Industrial by-product valorisation as new biomaterials: adsorption as a solution for the environmental problems caused by pharmaceuticals

One of the most important environmental problems the modern world has to tackle with is water pollution derived from emerging pollutants (EPs). Pharmaceutical consumption has been increasing for decades, turning pharmaceuticals (PhACs) into the most frequently detected EPs. These compounds are persistent and resistant to degradation, so they can have harmful consequences on the environment and human health. Adsorption is a suitable alternative for the removal of PhACs from wastewater. The objective of this study is the production of biomaterials that can act as adsorbents. Based on circular economy principles, the raw material for the synthesis of the biomaterials was an industrial by-product (pine bark), which underwent surface modification through chemical and high-pressure modification processes. In the case of the chemical modifications, the experimental tested conditions included the particle size (1-1.4 mm), temperature (25 oC), time (24 h), agitation (180 rpm), solid:liquid ratio (1:30 - 1:100 g/mL), chemical reagent (acid: HNO3 1M, base: NaOH 2.5 M, oxidising agent: H2O2 1 M). High-pressure modifications were conducted in an autoclave with the following conditions: particle size (1-1.4 mm), temperature (121 oC), time (30 min), solid:liquid ratio (1:50 g/mL). The produced biosorbents were washed with distilled water until no colour and constant pH and then dried. Biomaterials were used to remove two PhACs, fluoxetine (FLX) and carbamazepine (CBZ), in a binary system. Adsorption tests were performed using solid:liquid ratio (10 g/L), FLX 5 mg/L, CBZ 5 mg/L, natural pH (5.5), constant agitation (160 rpm) and temperature (25 oC). The best adsorption results for both PhACs were obtained with the biosorbent produced by chemical modification using NaOH. In the case of CBZ, this biosorbent reached removal levels of 30.09% in 48 h. FLX adsorption was much faster, thus after 2.5 min around 78.71% of removal was obtained with a maximum at 30 min (97.10%). The obtained results show that chemical modification using NaOH allows, in a simple way, the transformation of wastes into biomaterials with high adsorptive capacities.This research has been financially supported Project PID2020-113667GB-I00 funded by MCIN / AEI /10.13039/501100011033 and PDC2021-121394-I00 funded by MCIN / AEI /10.13039/501100011033 and by the European Union Next Generation EU / PRTR. Authors are grateful to the Spanish Ministry of Science, Innovation and Universities by founding the researcher Valeria Acevedo-García (FPI program PRE2018-086993). Also, the authors want to thank that this study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit.info:eu-repo/semantics/publishedVersio

Related Enteric Viruses Have Different Requirements for Host Microbiota in Mice

Accumulating evidence suggests that intestinal bacteria promote enteric virus infection in mice. For example, previous work demonstrated that antibiotic treatment of mice prior to oral infection with poliovirus reduced viral replication and pathogenesis. Here, we examined the effect of antibiotic treatment on infection with coxsackievirus B3 (CVB3), a picornavirus closely related to poliovirus. We treated mice with a mixture of five antibiotics to deplete host microbiota and examined CVB3 replication and pathogenesis following oral inoculation. We found that, as seen with poliovirus, CVB3 shedding and pathogenesis were reduced in antibiotic-treated mice. While treatment with just two antibiotics, vancomycin and ampicillin, was sufficient to reduce CVB3 replication and pathogenesis, this treatment had no effect on poliovirus. The quantity and composition of bacterial communities were altered by treatment with the five-antibiotic cocktail and by treatment with vancomycin and ampicillin. To determine whether more-subtle changes in bacterial populations impact viral replication, we examined viral infection in mice treated with milder antibiotic regimens. Mice treated with one-tenth the standard concentration of the normal antibiotic cocktail supported replication of poliovirus but not CVB3. Importantly, a single dose of one antibiotic, streptomycin, was sufficient to reduce CVB3 shedding and pathogenesis while having no effect on poliovirus shedding and pathogenesis. Overall, replication and pathogenesis of CVB3 are more sensitive to antibiotic treatment than poliovirus, indicating that closely related viruses may differ with respect to their reliance on microbiota. IMPORTANCE Recent data indicate that intestinal bacteria promote intestinal infection of several enteric viruses. Here, we show that coxsackievirus, an enteric virus in the picornavirus family, also relies on microbiota for intestinal replication and pathogenesis. Relatively minor depletion of the microbiota was sufficient to decrease coxsackievirus infection, while poliovirus infection was unaffected. Surprisingly, a single dose of one antibiotic was sufficient to reduce coxsackievirus infection. Therefore, these data indicate that closely related viruses may differ with respect to their reliance on microbiota

Genome-wide association analysis unveils novel QTLs for seminal root system architecture traits in Ethiopian durum wheat

Background: Genetic improvement of root system architecture is essential to improve water and nutrient use efficiency of crops or to boost their productivity under stress or non-optimal soil conditions. One hundred ninety-two Ethiopian durum wheat accessions comprising 167 historical landraces and 25 modern cultivars were assembled for GWAS analysis to identify QTLs for root system architecture (RSA) traits and genotyped with a high-density 90 K wheat SNP array by Illumina. Results: Using a non-roll, paper-based root phenotyping platform, a total of 2880 seedlings and 14,947 seminal roots were measured at the three-leaf stage to collect data for total root length (TRL), total root number (TRN), root growth angle (RGA), average root length (ARL), bulk root dry weight (RDW), individual root dry weight (IRW), bulk shoot dry weight (SDW), presence of six seminal roots per seedling (RT6) and root shoot ratio (RSR). Analysis of variance revealed highly significant differences between accessions for all RSA traits. Four major (− log10P ≥ 4) and 34 nominal (− log10P ≥ 3) QTLs were identified and grouped in 16 RSA QTL clusters across chromosomes. A higher number of significant RSA QTL were identified on chromosome 4B particularly for root vigor traits (root length, number and/or weight). Conclusions: After projecting the identified QTLs on to a high-density tetraploid consensus map along with previously reported RSA QTL in both durum and bread wheat, fourteen nominal QTLs were found to be novel and could potentially be used to tailor RSA in elite lines. The major RGA QTLs on chromosome 6AL detected in the current study and reported in previous studies is a good candidate for cloning the causative underlining sequence and identifying the beneficial haplotypes able to positively affect yield under water- or nutrient-limited conditions

Characteristics of precipitation in the Santarém study region.

Abstract ID: 80. Publicado também on-line

Optical Light Curve of the Type Ia Supernova 1998bu in M96 and the Supernova Calibration of the Hubble Constant

We present the UBVRI light curves of the Type Ia supernova SN 1998bu which appeared in the nearby galaxy M96 (NGC 3368). M96 is a spiral galaxy in the Leo I group which has a Cepheid-based distance. Our photometry allows us to calculate the absolute magnitude and reddening of this supernova. These data, when combined with measurements of the four other well-observed supernovae with Cepheid based distances, allow us to calculate the Hubble constant with respect to the Hubble flow defined by the distant Calan/Tololo Type Ia sample. We find a Hubble constant of 64.0 +/- 2.2(internal) +/- 3.5(external) km/s/Mpc, consistent with most previous estimates based on Type Ia supernovae. We note that the two well-observed Type Ia supernovae in Fornax, if placed at the Cepheid distance to the possible Fornax spiral NGC 1365, are apparently too faint with respect to the Calan/Tololo sample calibrated with the five Type Ia supernovae with Cepheid distances to the host galaxies.Comment: AAS LaTeX, 20 pages, 4 figures, 6 tables, accepted for publication in the Astronomical Journal. Figure 1 (finding chart) not include

Multicriteria analysis for retrofitting of natural gas melting and heating furnaces for sustainable manufacturing and industry 4.0

Different retrofitting measures can be implemented at different levels of the industrial furnace, such as refractory layers, energy recovery solutions, new burners and fuel types, and monitoring and control systems. However, there is a high level of uncertainty about the possible implications of integrating new technologies, not only in the furnace but also on the upstream and downstream processes. In this regard, there is a lack of holistic approaches to design the optimal system configurations under a multicriteria perspective, especially when innovative technologies and multi-sectorial processes are involved. The present work proposes a holistic approach to natural gas melting and heating furnaces in energy-intensive industries. A multicriteria analysis, based on criteria and subcriteria, is applied to select the most profitable retrofitting solution using the analytic hierarchy process and stakeholder expertise. The methodology is based on technical indicators, i.e., life cycle assessment, life cycle cost, and thermoeconomic analysis, for evaluating the current state of existing natural gas furnaces. Once the current state is characterized, the methodology determines the potential of efficiency improvement, environmental impact reduction, and cost-savings caused mainly by the implementation of new retrofitting solutions including new refractories, new burner concepts (co-firing), and innovative energy recovery solutions based on phase change materials. Therefore, this methodology can be considered as the first stage that guarantees technical, environmental, and economic feasibility in evaluating the effects of new technologies on the overall system performance

Factors influencing wild chimpanzee (Pan troglodytes verus) relative abundance in an agriculture-swamp matrix outside protected areas

This study was funded by a grant from the Arcus Foundation No. G-PGM-1508-1368 to TH; PA was supported by the MINECO and the Universidad de Castilla-La Mancha (UCLM) through a 'Ramón y Cajal' contract (RYC-2012-11970), and Tacugama Chimpanzee Sanctuary provided logistical support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful to the Ministry of Agriculture, Forestry and Food Security of the Sierra Leone Government for granting us permission to conduct this research. This work would not have been possible without the collaboration of the people in the study communities. We also thank the outreach and management teams at the Tacugama Chimpanzee Sanctuary, in particular David Momoh, Joseph Marah, Konkofa Marah, Yirah Koroma, Bockarie Kanneh and Natalia Casado, for their assistance in the field. We are also extremely grateful to Dr. Raj Amin, Institute of Zoology in London, for providing the camera trap analysis software and to Jasper Gilardi for his help with processing camera trap images. Finally, we would also like to thank the two anonymous reviewers who provided useful suggestions for improving the quality of this manuscript.Human population growth and anthropogenic activities are exacerbating pressures on biodiversity globally. Land conversion is aggravating habitat fragmentation and non-human primates are increasingly compelled to live in forest-agricultural mosaics. In Sierra Leone, more than half of the wild chimpanzee population (Pan troglodytes verus) occurs outside protected areas and competes for resources with farmers. Our study area, in the Moyamba district in south-western Sierra Leone, is practically devoid of forest and is dominated by cultivated and fallow fields, swamps and mangroves. In this region, traditional slash-and-burn agriculture modifies annually the landscape, sparing swamps and mangroves and semi-domesticated oil palms (Elaeis guineensis). This study aimed to explore ecological and anthropogenic factors influencing chimpanzee relative abundance across this highly degraded and human-impacted landscape. Between 2015 and 2016, we deployed 24 camera traps systematically across 27 1.25x1.25 km grid cells. Cameras were operational over a period of 8 months. We used binomial iCAR models to examine to what extent anthropogenic (roads, settlements, abandoned settlements and human presence) and habitat variables (swamps, farmland and mangroves) shape chimpanzee relative abundance. The best model explained 43.16% of the variation with distance to roads and swamps emerging as the best predictors of chimpanzee relative abundance. Our results suggest that chimpanzees avoid roads and prefer to maintain proximity to swamps. There was no significant effect of settlements, abandoned settlements, mangroves or human presence. It appears that chimpanzees do not avoid areas frequented by people; although, our findings suggest temporal avoidance between the two species. We highlight the importance of studying chimpanzee populations living in anthropogenic habitats like agricultural-swamp matrixes to better understand factors influencing their distribution and inform conservation planning outside protected areas

Stress distribution of faceted particles in a silo after its partial discharge

We present experimental and numerical results of the effect that a partial discharge has on the morphological and micro-mechanical properties of non-spherical, convex particles in a silo. The comparison of the particle orientation after filling the silo and its subsequent partial discharge reveals important shearinduced orientation, which affects stress propagation. For elongated particles, the flow induces an increase in the packing disorder which leads to a reduction of the vertical stress propagation developed during the deposit generated prior to the partial discharge. For square particles, the flow favors particle alignment with the lateral walls promoting a behavior opposite to the one of the elongated particles: vertical force transmission, parallel to gravity, is induced. Hence, for elongated particles the flow developed during the partial discharge of the silo leads to force saturation with depth whereas for squares the flow induces hindering of the force saturation observed during the silo filling