Cytological features of uterine tumors resembling ovarian sex-cord tumors in liquid-based cervical cytology: a potential pitfall. Report of a unique and rare case.

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype. Most tumors are associated with a benign clinical course. We report the first cytological description of uterine UTROSCTs in liquid-based cervical cytology (LBC). A menopausal woman was discovered to have a uterine intraluminal polypoid mass protruding through the vagina. A Pap test was performed, and the LBC preparation showed isolated tumor cells with scant cytoplasm and slightly irregular, ovoid nuclei with fine chromatin and small nucleoli. Final histological evaluation identified a UTROSCT. This diagnostic possibility, albeit rare, should be included in the differential diagnosis when isolated malignant-appearing adenocarcinomatous cells are seen in women in the above scenario. As these features are not specific, they may result in misinterpretation with tumors that are more common and aggressive

The Quantum Geometry of N=(2,2) Non-Linear Sigma-Models

We consider a general N=(2,2) non-linear sigma-model in (2,2) superspace. Depending on the details of the complex structures involved, an off-shell description can be given in terms of chiral, twisted chiral and semi-chiral superfields. Using superspace techniques, we derive the conditions the potential has to satisfy in order to be ultra-violet finite at one loop. We pay particular attention to the effects due to the presence of semi-chiral superfields. A complete description of N=(2,2) strings follows from this.Comment: 9 pages, Late

Two-loop finiteness of D=2 supergravity

We establish two-loop (on shell) finiteness of certain supergravity theories in two dimensions. Possible implications of this result are discussedComment: 11 page

Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study.

Breast cancer is a highly heterogeneous disease. The efficacy of tailored therapeutic strategies relies on the precise detection of diagnostic biomarkers by immunohistochemistry (IHC). Therefore, considering the increasing incidence of breast cancer cases, a concomitantly time-efficient and accurate diagnosis is clinically highly relevant. Microfluidics is a promising innovative technology in the field of tissue diagnostic, enabling for rapid, reliable, and automated immunostaining. We previously reported the microfluidic-based HER2 (human epidermal growth factor receptor 2) detection in breast carcinomas to greatly correlate with the HER2 gene amplification level. Here, we aimed to develop a panel of microfluidic-based IHC protocols for prognostic and therapeutic markers routinely assessed for breast cancer diagnosis, namely HER2, estrogen/progesterone receptor (ER/PR), and Ki67 proliferation factor. The microfluidic IHC protocol for each marker was optimized to reach high staining quality comparable to the standard procedure, while concomitantly shortening the staining time to 16 min-excluding deparaffinization and antigen retrieval step-with a turnaround time reduction up to 7 folds. Comparison of the diagnostic score on 50 formaldehyde-fixed paraffin-embedded breast tumor resections by microfluidic versus standard staining showed high concordance (overall agreement: HER2 94%, ER 95.9%, PR 93.6%, Ki67 93.7%) and strong correlation (ρ coefficient: ER 0.89, PR 0.88, Ki67 0.87; p < 0.0001) for all the analyzed markers. Importantly, HER2 genetic reflex test for all discordant cases confirmed the scores obtained by the microfluidic technique. Overall, the microfluidic-based IHC represents a clinically validated equivalent approach to the standard chromogenic staining for rapid, accurate, and automated breast cancer diagnosis

Detección de Xanthomonas arboricola pv. pruni mediante inmunocaptura magnética y PCR en tiempo real: póster

PublishedTrabajo financiado por el Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), proyecto RTA2011-00140-C03-02 y por la Red CYTED FRUT-SAN 112RT044

D=2, N=2, Supersymmetric theories on Non(anti)commutative Superspace

The classical action of a two dimensional N=2 supersymmetric theory, characterized by a general K\"{a}hler potential, is written down on a non(anti)commutative superspace. The action has a power series expansion in terms of the determinant of the non(anti)commutativity parameter $C^{\alpha\beta}$. The theory is explicitly shown to preserve half of the N=2 supersymmetry, to all orders in (det C)^n. The results are further generalized to include arbitrary superpotentials as well.Comment: 32 pages, Latex; v2:minor typos corrected and a reference adde

Holonomy groups and W-symmetries

Irreducible sigma models, i.e. those for which the partition function does not factorise, are defined on Riemannian spaces with irreducible holonomy groups. These special geometries are characterised by the existence of covariantly constant forms which in turn give rise to symmetries of the supersymmetric sigma model actions. The Poisson bracket algebra of the corresponding currents is a W-algebra. Extended supersymmetries arise as special cases.Comment: pages 2

The WZNW Model at Two Loops

We study perturbatively the (conformal) WZNW model. At one loop we compute one-particle irreducible two- and three-point current correlation functions, both in the conventional version and in the classically equivalent, chiral, nonlocal, induced version of the model. At two loops we compute the two-point function and find that it vanishes (modulo infrared-induced logarithms). We use dimensional regularization and the $R^*$ operation for removing infrared divergences. The outcome of the calculations is insensitive to the treatment of the \varepsilon^{\m\n} tensor as a two-dimensional or $d$-dimensional object. Our results indicate that the one-particle irreducible current correlation functions constitute an effective action equal to the original WZNW action with the familiar level shift, $k\to k+\tilde h$.Comment: 40 pages, Latex, (4 postscript figures at end of file, to be split off into files called diag1.ps,...,diag4.ps),THU-93/1

Microscopic NN→NN∗(1440)NN\to NN^{\ast}(1440) transition potential: Determination of πNN∗(1440)\pi NN^{\ast}(1440) and σNN∗(1440)\sigma NN^{\ast}(1440) coupling constants

A $NN\to NN^{\ast}(1440)$ transition potential, based on an effective quark-quark interaction and a constituent quark cluster model for baryons, is derived in the Born-Oppenheimer approach. The potential shows significant differences with respect to those obtained by a direct scaling of the nucleon-nucleon interaction. From its asymptotic behavior we extract the values of $\pi NN^{\ast}(1440)$ and $\sigma NN^{\ast}(1440)$ coupling constants in a particular coupling schemeComment: 15 eps figures, Accepted for publication in Phys. Rev.

Non(anti)commutative N=(1,1/2) Supersymmetric U(1) Gauge Theory

We study a reduction of deformation parameters in non(anti)commutative N=2 harmonic superspace to those in non(anti)commutative N=1 superspace. By this reduction we obtain the exact gauge and supersymmetry transformations in the Wess-Zumino gauge of non(anti)commutative N=2 supersymmetric U(1) gauge theory defined in the deformed harmonic superspace. We also find that the action with the first order correction in the deformation parameter reduces to the one in the N=1 superspace by some field redefinition. We construct deformed N=(1,1/2) supersymmetry in N=2 supersymmetric U(1) gauge theory in non(anti)commutative N=1 superspace.Comment: 30 pages, LaTeX, V2: a reference adde