"ottoman street" in America: Turkish leatherworkers in peabody, Massachusetts

This article examines the role of Turkish leatherworkers in New Englands labor movement in the early twentieth century. It begins with the exodus of a large Ottoman population from eastern Anatolian provinces to eastern Massachusetts, and their employment in New Englands leather factories. Throughout the article, the rise of the leather business in eastern Massachusetts cities (including Peabody and Salem), the Turkish immigrants concentration on Peabodys Walnut Street (which came to be called Ottoman Street), the importance of kin and friends in providing practical information vital for adjusting to the new environment, and the coffee house as a response to industrial conditions are discussed at length. The author argues that, although many of the Turkish leatherworkers originated from rural backgrounds and had no experience in unionizing and striking, their quick adjustment to the industrial city and their growing awareness of labor rights was a result of lectures given within the Turkish community, changing circumstances in the old country and in the United States, such as the Balkan Wars and World War I, and their unchallenged place in the tanneries of Peabody, MA. © 2009 Copyright Internationaal Instituut voor Sociale Geschiedenis

Outposts of an Empire : early Turkish migration to Peabody, Massachusetts

Cataloged from PDF version of article.This thesis examines early (1890s-1920s) Turkish immigration to Peabody, Massachusetts. It is a case study which argues that the most prominent factor driving early Turkish migration to Peabody was economic. Thus the migration movement constituted a “brawn drain” from Anatolia to the “streets paved with gold.” As was the case with some European peoples who immigrated to the United States at the same period, the Turkish immigrants in Peabody, Massachusetts, did not intend to stay in the United States. They only wanted to earn money and return to the homeland as soon as possible. More importantly this thesis argues that the Turkish immigrants were part of a larger Ottoman migration to the United States. The Turks in Peabody were part of a chain of migration that included Armenians, Greeks, and Sephardic Jews. They, together with the Armenians, Jews and Greeks constructed an Ottoman microcosm in Peabody essentially recreating the millets of the Ottoman Empire in which inter-communal support helped the Turks contend with the strange new environment. By the early 1930s most of the Turkish immigrants in Peabody had returned to their homeland. Overall, this thesis provides new insight into the Turkish and Ottoman diaspora that challenges popular conceptions of continual strife between the Turks and members of the other Ottoman millets. Additionally, it shows that this early Turkish immigrant community was, in some ways, strikingly similar to later twentieth century Turkish immigrant communities, such as those in Germany during the 1960sAcehan, IşılM.S

Risk Factors Effecting Conversion from Laparoscopic Cholecystectomy to Open Surgery

Objective:Laparoscopic cholecystectomy has obvious advantages over open surgery, such as shorter hospital stay, lower morbidity, better cosmetic results and faster return to daily activities. However, in some cases, conversion to open technique may be inevitable for patient safety or for the management of complications having occurred. Although various risk factors have been identified in many studies, variables such as technical facilities, surgical technique and experience affect risk factors. Our study aims to identify these risk factors.Method:In this study, 2,483 cholecystectomy cases performed in the general surgery clinic of our hospital between December 2013 and 2016 were retrospectively analyzed. 110 cholecystectomy cases initiated with open surgery and performed during another operation were excluded from the study, and 88 patients who were started laparoscopic surgery and converted to open surgery were selected for the study. Information on the demographic and clinical characteristics of the patients was obtained from hospital records. The data of an equal number of consecutively selected patients from the patients who were completed laparoscopically were obtained and compared, and whether these factors had a significant effect on conversion to open surgery was evaluated.Results:The rate of conversion from laparoscopic cholecystectomy to open surgery was 3.7%. The most common reason for conversion to open surgery was adhesion due to inflammation (n=65, 73.9%). While male gender, advanced age, diabetes, median incision above the umbilicus, multiple millimetric calculus and increased wall thickness in ultrasonography had a significant effect on the conversion to open surgery (p0.05). The durations of hospitalization and operation were found to be significantly longer in the open group (p<0.001).Conclusion:Male gender, advanced age, presence of diabetes, presence of supra-umbilical median incision, multiple millimetric calculus and increased wall thickness in ultrasonography are associated with increased rates of conversion from laparoscopic cholecystectomy to open surgery. If the coexistence of parameters that we find significant is detected in the preoperative period, it may be possible to take precautions such as involving the experienced surgical team in the operation, planning the operating room, and providing more detailed information to the patient

Evaluation of scoring systems in terms of early prediction of severe acute pancreatitis and mortality in patients over 65 years of age.

Purpose: The aim of this study is to investigate the power of disease severity scores to predict the development of Severe Acute Pancreatitis (SAP) and mortality in the early period over 65 years old diagnosed with acute pancreatitis in the emergency department. Materials and Methods: We calculated RANSON (on admission) and Computed Tomography Severity Index (CTSI) in addition to Bedside Index for Severity in Acute Pancreatitis (BISAP) score on admission to the emergency department. Results: One hundred and sixty patients (46.9% over 80 years of age) were included in the study. We observed statistically higher length of hospitalization, longer duration of stay in the intensive care unit, SAP and higher mortality in patients over 80 years of age. When we examined the ROC curve, we determined that the AUC values of the BISAP score were highest in both SAP and mortality estimation (AUC: 0.911, 95% CI 0.861-0.962; AUC: 0.918, 95% CI 0.864-0.9722, respectively). Binary logistic analysis indicated a 4.7-fold increased risk for SAP and a 12.3-fold increased mortality for each unit increase in BISAP score value. Conclusion: BISAP may be a good predictor for SAP and mortality estimation on admission to the emergency department in patients over 65 years of age with acute pancreatitis

Nuclear translocation of cytochrome c during apoptosis

Release of cytochrome c from mitochondria is a major event during apoptosis. Released cytochrome c has been shown to activate caspase-dependent apoptotic signals. In this report, we provide evidence for a novel role of cytochrome c in caspase-independent nuclear apoptosis. We showed that cytochrome c, released from mitochondria upon apoptosis induction, gradually accumulates in the nucleus as evidenced by both immunofluorescence and subcellular fractionation. Parallel to nuclear accumulation of cytochrome c, acetylated histone H2A, but not unmodified H2A, was released from the nucleus to the cytoplasm. Addition of purified cytochrome c to isolated nuclei recapitulated the preferential release of acetylated, but not deacetylated, histone H2A. Cytochrome c was also found to induce chromatin condensation. These results suggest that the nuclear accumulation of cytochrome c may be directly involved in the remodeling of chromatin. Our results provide evidence of a novel role for cytochrome c in inducing nuclear apoptosis

Structural Features of Caspase-Activating Complexes

Apoptosis, also called programmed cell death, is an orderly cellular suicide program that is critical for the development, immune regulation and homeostasis of a multi-cellular organism. Failure to control this process can lead to serious human diseases, including many types of cancer, neurodegenerative diseases, and autoimmununity. The process of apoptosis is mediated by the sequential activation of caspases, which are cysteine proteases. Initiator caspases, such as caspase-2, -8, -9, and -10, are activated by formation of caspase-activating complexes, which function as a platform to recruit caspases, providing proximity for self-activation. Well-known initiator caspase-activating complexes include (1) DISC (Death Inducing Signaling Complex), which activates caspases-8 and 10; (2) Apoptosome, which activates caspase-9; and (3) PIDDosome, which activates caspase-2. Because of the fundamental biological importance of capases, many structural and biochemical studies to understand the molecular basis of assembly mechanism of caspase-activating complexes have been performed. In this review, we summarize previous studies that have examined the structural and biochemical features of caspase-activating complexes. By analyzing the structural basis for the assembly mechanism of the caspase-activating complex, we hope to provide a comprehensive understanding of caspase activation by these important oligomeric complexes

Quantitative imaging of tissue sections using infrared scanning technology

Quantification of immunohistochemically (IHC) labelled tissue sections typically yields semi‐quantitative results. Visualising infrared (IR) ‘tags’, with an appropriate scanner, provides an alternative system where the linear nature of the IR fluorophore emittance enables realistic quantitative fluorescence IHC (QFIHC). Importantly, this new technology enables entire tissue sections to be scanned, allowing accurate area and protein abundance measurements to be calculated from rapidly acquired images. Here, some of the potential benefits of using IR‐based tissue imaging are examined, and the following are demonstrated. Firstly, image capture and analysis using IR‐based scanning technology yields comparable area‐based quantification to those obtained from a modern high‐resolution digital slide scanner. Secondly, IR‐based dual target visualisation and expression‐based quantification is rapid and simple. Thirdly, IR‐based relative protein abundance QIHC measurements are an accurate reflection of tissue sample protein abundance, as demonstrated by comparison with quantitative fluorescent Western blotting data. In summary, it is proposed that IR‐based QFIHC provides an alternative method of rapid whole‐tissue section low‐resolution imaging for the production of reliable and accurate quantitative data

Relationship between cardiolipin metabolism and oxygen availability in Bacillus subtilis

AbstractWe report changes of the content of anionic phospholipids in Bacillus subtilis in response to hypoxic conditions and inhibition of terminal respiration. Cardiolipin accumulates rapidly when bacteria are suspended in non-growth medium under reduced aeration or exposed to the inhibitor cyanide; the increase of cardiolipin occurs at the expense of its precursor phosphatidylglycerol and is temperature-dependent. Depending on the extent of hypoxic stress, membranes containing different levels of cardiolipin can be isolated from B. subtilis cells. The NADH oxidase activity in cardiolipin-enriched membranes is cyanide-resistant; furthermore O2 consumption measurements indicated that cardiolipin-enriched cells are resistant to cyanide. Results point out a possible interdependence between the effect of cyanide on cardiolipin metabolism and the effect of cardiolipin on the effectiveness of cyanide inhibition

The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria

Prohibitin ring complexes in the mitochondrial inner membrane regulate cell proliferation as well as the dynamics and function of mitochondria. Although prohibitins are essential in higher eukaryotes, prohibitin-deficient yeast cells are viable and exhibit a reduced replicative life span. Here, we define the genetic interactome of prohibitins in yeast using synthetic genetic arrays, and identify 35 genetic interactors of prohibitins (GEP genes) required for cell survival in the absence of prohibitins. Proteins encoded by these genes include members of a conserved protein family, Ups1 and Gep1, which affect the processing of the dynamin-like GTPase Mgm1 and thereby modulate cristae morphogenesis. We show that Ups1 and Gep1 regulate the levels of cardiolipin and phosphatidylethanolamine in mitochondria in a lipid-specific but coordinated manner. Lipid profiling by mass spectrometry of GEP-deficient mitochondria reveals a critical role of cardiolipin and phosphatidylethanolamine for survival of prohibitin-deficient cells. We propose that prohibitins control inner membrane organization and integrity by acting as protein and lipid scaffolds

Ablation of the Pro-Apoptotic Protein Bax Protects Mice from Glucocorticoid-Induced Bone Growth Impairment

Dexamethasone (Dexa) is a widely used glucocorticoid to treat inflammatory diseases; however, a multitude of undesired effects have been reported to arise from this treatment including osteoporosis, obesity, and in children decreased longitudinal bone growth. We and others have previously shown that glucocorticoids induce apoptosis in growth plate chondrocytes. Here, we hypothesized that Bax, a pro-apoptotic member of the Bcl-2 family, plays a key role in Dexa-induced chondrocyte apoptosis and bone growth impairment. Indeed, experiments in the human HCS-2/8 chondrocytic cell line demonstrated that silencing of Bax expression using small-interfering (si) RNA efficiently blocked Dexa-induced apoptosis. Furthermore, ablation of Bax in female mice protected against Dexa-induced bone growth impairment. Finally, Bax activation by Dexa was confirmed in human growth plate cartilage specimens cultured ex vivo. Our findings could therefore open the door for new therapeutic approaches to prevent glucocorticoid-induced bone growth impairment through specific targeting of Bax