I Didn\u27t Raise My Boy To Be A Soldier

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Multiple Group Membership and Well-Being: Is There Always Strength in Numbers?

This is the final version of the article. Available from Frontiers Media via the DOI in this record.The research materials supporting this publication can be accessed by contacting Dr. Anders Larrabee Sønderlund at [email protected] growing body of research points to the value of multiple group memberships for individual well-being. However, much of this work considers group memberships very broadly and in terms of number alone. We conducted two correlational studies exploring how the relationship between multiple group membership and well-being is shaped by (a) the complexity of those groups within the overall self-concept (i.e., social identity complexity: SIC), and (b) the perceived value and visibility of individual group memberships to others (i.e., stigma). Study 1 (N = 112) found a positive relationship between multiple group membership and well-being, but only for individuals high in SIC. This effect was mediated by perceived identity expression and access to social support. Study 2 (N = 104) also found that multiple group memberships indirectly contributed to well-being via perceived identity expression and social support, as well as identity compatibility and perceived social inclusion. But, in this study the relationship between multiple group memberships and well-being outcomes was moderated by the perceived value and visibility of group memberships to others. Specifically, possessing multiple, devalued and visible group memberships compromised well-being relative to multiple valued group memberships, or devalued group memberships that were invisible. Together, these studies suggest that the benefits of multiple group membership depend on factors beyond their number. Specifically, the features of group memberships, individually and in combination, and the way in which these guide self-expression and social action, determine whether these are a benefit or burden for individual well-being

Development of Preventive Measures to Reduce Mortalities for Holding Live Wild-caught Flounder in Recirculating Aquaculture Systems

A substantial high-value market exists for wild-caught live summer flounder (Paralichthys dentatus). An important component of accessing this market is the ability to hold wild-caught flounder in land based recirculating aquaculture systems (RAS). A major constraint to holding summer flounder in land-based RAS is fish mortalities associated with the ectoparasite argulus spp. Very little information exists that provides a live flounder holding facility with FDA approved treatment options to prevent introduction of argulus from wild caught fish into holding systems. The project objective was to test the available FDA approved chemotherapeutics for treatment of ectoparasite infections in summer flounder. To validate treatment efficacy, 8 infected individuals were treated with bath treatments according to maximum recommended doses (250ppm formalin for 60 m; 200 ppm hydrogen peroxide for 30 m; and freshwater for 20 m) and then transferred to separate RAS to monitor for two weeks. Daily observations were made to determine if treatments were lethal to the attached argulus. Following the two week monitoring period, fish from all treatments showed no sign of a reduction in attached argulus. According to the findings of this study, there are currently no FDA approved treatments for argulus infections on summer flounder. It is recommended that a live wild flounder holding facility visually inspect all incoming fish for the presence of argulus and maintain fish in a quarantine system prior to holding in a RAS

Evaluation of the cytotoxic and genotoxic potential of Khat (Catha edulis Forsk) extracts on human T lymphoblastoid cell line

This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1). Statistically significant, dose-dependent increases in; CEM cell death at dose (> 400 μg ml-1), in DNA damage at dose (>200 μg ml-1) and in micronuclei frequency, at dose (>200 μg ml-1) were observed. The genetic damage effects of khat extract on human cell line observed in this study could serve as a major contribution towards the understanding and creating of awareness of an increased risk of cancer amongst long-term khat consumers

Kink oscillations of cooling coronal loops with variable cross-section

We study kink waves and oscillations in a thin expanding magnetic tube in the presence of flow. The tube consists of a core region and a thin transitional region at the tube boundary. In this region the plasma density monotonically decreases from its value in the core region to the value outside the tube. Both the plasma density and velocity of background flow vary along the tube and in time. Using the multiscale expansions we derive the system of two equations describing the kink oscillations. When there is no transitional layer the oscillations are described by the first of these two equations. We use this equation to study the effect of plasma density variation with time on kink oscillations of an expanding tube with a sharp boundary. We assume that the characteristic time of the density variation is much greater than the characteristic time of kink oscillations. Then we use the Wentzel-Kramer-Brillouin (WKB) method to derive the expression for the adiabatic invariant, which is the quantity that is conserved when the plasma density varies. The general theoretical results are applied to the kink oscillations of coronal magnetic loops. We consider an expanding loop with the half-circle shape and assume that the plasma temperature inside a loop decays exponentially with time. We numerically calculated the dependences of the fundamental mode frequency, the ratio of frequencies of the first overtone and fundamental mode, and the oscillation amplitude on time. We obtained that the oscillation frequency and amplitude increase and the frequency ratio decreases due to cooling. The amplitude increase is stronger for loops with a greater expansion factor. This effect is also more pronounced for higher loops. However, it is fairly moderate even for loops that are quite high

A low-investment, high-impact approach for training stronger and more confident graduate student science writers

Scientists in applied fields, including conservation biology, face increasing expectations to communicate their research across multiple audiences. As environmental issues become more complex, the need for scientists to clearly communicate with other scientists, managers, stakeholders, tribes, the public, and policy makers becomes ever critical. Despite this need, students in graduate science programs receive limited direct instruction in writing and little training in writing for audiences outside of academia or in different genres. To that end, we developed an interdisciplinary program that incorporates rhetorical theory and writing intensive pedagogy to train graduate science students to write more effectively across genres. During the pilot testing in the first year of this broader, multiyear program, we evaluated changes in the writing practices and confidence of participants as writers and scientists who completed a low-investment, two-workshop sequence that highlighted habitual writing, peer review, and writing for multiple audiences and multiple genres. In just six contact hours, we documented significant increases in students\u27 reporting maintaining a more consistent writing routine and writing environment, revising multiple drafts for writing projects, and being willing to have work reviewed by peers or mentors. Upon completion of both workshops, students reported an increase in their confidence as writers. The development of comprehensive graduate writing programs can be costly and time intensive, but our evaluation demonstrates that significant gains in writing capacity and confidence as writers were made by graduate science students with even a low level of investment. We urge graduate science faculty in all Science Technology Engineering Math disciplines to consider how they might offer this two-workshop sequence or similar low-investment interventions that will build writing capacity and confidence as writers and scientists in graduate students

The competent sentinel node: an association with an axillary presentation and an occult or a small primary invasive breast carcinoma

The concept of the sentinel node describes a primary or sentinel lymph node (SLN), which exists and through which tumour cells from a primary tumour in a particular location must first travel to spread to a particular regional lymph node group. In this series we present three patients presenting with a pathological axillary node associated with either an occult or very small primary breast cancer. In each case the primary tumour was found to have metastasised to the palpable node, however despite the significant enlargement of this node, no other axillary nodes were found to be affected on axillary node clearance. This has led us to postulate that the SLN in some cases contains unique characteristics that enable it to prevent further spread of the tumour up the lymphatic chain. Hence the term the competent sentinel node

EM-mosaic detects mosaic point mutations that contribute to congenital heart disease.

BackgroundThe contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tissue has not been determined.MethodsWe developed a new computational method, EM-mosaic (Expectation-Maximization-based detection of mosaicism), to analyze mosaicism in exome sequences derived primarily from blood DNA of 2530 CHD proband-parent trios. To optimize this method, we measured mosaic detection power as a function of sequencing depth. In parallel, we analyzed our cohort using MosaicHunter, a Bayesian genotyping algorithm-based mosaic detection tool, and compared the two methods. The accuracy of these mosaic variant detection algorithms was assessed using an independent resequencing method. We then applied both methods to detect mosaicism in cardiac tissue-derived exome sequences of 66 participants for which matched blood and heart tissue was available.ResultsEM-mosaic detected 326 mosaic mutations in blood and/or cardiac tissue DNA. Of the 309 detected in blood DNA, 85/97 (88%) tested were independently confirmed, while 7/17 (41%) candidates of 17 detected in cardiac tissue were confirmed. MosaicHunter detected an additional 64 mosaics, of which 23/46 (50%) among 58 candidates from blood and 4/6 (67%) of 6 candidates from cardiac tissue confirmed. Twenty-five mosaic variants altered CHD-risk genes, affecting 1% of our cohort. Of these 25, 22/22 candidates tested were confirmed. Variants predicted as damaging had higher variant allele fraction than benign variants, suggesting a role in CHD. The estimated true frequency of mosaic variants above 10% mosaicism was 0.14/person in blood and 0.21/person in cardiac tissue. Analysis of 66 individuals with matched cardiac tissue available revealed both tissue-specific and shared mosaicism, with shared mosaics generally having higher allele fraction.ConclusionsWe estimate that ~ 1% of CHD probands have a mosaic variant detectable in blood that could contribute to cardiac malformations, particularly those damaging variants with relatively higher allele fraction. Although blood is a readily available DNA source, cardiac tissues analyzed contributed ~ 5% of somatic mosaic variants identified, indicating the value of tissue mosaicism analyses

Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples

We report two approaches for linkage analysis of data consisting of replicate phenotypes. The first approach is specifically designed for the unusual (in human data) replicate structure of the Genetic Analysis Workshop 17 pedigree data. The second approach consists of a standard linkage analysis that, although not specifically tailored to data consisting of replicate genotypes, was envisioned as providing a sounding board against which our novel approach could be assessed. Both approaches are applied to the analysis of three quantitative phenotypes (Q1, Q2, and Q4) in two sets of African families. All analyses were carried out blind to the generating model (i.e., the “answers”). Using both methods, we found numerous significant linkage signals for Q1, although population colocalization was absent for most of these signals. The linkage analysis of Q2 and Q4 failed to reveal any strong linkage signals