X-ray Insights into the Nature of Quasars with Redshifted Broad Absorption Lines

We present $Chandra$ observations of seven broad absorption line (BAL) quasars at $z=0.863$-2.516 with redshifted BAL troughs (RSBALs). Five of our seven targets were detected by $Chandra$ in 4-13 ks exposures with ACIS-S. The $\alpha_{\rm ox}$ values, $\Delta\alpha_{\rm ox}$ values, and spectral energy distributions of our targets demonstrate they are all X-ray weak relative to expectations for non-BAL quasars, and the degree of X-ray weakness is consistent with that of appropriately-matched BAL quasars generally. Furthermore, our five detected targets show evidence for hard X-ray spectral shapes with a stacked effective power-law photon index of $\Gamma_{\rm eff}=0.5^{+0.5}_{-0.4}$. These findings support the presence of heavy X-ray absorption ($N_{\rm H}\approx 2 \times 10^{23}$ cm$^{-2}$) in RSBAL quasars, likely by the shielding gas found to be common in BAL quasars more generally. We use these X-ray measurements to assess models for the nature of RSBAL quasars, finding that a rotationally-dominated outflow model is favored while an infall model also remains plausible with some stipulations. The X-ray data disfavor a binary quasar model for RSBAL quasars in general.Comment: 11 pages, 5 figures, and 3 table

Surveillance of vector populations and malaria transmission during the 2009/10 El Niño event in the western Kenya highlands: opportunities for early detection of malaria hyper-transmission

<p>Abstract</p> <p>Background</p> <p>Vector control in the highlands of western Kenya has resulted in a significant reduction of malaria transmission and a change in the vectorial system. Climate variability as a result of events such as El Niño increases the highlands suitability for malaria transmission. Surveillance and monitoring is an important component of early transmission risk identification and management. However, below certain disease transmission thresholds, traditional tools for surveillance such as entomological inoculation rates may become insensitive. A rapid diagnostic kit comprising <it>Plasmodium falciparum </it>circumsporozoite surface protein and merozoite surface protein antibodies in humans was tested for early detection of transmission surges in the western Kenya highlands during an El Niño event (October 2009-February 2010).</p> <p>Methods</p> <p>Indoor resting female adult malaria vectors were collected in western Kenya highlands in four selected villages categorized into two valley systems, the U-shaped (Iguhu and Emutete) and the V-shaped valleys (Marani and Fort Ternan) for eight months. Members of the <it>Anopheles gambiae </it>complex were identified by PCR. Blood samples were collected from children 6-15 years old and exposure to malaria was tested using a circum-sporozoite protein and merozoite surface protein immunchromatographic rapid diagnostic test kit. Sporozoite ELISA was conducted to detect circum-sporozoite protein, later used for estimation of entomological inoculation rates.</p> <p>Results</p> <p>Among the four villages studied, an upsurge in antibody levels was first observed in October 2009. <it>Plasmodium falciparum </it>sporozoites were then first observed in December 2009 at Iguhu village and February 2010 at Emutete. Despite the upsurge in Marani and Fort Ternan no sporozoites were detected throughout the eight month study period. The antibody-based assay had much earlier transmission detection ability than the sporozoite-based assay. The proportion of <it>An. arabiensis </it>among <it>An. gambiae s.l</it>. ranged from 2.9-66.7% indicating a rearrangement of the sibling species of the <it>An. gambiae s.l </it>complex. This is possibly an adaptation to insecticide interventions and climate change.</p> <p>Conclusion</p> <p>The changing malaria transmission rates in the western Kenya highlands will lead to more unstable transmission, decreased immunity and a high vulnerability to epidemics unless surveillance tools are improved and effective vector control is sustained.</p

Association between glycaemic control and quality of life in diabetes mellitus

Background: Relationship between quality of life (QOL) and haemoglobin A1c (HbA1c) amongst diabetics in the community setting is unclear. Aims: Assess the association between QOL and change in HbA1c in diabetic patients over one year. Settings and Design: Cohort study of patients from four community clinics in California, USA. Methods: Diabetic patients identified from databases using International Classification of Disease (ICD-9) codes were asked to complete Short Form 36 (SF-36), which measures health-related QOL, and invited to attend monthly diabetes workshops. From December 2000 to December 2001, data were collected on multiple parameters, including HbA1c. SF-36 surveys were re-collected at project termination. Statistical Analysis: Regression analysis was used to correlate change in HbA1c with change in QOL physical component summary (PCS) and mental component summary (MCS) scores, while considering potential confounders. Results: Of 1679 eligible patients, 380 completed SF-36 at project initiation. 243 of those completed SF-36 at project termination. Pre and post HbA1c data were available for 170 of the 243 who completed SF-36 at both times. Average MCS increased by 8.46% and PCS decreased by 2.24%. After adjustment, a 5% decrease in HbA1c values was associated with a 1% increase in MCS. No association between changes in HbA1c and PCS was observed. Conclusions: Association between better HbA1c and improved mental, but not physical, QOL may reflect physical inconvenience of increased regimen complexity and mental empowerment from proactive disease management. Larger cohort studies with longer follow-up are needed to further elucidate the relationship between glycemic control and QOL

Tunable magnetic exchange interactions in manganese-doped inverted core/shell ZnSe/CdSe nanocrystals

Magnetic doping of semiconductor nanostructures is actively pursued for applications in magnetic memory and spin-based electronics. Central to these efforts is a drive to control the interaction strength between carriers (electrons and holes) and the embedded magnetic atoms. In this respect, colloidal nanocrystal heterostructures provide great flexibility via growth-controlled `engineering' of electron and hole wavefunctions within individual nanocrystals. Here we demonstrate a widely tunable magnetic sp-d exchange interaction between electron-hole excitations (excitons) and paramagnetic manganese ions using `inverted' core-shell nanocrystals composed of Mn-doped ZnSe cores overcoated with undoped shells of narrower-gap CdSe. Magnetic circular dichroism studies reveal giant Zeeman spin splittings of the band-edge exciton that, surprisingly, are tunable in both magnitude and sign. Effective exciton g-factors are controllably tuned from -200 to +30 solely by increasing the CdSe shell thickness, demonstrating that strong quantum confinement and wavefunction engineering in heterostructured nanocrystal materials can be utilized to manipulate carrier-Mn wavefunction overlap and the sp-d exchange parameters themselves.Comment: To appear in Nature Materials; 18 pages, 4 figures + Supp. Inf

A Tale of Two Current Sheets

I outline a new model of particle acceleration in the current sheet separating the closed from the open field lines in the force-free model of pulsar magnetospheres, based on reconnection at the light cylinder and "auroral" acceleration occurring in the return current channel that connects the light cylinder to the neutron star surface. I discuss recent studies of Pulsar Wind Nebulae, which find that pair outflow rates in excess of those predicted by existing theories of pair creation occur, and use those results to point out that dissipation of the magnetic field in a pulsar's wind upstream of the termination shock is restored to life as a viable model for the solution of the "$\sigma$" problem as a consequence of the lower wind 4-velocity implied by the larger mass loading.Comment: 17 pages, 6 figures, Invited Review, Proceedings of the "ICREA Workshop on The High-Energy Emission from Pulsars and their Systems", Sant Cugat, Spain, April 12-16, 201

Embracing additive manufacture: implications for foot and ankle orthosis design

<p>Abstract</p> <p>Background</p> <p>The design of foot and ankle orthoses is currently limited by the methods used to fabricate the devices, particularly in terms of geometric freedom and potential to include innovative new features. Additive manufacturing (AM) technologies, where objects are constructed via a series of sub-millimetre layers of a substrate material, may present the opportunity to overcome these limitations and allow novel devices to be produced that are highly personalised for the individual, both in terms of fit and functionality.</p> <p>Two novel devices, a foot orthosis (FO) designed to include adjustable elements to relieve pressure at the metatarsal heads, and an ankle foot orthosis (AFO) designed to have adjustable stiffness levels in the sagittal plane, were developed and fabricated using AM. The devices were then tested on a healthy participant to determine if the intended biomechanical modes of action were achieved.</p> <p>Results</p> <p>The adjustable, pressure relieving FO was found to be able to significantly reduce pressure under the targeted metatarsal heads. The AFO was shown to have distinct effects on ankle kinematics which could be varied by adjusting the stiffness level of the device.</p> <p>Conclusions</p> <p>The results presented here demonstrate the potential design freedom made available by AM, and suggest that it may allow novel personalised orthotic devices to be produced which are beyond the current state of the art.</p

Triorchidism at orchidopexy: a case report

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

SDSS-HET Survey of Kepler Eclipsing Binaries. Description of the Survey and First Results

The Kepler mission has provided a treasure trove of eclipsing binaries (EBs), observed at extremely high photometric precision, nearly continuously for several years. We are carrying out a survey of ~100 of these EBs to derive dynamical masses and radii with precisions of 3% or better. We use multiplexed near-infrared H-band spectroscopy from the Sloan Digital Sky Survey-III and -IV APOGEE instrument and optical spectroscopy from the Hobby–Eberly Telescope High-resolution Spectrograph to derive double-lined spectroscopic orbits and dynamical mass ratios (q) for the EB sample, two of which we showcase in this paper. This orbital information is combined with Kepler photometry to derive orbital inclination, dynamical masses of the system components, radii, and temperatures. These measurements are directly applicable for benchmarking stellar models that are integrating the next generation of improvements, such as the magnetic suppression of convection efficiency, updated opacity tables, and fine-tuned equations of state. We selected our EB sample to include systems with low-mass (M ≾ 0.8 M⊙) primary or secondary components, as well as many EBs expected to populate the relatively sparse parameter space below ~0.5 M⊙. In this paper, we describe our EB sample and the analytical techniques we are utilizing, and also present masses and radii for two systems that inhabit particularly underpopulated regions of mass–radius–period space: KIC 2445134 and KIC 3003991. Our joint spectroscopic and photometric analysis of KIC 2445134 (q = 0.411 ± 0.001) yields masses and radii of M_A = 1.29 ± 0.03 M⊙, M_B = 0.53 ± 0.01 M⊙, R_A = 1.42 ± 0.01 R⊙, R_B = 0.510 ± 0.004 R⊙, and a temperature ratio of T_B/T_A = 0.635 ± 0.001; our analysis of KIC 3003991 (q = 0.298 ± 0.006) yields M_A = 0.74 ± 0.04 M⊙, M_B = 0.222 ± 0.007 M⊙, R_A = 0.84 ± 0.01 R⊙, R_B = 0.250 ± 0.004 R⊙, and a temperature ratio of T_B/T_A = 0.662 ± 0.001

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the liver. The selective SIK inhibitor HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes, an effect that is abolished when an HG-9-91-01-insensitive mutant SIK is introduced or LKB1 is ablated. Although SIK2 was proposed as a key regulator of insulin-mediated suppression of gluconeogenesis, we provide genetic evidence that liver-specific ablation of SIK2 alone has no effect on gluconeogenesis and insulin does not modulate SIK2 phosphorylation or activity. Collectively, we demonstrate that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver