1,014 research outputs found
Spatially Resolved Magnetic Field Structure in the Disk of a T Tauri Star
Magnetic fields in accretion disks play a dominant role during the star
formation process but have hitherto been observationally poorly constrained.
Field strengths have been inferred on T Tauri stars themselves and possibly in
the innermost part of the accretion disk, but the strength and morphology of
the field in the bulk of the disk have not been observed. Unresolved
measurements of polarized emission (arising from elongated dust grains aligned
perpendicular to the field) imply average fields aligned with the disks.
Theoretically, the fields are expected to be largely toroidal, poloidal, or a
mixture of the two, which imply different mechanisms for transporting angular
momentum in the disks of actively accreting young stars such as HL Tau. Here we
report resolved measurements of the polarized 1.25 mm continuum emission from
HL Tau's disk. The magnetic field on a scale of 80 AU is coincident with the
major axis (~210 AU diameter) of the disk. From this we conclude that the
magnetic field inside the disk at this scale cannot be dominated by a vertical
component, though a purely toroidal field does not fit the data well either.
The unexpected morphology suggests that the magnetic field's role for the
accretion of a T Tauri star is more complex than the current theoretical
understanding.Comment: Accepted for publication in Natur
Scale without Conformal Invariance at Three Loops
We carry out a three-loop computation that establishes the existence of scale
without conformal invariance in dimensional regularization with the MS scheme
in d=4-epsilon spacetime dimensions. We also comment on the effects of scheme
changes in theories with many couplings, as well as in theories that live on
non-conformal scale-invariant renormalization group trajectories. Stability
properties of such trajectories are analyzed, revealing both attractive and
repulsive directions in a specific example. We explain how our results are in
accord with those of Jack & Osborn on a c-theorem in d=4 (and d=4-epsilon)
dimensions. Finally, we point out that limit cycles with turning points are
unlike limit cycles with continuous scale invariance.Comment: 21 pages, 3 figures, Erratum adde
A trapped field of 17.6 T in melt-processed, bulk Gd-Ba-Cu-O reinforced with shrink-fit steel
The ability of large grain, REBaCuO [(RE)BCO; RE =
rare earth] bulk superconductors to trap magnetic field is determined by their
critical current. With high trapped fields, however, bulk samples are subject
to a relatively large Lorentz force, and their performance is limited primarily
by their tensile strength. Consequently, sample reinforcement is the key to
performance improvement in these technologically important materials. In this
work, we report a trapped field of 17.6 T, the largest reported to date, in a
stack of two, silver-doped GdBCO superconducting bulk samples, each of diameter
25 mm, fabricated by top-seeded melt growth (TSMG) and reinforced with
shrink-fit stainless steel. This sample preparation technique has the advantage
of being relatively straightforward and inexpensive to implement and offers the
prospect of easy access to portable, high magnetic fields without any
requirement for a sustaining current source.The ability of large-grain (RE)Ba2Cu3O7−δ ((RE)BCO; RE = rare earth) bulk superconductors to trap magnetic fields is determined by their critical current. With high trapped fields, however, bulk samples are subject to a relatively large Lorentz force, and their performance is limited primarily by their tensile strength. Consequently, sample reinforcement is the key to performance improvement in these technologically important materials. In this work, we report a trapped field of 17.6 T, the largest reported to date, in a stack of two silver-doped GdBCO superconducting bulk samples, each 25 mm in diameter, fabricated by top-seeded melt growth and reinforced with shrink-fit stainless steel. This sample preparation technique has the advantage of being relatively straightforward and inexpensive to implement, and offers the prospect of easy access to portable, high magnetic fields without any requirement for a sustaining current source.This is the final published version, distributed under a Creative Commons Attribution License. This can also be found on the publisher's website at: http://iopscience.iop.org/0953-2048/27/8/08200
Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer
Aim: Tamoxifen (TAM) resistance remains a clinical issue in breast cancer. The authors previously reported that 15-hydroxyprostaglandin dehydrogenase (HPGD) was significantly downregulated in tamoxifen-resistant (TAMr) breast cancer cell lines. Here, the authors investigated the relationship between HPGD expression, TAM resistance and prediction of outcome in breast cancer.
Methods: HPGD overexpression and silencing studies were performed in isogenic TAMr and parental human breast cancer cell lines to establish the impact of HPGD expression on TAM resistance. HPGD expression and clinical outcome relationships were explored using immunohistochemistry and in silico analysis.
Results: Restoration of HPGD expression and activity sensitised TAMr MCF-7 cells to TAM and 17β-oestradiol, whilst HPGD silencing in parental MCF-7 cells reduced TAM sensitivity. TAMr cells released more prostaglandin E2 (PGE2) than controls, which was reduced in TAMr cells stably transfected with HPGD. Exogenous PGE2 signalled through the EP4 receptor to reduce breast cancer cell sensitivity to TAM. Decreased HPGD expression was associated with decreased overall survival in ERα-positive breast cancer patients.
Conclusions: HPGD downregulation in breast cancer is associated with reduced response to TAM therapy via PGE2-EP4 signalling and decreases patient survival. The data offer a potential target to develop combination therapies that may overcome acquired tamoxifen resistance
Vortex deformation and breaking in superconductors: A microscopic description
Vortex breaking has been traditionally studied for nonuniform critical
current densities, although it may also appear due to nonuniform pinning force
distributions. In this article we study the case of a
high-pinning/low-pinning/high-pinning layered structure. We have developed an
elastic model for describing the deformation of a vortex in these systems in
the presence of a uniform transport current density for any arbitrary
orientation of the transport current and the magnetic field. If is above a
certain critical value, , the vortex breaks and a finite effective
resistance appears. Our model can be applied to some experimental
configurations where vortex breaking naturally exists. This is the case for
YBaCuO (YBCO) low angle grain boundaries and films on vicinal
substrates, where the breaking is experienced by Abrikosov-Josephson vortices
(AJV) and Josephson string vortices (SV), respectively. With our model, we have
experimentally extracted some intrinsic parameters of the AJV and SV, such as
the line tension and compared it to existing predictions based on
the vortex structure.Comment: 11 figures in 13 files; minor changes after printing proof
Gauge fields and infinite chains of dualities
We show that the particle states of Maxwell's theory, in dimensions, can
be represented in an infinite number of ways by using different gauge fields.
Using this result we formulate the dynamics in terms of an infinite set of
duality relations which are first order in space-time derivatives. We derive a
similar result for the three form in eleven dimensions where such a possibility
was first observed in the context of E11. We also give an action formulation
for some of the gauge fields. In this paper we give a pedagogical account of
the Lorentz and gauge covariant formulation of the irreducible representations
of the Poincar\'e group, used previously in higher spin theories, as this plays
a key role in our constructions. It is clear that our results can be
generalised to any particle.Comment: 37 page
Classical and quantum N=2 supersymmetric black holes
We use heterotic/type-II prepotentials to study quantum/classical black holes
with half the supersymmetries unbroken. We show that, in the case of
heterotic string compactifications, the perturbatively corrected entropy
formula is given by the tree-level entropy formula with the tree-level coupling
constant replaced by the perturbative coupling constant. In the case of type-II
compactifications, we display a new entropy/area formula associated with
axion-free black-hole solutions, which depends on the electric and magnetic
charges as well as on certain topological data of Calabi--Yau three-folds,
namely the intersection numbers, the second Chern class and the Euler number of
the three-fold. We show that, for both heterotic and type-II theories, there is
the possibility to relax the usual requirement of the non-vanishing of some of
the charges and still have a finite entropy.Comment: 28 pages, LaTe
Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations
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