The Ursinus Weekly, March 15, 1937

Ditzel is chosen 1938 Ruby editor • Vernon D. Groff elected Weekly editor at annual board meeting • Interracial fellowship to present play on Wednesday • Editor announces formal Ruby to appear on campus in May • Class Day committee named • Prom and play chairmen report completed plans • Bodley, Hayashi named to sports captaincies • Dr. Daniel Poling returns to address chapel meeting • Bassman, Paris best matmen, review of wrestling reveals • Hedgerow theatre group pleases with fine work on plays of diverse theme; English marriage laws, savagery, and modern indifference to war are subjects • Ancient Weeklies show that olden collegiates knew everything we young moderns rave about • Easter program to be offered by the choir Thursday evening • Burtons, China sojourners, tell of conditions there • Co-eds drop first to Beaver sextette • Basketball hash-over reveals that men\u27s teams won but eleven games out of twenty-nine total played • Shreiner sextette leading pack in basketball league • Thoughts turn to baseball \u27tho snow covers diamond • Hess to address postponed history social-science meeting • York alumni hold largest session and elect officers • Ursinus students participate in three college night programshttps://digitalcommons.ursinus.edu/weekly/1925/thumbnail.jp

Third-generation leptoquark decays and collider searches

Collider searches for first-, second-, and third-generation scalar (S) or vector (V) leptoquarks (LQs) focus on the quark-lepton decay modes S,V -> q l. For SU(2)-doublet and -triplet leptoquarks with a sufficiently large splitting between the components, decays involving real W-boson emission (such as S_2^{(+5/3)} -> S_2^{(+2/3)} W^{+} and others) become possible and can change the patterns of leptoquark decays. For third-generation leptoquarks, where these mass splittings might be large, such modes could dominate certain leptoquark decays as they are (if kinematically allowed) guaranteed to be of order g^2 where g is the electroweak coupling. We calculate the decay rates for all such processes involving SU(2)-doublet and triplet, scalar and vector leptoquarks. Standard limits on mass splittings from precision electroweak measurements imply that only such decays involving SU(2)-doublet scalar LQs are likely kinematically possible.Comment: 13 pages, LaTeX, 2 separate postscript figure

Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma

Background: TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesophago-gastric adenocarcinomas, in this phase II study we assessed the efficacy and safety of TP300 in patients with gastric or gastro-oesophageal junction (GOJ) adenocarcinomas. Methods: Eligible patients had metastatic or locally advanced gastric or Siewert Types II or III GOJ inoperable adenocarcinoma. Patients were chemotherapy naïve unless this had been administered in the perioperative setting. TP300 was administered as a 1-h intravenous infusion every 3 weeks (a cycle) for up to 6 cycles at a starting dose of 8 mg/m2 with intra-patient escalation to 10 mg/m2 from cycle 2 in the absence of dose-limiting toxicity. Tumour responses (RECIST 1.1) were assessed every 6 weeks. Toxicity was recorded by NCI-CTCAE version 3.0. Using a modified two-stage Simon design (Stage I and II), a total of 43 patients were to be included providing there were 3 of 18 patients with objective response in Stage I of the study. Results: In Stage I of the study 20 patients (14 males, 6 females), median age 67 years (range 40 − 82), performance status ECOG 0/1, with GC [14] or GOJ carcinoma [6] were enrolled. Of the 16 evaluable patients, 11 received the planned dose increase to 10 mg/m2 at cycle 2, 2 decreased to 6 mg/m2, and 3 continued on 8 mg/m2. There were no objective responses after 2 cycles of treatment. Twelve patients had stable disease for 1 − 5 months and 4 had progressive disease. Median progression free survival (PFS) was 4.1 months (CI [1.6 − 4.9]), median time to progression (TTP) was 2.9 months (CI [1.4 − 4.2]). Grade 3/4 toxicities (worst grade all cycles) included 7 patients (35 %) with neutropenia, 4 patients (20 %) with anaemia, 2 patients (10 %) with thrombocytopenia, and 3 patients (15 %) with fatigue. This study was terminated at the end of Stage I due to a lack of the required (3/18) responders. Conclusions: This study of TP300 showed good drug tolerability but it failed to demonstrate sufficient efficacy as measured by radiological response

Modelling train delays with q-exponential functions

We demonstrate that the distribution of train delays on the British railway network is accurately described by q-exponential functions. We explain this by constructing an underlying superstatistical model.Comment: 12 pages, 5 figure

Polarized nuclear target based on parahydrogen induced polarization

We discuss a novel concept of a polarized nuclear target for accelerator fixed-target scattering experiments, which is based on parahydrogen induced polarization (PHIP). One may be able to reach a 33% free-proton polarization in the ethane molecule. The potential advantages of such a target include operation at zero magnetic field, fast ($\sim$100 Hz) polarization reversal, and operation with large intensity of an electron beam.Comment: 16 pages, 2 figure

Lower Bound on the Pseudoscalar Mass in the Minimal Supersymmetric Standard Model

In the Higgs sector of the Minimal Supersymmetric Standard Model, the mass of the pseudoscalar $A$ is an independent parameter together with $\tan \beta \equiv v_2/v_1$. If $m_A$ is small, then the process $e^+ e^- \to h + A$ is kinematically allowed and is suppressed only if $\tan \beta$ is small. On the other hand, the mass of the charged Higgs boson is now near $M_W$, and the decay $t \to b + h^+$ is enhanced if $\tan \beta$ is small. Since the former has not been observed, and the branching fraction of $t \to b + W$ cannot be too small (by comparing the experimentally derived $t \bar t$ cross section from the leptonic channels with the theoretical prediction), we can infer a phenomenological lower bound on $m_A$ of at least 60 GeV for all values of $\tan \beta$.Comment: 11 pages including 2 figs, reference adde

Can scalar leptoquarks explain the f_{D_s} puzzle?

Motivated by the disagreement between experimental and lattice QCD results on the D_s decay constant we systematically reinvestigate role of leptoquarks in charm meson decays. We consider scalar leptoquarks that transform as a weak interaction triplet, doublet, or singlet in a model independent approach, and also argue that in a particular SU(5) GUT model these leptoquark states, contained in the 45-dimensional Higgs representation, could be safe against proton decay bounds. Using the current experimental measurements in tau, kaon and charm sectors, we find that scalar leptoquarks cannot naturally explain the D_s --> mu nu and D_s --> tau nu decay widths simultaneously. While any contributions of the triplet leptoquarks are already excluded, the singlets could only contribute significantly to the D_s --> tau nu width. Finally, a moderate improvement of the experimental upper bound on the D^0 --> mu^+\mu^- decay width could exclude the doublet contribution to the D_s --> mu nu, while present experimental data limits its mass to be below 1.4 TeV. Possible new signatures at present and near future experiments are also briefly discussed.Comment: 8 pages, 2 figures, revtex forma

A Supersymmetric Model with an Extra U(1) Gauge Symmetry

In the standard model the proton is protected from decay naturally by gauge symmetries, whereas in the ordinary minimal supersymmetric standard model an ad hoc discrete symmetry is imposed for the proton stability. We present a new supersymmetric model in which the proton decay is forbidden by an extra U(1) gauge symmetry. Particle contents are necessarily increased to be free from anomalies, incorporating right-handed neutrinos. Both Dirac and Majorana masses are generated for neutrinos, yielding non-vanishing but small masses. The superpotential consists only of trilinear couplings and the mass parameter $\mu$ of the minimal model is induced by spontaneous breaking of the U(1) symmetry.Comment: 10 pages, Revte

Supersymmetric Extension of the Standard Model with Naturally Stable Proton

A new supersymmetric standard model based on N=1 supergravity is constructed, aiming at natural explanation for the proton stability without invoking an ad hoc discrete symmetry through R parity. The proton is protected from decay by an extra U(1) gauge symmetry. Particle contents are necessarily increased to be free from anomalies, making it possible to incorporate the superfields for right-handed neutrinos and an SU(2)-singlet Higgs boson. The vacuum expectation value of this Higgs boson, which induces spontaneous breakdown of the U(1) symmetry, yields large Majorana masses for the right-handed neutrinos, leading to small masses for the ordinary neutrinos. The linear coupling of SU(2)-doublet Higgs superfields, which is indispensable to the superpotential of the minimal supersymmetric standard model, is replaced by a trilinear coupling of the Higgs superfields, so that there is no mass parameter in the superpotential. The energy dependencies of the model parameters are studied, showing that gauge symmetry breaking is induced by radiative corrections. Certain ranges of the parameter values compatible with phenomena at the electroweak energy scale can be derived from universal values of masses-squared and trilinear coupling constants for scalar fields at a very high energy scale.Comment: 32 pages, Revtex, 7 figure

A Novel Mutation in the HSD17B10 Gene of a 10-Year-Old Boy with Refractory Epilepsy, Choreoathetosis and Learning Disability

Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) is a mitochondrial multifunctional enzyme encoded by the HSD17B10 gene. Missense mutations in this gene result in HSD10 deficiency, whereas a silent mutation results in mental retardation, X-linked, syndromic 10 (MRXS10). Here we report a novel missense mutation found in the HSD17B10 gene, namely c.194T\u3eC transition (rs104886492), brought about by the loss of two forked methyl groups of valine 65 in the HSD10 active site. The affected boy, who possesses mutant HSD10 (p.V65A), has a neurological syndrome with metabolic derangements, choreoathetosis, refractory epilepsy and learning disability. He has no history of acute decompensation or metabolic acidosis whereas his urine organic acid profile, showing elevated levels of 2-methyl-3-hydroxybutyrate and tiglylglycine, is characteristic of HSD10 deficiency. His HSD10 activity was much lower than the normal control level, with normal β-ketothiolase activity. The c.194T\u3eC mutation in HSD17B10 can be identified by the restriction fragment polymorphism analysis, thereby facilitating the screening of this novel mutation in individuals with intellectual disability of unknown etiology and their family members much easier. The patient\u27s mother is an asymptomatic carrier, and has a mixed ancestry (Hawaiian, Japanese and Chinese). This demonstrates that HSD10 deficiency patients are not confined to a particular ethnicity although previously reported cases were either Spanish or German descendants