1,111 research outputs found
Development and operational experience of magnetic horn system for T2K experiment
A magnetic horn system to be operated at a pulsed current of 320 kA and to
survive high-power proton beam operation at 750 kW was developed for the T2K
experiment. The first set of T2K magnetic horns was operated for over 12
million pulses during the four years of operation from 2010 to 2013, under a
maximum beam power of 230 kW, and protons were exposed to
the production target. No significant damage was observed throughout this
period. This successful operation of the T2K magnetic horns led to the
discovery of the oscillation phenomenon in 2013 by
the T2K experiment. In this paper, details of the design, construction, and
operation experience of the T2K magnetic horns are described.Comment: 22 pages, 40 figures, also submitted to Nuclear Instrument and
Methods in Physics Research,
Fundamental properties of Tsallis relative entropy
Fundamental properties for the Tsallis relative entropy in both classical and
quantum systems are studied. As one of our main results, we give the parametric
extension of the trace inequality between the quantum relative entropy and the
minus of the trace of the relative operator entropy given by Hiai and Petz. The
monotonicity of the quantum Tsallis relative entropy for the trace preserving
completely positive linear map is also shown without the assumption that the
density operators are invertible.
The generalized Tsallis relative entropy is defined and its subadditivity is
shown by its joint convexity. Moreover, the generalized Peierls-Bogoliubov
inequality is also proven
Observation of the first gravitational microlensing event in a sparse stellar field : the Tago event
We report the observation of the first gravitational microlensing event in a
sparse stellar field, involving the brightest (V=11.4 mag) andclosest (~ 1 kpc)
source star to date. This event was discovered by an amateurastronomer, A.
Tago, on 2006 October 31 as a transient brightening, by ~4.5 mag during a ~15
day period, of a normal A-type star (GSC 3656-1328) in the Cassiopeia
constellation. Analysis of both spectroscopic observations and the light curve
indicates that this event was caused by gravitational microlensing rather than
an intrinsically variable star. Discovery of this single event over a 30 year
period is roughly consistent with the expected microlensing rate for the whole
sky down to V = 12 mag stars. However, the probability for finding events with
such a high magnification (~ 50) is much smaller, by a factor ~1/50, which
implies that the true event rate may be higher than expected. This discovery
indicates the potential of all sky variability surveys, employing frequent
sampling by telescopes with small apertures and wide fields of view, for
finding such rare transient events, and using the observations to explore
galactic disk structure and search for exo-planets.Comment: 13 pages, 2 tables, 3 figures, accepted by Ap
The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity
Podoplanin (PDPN/Aggrus/T1α) binds to C-type lectin-like receptor-2 (CLEC-2) and induces platelet aggregation. PDPN is associated with malignant progression, tumor metastasis, and poor prognosis in several types of cancer. Although many anti-human PDPN (hPDPN) monoclonal antibodies (mAbs), such as D2-40 and NZ-1, have been established, these epitopes are limited to the platelet aggregation-stimulating (PLAG) domain (amino acids 29-54) of hPDPN. Recently, we developed a novel mouse anti-hPDPN mAb, LpMab-7, which is more sensitive than D2-40 and NZ-1, using the Cancer-specific mAb (CasMab) method. The epitope of LpMab-7 was shown to be entirely different from that of NZ-1, a neutralizing mAb against the PLAG domain according to an inhibition assay and lectin microarray analysis. In the present study, we produced a mouse-human chimeric anti-hPDPN mAb, chLpMab-7. ChLpMab-7 showed high antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Furthermore, chLpMab-7 inhibited the growth of hPDPN-expressing tumors in vivo. Although chLpMab-7 recognizes a non-PLAG domain of hPDPN, it suppressed the hematogenous metastasis of hPDPN-expressing tumors. These results indicated that chLpMab-7 suppressed tumor development and hematogenous metastasis in a neutralization-independent manner. In conclusion, hPDPN shows promise as a target in the development of a novel antibody-based therapy
Measurement of the forward-backward asymmetries for charm- and bottom-quark pair productions at =58GeV with electron tagging
We have measured, with electron tagging, the forward-backward asymmetries of
charm- and bottom-quark pair productions at =58.01GeV, based on
23,783 hadronic events selected from a data sample of 197pb taken with
the TOPAZ detector at TRISTAN. The measured forward-backward asymmetries are
and , which are consistent with the standard model
predictions.Comment: 19 pages, Latex format (article), 5 figures included. to be published
in Phys. Lett.
Measurement of the cross-section and forward-backward charge asymmetry for the b and c-quark in e+e- annihilation with inclusive muons at sqrt(s) = 58 GeV
We have studied inclusive muon events using all the data collected by the
TOPAZ detector at sqrt(s)=58 GeV with an integrated luminosity of 273pb-1. From
1328 inclusive muon events, we measured the ratio R_qq of the cross section for
qq-bar production to the total hadronic cross section and forward-backward
asymmetry A^q_FB for b and c quarks. The obtained results are R_bb =
0.13+-0.02(stat)+-0.01(syst), R_cc = 0.36+-0.05(stat)+-0.05(syst), A^b_FB =
-0.20+-0.16(stat)+-0.01(syst) and A^c_FB = -0.17+-0.14(stat)+-0.02(syst), in
fair agreement with a prediction of the standard model.Comment: To be published in EPJ C. 24 pages, 12 figure
Spectral Correlation in Incommensurate Multi-Walled Carbon Nanotubes
We investigate the energy spectra of clean incommensurate double-walled
carbon nanotubes, and find that the overall spectral properties are described
by the so-called critical statistics of Anderson metal-insulator transition. In
the energy spectra, there exist three different regimes characterized by
Wigner-Dyson, Poisson, and semi-Poisson distributions. This feature implies
that the electron transport in incommensurate multi-walled nanotubes can be
either diffusive, ballistic, or intermediate between them, depending on the
position of the Fermi energy.Comment: final version to appear in Phys. Rev. Let
Chimeric Anti-PDPN Antibody ChLpMab-2
Human podoplanin (hPDPN ), a platelet aggregationâinducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to Câtype lectinâlike receptor 2 (CLEC â2). The overexpression of hPDPN is involved in invasion and metastasis. AntiâhPDPN monoclonal antibodies (mAbs) such as NZ â1 have shown antitumor and antimetastatic activities by binding to the platelet aggregationâstimulating (PLAG ) domain of hPDPN . Recently, we developed a novel mouse antiâhPDPN mAb, LpMabâ2, using the cancerâspecific mAb (CasMab) technology. In this study we developed chLpMabâ2, a humanâmouse chimeric antiâhPDPN antibody, derived from LpMabâ2. chLpMabâ2 was produced using fucosyltransferase 8âknockout (KO ) Chinese hamster ovary (CHO )âS cell lines. By flow cytometry, chLpMabâ2 reacted with hPDPN âexpressing cancer cell lines including glioblastomas, mesotheliomas, and lung cancers. However, it showed low reaction with normal cell lines such as lymphatic endothelial and renal epithelial cells. Moreover, chLpMabâ2 exhibited high antibodyâdependent cellular cytotoxicity (ADCC ) against PDPN âexpressing cells, despite its low complementâdependent cytotoxicity. Furthermore, treatment with chLpMabâ2 abolished tumor growth in xenograft models of CHO /hPDPN , indicating that chLpMabâ2 suppressed tumor development via ADCC . In conclusion, chLpMabâ2 could be useful as a novel antibodyâbased therapy against hPDPN âexpressing tumors
Measurement of inclusive electron cross section in collisions at TRISTAN
We have studied open charm production in collisions with the
TOPAZ detector at the TRISTAN collider. In this study, charm
quarks were identified by electrons (and positrons) from semi-leptonic decays
of charmed hadrons. The data corresponded to an integrated luminosity of 95.3
pb at a center-of-mass energy of 58 GeV. The results are presented as
the cross sections of inclusive electron production in
collisions with an anti-tag condition, as well as the subprocess cross
sections, which correspond to resolved-photon processes. The latter were
measured by using a sub-sample with remnant jets. A comparison with various
theoretical predictions based on direct and resolved-photon processes showed
that our data prefer that with relatively large gluon contents in a photon at
small , with the next-to-leading order correction, and with a
charm-quark mass of 1.3 GeV.Comment: 26 pages, Latex format (article), 5 figures included, to be published
in Phys. Lett.
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