Microalbuminuria as a Predictor of Outcome in Non-Diabetic Patients Undergo Percutaneous Coronary Intervention for Acute Coronary Syndrome

Background: Acute coronary syndrome (ACS) is a medical emergency requiring prompt diagnosis and care. Percutaneous coronary intervention (PCI) has become integral part of management of coronary artery disease (CAD) and become lifesaving in acute STEMI patients. Microalbuminuria (MA) is a common phenomenon in patients with cardiovascular disease. Objective: To assess importance of microalbuminuria as a predictor of outcome in non-diabetic patients undergoing PCI for ACS. Subjects and methods: This study was conducted on 123 patients admitted with ACS and were divided equally into three groups [unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI) andSTEMI). The patients were then divided into patients with negative and positive microalbuminuria (MA). Echocardiography, coronary angiography and estimation of microalbuminuria level were done to all patients. Results: Mean age of patients 54.94 ± 9.86 years. There were 28 females (22.8%) and 95 males (77.2%). MA was more common in smokers than non-smokers were. There was statistically significant decrease in EF% and increase in WMSI in patients with positive MA than those with negative MA. There was statistically significant increase in the complications and mortality rate in patients with positive MA than those with negative MA. The univariate logistic regression analysis showed statistically significant association between presence of MA and wall motion score index (WMSI) >1.25, amount of dye > 160 ml, no reflow, occurrence of complications, EF pre ≤ 55%, and EF post ≤ 59%. Conclusion: Albuminuria was a strong predictor of outcome in non-diabetic patients underwent PCI for ACS

Validation for application of the Monte Carlo simulation code for 235U mass content verification for large size samples of nuclear materials

In this work, a new semi- absolute non-destructive assay technique has been developed to verify the mass content of 235U in the large sizes nuclear material samples of different enrichment through combination of experimental measurements and Mont Carlo calculations (version MCNP5). A good agreement was found between the calculated and declared values of the mass content of 235U of uranium oxide (UO2) samples. The results obtained from Mont Carlo calculations showed that the semi-absolute technique can be used with sufficient reliability to verify the uranium mass content in the large sizes nuclear material samples of different enrichment

Composição de aminoácidos de gerações precoces de feijão obtidas a partir de cruzamentos com parental de alto teor de metionina Amino acid composition in common bean of early generations developed from cross with high methionine content parental

O objetivo deste trabalho foi avaliar a composição de aminoácidos de gerações precoces de feijão, obtidas a partir de cruzamentos com parental de alto teor de metionina, e selecionar plantas F2 para o desenvolvimento de populações segregantes com alto teor de metionina. A partir do cruzamento entre BRS Valente e IAPAR 44 foram obtidas as gerações F1, F1 recíproco, F2, F2 recíproco, retrocruzamento 1 e retrocruzamento 2. Os aminoácidos foram quantificados por cromatografia líquida de alta eficiência (CLAE) e os dados obtidos foram submetidos à análise de variância e de variáveis canônicas. Os aminoácidos - ácido aspártico, ácido glutâmico, glicina, prolina, tirosina, cisteína, metionina e treonina - apresentaram variabilidade genética. Gerações precoces com alto teor de metionina foram obtidas sem que tenha havido limitação na disponibilidade dos demais aminoácidos essenciais. As duas primeiras variáveis canônicas explicaram 99,28% da variação total dos genótipos e três grupos foram formados. Plantas da geração F2 poderão ser selecionadas pelo programa de melhoramento para o desenvolvimento de populações segregantes de feijão com alto teor de metionina.<br>The objective of this research was to determine the amino acid composition in common bean early generations developed from controlled crossings with high methionine content parental, and to select F2 plants with high methionine content. BRS Valente and IAPAR 44 were crossed and the F1, F1 reciprocal, F2, F2 reciprocal, backcross 1 e backcross 2 generations were obtained. The amino acid contents were determinated by liquid chromatography of high performance (CLAE) and the data were submitted to analysis of variance and cannonical variables. Aspartic acid, glutamatic acid, glycine, proline, tyrosine, cysteine, methionine and threonine contents showed variability among genotypes. Early generations were obtained with high methionine content and essential amino acids contents were appropriate for consume. The first two cannonical variables explained 99.28% of the total variation of genotypes and three groups were formed. Plants of the F2 generation are able to be selected by breeding program for the development of segregation populations of common bean with high methionine content