente devido aos processos de extração empregados. Assim, quatro métodos de preparo de amostra foram estudados: saponificação direta a quente (SDQ), saponificação direta a frio (SDF)e extração por Bligh e Dyer (BD) ou soxhlet (SO) seguida de saponificação. Teores dos diterpenos e seus dehidroderivados obtidos por cromatografia líquida de alta eficiência acoplada a detector de arranjo de diodos e espectrometria de massa (HPLC-DAD-MS/MS) e perfis cromatográficos de café torrado, obtidos pelos quatro métodos, foram comparados. SDQ foi mais eficiente quanto à extração, mostrando melhor separação dos picos cromatográficos e teores de 930,2 (± 36,8), 113,2 (± 4,7), 568,6 (± 16,6) e 87,1 (± 3,7) mg 100 g-1 para caveol, dehidrocaveol, cafestol e dehidrocafestol, respectivamente. O extrato SDQ apresentou teores de diterpenos (caveol e cafestol) 15% superiores àqueles obtidos por SDF e até 88% maiores que pelos métodos SO e BD.Kahweol and cafestol, diterpenes from the unsaponifiable fraction of coffee, present known effects on human health such as anticarcinogenic and hipercholesterolemic activities. There are discrepancies regarding the levels reported for these compounds in roasted coffee, probably due to the extraction processes. Therefore, four sample preparation methods were studied: direct hot saponification (DHS), direct cold saponification (DCS)and Bligh and Dyer (BD) or Soxhlet (SO) extraction followed by saponification. The levels of diterpenes and their dehydro derivatives obtained by high performance liquid chromatography with diode array and mass spectrometry detectors (HPLC-DAD-MS/MS) and the chromatographic profiles of roasted coffee, obtained by these four methods, were compared. DHS was more efficient for extraction, showing better separation of chromatographic peaks and levels of 930.2 (± 36.8), 113.2 (± 4.7), 568.6 (± 16.6) and 87.1 (± 3.7) mg 100 g-1 for kahweol, dehydrokahweol, cafestol and dehydrocafestol, respectively. The DHS extract presented a diterpene content (kahweol and cafestol) 15% superior to that of DCS and up to 88% superior than using SO and BD methods.Caveol e cafestol, diterpenos da fração lipídica do café, têm efeitos conhecidos na saúde humana, como atividade anticarcinogênica e hipercolesterolêmica. Existem divergências quanto às concentrações desses compostos reportadas para café torrado, provavelmente devido aos processos de extração empregados. Assim, quatro métodos de preparo de amostra foram estudados: saponificação direta a quente (SDQ), saponificação direta a frio (SDF)e extração por Bligh e Dyer (BD) ou soxhlet (SO) seguida de saponificação. Teores dos diterpenos e seus dehidroderivados obtidos por cromatografia líquida de alta eficiência acoplada a detector de arranjo de diodos e espectrometria de massa (HPLC-DAD-MS/MS) e perfis cromatográficos de café torrado, obtidos pelos quatro métodos, foram comparados. SDQ foi mais eficiente quanto à extração, mostrando melhor separação dos picos cromatográficos e teores de 930,2 (± 36,8), 113,2 (± 4,7), 568,6 (± 16,6) e 87,1 (± 3,7) mg 100 g-1 para caveol, dehidrocaveol, cafestol e dehidrocafestol, respectivamente. O extrato SDQ apresentou teores de diterpenos (caveol e cafestol) 15% superiores àqueles obtidos por SDF e até 88% maiores que pelos métodos SO e BD.Kahweol and cafestol, diterpenes from the unsaponifiable fraction of coffee, present known effects on human health such as anticarcinogenic and hipercholesterolemic activities. There are discrepancies regarding the levels reported for these compounds in roasted coffee, probably due to the extraction processes. Therefore, four sample preparation methods were studied: direct hot saponification (DHS), direct cold saponification (DCS)and Bligh and Dyer (BD) or Soxhlet (SO) extraction followed by saponification. The levels of diterpenes and their dehydro derivatives obtained by high performance liquid chromatography with diode array and mass spectrometry detectors (HPLC-DAD-MS/MS) and the chromatographic profiles of roasted coffee, obtained by these four methods, were compared. DHS was more efficient for extraction, showing better separation of chromatographic peaks and levels of 930.2 (± 36.8), 113.2 (± 4.7), 568.6 (± 16.6) and 87.1 (± 3.7) mg 100 g-1 for kahweol, dehydrokahweol, cafestol and dehydrocafestol, respectively. The DHS extract presented a diterpene content (kahweol and cafestol) 15% superior to that of DCS and up to 88% superior than using SO and BD methods

Determination of losartan associated with chlorthalidone or hydrochlorothiazide in capsules by capillary zone electrophoresis

An alternative methodology by capillary zone electrophoresis (CZE) is proposed for the determination of losartan potassium (LOS) associated with chlorthalidone (CTD) or hydrochlorothiazide (HCT) in capsules, using 50 mmol L-1 of sodium carbonate buffer with detection at 226 nm. The electrolyte system was optimized, taking into account peak profiles, resolution, run times, baseline stability and repeatability (adsorption absence). The method was successfully applied to the analysis of pharmaceutical formulations purchased in manipulation drugstores. The analytes were baseline separated in less than 5 min. The results did not present significant difference in the 95% confidence interval in relation to the label claim values. The method can be applied to analyze these compounds and could also be employed in other similar formulated products containing these drugs

Callous-unemotional traits moderate anticipated guilt and wrongness judgments to everyday moral transgressions in adolescents

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.625328/full#supplementary-materialCallous-unemotional (CU) traits observed during childhood and adolescence are thought to be precursors of psychopathic traits in adulthood. Adults with high levels of psychopathic traits typically present antisocial behavior. Such behavior can be indicative of atypical moral processing. Evidence suggests that moral dysfunction in these individuals may stem from a disruption of affective components of moral processing rather than from an inability to compute moral judgments per se. No study to date has tested if the dissociation between affective and cognitive dimensions of moral processing linked to psychopathic traits in adulthood is also linked to CU traits during development. Here, 47 typically developing adolescents with varying levels of CU traits completed a novel, animated cartoon task depicting everyday moral transgressions and indicated how they would feel in such situations and how morally wrong the situations were. Adolescents with higher CU traits reported reduced anticipated guilt and wrongness appraisals of the transgressions. However, our key finding was a significant interaction between CU traits and anticipated guilt in predicting wrongness judgments. The strength of the association between anticipated guilt and wrongness judgement was significantly weaker for those with higher levels of CU traits. This evidence extends our knowledge on the cognitive-affective processing deficits that may underlie moral dysfunction in youth who are at heightened risk for antisocial behavior and psychopathy in adulthood. Future longitudinal research is required to elucidate whether there is an increased dissociation between different components of moral processing from adolescence to adulthood for those with high psychopathic traits.This study was supported by the Portuguese Foundation for Science and Technology (FCT) research grant awarded to AS-C (PTDC/MHC-PCN/2296/2014), co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-016747). The study was conducted at the Psychology Research Center (PSI/01662), School of Psychology, University of Minho, supported by FCT through the Portuguese State Budget (Ref.: UIDB/PSI/01662/2020)

Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions : a double blinded crossover study

Using a double-blinded randomized crossover design, this study aimed to evaluate acute postoperative pain management, swelling and trismus in 46 volunteers undergoing extractions of the two lower third molars, in similar positions, at two different appointments who consumed a tablet of either NE (naproxen 500 mg + esomepraz ole 20 mg) or only naproxen (500 mg) every 12 hours for 4 days. Parameters were analyzed: self-reported pain intensity using a visual analog scale (VAS) pre- and postoperative mouth opening; incidence, type and severity of adverse reactions; total quantity consumed of rescue medication; and pre- and postoperative swelling. Female volunteers reported significantly more postoperative pain at 1, 1.5, 2, 3 and 4hrs after surgery while also taking their first rescue medication at a time significantly earlier when consuming NE when compared to naproxen (3.7hrs and 6.7hrs). Conversely, no differences were found between each drug group in males. In conclusion, throughout the entire study, pain was mild after using either drug in both men and women with pain scores on average well below 40mm (VAS), although in women naproxen improved acute postoperative pain management when compared to NE

Life Cycle Inventory for artisanal production of Macauba liquor in the territory of Serro / Minas Gerais

A Macaúba (Acrocomia aculeata) é uma palmeira perene, com ampla produtividade. Presente em diferentes ecossistemas brasileiros, é encontrada na Região do Serro, Minas Gerais, como uma árvore nativa. Diante das diversas possibilidades de aproveitamento do fruto, o objetivo deste artigo é analisar os impactos ambientais advindos da produção do licor de macaúba, no território do Serro-MG, por meio da metodologia de Avaliação do Ciclo de Vida. O inventário realizado identificou um ciclo de vida que inclui 12 processos, desde o crescimento da fruta, até o consumo do licor. Por se tratar de uma bebida, cujo final do ciclo de vida gera resíduos passíveis de reuso e reciclagem, o principal impacto identificado refere-se às emissões de CO2 , advindas dos transportes necessários nos processos. Ainda assim, deve ser considerado o sequestro de carbono, realizado pelas próprias palmeiras de macaúba, durante seu crescimento.Macauba (Acrocomia aculeata) is a perennial palm tree, which has ample productivity. Present in different Brazilian ecosystems, it is found in the Serro Region, Minas Gerais, Brazil, as a native tree. Given the various possibilities of using the fruit, the objective of this paper is to analyse the environmental impacts arising from the production of macauba liquor, in the Serro-MG territory, through the Life Cycle Assessment methodology. The inventory carried out identified a life cycle that includes 12 processes, from the growth of the fruit to the consumption of the liquor. As it is a drink, the end of the life cycle of which generates waste that can be reused and recycled, the main impact identified refers to CO2 emissions, resulting from the necessary transport in the processes. Even so, carbon sequestration, carried out by the macauba palms themselves, during their growth must be considered