55 research outputs found
Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010
Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected and malnourished children are at increased risk for the disease. We conducted a systematic literature review to obtain age group–specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1–6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30–94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, had the highest incidence (227 cases [range 152–341] per 100,000 population) and number of cases (1.9 [range 1.3–2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164–1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed
Autoimmune sensorineural hearing loss as presenting manifestation of paediatric Behçet disease responding to adalimumab: a case report
Genome and Phylogenetic Analysis of Genes Involved in the Immune System of Solea senegalensis - Potential Applications in Aquaculture
Global aquaculture production continues to increase rapidly. One of the most important
species of marine fish currently cultivated in Southern Europe is Solea senegalensis,
reaching more than 300 Tn in 2017. In the present work, 14 Bacterial Artificial
Chromosome (BAC) clones containing candidate genes involved in the immune system
(b2m, il10, tlr3, tap1, tnfa, tlr8, trim25, lysg, irf5, hmgb2, calr, trim16, and mx), were
examined and compared with other species using multicolor Fluorescence in situ
Hybridization (mFISH), massive sequencing and bioinformatic analysis to determine the
genomic surroundings and syntenic chromosomal conservation of the genomic region
contained in each BAC clone. The mFISH showed that the groups of genes hmgb2-
trim25-irf5-b2m; tlr3-lysg; tnfa-tap1, and il10-mx-trim16 were co-localized on the same
chromosomes. Synteny results suggested that the studied BACs are placed in a smaller
number of chromosomes in S. senegalensis that in other species. Phylogenetic analyses
suggested that the evolutionary rate of immune system genes studied is similar among
the taxa studied, given that the clustering obtained was in accordance with the accepted
phylogenetic relationships among these species. This study contributes to a better
understanding of the structure and function of the immune system of the Senegalese
sole, which is essential for the development of new technologies and products to
improve fish health and productivity
Aucula magnifica (Schaus, 1904) (Lepidoptera: Noctuidae: Agaristinae): morphology of egg and last instar larvae
Efficacy of mirabegron in patients with and without prior antimuscarinic therapy for overactive bladder: a post hoc analysis of a randomized European-Australian Phase 3 trial
Immature stages of Spodoptera albula (Walker) (Lepidoptera: Noctuidae): Developmental parameters and host plants
A Review of the Copitarsia decolora (Guenée) (Lepidoptera: Noctuidae) Species Complex with the Description of a New Species from Chile and Argentina
Effects of Five Species of Chenopodiaceae on the Development and Reproductive Potential of Copitarsia decolora
Umbilical KeyPort bilateral laparoscopic orchiectomy in patient with complete androgen insensitivity syndrome
MAIN FINDINGS: A 22-year-old woman with complete androgen insensitivity syndrome (CAIS) presenting with primary amenorrhea and normal female external genitalia was referred for laparoscopic gonadectomy. She had been diagnosed several years earlier but was reluctant to undergo surgery. CASE HYPOTHESIS: Diagnosis of this X-linked recessive inherited syndrome characterizes by disturbance of virilization in males with an AR mutation, XY karyotipe, female genitalia and severely undescended testis with risk of malignization. The optimal time to orchidectomy is not settled; neither the real risk of malignancy in these patients. Early surgery impacts development of a complete female phenotype, with enlargement of the breasts. Based on modern diagnostic imaging using DCE-MRI and surgical technology with single port laparoscopic access we hypothesize that the optimum time for gonadectomy is not at the time of diagnosis, but once feminization has completed. PROMISING FUTURE IMPLICATIONS: An umbilical laparoendoscopic single-site access for bilateral gonadectomy appears to be the first choice approach as leaves no visible incision and diminishes the psychological impact of surgery in a patient with CAIS absolutely reassured as female. KeyPort, a single port access with duo-rotate instruments developed by Richard Wolf facilitates this surgery and allows excellent cosmetic results
- …