3,123 research outputs found

    Convex recovery of tensors using nuclear norm penalization

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    The subdifferential of convex functions of the singular spectrum of real matrices has been widely studied in matrix analysis, optimization and automatic control theory. Convex analysis and optimization over spaces of tensors is now gaining much interest due to its potential applications to signal processing, statistics and engineering. The goal of this paper is to present an applications to the problem of low rank tensor recovery based on linear random measurement by extending the results of Tropp to the tensors setting.Comment: To appear in proceedings LVA/ICA 2015 at Czech Republi

    Corticomotor map of the human masseter: effect of motor task

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    Abstract no. 2177published_or_final_versio

    Accuracy and computational efficiency of 2D urban surface flood modelling based on cellular automata

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    There is an emerging abundance freely available of high resolution (one meter or less) LIDAR data due to the advent of remote sensing, which enables wider applications of detailed flood risk modelling and analysis. Digital terrain surface data often comes in raster form, i.e., a square regular grid, and often requires conversion into a specific computational mesh for two-dimensional (2D) flood modelling that adopts triangular irregular meshes. 2D modelling of flood water movement through urban areas requires resolution of complex flow paths around buildings, which requires both high accuracy and computational efficiency. Water distribution and Wastewater systems in the UK contain over 700,000 km of water distribution and sewer pipes, which represents a large risk exposure from flooding caused by sewer surcharging or distribution pipe breaks. This makes it important for utilities to understand and predict where clean or dirty water flows will be directed when they leave the system. In order to establish risk assessment many thousands of simulations may be required calling for the most computational efficient models possible. Cellular Automata (CA) represents a method of running simulations based on a regular square grid, thus saving set-up time of configuring the terrain data into an irregular triangular mesh. It also offers a more uniform memory pattern for very fast modern, highly parallel hardware, such as general purpose graphical processing units (GPGPU). In this paper the performance of the CADDIES, a CA platform and associate flood modelling software caFloodPro, using a square regular grid and Von Neumann neighbourhood, is compared to industry standard software using triangular irregular meshes for similar resolutions. A minimum time step is used to control the computational complexity of the algorithm, which then creates a trade-off between the processing speeds of simulations and the accuracy resulting from the limitations used within the local rule to cope with relatively large time steps. This study shows that using CA based methods on regular square grids offers process speed increases in terms of 5-20 times over that of the industry standard software using irregular triangular meshes, while maintaining 98-99% flooding extent accuracy.This is the final version of the article. Available from Elsevier via the DOI in this record.There is an emerging abundance freely available of high resolution (one meter or less) LIDAR data due to the advent of remote sensing, which enables wider applications of detailed flood risk modelling and analysis. Digital terrain surface data often comes in raster form, i.e., a square regular grid, and often requires conversion into a specific computational mesh for two-dimensional (2D) flood modelling that adopts triangular irregular meshes. 2D modelling of flood water movement through urban areas requires resolution of complex flow paths around buildings, which requires both high accuracy and computational efficiency. Water distribution and Wastewater systems in the UK contain over 700,000 km of water distribution and sewer pipes, which represents a large risk exposure from flooding caused by sewer surcharging or distribution pipe breaks. This makes it important for utilities to understand and predict where clean or dirty water flows will be directed when they leave the system. In order to establish risk assessment many thousands of simulations may be required calling for the most computational efficient models possible. Cellular Automata (CA) represents a method of running simulations based on a regular square grid, thus saving set-up time of configuring the terrain data into an irregular triangular mesh. It also offers a more uniform memory pattern for very fast modern, highly parallel hardware, such as general purpose graphical processing units (GPGPU). In this paper the performance of the CADDIES, a CA platform and associate flood modelling software caFloodPro, using a square regular grid and Von Neumann neighbourhood, is compared to industry standard software using triangular irregular meshes for similar resolutions. A minimum time step is used to control the computational complexity of the algorithm, which then creates a trade-off between the processing speeds of simulations and the accuracy resulting from the limitations used within the local rule to cope with relatively large time steps. This study shows that using CA based methods on regular square grids offers process speed increases in terms of 5-20 times over that of the industry standard software using irregular triangular meshes, while maintaining 98-99% flooding extent accuracy

    Outpatient CBT for Motor Functional Neurological Disorder and Other Neuropsychiatric Conditions: A Retrospective Case Comparison

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    OBJECTIVE: No gold-standard treatment exists for motor functional neurological disorder (mFND), and limited evidence has been found for the effectiveness of cognitive-behavioral therapy (CBT) in treating the disorder. This study examined sociodemographic and clinical characteristics, treatment outcomes, and treatment dropout among patients with and without mFND who received CBT in a neuropsychiatric outpatient clinic in the United Kingdom. METHODS: Data from a large anonymized psychiatric register were used to identify patients who received outpatient CBT in a neuropsychiatry clinic between 2006 and 2016 and who had either mFND (N=98) or other neuropsychiatric conditions (ONP) (N=76, control group). The study examined sociodemographic characteristics, physical symptom improvement, and changes in clinical outcome and scores on three instruments measuring psychological distress, psychiatric sequelae of brain injury, and depression. RESULTS: The most common mFND symptoms were weakness, pain, and tremors. A logistic regression analysis found no sociodemographic differences between patients with mFND who dropped out early and those who completed CBT. Pre- and post-CBT scores on the three instruments were available for only a small subset of patients; both mFND and ONP patients showed significant improvements in overall scores. A logistic regression analysis found only a single predictor of symptom improvement in the mFND group: acceptance of a psychological explanation of symptoms prior to treatment. CONCLUSIONS: Improvements in physical and psychological functioning were similar for patients with mFND and patients with ONP who were treated in a specialist CBT clinic. This study provides evidence that CBT is feasible and effective for some patients with mFND

    Finite-size effects on multibody neutrino exchange

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    The effect of multibody massless neutrino exchanges between neutrons inside a finite-size neutron star is studied. We use an effective Lagrangian, which incorporates the effect of the neutrons on the neutrinos. Following Schwinger, it is shown that the total interaction energy density is computed by comparing the zero point energy of the neutrino sea with and without the star. It has already been shown that in an infinite-size star the total energy due to neutrino exchange vanishes exactly. The opposite claim that massless neutrino exchange would produce a huge energy is due to an improper summation of an infrared-divergent quantity. The same vanishing of the total energy has been proved exactly in the case of a finite star in a one-dimensional toy model. Here we study the three-dimensional case. We first consider the effect of a sharp star border, assumed to be a plane. We find that there is a non- vanishing of the zero point energy density difference between the inside and the outside due to the refraction index at the border and the consequent non-penetrating waves. An analytical and numerical calculation for the case of a spherical star with a sharp border confirms that the preceding border effect is the dominant one. The total result is shown to be infrared-safe, thus confirming that there is no need to assume a neutrino mass. The ultraviolet cut-offs, which correspond in some sense to the matching of the effective theory with the exact one, are discussed. Finally the energy due to long distance neutrino exchange is of the order of 10−8−−10−13GeVperneutron10^{-8} -- 10^{-13} GeV per neutron, i.e. negligible with respect to the neutron mass density.Comment: Latex file (Revtex), 34 pages, 8 postscripted figure

    Subcontractor trust issues on payment and valuation practices in UK private projects

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    Purpose Construction project delivery is hinged on the performance of the contractor and subcontractors. In many private construction projects in the UK, there are trust issues between the subcontractor and contractor, especially when there are no collateral warranties to protect the rights of the subcontractors. The purpose of this study is to investigate and identify the causations of distrust between subcontractors and contractors and proffered panaceas. Design/methodology/approach Qualitative open-ended questions were used. Twenty respondents, mainly supervisors, tradesmen, subcontractors and main contractors in the UK, were interviewed. The thematic analysis approach was used to identify the dominant themes. Findings The interview findings were presented descriptively, and the frequency approach identified more occurring themes from the interviewees’ responses. The six themes contributing to distrust between subcontractor and contractor are financial pressures, partnering approach, payment and trust, nature of trust, internal influence and unfair payment. Practical implications The findings of this study revealed that many subcontractors have limited knowledge of the clauses in contracts they are entering into. Thus, in addition to obtaining collateral warranties, subcontractors must carefully understand their contractual obligations and payment arrangements before agreeing to be part of a construction project. Originality/value Although this study aimed to shed light on the distrust between subcontractors and contractors in private UK construction projects, improvements in contract administration, subcontractors continued professional development and improved valuation processes can reduce distrust between subcontractors and contractors

    FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease.

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    Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD). As disturbed angiogenesis and endothelial dysfunction are strongly implicated in T2D and CVD, we aimed to investigate the association between a novel anti-angiogenic protein, FK506-binding protein like (FKBPL), and these diseases. Plasma FKBPL was quantified by ELISA cross-sectionally in 353 adults, consisting of 234 T2D and 119 non-diabetic subjects with/without CVD, matched for age, BMI and gender. FKBPL levels were higher in T2D (adjusted mean: 2.03 ng/ml ± 0.90 SD) vs. non-diabetic subjects (adjusted mean: 1.79 ng/ml ± 0.89 SD, p = 0.02), but only after adjustment for CVD status. In T2D, FKBPL was negatively correlated with fasting blood glucose, HbA1c and diastolic blood pressure (DBP), and positively correlated with age, known diabetes duration, waist/hip ratio, urinary albumin/creatinine ratio (ACR) and fasting C-peptide. FKBPL plasma concentrations were increased in the presence of CVD, but only in the non-diabetic group (CVD: 2.02 ng/ml ± 0.75 SD vs. no CVD: 1.68 ng/ml ± 0.79 SD, p = 0.02). In non-diabetic subjects, FKBPL was positively correlated with an established biomarker for CVD, B-type Natriuretic Peptide (BNP), and echocardiographic parameters of diastolic dysfunction. FKBPL was a determinant of CVD in the non-diabetic group in addition to age, gender, total-cholesterol and systolic blood pressure (SBP). FKBPL may be a useful anti-angiogenic biomarker in CVD in the absence of diabetes and could represent a novel CVD mechanism

    Arsenite oxidase in complex with antimonite and arsenite oxyanions - insights into the catalytic mechanism

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    Arsenic contamination of groundwater is among one of the biggest health threats affecting millions of people in the world. There is an urgent need for efficient arsenic biosensors where the use of arsenic metabolizing enzymes can be explored. In this work we have solved the crystal structures of four complexes of arsenite oxidase (Aio) obtained in complex with arsenic and antimony oxyanions and the structures determined correspond to intermediate states of the enzymatic mechanism. These structural data were complemented with DFT calculations providing a unique view of the molybdenum active site at different time points that, together with mutagenesis data, enabled to clarify the enzymatic mechanism and the molecular determinants for the oxidation of As(III) to the less toxic As(V) species
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