Correlation of mechanical factors and gallbladder pain

Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of those operated on, so a reliable pain-prediction model is needed. In this paper, a mechanical model is developed for the human biliary system during the emptying phase, based on a clinical test in which GB volume changes are measured in response to a standard stimulus and a recorded pain profile. The model can describe the bile emptying behaviour, the flow resistance in the biliary ducts, the peak total stress, including the passive and active stresses experienced by the GB during emptying. This model is used to explore the potential link between GB pain and mechanical factors. It is found that the peak total normal stress may be used as an effective pain indicator for GB pain. When this model is applied to clinical data of volume changes due to Cholecystokinin stimulation and pain from 37 patients, it shows a promising success rate of 88.2% in positive pain prediction

MANAGEMENT OF SOLITARY THYROID NODULES IN RURAL AFRICA

Objectives: To review a simple protocol for the management of solitary thyroid nodulesand to document the spectrum of pathological diagnoses associated with this condition.Design: A retrospective review of all solitary solid thyroid nodules excised over a threeyearperiod from 1st January 1999 to 31st December 2001.Setting: A rural church-based hospital in Kenya.Subjects: All patients undergoing thyroidectomy for solitary solid thyroid nodule overa three-year period at Kijabe Hospital.Interventions: A simple protocol was used to manage this condition involving history,clinical examination, needle aspiration of the lesion, and excision when clinicallyindicated.Main Outcome Measures: Clinical diagnosis, tribe, operation performed, pathology, andcomplications of surgery.Results: Eighty-one operations were performed for a solitary thyroid nodule. The mostcommon operations were lobectomy and isthmusectomy. There were two complicationsaneck haematoma that required surgery and one recurrent laryngeal nerve injury. Thecommonest pathological diagnosis was multinodular goitre (42%). There was a 16%malignancy rate with eight papillary carcinomas, five follicular carcinomas, and onehurthle cell carcinoma.Conclusions: The simple protocol described gives good results in a rural African hospital.Solitary solid thyroid nodules should be routinely excised due to the 16% malignancyrate in this condition. There is a possibility that there is a shift in the ratio of papillaryto follicular carcinomas compared to older African studies and this would be aninteresting area for further study

Quantum Chaos in Open versus Closed Quantum Dots: Signatures of Interacting Particles

This paper reviews recent studies of mesoscopic fluctuations in transport through ballistic quantum dots, emphasizing differences between conduction through open dots and tunneling through nearly isolated dots. Both the open dots and the tunnel-contacted dots show random, repeatable conductance fluctuations with universal statistical proper-ties that are accurately characterized by a variety of theoretical models including random matrix theory, semiclassical methods and nonlinear sigma model calculations. We apply these results in open dots to extract the dephasing rate of electrons within the dot. In the tunneling regime, electron interaction dominates transport since the tunneling of a single electron onto a small dot may be sufficiently energetically costly (due to the small capacitance) that conduction is suppressed altogether. How interactions combine with quantum interference are best seen in this regime.Comment: 15 pages, 11 figures, PDF 2.1 format, to appear in "Chaos, Solitons & Fractals

Ultra-high energy cosmic ray investigations by means of EAS muon density measurements

A new approach to investigations of ultra-high energy cosmic rays based on the ground-level measurements of the spectra of local density of EAS muons at various zenith angles is considered. Basic features of the local muon density phenomenology are illustrated using a simple semi-analytical model. It is shown that muon density spectra are sensitive to the spectrum slope, primary composition, and to the features of hadronic interaction. New experimental data on muon bundles at zenith angles from 30 degrees to horizon obtained with the coordinate detector DECOR are compared with CORSIKA-based simulations. It is found that measurements of muon density spectra in inclined EAS give possibility to study characteristics of primary cosmic ray flux in a very wide energy range from 10^15 to 10^19 eV.Comment: 7 pages, 7 figures. Presented at CRIS-2006, Catania, Italy, May 29 - June 2, 2006. Accepted for publication in Nucl. Phys. B (Proc. Suppl.

Probe-configuration dependent dephasing in a mesoscopic interferometer

Dephasing in a ballistic four-terminal Aharonov-Bohm geometry due to charge and voltage fluctuations is investigated. Treating two terminals as voltage probes, we find a strong dependence of the dephasing rate on the probe configuration in agreement with a recent experiment by Kobayashi et al. (J. Phys. Soc. Jpn. 71, 2094 (2002)). Voltage fluctuations in the measurement circuit are shown to be the source of the configuration dependence.Comment: 4 pages, 3 figure

Dephasing in Open Quantum Dots

Shape-averaged magnetoconductance (weak localization) is used for the first time to obtain the electron phase coherence time $\tau_{\phi}$ in open ballistic GaAs quantum dots. Values for $\tau_{\phi}$ in the range of temperature T from 0.335 to 4 K are found to be independent of dot area, and are not consistent with the $\tau_{\phi} \propto T^{-2}$ behavior expected for isolated dots. Surprisingly, $\tau_{\phi}(T)$ agrees quantitatively with the predicted dephasing time for disordered two-dimensional electron systems.Comment: 9 pages, 4 figure

Ultra Long Period Cepheids: a primary standard candle out to the Hubble flow

The cosmological distance ladder crucially depends on classical Cepheids (with P=3-80 days), which are primary distance indicators up to 33 Mpc. Within this volume, very few SNe Ia have been calibrated through classical Cepheids, with uncertainty related to the non-linearity and the metallicity dependence of their period-luminosity (PL) relation. Although a general consensus on these effects is still not achieved, classical Cepheids remain the most used primary distance indicators. A possible extension of these standard candles to further distances would be important. In this context, a very promising new tool is represented by the ultra-long period (ULP) Cepheids (P \geq 80 days), recently identified in star-forming galaxies. Only a small number of ULP Cepheids have been discovered so far. Here we present and analyse the properties of an updated sample of 37 ULP Cepheids observed in galaxies within a very large metallicity range of 12+log(O/H) from ~7.2 to 9.2 dex. We find that their location in the colour(V-I)-magnitude diagram as well as their Wesenheit (V-I) index-period (WP) relation suggests that they are the counterparts at high luminosity of the shorter-period (P \leq 80 days) classical Cepheids. However, a complete pulsation and evolutionary theoretical scenario is needed to properly interpret the true nature of these objects. We do not confirm the flattening in the studied WP relation suggested by Bird et al. (2009). Using the whole sample, we find that ULP Cepheids lie around a relation similar to that of the LMC, although with a large spread (~0.4 mag).Comment: 8 pages, 4 figures, accepted for publication in Astrophysics & Space Scienc

New constraints on the mass composition of cosmic rays above 10^17 eV from Volcano Ranch measurements

Linsley used the Volcano Ranch array to collect data on the lateral distribution of showers produced by cosmic rays at energies above 10^17 eV. Very precise measurements of the steepness of the lateral distribution function were made on 366 events. The current availability of sophisticated hadronic interaction models has prompted an interpretation of the measurements. In this analysis we use the AIRES Monte Carlo code to generate showers, together with GEANT4 to simulate the detector response to ground particles. The results show that, with the assumption of a bi-modal proton and iron mix, iron is the dominant component of cosmic rays between 5x10^17 and 10^19 eV, assuming that hadronic interactions are well-described by QGSJET at this energy range.Comment: Submitted to Astropart. Phy

Long Lived Superheavy Dark Matter with Discrete Gauge Symmetries

The recently observed ultra-high energy (UHE) cosmic rays beyond the Greisen-Zatsepin-Kuzmin bound can be explained by the decays of some superheavy $X$ particles forming a part of dark matter in our universe. We consider various discrete gauge symmetries ${\bf Z}_N$ to ensure the required long lifetime ($\tau_X \simeq 10^{10}-10^{22} years$) of the $X$ particle to explain the UHE cosmic rays in the minimal supersymmetric standard model (MSSM) with massive Majorana neutrinos. We show that there is no anomaly-free discrete gauge symmetry to make the lifetime of the $X$ particle sufficiently long in the MSSM with the $X$ particle. We find, however, possible solutions to this problem especially by enlarging the particle contents in the MSSM. We show a number of solutions introducing an extra pair of singlets $Y$ and $\bar{Y}$ which have fractional ${\bf Z}_N$ (N=2,3) charges. The present experimental constraints on the $X$ particle are briefly discussed.Comment: 27 pages, Late

Light cone QCD sum rules study of the semileptonic heavy ΞQ\Xi_{Q} and ΞQ′\Xi'_{Q} transitions to Ξ\Xi and Σ\Sigma baryons

The semileptonic decays of heavy spin--1/2, $\Xi_{b(c)}$ and $\Xi'_{b(c)}$ baryons to the light spin-- 1/2, $\Xi$ and $\Sigma$ baryons are investigated in the framework of the light cone QCD sum rules. In particular, using the most general form of the interpolating currents for the heavy baryons as well as the distribution amplitudes of the $\Xi$ and $\Sigma$ baryons, we calculate all form factors entering the matrix elements of the corresponding effective Hamiltonians in full QCD. Having calculated the responsible form factors, we evaluate the decay rates and branching fractions of the related transitions.Comment: 30 Pages, 5 Figures and 18 Table