950 research outputs found

    Organizational Practices and Second-Generation Gender Bias: A Qualitative Inquiry into the Career Progression of US State-Level Managers

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    Ely and Meyerson’s gendered organizations framework reconceptualizes traditional gender differences defined by biology and lack of structural opportunities, to a complex set of social relations in the workplace. We apply this framework to second-generation gender bias to further understand impediments to women’s career progression in the public sector workplace. In-depth interviews of state-level administrators in U.S. public sector agencies indicate that “narratives” perpetuate second-generation gender bias that is deeply ingrained in organizational practices and policies, especially for women and women of color. This framework can be applied to future studies examining the gendered nature of organizations in different workplace settings. Moving beyond already identified barriers, this study offers a comprehensive framework to understand how second-generation gender bias is central to long-standing workplace inequities

    NOIR: Neural Signal Operated Intelligent Robots for Everyday Activities

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    We present Neural Signal Operated Intelligent Robots (NOIR), a general-purpose, intelligent brain-robot interface system that enables humans to command robots to perform everyday activities through brain signals. Through this interface, humans communicate their intended objects of interest and actions to the robots using electroencephalography (EEG). Our novel system demonstrates success in an expansive array of 20 challenging, everyday household activities, including cooking, cleaning, personal care, and entertainment. The effectiveness of the system is improved by its synergistic integration of robot learning algorithms, allowing for NOIR to adapt to individual users and predict their intentions. Our work enhances the way humans interact with robots, replacing traditional channels of interaction with direct, neural communication. Project website: https://noir-corl.github.io/

    Revisiting anomalous \u3cem\u3eB\u3c/em\u3e(\u3cem\u3eE\u3c/em\u3e2;4\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e1\u3c/sub\u3e→2\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e1\u3c/sub\u3e)/\u3cem\u3eB\u3c/em\u3e(\u3cem\u3eE\u3c/em\u3e2;2\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e1\u3c/sub\u3e→0\u3csup\u3e+\u3c/sup\u3e\u3csub\u3e1\u3c/sub\u3e) values in \u3csup\u3e98\u3c/sup\u3eRu and \u3csup\u3e180\u3c/sup\u3ePt

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    Recently, a set of nine nonmagic nuclei with anomalous values of the B(E2) ratio B4/2 ≡ B(E2; 4+1 → 2+1)/B(E2; 2+1 → 0+1) were identified. Such values are outside the range allowed by current collective models. In the present work, the B(E2; 4+1 → 2+1) values for two of these nuclei, 98Ru and 180Pt, were re-measured to determine if the current literature values for these nuclei are correct. 98Ru was studied in a 27Al(98Ru,98Ru∗) Coulomb excitation experiment in inverse kinematics, while the lifetime of the 4+1 state in 180Pt was measured in a 122Sn(62Ni, 4n)180Pt recoil distance method (RDM) experiment. For both nuclei, the remeasured B4/2 values are well above 1, removing the deviations from collective models

    Analyzing Thioflavin T Binding to Amyloid Fibrils by an Equilibrium Microdialysis-Based Technique

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    A new approach for the determination of the amyloid fibril – thioflavin T (ThT) binding parameters (the number of binding modes, stoichiometry, and binding constants of each mode) is proposed. This approach is based on the absorption spectroscopy determination of the concentration of free and bound to fibril dye in solutions, which are prepared by equilibrium microdialysis. Furthermore, the proposed approach allowed us, for the first time, to determine the absorption spectrum, molar extinction coefficient, and fluorescence quantum yield of the ThT bound to fibril by each binding modes. This approach is universal and can be used for determining the binding parameters of any dye interaction with a receptor, such as ANS binding to proteins in the molten globule state or to protein amorphous aggregates

    3-Benzyl-6-butyl-5-propyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one

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    In the title compound, C18H23N5O2, the triazolopyrimidine ring system is essentially planar, with a maximum displacement of 0.032 (2) Å, and forms a dihedral angle of 87.59 (15)° with the phenyl ring. In the crystal, mol­ecules are linked by inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions into chains parallel to the c axis

    Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2(V617F) Mice

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    Rationale: The mechanisms driving atherothrombotic risk in individuals with JAK2(V617F) (Jak2(VF)) positive clonal hematopoiesis or myeloproliferative neoplasms are poorly understood. Objective: The goal of this study was to assess atherosclerosis and underlying mechanisms in hypercholesterolemic mice with hematopoietic Jak2(VF) expression. Methods and Results: Irradiated low-density lipoprotein receptor knockout (Ldlr(-/-)) mice were transplanted with bone marrow from wild-type or Jak2(VF) mice and fed a high-fat high-cholesterol Western diet. Hematopoietic functions and atherosclerosis were characterized. After 7 weeks of Western diet, Jak2(VF) mice showed increased atherosclerosis. Early atherosclerotic lesions showed increased neutrophil adhesion and content, correlating with lesion size. After 12 weeks of Western diet, Jak2(VF) lesions showed increased complexity, with larger necrotic cores, defective efferocytosis, prominent iron deposition, and costaining of erythrocytes and macrophages, suggesting erythrophagocytosis. Jak2(VF) erythrocytes were more susceptible to phagocytosis by wild-type macrophages and showed decreased surface expression of CD47, a "don't-eat-me" signal. Human JAK2VF erythrocytes were also more susceptible to erythrophagocytosis. Jak2(VF) macrophages displayed increased expression and production of proinflammatory cytokines and chemokines, prominent inflammasome activation, increased p38 MAPK (mitogen-activated protein kinase) signaling, and reduced levels of MerTK (c-Mer tyrosine kinase), a key molecule mediating efferocytosis. Increased erythrophagocytosis also suppressed efferocytosis. Conclusions: Hematopoietic Jak2(VF) expression promotes early lesion formation and increased complexity in advanced atherosclerosis. In addition to increasing hematopoiesis and neutrophil infiltration in early lesions, Jak2(VF) caused cellular defects in erythrocytes and macrophages, leading to increased erythrophagocytosis but defective efferocytosis. These changes promote accumulation of iron in plaques and increased necrotic core formation which, together with exacerbated proinflammatory responses, likely contribute to plaque instability
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