Observers in an accelerated universe

If the current acceleration of our Universe is due to a cosmological constant, then a Coleman-De Luccia bubble will nucleate in our Universe. In this work, we consider that our observations could be likely in this framework, consisting in two infinite spaces, if a foliation by constant mean curvature hypersurfaces is taken to count the events in the spacetime. Thus, we obtain and study a particular foliation, which covers the existence of most observers in our part of spacetime.Comment: revised version, accepted in EPJ

Search for cosmological mu variation from high redshift H2 absorption; a status report

Observations of H2 spectra in the line-of-sight of distant quasars may reveal a variation of the proton-electron mass ratio mu=m_p/m_e at high redshift, typically for z>2. Currently four high-quality systems (Q0347-383, Q0405-443, Q0528-250 and J2123-005) have been analyzed returning a constraint Dmu/mu < 1 x 10^{-5}. We present data and a mu-variation analysis of another system, Q2348-011 at redshift z_{abs}=2.42, delivering dmu/mu = (-1.5 \pm 1.6) x 10^{-5}. In addition to observational data the status of the laboratory measurements is reviewed. The future possibilities of deriving a competitive constraint on Dmu/mu from the known high-redshift H2 absorbers is investigated, resulting in the identification of a number of potentially useful systems for detecting mu-variation.Comment: 13 Pages, 4 Figures, JENAM conference (Lisbon); accepte

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for delivery of drugs in order to treat diseases associated with the lymphatic system. Lipophilic prodrug approaches have been used in the past to take advantage of the intestinal lymphatic transport processes to deliver drugs to the intestinal lymphatics. Most of the approaches previously adopted were based on very bulky prodrug moieties such as those mimicking triglycerides (TG). We now report a study in which a lipophilic prodrug approach was used to efficiently deliver bexarotene (BEX) and retinoic acid (RA) to the intestinal lymphatic system using activated ester prodrugs. A range of carboxylic ester prodrugs of BEX were designed and synthesised and all of the esters showed improved association with chylomicrons, which indicated an improved potential for delivery to the intestinal lymphatic system. The conversion rate of the prodrugs to BEX was the main determinant in delivery of BEX to the intestinal lymphatics, and activated ester prodrugs were prepared to enhance the conversion rate. As a result, an 4-(hydroxymethyl)-1,3-dioxol-2-one ester prodrug of BEX was able to increase the exposure of the mesenteric lymph nodes (MLNs) to BEX 17-fold compared to when BEX itself was administered. The activated ester prodrug approach was also applied to another drug, RA, where the exposure of the MLNs was increased 2.4-fold through the application of a similar cyclic activated prodrug. Synergism between BEX and RA was also demonstrated in vitro by cell growth inhibition assays using lymphoma cell lines. In conclusion, the activated ester prodrug approach results in efficient delivery of drugs to the intestinal lymphatic system, which could benefit patients affected by a large number of pathological conditions

Varying constants, Gravitation and Cosmology

Fundamental constants are a cornerstone of our physical laws. Any constant varying in space and/or time would reflect the existence of an almost massless field that couples to matter. This will induce a violation of the universality of free fall. It is thus of utmost importance for our understanding of gravity and of the domain of validity of general relativity to test for their constancy. We thus detail the relations between the constants, the tests of the local position invariance and of the universality of free fall. We then review the main experimental and observational constraints that have been obtained from atomic clocks, the Oklo phenomenon, Solar system observations, meteorites dating, quasar absorption spectra, stellar physics, pulsar timing, the cosmic microwave background and big bang nucleosynthesis. At each step we describe the basics of each system, its dependence with respect to the constants, the known systematic effects and the most recent constraints that have been obtained. We then describe the main theoretical frameworks in which the low-energy constants may actually be varying and we focus on the unification mechanisms and the relations between the variation of different constants. To finish, we discuss the more speculative possibility of understanding their numerical values and the apparent fine-tuning that they confront us with.Comment: 145 pages, 10 figures, Review for Living Reviews in Relativit

On teaching experimental reactor physics in times of pandemic

The COVID-19 induced restrictions have prevented reactor physics students from attending in-person reactor physics exercises which are a vital part of their education. Jozef Stefan Institute has organized remote exercises with the help of off-the-shelf technology, including multiple videoconferencing setups, remote desktop software, portable cameras, a dome camera, shared spreadsheets, and a common whiteboard. The students were encouraged to actively participate in the exercises by giving instructions to the reactor operator, asking and answering questions, logging data, operating digital acquisition systems, and performing analysis during the exercise. The first remote exercises were organized as a five-day course of experimental reactor physics for students from Uppsala University. The feedback was collected after the course using an anonymous online form and was generally positive but has revealed some problems with sound quality which were resolved later. The Jozef Stefan Institute can also organize a remote course during a full lockdown when the reactor is not able to operate using the in-house developed Research Reactor Simulator based on a point kinetics approximation and a simple thermohydraulic module

COSY Slow Orbit Feedback System

The Cooler Synchrotron (COSY) at Forschungszentrum Jülich is currently carrying out the preparation for a direct measurement of the electric Dipole Moment (EDM) of the deuteron using an RF Wien filter*,**. In a magnetic storage ring with the spin vector aligned along the direction of motion, the EDM manifests in a buildup of the vertical spin component. Besides this signal, radial magnetic fields due to a distortion of the vertical closed orbit can produce a similar signal. This signal is a systematic limit of the proposed measurement procedure. Based on simulation studies***, a vertical closed orbit distortion with a RMS smaller than 0.1 mm is required to achieve a sensitivity of 10⁻¹⁹ e.cm or better. In order to accomplish this challenging goal, a slow orbit feedback system was proposed and recently commissioned at COSY. The design and commissioning results will be presented, and the future plan will also be discussed