10 research outputs found
Expression of Musashi-1 During Osteogenic Differentiation of Oral MSC: An In Vitro Study
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/05/2019
- Field of study
Supplementary materials can be found at https://www.mdpi.com/1422-0067/20/9/2171/s1Background: Musashi-1 (MSI1) is a negative regulator of mesenchymal stromal cell (MSC) differentiation which in turn favors cell proliferation. However, little is known about its expression by MSC from the oral cavity and in the context of osteogenic differentiation. Aim: The aim of this study was to analyze the expression of MSI1 in the context of osteogenic differentiation of MSC derived from the oral cavity. Material/methods: For this in vitro study, MSC were isolated from six different origins of the oral cavity. They were extensively characterized in terms of proliferative and clonogenicity potential, expression of stemness genes (MYC, NANOG, POU5F1, and SOX2), expression of surface markers (CD73, CD90, CD105, CD14, CD31, CD34, and CD45) and adipo-, chondro- and osteogenic differentiation potential. Then, osteogenic differentiation was induced and the expression of MSI1 mRNA and other relevant markers of osteogenic differentiation, including RUNX2 and Periostin, were also evaluated. Results: Cell populations from the alveolar bone (pristine or previously grafted with xenograft), dental follicle, dental germ, dental pulp, and periodontal ligament were obtained. The analysis of proliferative and clonogenicity potential, expression of the stemness genes, expression of surface markers, and differentiation potential showed similar characteristics to those of previously published MSC from the umbilical cord. Under osteogenic differentiation conditions, all MSC populations formed calcium deposits and expressed higher SPARC. Over time, the expression of MSI1 followed different patterns for the different MSC populations. It was not significantly different than the expression of RUNX2. In contrast, the expression of MSI1 and POSTN and RUNX2 were statistically different in most MSC populations. Conclusion: In the current study, a similar expression pattern of MSI1 and RUNX2 during in vitro osteogenic differentiation was identified.The authors of this investigation were partially supported by Research Groups #CTS-138 (F.O.) and #CTS-1028 (M.P.-M., P.G.-M.) (Junta de Andalucía, Spain), a grant from MIS Implant Technologies Ltd. (M.P.-M., D.A.-G., P.G.-M.), the Youth Employment Initiative (YEI) from the European Commission (R.S.-U.), and the Instituto de Salud Carlos III, Spain (www.isciii.es) and Fondo Europeo de Desarrollo Regional (FEDER, from the European Union), through the research grants PI15/00794 and CPII15/00032 (P.A)
Expression of Musashi-1 Increases in Bone Healing
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 26/03/2021
- Field of study
Musashi-1 (MSI1) is an RNA-binding protein that regulates progenitor cells in adult and developing organisms to maintain self-renewal capacities. The role of musashi-1 in the bone healing environment and its relation with other osteogenic factors is unknown. In the current study, we analyze the expression of MSI1 in an experimental model of rat femoral bone fractures. We also analyze the relation between MSI1 expression and the expression of two osteogenic markers: periostin (POSTN) and runt-related transcription factor 2 (RUNX2). We use histological, immunohistochemical, and qPCR techniques to evaluate bone healing and the expression of MSI1, POSTN, and RUNX2 over time (4, 7, and 14 days). We compare our findings with non-fractured controls. We find that in bone calluses, the number of cells expressing MSI1 and RUNX2 increase over time and the intensity of POSTN expression decreases over time. Within bone calluses, we find the presence of MSI1 expression in mesenchymal stromal cells, osteoblasts, and osteocytes but not in hypertrophic chondrocytes. After 14 days, the expression of MSI1, POSTN, and RUNX2 was significantly correlated. Thus, we conclude that musashi-1 potentially serves in the osteogenic differentiation of mesenchymal stromal cells and bone healing. Therefore, further studies are needed to determine the possibility of musashi-1's role as a clinical biomarker of bone healing and therapeutic agent for bone regeneration.The authors of this manuscript were partially supported by Research Groups #CTS-138 and #CTS-1028 (Junta de Andalucía, Spain).Ye
Evidencing the natural and anthropogenic processes controlling trace metals dynamic in a highly stratified estuary: The Krka River estuary (Adriatic, Croatia)
- Author
- Abe
- Abril
- Admiraal
- Al-Farawati
- Alvarez-Salgado
- Ana-Marija Cindrić
- Annibaldi
- Benjamin Oursel
- Benoit
- Bilinski
- Bilinski
- Bilinski
- Bourg
- Bruland
- Cai
- Canavan
- Cauwet
- Cetinic
- Chiffoleau
- Cobelo-Garcia
- Cobelo-Garcia
- Comans
- Cukrov
- Cukrov
- Cédric Garnier
- Dabrin
- Dabrin
- Dai
- Dai
- Dang
- Dario Omanović
- Dassenakis
- Dassenakis
- Denant
- Deycard
- Donat
- Dorten
- Duarte
- Duran
- Elbaz-Poulichet
- Elbaz-Poulichet
- Elbaz-Poulichet
- Elbaz-Poulichet
- Fichet
- Fu
- Grzetic
- Guo
- Hatje
- Hatje
- Ivanka Pižeta
- Jean
- Jiann
- Kniewald
- Koshikawa
- Kraepiel
- Legovic
- Legovic
- Legovic
- Legovic
- Legovic
- Lorrain
- Louis
- Lourino-Cabana
- Mantoura
- Martino
- Munksgaard
- Ollivier
- Omanović
- Oursel
- Oursel
- Ouseph
- Paucot
- Paulson
- Petit
- Petricioli
- Rigaud
- Robert
- Santore
- Sempere
- Sunda
- Supraha
- Svensen
- Takata
- Tankere
- Tessier
- Turner
- Turner
- Vega
- Veyssy
- Vukosav
- Waeles
- Waeles
- Waeles
- Waeles
- Waeles
- Waeles
- Ytreberg
- Zutic
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project
- Author
- Abdelsalam Ahmed
- Abril Victorino Johanna
- Aguilar Gerardo
- Akbas Turkay
- Akinyi Frisch
- Al-Khalid Muhammad
- Aldarsani Ayman
- Aldecoa Cesat
- Alejandra Pino Carina
- Alejandro Sanchez-Hurtado Luis
- Alexis Montenegro Martin
- Alli Ahmad
- Almekhlafi Ghaleb
- Alsheikhly Ahmed Subhy
- Alsisi Adel
- Alvarez Brian
- Alves Ricardo
- Anisoglou Souzana
- Antonelli Massimo
- Antypa Elli
- Arias Mario
- Armstrong Maureen
- Arroyo-Sanchez Abel
- Arvaniti Kostoula
- Aslan Nesrin Ahu
- Atchade Enora
- Attwood Ben
- Aurora Miyazaki Erica
- Austin Pauline
- Awad Yasser
- Azad Raman
- Bakker Jan
- Bala Miklosh
- Balasini Carina
- Baldomera Silva Ramona
- Baranowski Bronislaw
- Barbagallo Maria
- Barjon Genevieve
- Baronia Arvind
- Beatriz Farfan Angelica
- Beatriz Hidalgo Irene
- Beck Oliver
- Belavic Matija
- Belda Javier
- Bellocchio Adelina
- Belskiy Vladislav
- Benitez-Cano Martinez Adela
- Bettini Lisandro
- Bhandary Rakesh
- Bhowmick Kaushik
- Bianchi Luciana
- Bilinska Julia
- Biskup Ewelina
- Bitzani Militisa
- Blahut Ladislav
- Blot Koen
- Blot Stijn
- Bodulica Bruna
- Bonetto Natalia
- Boraso Sabrina
- Bormans Laura
- Bosman Gerrit
- Box Roberta
- Boyd Christine
- Boyd Owen
- Brazzi Luca
- Brescia Giovanni
- Brevard Sidney
- Burtin Philippe
- Campbell Lewis
- Camsooksai Julie
- Canale Mariana
- Candeias Carlos
- Capponi Paola
- Cardenas Yenny
- Cardonnet Luis
- Carlos Lopez-Delgado Juan
- Castro Guiomar
- Catalan Monzon Ignacio
- Celis Edgar
- Cesio Cristian
- Chalkiadaki Anthoula
- Charalambous Eliana
- Chasou Eleftheria
- Chavan Nitin
- Chediack Viviana
- Chinery Elaine
- Chinthamuneedi Meher
- Chouris Isaac
- Christian Pozo Norberto
- Christopoulos Christos
- Chtsomkasem Anusang
- Cimic Nedim
- Cinnella Gilda
- Coggon Mandy
- Cole Stephen
- Collange Oliver
- Collin Vincent
- Colorado-Dominguez Ever
- Cordoba Nielfa Maria del Carmen
- Cornet Alexander Daniel
- Corradi Francesco
- Correger Enrique
- Cortegiani Andrea
- Costa Rui Pedro
- Cotoia Antonella
- Couce Rocio
- Creagh-Brown Ben
- Creagh-Brown Benedict
- Cruz Carina
- Cruz Godoy
- Cunto Eleonora
- Czuczwar Miroslaw
- Dalton Julian
- Dams Karolien
- Davis Noelle
- De Backer Daniel
- De Bels David
- de la Torre-Prados Maria-Victoria
- de Lange Dylan
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Jan
- Debarre Matthieu
- del Rio-Carbajo Lorena
- Delia Gomez Cristina
- Demirkiran Oktay
- Deschepper Mieke
- Diakaki Chryssa
- Dickens Justin
- Dikmen Yalim
- Dimopoulos George
- Doble Patricia
- Doglia Juan
- Dohnal Martin
- Doklestic Krstina
- Domingo-Marin Sara
- Domingos Guilherme
- Dominguez Cecilia
- Dormans Tom
- Dubois Jasperina
- Duclos Gary
- Dugernier Thieny
- Dullenkopf Alexander
- Dupont Herve
- Dupuis Claire
- Eckmann Christian
- Einav Sharon
- Elizabeth Quevedo Noelia
- Elke Gunnar
- Elli-Nikki
- Emmerich Monica
- Esteban Chacon Mercedes
- Fahmy Abdelraouf
- Farazi-Chongouki Christos
- Fernandez Natalia
- Fernandez Ruben
- Ferney Bernal Buitrago
- Ferreira Alcina
- Ferreira Amelia
- Filipovic-Grcic Ina
- Fjeldsoee-Nielsen Hans
- Fletcher Jason
- Flioni
- Flocco Romeo
- Flores Gonzalez Jesus
- Floros John
- Forfori Francesco
- Foucrier Arnaud
- Francois Guy
- Fromentin Melanie
- Fumale Mariela
- Funes Nelson Nydia
- Furneval Julie
- Gaigolnik Denis
- Galarza Barrachina Laura
- Garcia Bernedo Carlos
- Garcia Pena Jose Manuel
- Garcia Mariel
- Garcia-Alvarez Raquel
- Garcia-Guillen Francisco J
- Georgakopoulos Panagiotis
- George Michelle
- Gianella Malca Gonzalo Ernesto
- Gibson Bethan
- Girardis Massimo
- Gomes Pedro
- Gonzalez Estevarena Luis
- Gonzalez Garcia Joseba
- Gonzalez Susana
- Gorordo Luis
- Grangeat Sergio Hugo
- Grecu Irina
- Grigoras Ioana
- Gritsan Alexey
- Groba Casiano Barrera
- Groh Carina
- Grubissich Nicolas
- Gumus Ayca
- Gunst Jan
- Gurjar Mohan
- Haas Lenneke
- Haentjens Lionel
- Hagan Samantha
- Hamilton Mark
- Han Yi
- Hashemian Seyed Mohammadreza
- Hayashi Yoshiro
- Hecketsweiler Stephane
- Hegazy Mohammed
- Hemmings Noel
- Henein Akram
- Hermosa Cecilia
- Herrera Luis
- Hersey Peter
- Hilario Mendonca Pedro Muguel
- Hooker Nicolas
- Hopkins Philip
- Humphreys Sally
- Ijaz Nazia
- Ilutovich Santiago
- Innes Richard
- Izura Javier
- Jain Nikhilesh
- Jamadarkhana Sunil
- Jankovic Radmilo
- Jansen Jan
- Javeri Yash
- Javier Redondo Francisco
- Jha Rajeev
- Jimenez Roberto
- Johnson-Jackson Roxanne
- Jorens Philippe
- Jorge Descotte Emiliano
- Jovanovic Bojan
- Julian Tiranti Roberto
- Kahveci Ferda
- Kalff Karel Martijn
- Kalogeromitros Alexandros
- Karakosta Agathi
- Karampela Niki
- Karathanou Antigoni
- Kaye Callum
- Kelly Catriona
- Kent Linda
- Kesecioglu Jozef
- Kieslichova Eva
- Kishihara Yuki
- Kizilaslan Deniz
- Koch Christian
- Kokkini Sofia
- Kol Mark
- Kolonia Virginia
- Kontou Paschalina
- Kontoudaki Eftychia
- Kos Zdenek
- Kostoula Arvaniti
- Kott Matthias
- Koulenti Despoina
- Koulouras Vasilios
- Kounougeri Katerina
- Kratochvil Milan
- Kricka Irena Bozanic
- Krogh Birgitte Marianne
- Krystopchuk Andriy
- Kuharic Janja
- Kulabukhov Vladimir
- Kulkarni Shilpa
- Kydona Christina
- Kyritsi Aikaterini
- Labeau Sonia
- Lampiri Clairi
- Lamrous Amin
- Land Farid
- Lang Martin
- Lascar Florencia Maria
- Lasocki Sigismond
- Laura Pastorino Maria
- Leal Dina
- Lee Sarah
- Leguizamon Mariela
- Leone Marc
- Li Xinyu
- Lipman Jeffrey
- Lipovestky Fernando
- Lopes Marques de Carvalho Maria Raquel
- Lopez-Arcas Calleja Pablo
- Lovesio Luciano
- Lowe Alastair
- Lu Weihua
- Luczak Karolina
- Lujan Rodolfo
- Maca Jan
- Mahjoub Yazine
- Mahmoodpoor Ata
- Malaska Jan
- Mallat Jihad
- Malliotakis Polychronis
- Mandourah Yasser
- Mandragos Konstantinos
- Manzur Adriana
- Marcotte Guillaume
- Margarson Michael
- Marmanidou Kyriaki
- Martin Abegao Esteban
- Martin Patricio
- Martinez Manuel
- Martinez-Sagasti Fernando
- Maseda Emilio
- Masjedi Mansoor
- Mastora Zafiria
- Matallana Zapata Diego Fernando
- McNamee Lia
- Mehmet Inal
- Memis Dilek
- Mikaszewska-Sokolewicz Malgorzata
- Mikstacki Adam
- Minguez Victoria
- Miranda Ariel M
- Miriam Miranda Edith
- Mirkovic Tomislav
- Misiewska-Kaczur Agnieszka
- Misseri Giovanni
- Misset Benoit
- Molano-Franco Daniel
- Molinos Elena
- Monserrat Lloria Maria
- Montague Laura
- Montravers Philippe
- Mora Jose
- Morales Freddy
- Moreno-Gonzalez Gabriel
- Morgan Pat
- Morton Ben
- Musaeva Tatiana
- NadezhdaZubareva
- Naglry Eva
- Namendys-Silva Silvio A
- Naylor Amanda
- Naylor Douglas
- Nica Alexandru
- Nicolotti Davide
- Nielsen Louise Gramstrup
- Nikandish Reza
- Nikolaou Charikleia
- Nora David
- Nutt Christopher
- Nuvials Xavier
- O'Kane Sinead
- O'Neill Orla
- Obraz Melanija
- Ostermann Marlies
- Ozcelik Menekse
- Ozgultekin Asu
- Ozkan Zeynep
- Page Valerie
- Paiva Jose-Artur
- Pantazopoulos Ioannis
- Papageorgiou Eirini
- Papanikolaou Metaxia
- Papathanakos Georgios
- Papavasilopoulou Theonymfi
- Paraforou Theoniki
- Pardo Oviedo Juan Mauricio
- Parera Prous Anna
- Paridou Alexandra
- Parker Robert
- Parsons Penny
- Pascoalinho Dulce
- Patrascanu Emilia
- Paugam-Burtz Catherine
- Paul Cherish
- Paul John
- Paz Daniel
- Pearson Suzanne
- Pelagalli Lorella
- Pellegrini Carlos
- Pentari Anastasia
- Pentheroudaki Alexandra
- Pereira Jose-Manuel
- Pereira Rui Antunes
- Pereyra Cecilia
- Petridou Christina
- Picos Gil Santiago Alberto
- Pinilla Dario
- Plowright Catherine
- Pneumatikos Ioannis
- Polgarova Petra
- Popescu Mihai
- Pota Vincenzo
- Pottecher Julien
- Prekates Athanasios
- Protus Marek
- Psallida Vasiliki
- Pulak Paul
- Qu Changjing
- Queti Felipe
- Radovanovic Dragana
- Radu Vasiliki
- Rallis Michael
- Ramazanoglu Atilla
- Ramos Agnel
- Ravani Ifigeneia
- Reece-Anthony Rosie
- Rees David
- Rello Jordi
- Remache Vargas Nelson
- Reschreiter Henrik
- Rezende-Neto Joao
- Ribeiro Rosa
- Richards Guy
- Rico-Feijoo Jesus
- Rivadeneira Francisco
- Rizoli Sandro
- Roberts Brigit
- Roche-Campo Ferran
- Rojas Jose
- Rolando MorochoTutillo Diego
- Romanou Vasiliki
- Romero-Meja Erick
- Rose Bernd Oliver
- Russo Alessandro
- Ryan Christine
- Rzymski Stanislaw
- Sabetian Golnar
- Saha Bhaskar
- Sakellaridis Konstantinos
- Salgado Yepez Estuardo
- Salinas Irene
- Sanchez Iniesta Rafael
- Sanchez Minope John Thomas
- Sanchez-Zamora Purificacion
- Sander Michael
- Sangaralingham Sivatharshini
- Santillan Paul
- Santolaya Ignacio
- Santos Anabela
- Santos Lurdes
- Saraguro Orozco Alexandra
- Sarakatsanos Ioannis
- Sathe Prachee
- Satinsky Igor
- Saul Pablo
- Sawinski Mariusz
- Scarone Nahuel
- Schwarz Peter
- Scott Carmen
- Segura Lise
- Serafini Giulia
- Sertaridou Eleni
- Shah Bhagyesh
- Shiotsuka Junji
- Shyamsundar Murali
- Silversides Jonathon
- Silvina Dietz Lorena
- Simion Davide
- Simon Marc
- Simon Philipp
- Skoric-Jokic Svetlana
- Smith Julie
- Smuszkiewicz Piotr
- Soledad Gumiela Natalia
- Solera Marin Jorge
- Spadaro Savino
- Starr Therese
- Stokkos Konstantinos
- Sulkowski Wiktor
- Summers Charlotte
- Sutton Giselle
- Swit Beata
- Szakmany Tamas
- Tamowicz Barbara
- Tejeda-Huezo Brigitte
- Tesniere Antoine
- Thakkar Chirag
- Tiberio Ivo
- Timsit Jean-Francois
- Tita Agustin
- Tolosa Carina
- Tomasevic Boris
- Tomescu Dana
- Toppin Patrick
- Torrente Sergio
- Toth-Tarsoly Piroska
- Trenado Alvarez Josep
- Tribulev Maxim
- Trinder John
- Trojanowska Iwona
- Trongtrakul Konlawij
- Trosiak Marta
- Tsigou Evdoxia
- Tsimpoukas Fotios
- Tsioka Agoritsa
- Tsoumaropoulos Georgios
- Tzanidakis Charalampos
- Umezawa Makikado Luis Daniel
- Unal Mustafa Necmettin
- Unlu Nurdan
- Urkmez Seval
- Vakalos Aristeidis
- Valgolio Emanuel
- Vallverdu Vidal Montserrat
- van den Oever Huub
- Van Duijn Ditty
- Veber Benoit
- Velickovic Dejan
- Velickovic Jelena
- Venkatesan Kumaresh
- Vermeijden Wytze
- Vidal-Cortes Pablo
- Villa Lopez Isabel Maria
- Villamagua Boris
- Villazala Ruben
- Vittone Ferdinando Giorgio
- Vogelaers Dirk
- Volta Carlo
- Vondras Petr
- Vos Piet
- Voudouris Antonios
- Vrettou Efstratia
- Vudrag Maja
- Vukovic Anita
- Vymazal Tomas
- Warhurst Timothy
- Wendon Julia
- Wibrow Bradley
- Wittebole Xavier
- Wong Helen
- Wood James
- Wrigge Hermann
- Wright Christopher
- Yamamoto Ryohei
- Yasuda Hideto
- Yates Bryan
- Young Lorna
- Yu Tao
- Zabolotskikh Igor
- Zakalik Graciela
- Zalba-Etayo Begona
- Zazu Alan
- Zhao Xiaobei
- Zunic Josip
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/10/2019
- Field of study
PURPOSE: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). METHODS: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. RESULTS: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. CONCLUSION: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection.status: publishe
Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units
- Author
- Abdelsalam Ahmed
- Abegao Esteban Martin
- Aguilar Gerardo
- Akbaş Türkay
- Akinyi Frisch
- Al-Khalid Muhammad
- Aldarsani Ayman
- Aldecoa Cesat
- Alli Ahmad
- Almekhlafi Ghaleb
- Alsheikhly Ahmed Subhy
- Alsisi Adel
- Alvarez Brian
- Alvarez Josep Trenado
- Alves Ricardo
- Anisoglou Souzana
- Antonelli Massimo
- Antonelli Massimo
- Antypa Elli
- Arias Mario
- Armstrong Maureen
- Arroyo-Sanchez Abel
- Arvaniti Kostoula
- Aslan Nesrin Ahu
- Atchade Enora
- Attwood Ben
- Austin Pauline
- Awad Yasser
- Azad Raman
- Bakker Jan
- Bala Miklosh
- Balasini Carina
- Baranowski Bronisław
- Barbagallo Maria
- Barjon Geneviève
- Baronia Arvind
- Barrachina Laura Galarza
- Beck Oliver
- Belavic Matija
- Belda Javier
- Bellocchio Adelina
- Belskiy Vladislav
- Bernedo Carlos Garcia
- Bettini Lisandro
- Bhandary Rakesh
- Bhowmick Kaushik
- Bianchi Luciana
- Bilinska Julia
- Biskup Ewelina
- Bitzani Militisa
- Blahut Ladislav
- Blot Koen
- Blot Stijn
- Bodulica Bruna
- Bonetto Natalia
- Boraso Sabrina
- Bormans Laura
- Bosman Gerrit
- Box Roberta
- Boyd Christine
- Boyd Owen
- Brazzi Luca
- Brescia Giovanni
- Brevard Sidney
- Burtin Philippe
- Calleja Pablo López-Arcas
- Campbell Lewis
- Camsooksai Julie
- Canale Mariana
- Candeias Carlos
- Capponi Paola
- Cardenas Yenny
- Cardenas Yenny
- Cardonnet Luis
- Castro Guiomar
- Celis Edgar
- Cesio Cristian
- Chacon Mercedes Esteban
- Chalkiadaki Anthoula
- Charalambous Eliana
- Chasou Eleftheria
- Chavan Nitin
- Chediack Viviana
- Chinery Elaine
- Chinthamuneedi Meher
- Chouris Isaac
- Christopoulos Christos
- Chtsomkasem Anusang
- Cimic Nedim
- Cinnella Gilda
- Coggon Mandy
- Cole Stephen
- Collange Oliver
- Collin Vincent
- Colorado-Dominguez Ever
- Cornet Alexander Daniel
- Corradi Francesco
- Correger Enrique
- Cortegiani Andrea
- Costa Rui Pedro
- Cotoia Antonella
- Couce Rocio
- Creagh-Brown Ben
- Creagh-Brown Benedict
- Cruz Carina
- Cunto Eleonora
- Czuczwar Miroslaw
- Dalton Julian
- Dams Karolien
- Davis Noelle
- De Backer Daniel
- De Bels David
- de Carvalho Maria Raquel Lopes Marques
- de la Torre-Prados Maria-Victoria
- de Lange Dylan
- de Lange Dylan
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Jan
- Debarre Matthieu
- Del Carmen Cordoba Nielfa Maria
- Del Río-Carbajo Lorena
- Demirkiran Oktay
- Deschepper Mieke
- Descotte Emiliano Jorge
- Diakaki Chryssa
- Dickens Justin
- Dietz Lorena Silvina
- Dikmen Yalim
- Dikmen Yalim
- Dimopoulos George
- Doble Patricia
- Doglia Juan
- Dohnal Martin
- Doklestic Krstina
- Domingo-Marín Sara
- Domingos Guilherme
- Dominguez Cecilia
- Dormans Tom
- Dubois Jasperina
- Duclos Gary
- Dugernier Thierry
- Dullenkopf Alexander
- Dupont Hervé
- Dupuis Claire
- Eckmann Christian
- Einav Sharon
- Elke Gunnar
- Elli-Nikki [missing]
- Emmerich Monica
- Estevarena Luis Gonzalez
- Fahmy Abdelraouf
- Farazi-Chongouki Christos
- Farfan Angelica Beatriz
- Fernandez Natalia
- Fernandez Ruben
- Ferney Bernal Buitrago
- Ferreira Alcina
- Ferreira Amélia
- Filipovic-Grcic Ina
- Fjeldsoee-Nielsen Hans
- Fletcher Jason
- Flioni [missing]
- Flocco Romeo
- Floros John
- for the Abdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the European Society of Intensive Care Medicine [missing]
- Forfori Francesco
- Foucrier Arnaud
- Francois Guy
- Fromentin Mélanie
- Fumale Mariela
- Furneval Julie
- Gaigolnik Denis
- Garcia Joseba Gonzalez
- Garcia Mariel
- Garcia-Alvarez Raquel
- Garcia-Guillen Francisco J.
- Georgakopoulos Panagiotis
- George Michelle
- Gibson Bethan
- Gil Santiago Alberto Picos
- Girardis Massimo
- Girardis Massimo
- Gomes Pedro
- Gomez Cristina Delia
- Gonzalez Susana
- González Jesús Flores
- Gorordo Luis
- Grangeat Sergio Hugo
- Grecu Irina
- Grecu Irina
- Grigoras Ioana
- Gritsan Alexey
- Gritsan Alexey
- Groba Casiano Barrera
- Groh Carina
- Grubissich Nicolas
- Gumiela Natalia Soledad
- Gumus Ayca
- Gunst Jan
- Gurjar Mohan
- Haas Lenneke
- Haentjens Lionel
- Hagan Samantha
- Hamilton Mark
- Han Yi
- Hashemian Seyed Mohammadreza
- Hayashi Yoshiro
- Hecketsweiler Stephane
- Hegazy Mohammed
- Hemmings Noel
- Henein Akram
- Hermosa Cecilia
- Herrera Luis
- Hersey Peter
- Hidalgo Irene Beatriz
- Hooker Nicolas
- Hopkins Philip
- Humphreys Sally
- Ijaz Nazia
- Ilutovich Santiago
- Iniesta Rafael Sánchez
- Innes Richard
- Izura Javier
- Jain Nikhilesh
- Jamadarkhana Sunil
- Jankovic Radmilo
- Jansen Jan
- Javeri Yash
- Jha Rajeev
- Jimenez Roberto
- Johnson-Jackson Roxanne
- Jorens Philippe
- Jovanovic Bojan
- Jovanovic Bojan
- Kahveci Ferda
- Kalff Karel Martijn
- Kalogeromitros Alexandros
- Karakosta Agathi
- Karampela Niki
- Karathanou Antigoni
- Kaye Callum
- Kelly Catriona
- Kent Linda
- Kieslichová Eva
- Kishihara Yuki
- Kizilaslan Deniz
- Koch Christian
- Kokkini Sofia
- Kol Mark
- Kolonia Virginia
- Kontou Paschalina
- Kontoudaki Eftychia
- Kos Zdenek
- Kostoula Arvaniti
- Kott Matthias
- Kott Matthias
- Koulenti Despoina
- Koulenti Despoina
- Koulouras Vasilios
- Kounougeri Katerina
- Kratochvil Milan
- Kricka Irena Bozanic
- Krogh Birgitte Marianne
- Krystopchuk Andriy
- Kuharic Janja
- Kulabukhov Vladimir
- Kulkarni Shilpa
- Kydona Christina
- Kyritsi Aikaterini
- Labeau Sonia
- Lampiri Clairi
- Lamrous Amin
- Lamrous Amin
- Lang Martin
- Lascar Florencia Maria
- Lasocki Sigismond
- Leal Dina
- Lee Sarah
- Leguizamon Mariela
- Leone Marc
- Li Xinyu
- Lipman Jeffrey
- Lipovestky Fernando
- Lipovestky Fernando
- Lloria Maria Monserrat
- Lopez Isabel Maria Villa
- Lopez-Delgado Juan Carlos
- Lovesio Luciano
- Lowe Alastair
- Luczak Karolina
- Lujan Rodolfo
- Maca Jan
- Mahjoub Yazine
- Mahmoodpoor Ata
- Makikado Luis Daniel Umezawa
- Makikado Luis Daniel Umezawa
- Malaska Jan
- Malca Gonzalo Ernesto Gianella
- Mallat Jihad
- Malliotakis Polychronis
- Mandourah Yasser
- Mandragos Konstantinos
- Manzur Adriana
- Marcotte Guillaume
- Margarson Michael
- Marin Jorge Solera
- Marmanidou Kyriaki
- Martin Patricio
- Martinez Manuel
- Martinez-Sagasti Fernando
- Martínez Adela Benítez-Cano
- Maseda Emilio
- Maseda Emilio
- Masjedi Mansoor
- Mastora Zafiria
- McNamee Lia
- Mehmet Inal
- Memis Dilek
- Mendonca Pedro Muguel Hilario
- Mikaszewska-Sokolewicz Malgorzata
- Mikstacki Adam
- Mikstacki Adam
- Minguez Victoria
- Miranda Ariel M.
- Miranda Edith Miriam
- Mirkovic Tomislav
- Misiewska-Kaczur Agnieszka
- Misseri Giovanni
- Misset Benoît
- Miyazaki Erica Aurora
- Miñope John Thomas Sanchez
- Molano-Franco Daniel
- Molinos Elena
- Montague Laura
- Montenegro Martin Alexis
- Montravers Philippe
- Montravers Philippe
- Montravers Philippe
- Monzon Ignacio Catalan
- Mora José
- Morales Freddy
- Moreno-Gonzalez Gabriel
- Morgan Pat
- MorochoTutillo Diego Rolando
- Morton Ben
- Musaeva Tatiana
- Nagky Eva
- Naylor Amanda
- Naylor Douglas
- Nelson Nydia Funes
- Nica Alexandru
- Nicolotti Davide
- Nielsen Louise Gramstrup
- Nikandish Reza
- Nikolaou Charikleia
- Nora David
- Nutt Christopher
- Nuvials Xavier
- Obraz Melanija
- Orozco Alexandra Saraguro
- Ostermann Marlies
- Oviedo Juan Mauricio Pardo
- Ozcelik Menekse
- Ozgultekin Asu
- Ozkan Zeynep
- O’Kane Sinead
- O’Neill Orla
- Page Valerie
- Paiva José-Artur
- Paiva José-Artur
- Pantazopoulos Ioannis
- Papageorgiou Eirini
- Papanikolaou Metaxia
- Papathanakos Georgios
- Papavasilopoulou Theonymfi
- Paraforou Theoniki
- Paridou Alexandra
- Parker Robert
- Parsons Penny
- Pascoalinho Dulce
- Pastorino Maria Laura
- Patrascanu Emilia
- Paugam-Burtz Catherine
- Paul Cherish
- Paul John
- Paz Daniel
- Pearson Suzanne
- Pelagalli Lorella
- Pellegrini Carlos
- Pentari Anastasia
- Pentheroudaki Alexandra
- Pereira José-Manuel
- Pereira Rui Antunes
- Pereyra Cecilia
- Pereyra Cecilia
- Petridou Christina
- Peña Jose Manuel Garcia
- Pinilla Dario
- Pino Carina Alejandra
- Plowright Catherine
- Pneumatikos Ioannis
- Polgarova Petra
- Popescu Mihai
- Pota Vincenzo
- Pottecher Julien
- Pozo Norberto Christian
- Pozo Norberto Christian
- Pozo Norberto Christian
- Prekates Athanasios
- Protus Marek
- Prous Anna Parera
- Psallida Vasiliki
- Pulak Paul
- Qu Changjing
- Queti Felipe
- Quevedo Noelia Elizabeth
- Radovanovic Dragana
- Radu Vasiliki
- Rallis Michael
- Ramazanoglu Atilla
- Ramos Agñel
- Ravani Ifigeneia
- Redondo Francisco Javier
- Reece-Anthony Rosie
- Rees David
- Rello Jordi
- Reschreiter Henrik
- Rezende-Neto Joao
- Rezende-Neto Joao
- Ribeiro Rosa
- Richards Guy
- Rico-Feijoo Jesus
- Rivadeneira Francisco
- Rizoli Sandro
- Roberts Brigit
- Roche-Campo Ferran
- Rojas José
- Romanou Vasiliki
- Romero-Meja Erick
- Rose Bernd Oliver
- Russo Alessandro
- Ryan Christine
- Rzymski Stanislaw
- Sabetian Golnar
- Saha Bhaskar
- Sakellaridis Konstantinos
- Salinas Irene
- Sanchez-Hurtado Luis Alejandro
- Sanchez-Zamora Purificacion
- Sander Michael
- Sangaralingham Sivatharshini
- Santillan Paul
- Santolaya Ignacio
- Santos Anabela
- Santos Lurdes
- Sarakatsanos Ioannis
- Sathe Prachee
- Satinsky Igor
- Saul Pablo
- Sawinski Mariusz
- Scarone Nahuel
- Schwarz Peter
- Scott Carmen
- Segura Lise
- Serafini Giulia
- Sertaridou Eleni
- Shah Bhagyesh
- Shiotsuka Junji
- Shyamsundar Murali
- Silva Ramona Baldomera
- Silversides Jonathon
- Simion Davide
- Simon Marc
- Simon Philipp
- Skoric-Jokic Svetlana
- Smith Julie
- Smuszkiewicz Piotr
- Spadaro Savino
- Starr Therese
- Stokkos Konstantinos
- Sulkowski Wiktor
- Summers Charlotte
- Sutton Giselle
- Swit Beata
- Szakmany Tamas
- Tamowicz Barbara
- Tejeda-Huezo Brigitte
- Tesnière Antoine
- Thakkar Chirag
- Tiberio Ivo
- Timsit Jean-François
- Tiranti Roberto Julian
- Tita Agustin
- Tolosa Carina
- Tomasevic Boris
- Tomescu Dana
- Tomescu Dana
- Toppin Patrick
- Torrente Sergio
- Toth-Tarsoly Piroska
- Tribulev Maxim
- Trinder John
- Trojanowska Iwona
- Trongtrakul Konlawij
- Trosiak Marta
- Tsigou Evdoxia
- Tsimpoukas Fotios
- Tsioka Agoritsa
- Tsoumaropoulos Georgios
- Tzanidakis Charalampos
- Unal Mustafa Necmettin
- Urkmez Seval
- Vakalos Aristeidis
- Valgolio Emanuel
- Van den Berge Andries
- van den Oever Huub
- Van Duijn Ditty
- Vargas Nelson Remache
- Veber Benoît
- Velickovic Dejan
- Velickovic Jelena
- Venkatesan Kumaresh
- Vermeijden Wytze
- Victorino Johanna Abril
- Vidal Montserrat Vallverdú
- Vidal-Cortes Pablo
- Villamagua Boris
- Villazala Ruben
- Vittone Ferdinando Giorgio
- Vogelaers Dirk
- Volta Carlo
- Vondras Petr
- Vos Piet
- Voudouris Antonios
- Vrettou Efstratia
- Vudrag Maja
- Vukovic Anita
- Vukovic Anita
- Vymazal Tomas
- Warhurst Timothy
- Weihua Lu
- Wendon Julia
- Wibrow Bradley
- Wittebole Xavier
- Wong Helen
- Wood James
- Wrigge Hermann
- Wright Christopher
- Yamamoto Ryohei
- Yasuda Hideto
- Yates Bryan
- Yepez Estuardo Salgado
- Young Lorna
- Yu Tao
- Zabolotskikh Igor
- Zakalik Graciela
- Zalba-Etayo Begoña
- Zand Farid
- Zapata Diego Fernando Matallana
- Zazu Alan
- Zhao Xiaobei
- Zubareva Nadezhda
- Zunic Josip
- Ñamendys-Silva Silvio A.
- Ünlü Nurdan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
evere intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. In this study, we report on resistance profiles of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis and Enterococcus faecium in distinct European geographic regions based on an observational cohort study on intra-abdominal infections in intensive care unit (ICU) patients. Resistance against aminopenicillins, fluoroquinolones, and third-generation cephalosporins in E. coli, K. pneumoniae and P. aeruginosa is problematic, as is carbapenem-resistance in the latter pathogen. For E. coli and K. pneumoniae, resistance is mainly an issue in Central Europe, Eastern and South-East Europe, and Southern Europe, while resistance in P. aeruginosa is additionally problematic in Western Europe. Vancomycin-resistance in E. faecalis is of lesser concern but requires vigilance in E. faecium in Central and Eastern and South-East Europe. In the subcohort of patients with secondary peritonitis presenting with either sepsis or septic shock, the appropriateness of empiric antimicrobial therapy was not associated with mortality. In contrast, failure of source control was strongly associated with mortality. The relevance of these new insights for future recommendations regarding empiric antimicrobial therapy in intra-abdominal infections is discussed.Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by diseasespecific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. In this study, we report on resistance profiles of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis and Enterococcus faecium in distinct European geographic regions based on an observational cohort study on intra-abdominal infections in intensive care unit (ICU) patients. Resistance against aminopenicillins, fluoroquinolones, and third-generation cephalosporins in E. coli, K. pneumoniae and P. aeruginosa is problematic, as is carbapenem-resistance in the latter pathogen. For E. coli and K. pneumoniae, resistance is mainly an issue in Central Europe, Eastern and South-East Europe, and Southern Europe, while resistance in P. aeruginosa is additionally problematic in Western Europe. Vancomycin-resistance in E. faecalis is of lesser concern but requires vigilance in E. faecium in Central and Eastern and South-East Europe. In the subcohort of patients with secondary peritonitis presenting with either sepsis or septic shock, the appropriateness of empiric antimicrobial therapy was not associated with mortality. In contrast, failure of source control was strongly associated with mortality. The relevance of these new insights for future recommendations regarding empiric antimicrobial therapy in intra-abdominal infections is discussed
Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis
- Author
- Abdelsalam Ahmed
- Abegao Esteban Martin
- Aguilar Gerardo
- Akbaş Türkay
- Akinyi Frisch
- Al-Khalid Muhammad
- Aldarsani Ayman
- Aldecoa Cesat
- Alli Ahmad
- Almekhlafi Ghaleb
- Alsheikhly Ahmed Subhy
- Alsisi Adel
- Alvarez Brian
- Alvarez Josep Trenado
- Alves Ricardo
- Anisoglou Souzana
- Antonelli Massimo
- Antonelli Massimo
- Antypa Elli
- Arias Mario
- Armstrong Maureen
- Arroyo-Sanchez Abel
- Arvaniti Kostoula
- Arvaniti Kostoula
- Aslan Nesrin Ahu
- Atchade Enora
- Attwood Ben
- Austin Pauline
- Awad Yasser
- Azad Raman
- Bakker Jan
- Bala Miklosh
- Balasini Carina
- Baranowski Bronisław
- Barbagallo Maria
- Barjon Geneviève
- Baronia Arvind
- Barrachina Laura Galarza
- Beck Oliver
- Belavic Matija
- Belda Javier
- Bellocchio Adelina
- Belskiy Vladislav
- Bernedo Carlos Garcia
- Bettini Lisandro
- Bhandary Rakesh
- Bhowmick Kaushik
- Bianchi Luciana
- Bilinska Julia
- Biskup Ewelina
- Bitzani Militisa
- Blahut Ladislav
- Blot Koen
- Blot Stijn
- Bodulica Bruna
- Bonetto Natalia
- Boraso Sabrina
- Bormans Laura
- Bosman Gerrit
- Box Roberta
- Boyd Christine
- Boyd Owen
- Brazzi Luca
- Brescia Giovanni
- Brevard Sidney
- Brown Ben Creagh
- Burtin Philippe
- Calleja Pablo López-Arcas
- Campbell Lewis
- Camsooksai Julie
- Canale Mariana
- Candeias Carlos
- Capponi Paola
- Cardenas Yenny
- Cardonnet Luis
- Castro Guiomar
- Celis Edgar
- Cesio Cristian
- Chacon Mercedes Esteban
- Chalkiadaki Anthoula
- Charalambous Eliana
- Chasou Eleftheria
- Chavan Nitin
- Chediack Viviana
- Chinery Elaine
- Chinthamuneedi Meher
- Chouris Isaac
- Christopoulos Christos
- Chtsomkasem Anusang
- Cimic Nedim
- Coggon Mandy
- Cole Stephen
- Collange Oliver
- Collin Vincent
- Colorado-Dominguez Ever
- Cordoba Nielfa del Carmen
- Cornet Alexander Daniel
- Corradi Francesco
- Correger Enrique
- Cortegiani Andrea
- Costa Rui Pedro
- Cotoia Antonella
- Couce Rocio
- Creagh-Brown Ben
- Creagh-Brown Benedict
- Cruz Carina
- Cunto Eleonora
- Czuczwar Miroslaw
- Dalton Julian
- Dams Karolien
- Davis Noelle
- De Backer Daniel
- De Bels David
- de Carvalho Maria Raquel Lopes Marques
- de la Torre-Prados Maria Victoria
- de Lange Dylan
- de Lange Dylan
- de Lange Dylan
- De Pascale Gennaro
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Jan
- De Waele Jan
- De Waele Jan
- Debarre Matthieu
- del Río-Carbajo Lorena
- Demirkiran Oktay
- Deschepper Mieke
- Descotte Emiliano Jorge
- Diakaki Chryssa
- Dickens Justin
- Dietz Lorena Silvina
- Dikmen Yalim
- Dikmen Yalim
- Dikmen Yalim
- Dimopoulos George
- Dimopoulos George
- Doble Patricia
- Doglia Juan
- Dohnal Martin
- Doklestic Krstina
- Domingo-Marín Sara
- Domingos Guilherme
- Dominguez Cecilia
- Dormans Tom
- Dubois Jasperina
- Duclos Gary
- Dugernier Thierry
- Dullenkopf Alexander
- Dupont Hervé
- Dupuis Claire
- Eckmann Christian
- Einav Sharon
- Elke Gunnar
- Emmerich Monica
- Estevarena Luis Gonzalez
- Fahmy Abdelraouf
- Farazi-Chongouki Christos
- Farfan Angelica Beatriz
- Fernandez Natalia
- Fernandez Ruben
- Ferney Bernal Buitrago
- Ferreira Alcina
- Ferreira Amélia
- Filipovic-Grcic Ina
- Fjeldsoee-Nielsen Hans
- Fletcher Jason
- Flioni Elli-Nikki
- Flocco Romeo
- Floros John
- Forfori Francesco
- Foucrier Arnaud
- Francois Guy
- Fromentin Mélanie
- Fumale Mariela
- Furneval Julie
- Gaigolnik Denis
- Garcia Joseba Gonzalez
- Garcia Mariel
- Garcia-Alvarez Raquel
- Garcia-Guillen Francisco J
- Georgakopoulos Panagiotis
- George Michelle
- Gibson Bethan
- Gil Santiago Alberto Picos
- Girardis Massimo
- Girardis Massimo
- Girardis Massimo
- Gomes Pedro
- Gomez Cristina Delia
- Gonzalez Susana
- González Jesús Flores
- Gorordo Luis
- Grangeat Sergio Hugo
- Grecu Irina
- Grecu Irina
- Grigoras Ioana
- Gritsan Alexey
- Gritsan Alexey
- Groba Casiano Barrera
- Groh Carina
- Grubissich Nicolas
- Gumiela Natalia Soledad
- Gumus Ayca
- Gunst Jan
- Gurjar Mohan
- Haas Lenneke
- Haentjens Lionel
- Hagan Samantha
- Hamilton Mark
- Han Yi
- Hashemian Seyed Mohammadreza
- Hayashi Yoshiro
- Hecketsweiler Stephane
- Hegazy Mohammed
- Hemmings Noel
- Henein Akram
- Hermosa Cecilia
- Herrera Luis
- Hersey Peter
- Hidalgo Irene Beatriz
- Hooker Nicolas
- Hopkins Philip
- Humphreys Sally
- Ijaz Nazia
- Ilutovich Santiago
- Iniesta Rafael Sánchez
- Innes Richard
- Izura Javier
- Jain Nikhilesh
- Jamadarkhana Sunil
- Jankovic Radmilo
- Jansen Jan
- Javeri Yash
- Jha Rajeev
- Jimenez Roberto
- Johnson-Jackson Roxanne
- Jorens Philippe
- Jovanovic Bojan
- Jovanovic Bojan
- Kahveci Ferda
- Kalff Karel Martijn
- Kalogeromitros Alexandros
- Karakosta Agathi
- Karampela Niki
- Karathanou Antigoni
- Kaye Callum
- Kelly Catriona
- Kent Linda
- Kesecioglu Jozef
- Kieslichová Eva
- Kishihara Yuki
- Kizilaslan Deniz
- Koch Christian
- Kokkini Sofia
- Kol Mark
- Kontou Paschalina
- Kontoudaki Eftychia
- Kos Zdenek
- Kostoula Arvaniti
- Kott Matthias
- Kott Matthias
- Koulenti Despoina
- Koulenti Despoina
- Koulenti Despoina
- Koulouras Vasilios
- Kounougeri Katerina
- Kratochvil Milan
- Kricka Irena Bozanic
- Krogh Birgitte Marianne
- Krystopchuk Andriy
- Kuharic Janja
- Kulabukhov Vladimir
- Kulkarni Shilpa
- Kydona Christina
- Kyritsi Aikaterini
- Labeau Sonia
- Lampiri Clairi
- Lamrous Amin
- Lascar Florencia Maria
- Lasocki Sigismond
- Leal Dina
- Lee Sarah
- Leguizamon Mariela
- Leone Marc
- Li Xinyu
- Lipman Jeffrey
- Lipovestky Fernando
- Lipovestky Fernando
- Lipovetsky Fernando
- Lloria Maria Monserrat
- Lopez Isabel Maria Villa
- Lopez-Delgado Juan Carlos
- Lovesio Luciano
- Lowe Alastair
- Luczak Karolina
- Lujan Rodolfo
- Maca Jan
- Mahjoub Yazine
- Mahmoodpoor Ata
- Makikado Luis Daniel Umezawa
- Makikado Luis Daniel Umezawa
- Malaska Jan
- Malca Gonzalo Ernesto Gianella
- Mallat Jihad
- Malliotakis Polychronis
- Mandourah Yasser
- Mandragos Konstantinos
- Manzur Adriana
- Marcotte Guillaume
- Margarson Michael
- Marin Jorge Solera
- Marmanidou Kyriaki
- Martin Patricio
- Martinez Manuel
- Martinez-Sagasti Fernando
- Martínez Adela Benítez-Cano
- Maseda Emilio
- Maseda Emilio
- Maseda Emilio
- Masjedi Mansoor
- Mastora Zafiria
- McNamee Lia
- Mehmet Inal
- Memis Dilek
- Mendonca Pedro Muguel Hilario
- Mikaszewska-Sokolewicz Malgorzata
- Mikstacki Adam
- Mikstacki Adam
- Mikstacki Adam
- Minguez Victoria
- Miranda Ariel M
- Miranda Edith Miriam
- Mirkovic Tomislav
- Misiewska-Kaczur Agnieszka
- Misseri Giovanni
- Misset Benoît
- Miyazaki Erica Aurora
- Miñope John Thomas Sanchez
- Molano-Franco Daniel
- Molinos Elena
- Montague Laura
- Montenegro Martin Alexis
- Montravers Philippe
- Montravers Philippe
- Montravers Philippe
- Monzon Ignacio Catalan
- Mora José
- Morales Freddy
- Moreno-Gonzalez Gabriel
- Morgan Pat
- MorochoTutillo Diego Rolando
- Morton Ben
- Musaeva Tatiana
- Nagky Eva
- Naylor Amanda
- Naylor Douglas
- Nelson Nydia Funes
- Nica Alexandru
- Nicolotti Davide
- Nielsen Louise Gramstrup
- Nikandish Reza
- Nikolaou Charikleia
- Nora David
- Nutt Christopher
- Nuvials Xavier
- Obraz Melanija
- Orozco Alexandra Saraguro
- Ostermann Marlies
- Oviedo Juan Mauricio Pardo
- Ozgultekin Asu
- Ozkan Zeynep
- O’Kane Sinead
- O’Neill Orla
- Page Valerie
- Paiva José-Artur
- Paiva José-Artur
- Paiva José-Artur
- Pantazopoulos Ioannis
- Papageorgiou Eirini
- Papanikolaou Metaxia
- Papathanakos Georgios
- Papavasilopoulou Theonymfi
- Paraforou Theoniki
- Paridou Alexandra
- Parker Robert
- Parsons Penny
- Pascoalinho Dulce
- Pastorino Maria Laura
- Patrascanu Emilia
- Paugam-Burtz Catherine
- Paul Cherish
- Paul John
- Paz Daniel
- Pearson Suzanne
- Pelagalli Lorella
- Pellegrini Carlos
- Pentari Anastasia
- Pentheroudaki Alexandra
- Pereira José-Manuel
- Pereira Rui Antunes
- Pereyra Cecilia
- Pereyra Cecilia
- Pereyra Cecilia
- Petridou Christina
- Peña Jose Manuel Garcia
- Pinilla Dario
- Pino Carina Alejandra
- Plowright Catherine
- Pneumatikos Ioannis
- Polgarova Petra
- Popescu Mihai
- Pota Vincenzo
- Pottecher Julien
- Pozo Norberto Christian
- Pozo Norberto Christian
- Prekates Athanasios
- Protus Marek
- Prous Anna Parera
- Psallida Vasiliki
- Pulak Paul
- Qu Changjing
- Queti Felipe
- Quevedo Noelia Elizabeth
- Radovanovic Dragana
- Radu Vasiliki
- Rallis Michael
- Ramazanoglu Atilla
- Ramos Agñel
- Ravani Ifigeneia
- Redondo Francisco Javier
- Reece-Anthony Rosie
- Rees David
- Rello Jordi
- Rello Jordi
- Reschreiter Henrik
- Rezende-Neto Joao
- Rezende-Neto Joao
- Ribeiro Rosa
- Richards Guy
- Rico-Feijoo Jesus
- Rivadeneira Francisco
- Rizoli Sandro
- Roberts Brigit
- Roche-Campo Ferran
- Rojas José
- Romanou Vasiliki
- Romero-Meja Erick
- Rose Bernd Oliver
- Russo Alessandro
- Ryan Christine
- Rzymski Stanislaw
- Sabetian Golnar
- Saha Bhaskar
- Sakellaridis Konstantinos
- Salinas Irene
- Sanchez-Hurtado Luis Alejandro
- Sanchez-Zamora Purificacion
- Sander Michael
- Sangaralingham Sivatharshini
- Santillan Paul
- Santolaya Ignacio
- Santos Anabela
- Santos Lurdes
- Sarakatsanos Ioannis
- Sathe Prachee
- Satinsky Igor
- Saul Pablo
- Sawinski Mariusz
- Scarone Nahuel
- Schwarz Peter
- Scott Carmen
- Segura Lise
- Serafini Giulia
- Sertaridou Eleni
- Shah Bhagyesh
- Shiotsuka Junji
- Shyamsundar Murali
- Silva Ramona Baldomera
- Silversides Jonathon
- Simion Davide
- Simon Marc
- Simon Philipp
- Skoric-Jokic Svetlana
- Smith Julie
- Smuszkiewicz Piotr
- Spadaro Savino
- Starr Therese
- Stokkos Konstantinos
- Sulkowski Wiktor
- Summers Charlotte
- Sutton Giselle
- Swit Beata
- Szakmany Tamas
- Tamowicz Barbara
- Tejeda-Huezo Brigitte
- Tesnière Antoine
- Thakkar Chirag
- Tiberio Ivo
- Timsit Jean-Francois
- Timsit Jean-François
- Tiranti Roberto Juli an
- Tita Agustin
- Tolosa Carina
- Tomasevic Boris
- Tomescu Dana
- Tomescu Dana
- Toppin Gilda Cinnella Patrick
- Torrente Sergio
- Toth-Tarsoly Piroska
- Tribulev Maxim
- Trinder John
- Trojanowska Iwona
- Trongtrakul Konlawij
- Trosiak Marta
- Tsigou Evdoxia
- Tsimpoukas Fotios
- Tsioka Agoritsa
- Tsoumaropoulos Georgios
- Tzanidakis Charalampos
- Unal Mustafa Necmettin
- Urkmez Seval
- Vakalos Aristeidis
- Valgolio Emanuel
- van den Oever Huub
- Van Duijn Ditty
- Vargas Nelson Remache
- Veber Benoît
- Velickovic Dejan
- Velickovic Jelena
- Venkatesan Kumaresh
- Vermeijden Wytze
- Victorino Johanna Abril
- Vidal Montserrat Vallverdú
- Vidal-Cortes Pablo
- Villamagua Boris
- Villazala Ruben
- Vittone Ferdinando Giorgio
- Vogelaers Dirk
- Volta Carlo
- Vondras Petr
- Vos Piet
- Voudouris Antonios
- Vrettou Efstratia
- Vudrag Maja
- Vukovic Anita
- Vukovic Anita
- Vymazal Tomas
- Warhurst Timothy
- Weihua Lu
- Wendon Julia
- Wibrow Bradley
- Wittebole Xavier
- Wood James
- Wrigge Hermann
- Wright Christopher
- Yamamoto Ryohei
- Yasuda Hideto
- Yates Bryan
- Yepez Estuardo Salgado
- Young Lorna
- Yu Tao
- Zabolotskikh Igor
- Zakalik Graciela
- Zalba-Etayo Begoña
- Zand Farid
- Zapata Diego Fernando Matallana
- Zazu Alan
- Zhao Xiaobei
- Zubareva Nadezhda
- Zunic Josip
- Ñamendys-Silva Silvio A
- Ünlü Nurdan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Purpose: To describe data on epidemiology, microbiology, clinical characteristics and outcome of adult patients admitted in the intensive care unit (ICU) with secondary peritonitis, with special emphasis on antimicrobial therapy and source control.
Methods: Post hoc analysis of a multicenter observational study (Abdominal Sepsis Study, AbSeS) including 2621 adult ICU patients with intra-abdominal infection in 306 ICUs from 42 countries. Time-till-source control intervention was calculated as from time of diagnosis and classified into 'emergency' (< 2 h), 'urgent' (2-6 h), and 'delayed' (> 6 h). Relationships were assessed by logistic regression analysis and reported as odds ratios (OR) and 95% confidence interval (CI).
Results: The cohort included 1077 cases of microbiologically confirmed secondary peritonitis. Mortality was 29.7%. The rate of appropriate empiric therapy showed no difference between survivors and non-survivors (66.4% vs. 61.3%, p = 0.1). A stepwise increase in mortality was observed with increasing Sequential Organ Failure Assessment (SOFA) scores (19.6% for a value ≤ 4-55.4% for a value > 12, p < 0.001). The highest odds of death were associated with septic shock (OR 3.08 [1.42-7.00]), late-onset hospital-acquired peritonitis (OR 1.71 [1.16-2.52]) and failed source control evidenced by persistent inflammation at day 7 (OR 5.71 [3.99-8.18]). Compared with 'emergency' source control intervention (< 2 h of diagnosis), 'urgent' source control was the only modifiable covariate associated with lower odds of mortality (OR 0.50 [0.34-0.73]).
Conclusion: 'Urgent' and successful source control was associated with improved odds of survival. Appropriateness of empirical antimicrobial treatment did not significantly affect survival suggesting that source control is more determinative for outcome
Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project
- Author
- Abdelsalam Ahmed
- Abril Victorino Johanna
- Aguilar Gerardo
- Akbas Turkay
- Akinyi Frisch
- Al-Khalid Muhammad
- Aldarsani Ayman
- Aldecoa Cesat
- Alejandra Pino Carina
- Alejandro Sanchez-Hurtado Luis
- Alexis Montenegro Martin
- Alli Ahmad
- Almekhlafi Ghaleb
- Alsheikhly Ahmed Subhy
- Alsisi Adel
- Alvarez Brian
- Alves Ricardo
- Anisoglou Souzana
- Antonelli Massimo
- Antypa Elli
- Arias Mario
- Armstrong Maureen
- Arroyo-Sanchez Abel
- Arvaniti Kostoula
- Aslan Nesrin Ahu
- Atchade Enora
- Attwood Ben
- Aurora Miyazaki Erica
- Austin Pauline
- Awad Yasser
- Azad Raman
- Bakker Jan
- Bala Miklosh
- Balasini Carina
- Baldomera Silva Ramona
- Baranowski Bronislaw
- Barbagallo Maria
- Barjon Genevieve
- Baronia Arvind
- Beatriz Farfan Angelica
- Beatriz Hidalgo Irene
- Beck Oliver
- Belavic Matija
- Belda Javier
- Bellocchio Adelina
- Belskiy Vladislav
- Benitez-Cano Martinez Adela
- Bettini Lisandro
- Bhandary Rakesh
- Bhowmick Kaushik
- Bianchi Luciana
- Bilinska Julia
- Biskup Ewelina
- Bitzani Militisa
- Blahut Ladislav
- Blot Koen
- Blot Stijn
- Bodulica Bruna
- Bonetto Natalia
- Boraso Sabrina
- Bormans Laura
- Bosman Gerrit
- Box Roberta
- Boyd Christine
- Boyd Owen
- Brazzi Luca
- Brescia Giovanni
- Brevard Sidney
- Burtin Philippe
- Campbell Lewis
- Camsooksai Julie
- Canale Mariana
- Candeias Carlos
- Capponi Paola
- Cardenas Yenny
- Cardonnet Luis
- Carlos Lopez-Delgado Juan
- Castro Guiomar
- Catalan Monzon Ignacio
- Celis Edgar
- Cesio Cristian
- Chalkiadaki Anthoula
- Charalambous Eliana
- Chasou Eleftheria
- Chavan Nitin
- Chediack Viviana
- Chinery Elaine
- Chinthamuneedi Meher
- Chouris Isaac
- Christian Pozo Norberto
- Christopoulos Christos
- Chtsomkasem Anusang
- Cimic Nedim
- Cinnella Gilda
- Coggon Mandy
- Cole Stephen
- Collange Oliver
- Collin Vincent
- Colorado-Dominguez Ever
- Cordoba Nielfa Maria del Carmen
- Cornet Alexander Daniel
- Corradi Francesco
- Correger Enrique
- Cortegiani Andrea
- Costa Rui Pedro
- Cotoia Antonella
- Couce Rocio
- Creagh-Brown Ben
- Creagh-Brown Benedict
- Cruz Carina
- Cruz Godoy
- Cunto Eleonora
- Czuczwar Miroslaw
- Dalton Julian
- Dams Karolien
- Davis Noelle
- De Backer Daniel
- De Bels David
- de la Torre-Prados Maria-Victoria
- de Lange Dylan
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Jan
- Debarre Matthieu
- del Rio-Carbajo Lorena
- Delia Gomez Cristina
- Demirkiran Oktay
- Deschepper Mieke
- Diakaki Chryssa
- Dickens Justin
- Dikmen Yalim
- Dimopoulos George
- Doble Patricia
- Doglia Juan
- Dohnal Martin
- Doklestic Krstina
- Domingo-Marin Sara
- Domingos Guilherme
- Dominguez Cecilia
- Dormans Tom
- Dubois Jasperina
- Duclos Gary
- Dugernier Thieny
- Dullenkopf Alexander
- Dupont Herve
- Dupuis Claire
- Eckmann Christian
- Einav Sharon
- Elizabeth Quevedo Noelia
- Elke Gunnar
- Elli-Nikki
- Emmerich Monica
- Esteban Chacon Mercedes
- Fahmy Abdelraouf
- Farazi-Chongouki Christos
- Fernandez Natalia
- Fernandez Ruben
- Ferney Bernal Buitrago
- Ferreira Alcina
- Ferreira Amelia
- Filipovic-Grcic Ina
- Fjeldsoee-Nielsen Hans
- Fletcher Jason
- Flioni
- Flocco Romeo
- Flores Gonzalez Jesus
- Floros John
- Forfori Francesco
- Foucrier Arnaud
- Francois Guy
- Fromentin Melanie
- Fumale Mariela
- Funes Nelson Nydia
- Furneval Julie
- Gaigolnik Denis
- Galarza Barrachina Laura
- Garcia Bernedo Carlos
- Garcia Pena Jose Manuel
- Garcia Mariel
- Garcia-Alvarez Raquel
- Garcia-Guillen Francisco J
- Georgakopoulos Panagiotis
- George Michelle
- Gianella Malca Gonzalo Ernesto
- Gibson Bethan
- Girardis Massimo
- Gomes Pedro
- Gonzalez Estevarena Luis
- Gonzalez Garcia Joseba
- Gonzalez Susana
- Gorordo Luis
- Grangeat Sergio Hugo
- Grecu Irina
- Grigoras Ioana
- Gritsan Alexey
- Groba Casiano Barrera
- Groh Carina
- Grubissich Nicolas
- Gumus Ayca
- Gunst Jan
- Gurjar Mohan
- Haas Lenneke
- Haentjens Lionel
- Hagan Samantha
- Hamilton Mark
- Han Yi
- Hashemian Seyed Mohammadreza
- Hayashi Yoshiro
- Hecketsweiler Stephane
- Hegazy Mohammed
- Hemmings Noel
- Henein Akram
- Hermosa Cecilia
- Herrera Luis
- Hersey Peter
- Hilario Mendonca Pedro Muguel
- Hooker Nicolas
- Hopkins Philip
- Humphreys Sally
- Ijaz Nazia
- Ilutovich Santiago
- Innes Richard
- Izura Javier
- Jain Nikhilesh
- Jamadarkhana Sunil
- Jankovic Radmilo
- Jansen Jan
- Javeri Yash
- Javier Redondo Francisco
- Jha Rajeev
- Jimenez Roberto
- Johnson-Jackson Roxanne
- Jorens Philippe
- Jorge Descotte Emiliano
- Jovanovic Bojan
- Julian Tiranti Roberto
- Kahveci Ferda
- Kalff Karel Martijn
- Kalogeromitros Alexandros
- Karakosta Agathi
- Karampela Niki
- Karathanou Antigoni
- Kaye Callum
- Kelly Catriona
- Kent Linda
- Kesecioglu Jozef
- Kieslichova Eva
- Kishihara Yuki
- Kizilaslan Deniz
- Koch Christian
- Kokkini Sofia
- Kol Mark
- Kolonia Virginia
- Kontou Paschalina
- Kontoudaki Eftychia
- Kos Zdenek
- Kostoula Arvaniti
- Kott Matthias
- Koulenti Despoina
- Koulouras Vasilios
- Kounougeri Katerina
- Kratochvil Milan
- Kricka Irena Bozanic
- Krogh Birgitte Marianne
- Krystopchuk Andriy
- Kuharic Janja
- Kulabukhov Vladimir
- Kulkarni Shilpa
- Kydona Christina
- Kyritsi Aikaterini
- Labeau Sonia
- Lampiri Clairi
- Lamrous Amin
- Land Farid
- Lang Martin
- Lascar Florencia Maria
- Lasocki Sigismond
- Laura Pastorino Maria
- Leal Dina
- Lee Sarah
- Leguizamon Mariela
- Leone Marc
- Li Xinyu
- Lipman Jeffrey
- Lipovestky Fernando
- Lopes Marques de Carvalho Maria Raquel
- Lopez-Arcas Calleja Pablo
- Lovesio Luciano
- Lowe Alastair
- Luczak Karolina
- Lujan Rodolfo
- Maca Jan
- Mahjoub Yazine
- Mahmoodpoor Ata
- Malaska Jan
- Mallat Jihad
- Malliotakis Polychronis
- Mandourah Yasser
- Mandragos Konstantinos
- Manzur Adriana
- Marcotte Guillaume
- Margarson Michael
- Marmanidou Kyriaki
- Martin Abegao Esteban
- Martin Patricio
- Martinez Manuel
- Martinez-Sagasti Fernando
- Maseda Emilio
- Masjedi Mansoor
- Mastora Zafiria
- Matallana Zapata Diego Fernando
- McNamee Lia
- Med European Soc Intensive Care
- Mehmet Inal
- Memis Dilek
- Mikaszewska-Sokolewicz Malgorzata
- Mikstacki Adam
- Minguez Victoria
- Miranda Ariel M
- Miriam Miranda Edith
- Mirkovic Tomislav
- Misiewska-Kaczur Agnieszka
- Misseri Giovanni
- Misset Benoit
- Molano-Franco Daniel
- Molinos Elena
- Monserrat Lloria Maria
- Montague Laura
- Montravers Philippe
- Mora Jose
- Morales Freddy
- Moreno-Gonzalez Gabriel
- Morgan Pat
- Morton Ben
- Musaeva Tatiana
- NadezhdaZubareva
- Naglry Eva
- Namendys-Silva Silvio A
- Naylor Amanda
- Naylor Douglas
- Nica Alexandru
- Nicolotti Davide
- Nielsen Louise Gramstrup
- Nikandish Reza
- Nikolaou Charikleia
- Nora David
- Nutt Christopher
- Nuvials Xavier
- O'Kane Sinead
- O'Neill Orla
- Obraz Melanija
- Ostermann Marlies
- Ozcelik Menekse
- Ozgultekin Asu
- Ozkan Zeynep
- Page Valerie
- Paiva Jose-Artur
- Pantazopoulos Ioannis
- Papageorgiou Eirini
- Papanikolaou Metaxia
- Papathanakos Georgios
- Papavasilopoulou Theonymfi
- Paraforou Theoniki
- Pardo Oviedo Juan Mauricio
- Parera Prous Anna
- Paridou Alexandra
- Parker Robert
- Parsons Penny
- Pascoalinho Dulce
- Patrascanu Emilia
- Paugam-Burtz Catherine
- Paul Cherish
- Paul John
- Paz Daniel
- Pearson Suzanne
- Pelagalli Lorella
- Pellegrini Carlos
- Pentari Anastasia
- Pentheroudaki Alexandra
- Pereira Jose-Manuel
- Pereira Rui Antunes
- Pereyra Cecilia
- Petridou Christina
- Picos Gil Santiago Alberto
- Pinilla Dario
- Plowright Catherine
- Pneumatikos Ioannis
- Polgarova Petra
- Popescu Mihai
- Pota Vincenzo
- Pottecher Julien
- Prekates Athanasios
- Protus Marek
- Psallida Vasiliki
- Pulak Paul
- Qu Changjing
- Queti Felipe
- Radovanovic Dragana
- Radu Vasiliki
- Rallis Michael
- Ramazanoglu Atilla
- Ramos Agnel
- Ravani Ifigeneia
- Reece-Anthony Rosie
- Rees David
- Rello Jordi
- Remache Vargas Nelson
- Reschreiter Henrik
- Rezende-Neto Joao
- Ribeiro Rosa
- Richards Guy
- Rico-Feijoo Jesus
- Rivadeneira Francisco
- Rizoli Sandro
- Roberts Brigit
- Roche-Campo Ferran
- Rojas Jose
- Rolando MorochoTutillo Diego
- Romanou Vasiliki
- Romero-Meja Erick
- Rose Bernd Oliver
- Russo Alessandro
- Ryan Christine
- Rzymski Stanislaw
- Sabetian Golnar
- Saha Bhaskar
- Sakellaridis Konstantinos
- Salgado Yepez Estuardo
- Salinas Irene
- Sanchez Iniesta Rafael
- Sanchez Minope John Thomas
- Sanchez-Zamora Purificacion
- Sander Michael
- Sangaralingham Sivatharshini
- Santillan Paul
- Santolaya Ignacio
- Santos Anabela
- Santos Lurdes
- Saraguro Orozco Alexandra
- Sarakatsanos Ioannis
- Sathe Prachee
- Satinsky Igor
- Saul Pablo
- Sawinski Mariusz
- Scarone Nahuel
- Schwarz Peter
- Scott Carmen
- Segura Lise
- Serafini Giulia
- Sertaridou Eleni
- Shah Bhagyesh
- Shiotsuka Junji
- Shyamsundar Murali
- Silversides Jonathon
- Silvina Dietz Lorena
- Simion Davide
- Simon Marc
- Simon Philipp
- Skoric-Jokic Svetlana
- Smith Julie
- Smuszkiewicz Piotr
- Soledad Gumiela Natalia
- Solera Marin Jorge
- Spadaro Savino
- Starr Therese
- Stokkos Konstantinos
- Sulkowski Wiktor
- Summers Charlotte
- Sutton Giselle
- Swit Beata
- Szakmany Tamas
- Tamowicz Barbara
- Tejeda-Huezo Brigitte
- Tesniere Antoine
- Thakkar Chirag
- Tiberio Ivo
- Timsit Jean-Francois
- Tita Agustin
- Tolosa Carina
- Tomasevic Boris
- Tomescu Dana
- Toppin Patrick
- Torrente Sergio
- Toth-Tarsoly Piroska
- Trenado Alvarez Josep
- Tribulev Maxim
- Trinder John
- Trojanowska Iwona
- Trongtrakul Konlawij
- Trosiak Marta
- Tsigou Evdoxia
- Tsimpoukas Fotios
- Tsioka Agoritsa
- Tsoumaropoulos Georgios
- Tzanidakis Charalampos
- Umezawa Makikado Luis Daniel
- Unal Mustafa Necmettin
- Unlu Nurdan
- Urkmez Seval
- Vakalos Aristeidis
- Valgolio Emanuel
- Vallverdu Vidal Montserrat
- van den Oever Huub
- Van Duijn Ditty
- Veber Benoit
- Velickovic Dejan
- Velickovic Jelena
- Venkatesan Kumaresh
- Vermeijden Wytze
- Vidal-Cortes Pablo
- Villa Lopez Isabel Maria
- Villamagua Boris
- Villazala Ruben
- Vittone Ferdinando Giorgio
- Vogelaers Dirk
- Volta Carlo
- Vondras Petr
- Vos Piet
- Voudouris Antonios
- Vrettou Efstratia
- Vudrag Maja
- Vukovic Anita
- Vymazal Tomas
- Warhurst Timothy
- Weihua Lu
- Wendon Julia
- Wibrow Bradley
- Wittebole Xavier
- Wong Helen
- Wood James
- Wrigge Hermann
- Wright Christopher
- Yamamoto Ryohei
- Yasuda Hideto
- Yates Bryan
- Young Lorna
- Yu Tao
- Zabolotskikh Igor
- Zakalik Graciela
- Zalba-Etayo Begona
- Zazu Alan
- Zhao Xiaobei
- Zunic Josip
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Purpose
To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).
Methods
We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.
Results
The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.
Conclusion
This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
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- Ye Geoffrey
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- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
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- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
- Bird Jonathan
- Birindelli Arianna
- Birks Sarah
- Birutis Justas
- Björklund Ida
- Blackman Brighid
- Blackwell James
- Blanco-Colino Ruth
- Blok Robin
- Blomme Nina
- Blomqvist Malin
- Blunnie Eimear
- Bnhameida Sondos
- Boddy Alex
- Bodur Muhammed Selim
- Boereboom Catherine
- Bogusevicius Algirdas
- Bolzonaro Elisa
- Bonavina Luigi
- Bondurri Andrea
- Bonghaseh Divine Tim
- Bono Lorenzo
- Borda-Luque Giuliano
- Borg Elaine
- Borghi Felice
- Borham Hala
- Borowski David W
- Bortolasi Luca
- Bosch Marina
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- Falato Armando
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- Forero-Torres Alexander
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- Hall Timothy
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- Trostchansky Ivan
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- Trugeda-Carrera Maria Soledad
- Trujillo Díaz Jeancarlos
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- Tsandiraki Justin
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- van Berge Henegouwen Mark I.
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- Vaughan-Shaw Peter G
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- Warwicker Sean
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- Watts Daniel
- Weiser Thomas G
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- Wilson Michael
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- Wogensen Fredrik
- Wondoh Paul M.
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- Wong Jane J
- Wong Jeremy
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- Wong Tsz Lun Ernest
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- Yüksel Osman
- Zabiyaka Mikhail
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- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research