1,030 research outputs found
A Community Conversation on Adolescent Pregnancy and Parenting Services: Networks of Support, Gatekeepers to Care, and Non-Compulsory Fathering in a Black Urban Community
This study employed Community-Based Participatory Research (CBPR) methods to document needs and capacity around adolescent pregnancy and parenting in one predominately Black, low-income urban community. Using an iterative focus group method, we engaged 60 participants in a two-day community conversation. Quantitative data from an enrollment questionnaire and qualitative transcripts of the discussions are analyzed. Our results indicate that the community’s greatest capacity lies in a network of women. Men tend to participate in parenting more holistically once formal paternity is established. Neighborhood women typically introduce adolescents to prenatal care, so delays in revealing the pregnancy to them serves as a barrier to accessing prenatal care. Overall, participants want health agencies to uphold their formal social contracts with the community, but to entrust informal services to community members who have the necessary insight and expertise to deliver support and information that is usable in their social context
Excitation of High-Spin States by Inelastic Proton Scattering
This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit
The MOLDY short-range molecular dynamics package
We describe a parallelised version of the MOLDY molecular dynamics program.
This Fortran code is aimed at systems which may be described by short-range
potentials and specifically those which may be addressed with the embedded atom
method. This includes a wide range of transition metals and alloys. MOLDY
provides a range of options in terms of the molecular dynamics ensemble used
and the boundary conditions which may be applied. A number of standard
potentials are provided, and the modular structure of the code allows new
potentials to be added easily. The code is parallelised using OpenMP and can
therefore be run on shared memory systems, including modern multicore
processors. Particular attention is paid to the updates required in the main
force loop, where synchronisation is often required in OpenMP implementations
of molecular dynamics. We examine the performance of the parallel code in
detail and give some examples of applications to realistic problems, including
the dynamic compression of copper and carbon migration in an iron-carbon alloy
Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53
The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers. Here, we identify different classes of small molecules that bind to this crevice and determine their binding modes by X-ray crystallography. These structures reveal two major conformational states of the pocket and a cryptic, transiently open hydrophobic subpocket that is modulated by Cys220. In one instance, specifically targeting this transient protein state by a pyrrole moiety resulted in a 40-fold increase in binding affinity. Molecular dynamics simulations showed that both open and closed states of this subsite were populated at comparable frequencies along the trajectories. Our data extend the framework for the design of high-affinity Y220C mutant binders for use in personalized anticancer therapy and, more generally, highlight the importance of implementing protein dynamics and hydration patterns in the drug-discovery process
Electromagnetic Probes
A review is presented of dilepton and real photon measurements in
relativistic heavy ion collisions over a very broad energy range from the low
energies of the BEVALAC up to the highest energies available at RHIC. The
dileptons cover the invariant mass range \mll = 0 - 2.5 GeV/c, i.e. the
continuum at low and intermediate masses and the light vector mesons, . The review includes also measurements of the light vector mesons
in elementary reactions.Comment: To be published in Landolt-Boernstein Volume 1-23A; 40 pages, 24
figures. Final version updated with small changes to the text, updated
references and updated figure
Limiting fragmentation in hadron-hadron collisions at high energies
Limiting fragmentation in proton-proton, deuteron-nucleus and nucleus-nucleus
collisions is analyzed in the framework of the Balitsky-Kovchegov equation in
high energy QCD. Good agreement with experimental data is obtained for a wide
range of energies. Further detailed tests of limiting fragmentation at RHIC and
the LHC will provide insight into the evolution equations for high energy QCD.Comment: 28 pages, 10 figures (2 new figures, text slightly expanded, and some
additional references
Meson exchange currents in electromagnetic one-nucleon emission
The role of meson exchange currents (MEC) in electron- and photon-induced
one-nucleon emission processes is studied in a nonrelativistic model including
correlations and final state interactions. The nuclear current is the sum of a
one-body and of a two-body part. The two-body current includes pion seagull,
pion-in-flight and the isobar current contributions. Numerical results are
presented for the exclusive 16O(e,e'p)15N and 16O(\gamma,p)15N reactions. MEC
effects are in general rather small in (e,e'p), while in (\gamma,p) they are
always large and important to obtain a consistent description of (e,e'p) and
(\gamma,p) data, with the same spectroscopic factors. The calculated (\gamma,p)
cross sections are sensitive to short-range correlations at high values of the
recoil momentum, where MEC effects are larger and overwhelm the contribution of
correlations.Comment: 9 pages, 6 figure
Gravitational Coupling and Dynamical Reduction of The Cosmological Constant
We introduce a dynamical model to reduce a large cosmological constant to a
sufficiently small value. The basic ingredient in this model is a distinction
which has been made between the two unit systems used in cosmology and particle
physics. We have used a conformal invariant gravitational model to define a
particular conformal frame in terms of large scale properties of the universe.
It is then argued that the contributions of mass scales in particle physics to
the vacuum energy density should be considered in a different conformal frame.
In this manner, a decaying mechanism is presented in which the conformal factor
appears as a dynamical field and plays a key role to relax a large effective
cosmological constant. Moreover, we argue that this model also provides a
possible explanation for the coincidence problem.Comment: To appear in GR
The Kuiper Belt and Other Debris Disks
We discuss the current knowledge of the Solar system, focusing on bodies in
the outer regions, on the information they provide concerning Solar system
formation, and on the possible relationships that may exist between our system
and the debris disks of other stars. Beyond the domains of the Terrestrial and
giant planets, the comets in the Kuiper belt and the Oort cloud preserve some
of our most pristine materials. The Kuiper belt, in particular, is a
collisional dust source and a scientific bridge to the dusty "debris disks"
observed around many nearby main-sequence stars. Study of the Solar system
provides a level of detail that we cannot discern in the distant disks while
observations of the disks may help to set the Solar system in proper context.Comment: 50 pages, 25 Figures. To appear in conference proceedings book
"Astrophysics in the Next Decade
Phi meson production in Au+Au and p+p collisions at sqrt (s)=200 GeV
We report the STAR measurement of Phi meson production in Au+Au and p+p
collisions at sqrt (s)=200 GeV. Using the event mixing technique, the Phi
spectra and yields are obtained at mid-rapidity for five centrality bins in
Au+Au collisions and for non-singly-diffractive p+p collisions. It is found
that the Phi transverse momentum distributions from Au+Au collisions are better
fitted with a single-exponential while the p+p spectrum is better described by
a double-exponential distribution. The measured nuclear modification factors
indicate that Phi production in central Au+Au collisions is suppressed relative
to peripheral collisions when scaled by the number of binary collisions. The
systematics of versus centrality and the constant Phi/K- ratio versus beam
species, centrality, and collision energy rule out kaon coalescence as the
dominant mechanism for Phi production.Comment: 6 pages, 3 figures, submitted to Phys. Rev. Let
- …