Prevention of Decubitus Ulcers in the Clinical Setting

https://scholarworks.moreheadstate.edu/student_scholarship_posters/1084/thumbnail.jp

Concert recording 2018-02-20b

[Track 1]. Se tu m\u27ami / Alessandro Parisotti -- [Track 2]. Feldeinsamkeit / Johannes Brahms -- [Track 3]. Im abendrot / Franz Schubert -- [Track 4]. Les chemins d\u27lamour / Francis Poulenc -- [Track 5]. Oh, glory! / Hall Johnson, arranger -- [Track 6]. Heiss mich nicht reden / Robert Schumann

Cosmological perturbations on local systems

We study the effect of cosmological expansion on orbits--galactic, planetary, or atomic--subject to an inverse-square force law. We obtain the laws of motion for gravitational or electrical interactions from general relativity--in particular, we find the gravitational field of a mass distribution in an expanding universe by applying perturbation theory to the Robertson-Walker metric. Cosmological expansion induces an ($\ddot a/a) \vec r$ force where $a(t)$ is the cosmological scale factor. In a locally Newtonian framework, we show that the $(\ddot a/a) \vec r$ term represents the effect of a continuous distribution of cosmological material in Hubble flow, and that the total force on an object, due to the cosmological material plus the matter perturbation, can be represented as the negative gradient of a gravitational potential whose source is the material actually present. We also consider the effect on local dynamics of the cosmological constant. We calculate the perihelion precession of elliptical orbits due to the cosmological constant induced force, and work out a generalized virial relation applicable to gravitationally bound clusters.Comment: 10 page

Concert recording 2018-02-20a

[Track 1]. Fünf Orchesterlieder nach Ansichtenkartentexten von Peter Altenberg, op. 4. I. Seele, wie bist du schöner... [Track 2]. II. Sahst du nach dem Gewitterregen [Track 3]. III. Über die Grenzen des All [Track 4]. IV. Nichts ist gekommen [Track 5]. V. Hier ist Friede / Alban Berg -- [Track 6]. Flowers of heaven. Three songs on Korean poetry for soprano and cello. I. The home village [Track 7]. II. Wildflowers of the mountain [Track 8]. III. Return to heaven / Robert Mueller -- [Track 9]. Buru for voice and chamber ensemble / Suhki Kang -- [Track 10]. Little sketches for soprano and flute / Ivan Elezovic -- [Track 11]. Labyrinth of love for soprano and small chamber ensemble. II. Eros (Sappho fragment 47) [Track 12]. VI. Liz\u27s lament [Track 13]. VIII. Short talk on the sensation of aeroplane takeoff / Michael Daugherty

Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands

5-HT and 5-HT receptors have been at the center of discussions recently due in part to their major role in the etiology of major central nervous system diseases such as depression, sleep disorders, and schizophrenia. As part of our search to identify dual targeting ligands for these receptors, we have carried out a systematic modification of a selective 5HT receptor ligand culminating in the identification of several dual 5-HT and 5-HT receptor ligands. Compound , a butyrophenone derivative of tetrahydroisoquinoline (THIQ), was identified as the most potent agent with low nanomolar binding affinities to both receptors. Interestingly, compound also displayed moderate affinity to other clinically relevant dopamine receptors. Thus, it is anticipated that compound may serve as a lead for further exploitation in our quest to identify new ligands with the potential to treat diseases of CNS origin

Concert recording 2019-03-30c

[Track 1]. Kokopelli / Katherine Hoover -- [Track 2]. Mélodie in C-sharp minor, op. 4, no. 2 Notturno in G minor / Fanny Cecile Mendelssohn -- [Track 3]. Cowboy songs / Libby Larsen -- [Track 4]. Sound bytes. I. Invention II. Thirds III. Short circuit IV. Get up / Katherine Hoover -- [Track 5]. Overheard on a saltmarsh / Erin Goad -- [Track 6]. Sonatina for clarinet and piano / Caroline Schleicher Krämer -- [Track 7]. Winter spirits / Katherine Hoover -- [Track 8]. The butterfly from I never saw another butterfly / Lori Laitman -- [Track 9]. Erratic polka from Demented dances / Elizabeth Greener -- [Track 10]. Original Latin-American flute duets. I. Pasaje folia II. Torbellino III. Bolero Rhumba IV. Polka Chocoana / Carmen Liliana Marulanda -- [Track 11]. Trio for flute, oboe, and piano / Madeleine Dring

Concert recording 2018-02-09

[Track 1]. Marche á huit instrumens á vent / Nannette Streicher -- [Track 2]. Dixtuor pour instruments á vent. I. Allegro moderato II. Moderato [Track 3]. III. Andante - Allegro scherzando [Track 4]. IV. Cantabile [Track 5]. V. Allegro risoluto / Claude Arrieu, née Louise Marie Simon -- [Track 6]. Octet for windinstruments / Tera de Marez Oyens -- [Track 7]. The unfortunate traveller, suite for brass band. I. Introduction II. Scherzo [Track 8]. III. Interlude [Track 9]. IV. March / Imogen Holst

Unexpected Inheritance: Multiple Integrations of Ancient Bornavirus and Ebolavirus/Marburgvirus Sequences in Vertebrate Genomes

Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the course of evolution. Until recently they were thought to be the only type of RNA viruses to be so represented, because integration of a DNA copy of their genome is required for their replication. In this study, an extensive sequence comparison was conducted in which 5,666 viral genes from all known non-retroviral families with single-stranded RNA genomes were matched against the germline genomes of 48 vertebrate species, to determine if such viruses could also contribute to the vertebrate genetic heritage. In 19 of the tested vertebrate species, we discovered as many as 80 high-confidence examples of genomic DNA sequences that appear to be derived, as long ago as 40 million years, from ancestral members of 4 currently circulating virus families with single strand RNA genomes. Surprisingly, almost all of the sequences are related to only two families in the Order Mononegavirales: the Bornaviruses and the Filoviruses, which cause lethal neurological disease and hemorrhagic fevers, respectively. Based on signature landmarks some, and perhaps all, of the endogenous virus-like DNA sequences appear to be LINE element-facilitated integrations derived from viral mRNAs. The integrations represent genes that encode viral nucleocapsid, RNA-dependent-RNA-polymerase, matrix and, possibly, glycoproteins. Integrations are generally limited to one or very few copies of a related viral gene per species, suggesting that once the initial germline integration was obtained (or selected), later integrations failed or provided little advantage to the host. The conservation of relatively long open reading frames for several of the endogenous sequences, the virus-like protein regions represented, and a potential correlation between their presence and a species' resistance to the diseases caused by these pathogens, are consistent with the notion that their products provide some important biological advantage to the species. In addition, the viruses could also benefit, as some resistant species (e.g. bats) may serve as natural reservoirs for their persistence and transmission. Given the stringent limitations imposed in this informatics search, the examples described here should be considered a low estimate of the number of such integration events that have persisted over evolutionary time scales. Clearly, the sources of genetic information in vertebrate genomes are much more diverse than previously suspected

Comparative Bacterial Proteomics: Analysis of the Core Genome Concept

While comparative bacterial genomic studies commonly predict a set of genes indicative of common ancestry, experimental validation of the existence of this core genome requires extensive measurement and is typically not undertaken. Enabled by an extensive proteome database developed over six years, we have experimentally verified the expression of proteins predicted from genomic ortholog comparisons among 17 environmental and pathogenic bacteria. More exclusive relationships were observed among the expressed protein content of phenotypically related bacteria, which is indicative of the specific lifestyles associated with these organisms. Although genomic studies can establish relative orthologous relationships among a set of bacteria and propose a set of ancestral genes, our proteomics study establishes expressed lifestyle differences among conserved genes and proposes a set of expressed ancestral traits

Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies

First published: 16 February 202