Searches with Mono-Leptons

We explore the implications of the mono-lepton plus missing transverse energy signature at the LHC, and point out its significance on understanding how dark matter interacts with quarks, where the signature arises from dark matter pair production together with a leptonically decaying W boson radiated from the initial state quarks. We derive limits using the existing W' searches at the LHC, and find an interesting interference between the contributions from dark matter couplings to up-type and down-type quarks. Mono-leptons can actually furnish the strongest current bound on dark matter interactions for axial vector (spin-dependent) interactions and iso-spin violating couplings. Should a signal of dark matter production be observed, this process can also help disentangle the dark matter couplings to up- and down-type quarks.Comment: four pages; six figures; the LHC 8 TeV results have been updated; final version in PL

“Are Machines Better Than Humans in Image Tagging?” - A User Study Adds to the Puzzle

“Do machines perform better than humans in visual recognition tasks?” Not so long ago, this question would have been considered even somewhat provoking and the answer would have been clear: “No”. In this paper, we present a comparison of human and machine performance with respect to annotation for multimedia retrieval tasks. Going beyond recent crowdsourcing studies in this respect, we also report results of two extensive user studies. In total, 23 participants were asked to annotate more than 1000 images of a benchmark dataset, which is the most comprehensive study in the field so far. Krippendorff’s α is used to measure inter-coder agreement among several coders and the results are compared with the best machine results. The study is preceded by a summary of studies which compared human and machine performance in different visual and auditory recognition tasks. We discuss the results and derive a methodology in order to compare machine performance in multimedia annotation tasks at human level. This allows us to formally answer the question whether a recognition problem can be considered as solved. Finally, we are going to answer the initial question

Gamma Ray Line Constraints on Effective Theories of Dark Matter

A monochromatic gamma ray line results when dark matter particles in the galactic halo annihilate to produce a two body final state which includes a photon. Such a signal is very distinctive from astrophysical backgrounds, and thus represents an incisive probe of theories of dark matter. We compare the recent null results of searches for gamma ray lines in the galactic center and other regions of the sky with the predictions of effective theories describing the interactions of dark matter particles with the Standard Model. We find that the null results of these searches provide constraints on the nature of dark matter interactions with ordinary matter which are complementary to constraints from other observables, and stronger than collider constraints in some cases.Comment: 20 pages, 9 figure

Dark sectors 2016 Workshop: community report

This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years

Dominant features in three-dimensional turbulence structure: comparison of non-uniform accelerating and decelerating flows

The results are presented from an experimental study to investigate three-dimensional turbulence structure profiles, including turbulence intensity and Reynolds stress, of different non-uniform open channel flows over smooth bed in subcritical flow regime. In the analysis, the uniform flow profiles have been used to compare with those of the non-uniform flows to investigate their time-averaged spatial flow turbulence structure characteristics. The measured non-uniform velocity profiles are used to verify the von Karman constant κ and to estimate sets of log-law integration constant B r and wake parameter П, where their findings are also compared with values from previous studies. From κ, B r and П findings, it has been found that the log-wake law can sufficiently represent the non-uniform flow in its non-modified form, and all κ, B r and П follow universal rules for different bed roughness conditions. The non-uniform flow experiments also show that both the turbulence intensity and Reynolds stress are governed well by exponential pressure gradient parameter β equations. Their exponential constants are described by quadratic functions in the investigated β range. Through this experimental study, it has been observed that the decelerating flow shows higher empirical constants, in both the turbulence intensity and Reynolds stress compared to the accelerating flow. The decelerating flow also has stronger dominance to determine the flow non-uniformity, because it presents higher Reynolds stress profile than uniform flow, whereas the accelerating flow does not

Effective field theory of dark matter: a global analysis

We present global fits of an effective field theory description of real, and complex scalar dark matter candidates. We simultaneously take into account all possible dimension 6 operators consisting of dark matter bilinears and gauge invariant combinations of quark and gluon fields. We derive constraints on the free model parameters for both the real (five parameters) and complex (seven) scalar dark matter models obtained by combining Planck data on the cosmic microwave background, direct detection limits from LUX, and indirect detection limits from the Fermi Large Area Telescope. We find that for real scalars indirect dark matter searches disfavour a dark matter particle mass below 100 GeV. For the complex scalar dark matter particle current data have a limited impact due to the presence of operators that lead to p-wave annihilation, and also do not contribute to the spin-independent scattering cross-section. Although current data are not informative enough to strongly constrain the theory parameter space, we demonstrate the power of our formalism to reconstruct the theoretical parameters compatible with an actual dark matter detection, by assuming that the excess of gamma rays observed by the Fermi Large Area Telescope towards the Galactic centre is entirely due to dark matter annihilations. Please note that the excess can very well be due to astrophysical sources such as millisecond pulsars. We find that scalar dark matter interacting via effective field theory operators can in principle explain the Galactic centre excess, but that such interpretation is in strong tension with the non-detection of gamma rays from dwarf galaxies in the real scalar case. In the complex scalar case there is enough freedom to relieve the tension

Improving household surveys and use of data to address health inequities in three Asian cities: protocol for the Surveys for Urban Equity (SUE) mixed methods and feasibility study

Introduction: As rapid urbanisation transforms the sociodemographic structures within cities, standard survey methods, which have remained unchanged for many years, under-represent the urban poorest. This leads to an overly positive picture of urban health, distorting appropriate allocation of resources between rural and urban and within urban areas. Here, we present a protocol for our study which (i) tests novel methods to improve representation of urban populations in household surveys and measure mental health and injuries, (ii) explores urban poverty and compares measures of poverty and ‘slumness’ and (iii) works with city authorities to understand, and potentially improve, utilisation of data on urban health for planning more equitable services. Methods and analysis: We will conduct household surveys in Kathmandu, Hanoi and Dhaka to test novel methods: (i) gridded population sampling; (ii) enumeration using open-access online maps and (iii) one-stage versus two-stage cluster sampling. We will test reliability of an observational tool to categorise neighbourhoods as slum areas. Within the survey, we will assess the appropriateness of a short set of questions to measure depression and injuries. Questionnaire data will also be used to compare asset-based, consumption-based and income-based measures of poverty. Participatory methods will identify perceptions of wealth in two communities in each city. The analysis will combine quantitative and qualitative findings to recommend appropriate measures of poverty in urban areas. We will conduct qualitative interviews and establish communities of practice with government staff in each city on use of data for planning. Framework approach will be used to analyse qualitative data allowing comparison across city settings. Ethics and dissemination: Ethical approvals have been granted by ethics committees from the UK, Nepal, Bangladesh and Vietnam. Findings will be disseminated through conference papers, peer-reviewed open access articles and workshops with policy-makers and survey experts in Kathmandu, Hanoi and Dhaka

A Novel Soluble Immune-Type Receptor (SITR) in Teleost Fish: Carp SITR Is Involved in the Nitric Oxide-Mediated Response to a Protozoan Parasite

Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors. Different Ig-like immune receptor families have been reported in mammals, birds, amphibians and fish. Most innate immune receptors of the IgSF are type I transmembrane proteins containing one or more extracellular Ig-like domains and their regulation of effector functions is mediated intracellularly by distinct stimulatory or inhibitory pathways. Methodology/Principal Findings - Carp SITR was found in a substracted cDNA repertoire from carp macrophages, enriched for genes up-regulated in response to the protozoan parasite Trypanoplasma borreli. Carp SITR is a type I protein with two extracellular Ig domains in a unique organisation of a N-proximal V/C2 (or I-) type and a C-proximal V-type Ig domain, devoid of a transmembrane domain or any intracytoplasmic signalling motif. The carp SITR C-proximal V-type Ig domain, in particular, has a close sequence similarity and conserved structural characteristics to the mammalian CD300 molecules. By generating an anti-SITR antibody we could show that SITR protein expression was restricted to cells of the myeloid lineage. Carp SITR is abundantly expressed in macrophages and is secreted upon in vitro stimulation with the protozoan parasite T. borreli. Secretion of SITR protein during in vivo T. borreli infection suggests a role for this IgSF receptor in the host response to this protozoan parasite. Overexpression of carp SITR in mouse macrophages and knock-down of SITR protein expression in carp macrophages, using morpholino antisense technology, provided evidence for the involvement of carp SITR in the parasite-induced NO production. Conclusion/Significance - We report the structural and functional characterization of a novel soluble immune-type receptor (SITR) in a teleost fish and propose a role for carp SITR in the NO-mediated response to a protozoan parasite

Bacteriophage-encoded depolymerases: their diversity and biotechnological applications

Bacteriophages (phages), natural enemies of bacteria, can encode enzymes able to degrade polymeric substances. These substances can be found in the bacterial cell surface, such as polysaccharides, or are produced by bacteria when they are living in biofilm communities, the most common bacterial lifestyle. Consequently, phages with depolymerase activity have a facilitated access to the host receptors, by degrading the capsular polysaccharides, and are believed to have a better performance against bacterial biofilms, since the degradation of extracellular polymeric substances by depolymerases might facilitate the access of phages to the cells within different biofilm layers. Since the diversity of phage depolymerases is not yet fully explored, this is the first review gathering information about all the depolymerases encoded by fully sequenced phages. Overall, in this study, 160 putative depolymerases, including sialidases, levanases, xylosidases, dextranases, hyaluronidases, peptidases as well as pectate/pectin lyases, were found in 143 phages (43 Myoviridae, 47 Siphoviridae, 37 Podoviridae, and 16 unclassified) infecting 24 genera of bacteria. We further provide information about the main applications of phage depolymerases, which can comprise areas as diverse as medical, chemical, or food-processing industry.DPP acknowledges the financial support from the Portuguese Foundation for Science and Technology (FCT) through the grant SFRH/BD/76440/2011. SS is an FCT investigator (IF/01413/2013). The authors also thank FCT for the Strategic Project of the UID/BIO/04469/2013 unit, FCT and European Union funds (FEDER/COMPETE) for the project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER027462)