20 research outputs found
New insight into kinetics behavor of the structural formation process in Agar gelation
A time-resolved experimental study on the kinetics and relaxation of the
structural formation process in gelling Agar-water solutions was carried out
using our custom-built torsion resonator. The study was based on measurements
of three naturally cooled solutions with agar concentrations of 0.75%, 1.0% and
2.0% w/w. It was found that the natural-cooling agar gelation process could be
divided into three stages, sol stage (Stage I), gelation zone (Stage II) and
gel stage (Stage III), based on the time/temperature evolutions of the
structural development rate (SDR). An interesting fluctuant decaying behavior
of SDR was observed in Stage II and III, indicative of a sum of multiple
relaxation processes and well described by a multiple-order Gaussisn-like
equation: . More interestingly, the temperature dependences of the fitted
values of Wn in Stage II and Stage III were found to follow the different
Arrhenius laws, with different activation energies of EaII= 39-74 KJ/mol and
EaIII~7.0 KJ/mol. The two different Arrhenius-like behaviors respectively
suggest that dispersions in Stage II be attributed to the relaxation of the
self-assembly of agar molecules or the growth of junction zones en route to
gelation, in which the formation or fission of hydrogen bonding interactions
plays an important role; and that dispersions in Stage III be attributed to the
relaxation dynamics of water released from various size domains close to the
domain of the viscous flow of water during the syneresis process.Comment: 24 pages, 4 figures, 1 tabl
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Scaling α- and β-diversity: bryophytes along an elevational gradient on a subtropical oceanic Island (La Palma, Canary Islands)
International audienc
Scaling α- and β-diversity: bryophytes along an elevational gradient on a subtropical oceanic Island (La Palma, Canary Islands)
Home-based neonatal care by community health workers for preventing mortality in neonates in low- and middle-income countries: a systematic review
Taxonomic diversity and morphological disparity of paleozoic ammonoids
The Ammonoidea are well represented in terms of numbers of species over a large range of time and they have survived many extinction events. The time interval from the Early Devonian through to the Triassic has seen ammonoid groups evolve and become extinct. The evolutionary history of the Paleozoic ammonoids was punctuated by some extinction events with near extinction events and subsequent recoveries. A Principal Components Analysis (PCA) based on the conch width index (CWI), umbilical width index (UWI) and whorl expansion rate (WER) parameters from 4834 ammonoid species of Devonian to Triassic age produced an empirical morphospace this time interval. The morphospace of Paleozoic ammonoids shows some subtle changes between the periods, but generally, the occupied area is remarkably similar
Structure of the human smoothened receptor bound to an antitumour agent
The smoothened (SMO) receptor, a key signal transducer in the Hedgehog (Hh) signaling pathway is both responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. The SMO receptor is classified as a class Frizzled (class F) G protein-coupled receptor (GPCR), although the canonical Hh signaling pathway involves the transcription factor Gli and the sequence similarity with class A GPCRs is less than 10%. Here we report the crystal structure at 2.5 Å resolution of the transmembrane domain of the human SMO receptor bound to the small molecule antagonist LY2940680. Although the SMO receptor shares the seven transmembrane helical (7TM) fold, most conserved motifs for class A GPCRs are absent, and the structure reveals an unusually complex arrangement of long extracellular loops stabilized by four disulfide bonds. The ligand binds at the extracellular end of the 7TM bundle and forms extensive contacts with the loops