788 research outputs found
Quantum superconductor-metal transition
We consider a system of superconducting grains embedded in a normal metal. At
zero temperature this system exhibits a quantum superconductor-normal metal
phase transition. This transition can take place at arbitrarily large
conductance of the normal metal.Comment: 13 pages, 1 figure include
On the quantum and classical scattering times due to charged dislocations in an impure electron gas
We derive the ratio of transport and single particle relaxation times in
three and two - dimensional electron gases due to scattering from charged
dislocations in semiconductors. The results are compared to the respective
relaxation times due to randomly placed charged impurities. We find that the
ratio is larger than the case of ionized impurity scattering in both three and
two-dimensional electron transport.Comment: 4 pages, 3 figure
Ustekinumab for the treatment of moderate‐to‐severe plaque psoriasis in paediatric patients (≥ 6 to < 12 years of age): efficacy, safety, pharmacokinetic and biomarker results from the open‐label CADMUS Jr study
Background Limited options are available for treatment of paediatric psoriasis. Objectives To evaluate the efficacy and safety of ustekinumab in paediatric patients with psoriasis (>= 6 to = 60 to 100 kg: 90 mg) administered by subcutaneous injection at weeks 0 and 4, then every 12 weeks through week 40. Study endpoints (all at week 12) included the proportions of patients achieving a Physician's Global Assessment score of cleared/minimal (PGA 0/1) and >= 75%/90% improvement in Psoriasis Area and Severity Index (PASI 75/90), and change in Children's Dermatology Life Quality Index (CDLQI). Serum ustekinumab concentrations, antidrug antibodies and cytokine levels were measured through week 52. Safety was evaluated through week 56. Results In total, 44 patients (median age 9 center dot 5 years) received at least one dose of ustekinumab. Three patients discontinued the study agent through week 40. At week 12, 77% of patients achieved PGA 0/1, 84% achieved PASI 75 and 64% achieved PASI 90 response. The mean change in CDLQI was -6 center dot 3. Trough serum ustekinumab concentrations reached steady state at weeks 28-52. The incidence of antidrug antibodies was 10% (n = 4). Mean serum concentrations of interleukin-17A/F and interleukin-22 were significantly reduced at weeks 12 and 52. Overall, 34 patients (77%) had at least one adverse event and three (7%) had a serious adverse event. Conclusions Ustekinumab effectively treated moderate-to-severe psoriasis in paediatric patients, and no new safety concerns were identified.
What is already known about this topic? Ustekinumab is approved for use in adolescents (>= 12 to = 18 years) with moderate-to-severe psoriasis.
What does this study add? Ustekinumab effectively treats moderate-to-severe psoriasis in paediatric patients (>= 6 to < 12 years of age), with no new safety concerns
Low Energy Theory for 2 flavors at High Density QCD
We construct the effective Lagrangian describing the low energy excitations
for Quantum Chromodynamics with two flavors at high density. The non-linear
realization framework is employed to properly construct the low energy
effective theory. The light degrees of freedom, as required by 't Hooft anomaly
conditions, contain massless fermions which we properly include in the
effective Lagrangian. We also provide a discussion of the linearly realized
Lagrangian.Comment: 17 pages, RevTeX format, references added. To appear in Phys. Rev.
Anomalous Quantum Diffusion at the Superfluid-Insulator Transition
We consider the problem of the superconductor-insulator transition in the
presence of disorder, assuming that the fermionic degrees of freedom can be
ignored so that the problem reduces to one of Cooper pair localization. Weak
disorder drives the critical behavior away from the pure critical point,
initially towards a diffusive fixed point. We consider the effects of Coulomb
interactions and quantum interference at this diffusive fixed point. Coulomb
interactions enhance the conductivity, in contrast to the situation for
fermions, essentially because the exchange interaction is opposite in sign. The
interaction-driven enhancement of the conductivity is larger than the
weak-localization suppression, so the system scales to a perfect conductor.
Thus, it is a consistent possibility for the critical resistivity at the
superconductor-insulator transition to be zero, but this value is only
approached logarithmically. We determine the values of the critical exponents
and comment on possible implications for the interpretation of
experiments
Non-zero temperature transport near quantum critical points
We describe the nature of charge transport at non-zero temperatures ()
above the two-dimensional () superfluid-insulator quantum critical point. We
argue that the transport is characterized by inelastic collisions among
thermally excited carriers at a rate of order . This implies that
the transport at frequencies is in the hydrodynamic,
collision-dominated (or `incoherent') regime, while is
the collisionless (or `phase-coherent') regime. The conductivity is argued to
be times a non-trivial universal scaling function of , and not independent of , as has been previously
claimed, or implicitly assumed. The experimentally measured d.c. conductivity
is the hydrodynamic limit of this function, and is a
universal number times , even though the transport is incoherent.
Previous work determined the conductivity by incorrectly assuming it was also
equal to the collisionless limit of the scaling
function, which actually describes phase-coherent transport with a conductivity
given by a different universal number times . We provide the first
computation of the universal d.c. conductivity in a disorder-free boson model,
along with explicit crossover functions, using a quantum Boltzmann equation and
an expansion in . The case of spin transport near quantum
critical points in antiferromagnets is also discussed. Similar ideas should
apply to the transitions in quantum Hall systems and to metal-insulator
transitions. We suggest experimental tests of our picture and speculate on a
new route to self-duality at two-dimensional quantum critical points.Comment: Feedback incorporated into numerous clarifying remarks; additional
appendix discusses relationship to transport in dissipative quantum mechanics
and quantum Hall edge state tunnelling problems, stimulated by discussions
with E. Fradki
Lifetime Differences, direct CP Violation and Partial Widths in D0 Meson Decays to K+K- and pi+pi-
We describe several measurements using the decays D0->K+K- and pi+pi-. We
find the ratio of partial widths, Gamma(D0->K+K-)/Gamma(D0->pi+pi-), to be
2.96+/-0.16+/-0.15, where the first error is statistical and the second is
systematic. We observe no evidence for direct CP violation, obtaining A_CP(KK)
= (0.0+/-2.2+/-0.8)% and A_CP(pipi = (1.9+/-3.2+/-0.8)%. In the limit of no CP
violation we measure the mixing parameter y_CP = -0.012+/-0.025+/-0.014 by
measuring the lifetime difference between D0->K+ K- or pi+pi- and the CP
neutral state, D0->K-pi+. We see no evidence for mixing.Comment: 14 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, submitted to PRD, Rapid Communicatio
Dynamic analysis of a simply supported beam resting on a nonlinear elastic foundation under compressive axial load using nonlinear normal modes techniques under three-to-one internal resonance condition
Global Search for New Physics with 2.0/fb at CDF
Data collected in Run II of the Fermilab Tevatron are searched for
indications of new electroweak-scale physics. Rather than focusing on
particular new physics scenarios, CDF data are analyzed for discrepancies with
the standard model prediction. A model-independent approach (Vista) considers
gross features of the data, and is sensitive to new large cross-section
physics. Further sensitivity to new physics is provided by two additional
algorithms: a Bump Hunter searches invariant mass distributions for "bumps"
that could indicate resonant production of new particles; and the Sleuth
procedure scans for data excesses at large summed transverse momentum. This
combined global search for new physics in 2.0/fb of ppbar collisions at
sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D
Rapid Communication
Observation of Orbitally Excited B_s Mesons
We report the first observation of two narrow resonances consistent with
states of orbitally excited (L=1) B_s mesons using 1 fb^{-1} of ppbar
collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the
Fermilab Tevatron. We use two-body decays into K^- and B^+ mesons reconstructed
as B^+ \to J/\psi K^+, J/\psi \to \mu^+ \mu^- or B^+ \to \bar{D}^0 \pi^+,
\bar{D}^0 \to K^+ \pi^-. We deduce the masses of the two states to be m(B_{s1})
= 5829.4 +- 0.7 MeV/c^2 and m(B_{s2}^*) = 5839.7 +- 0.7 MeV/c^2.Comment: Version accepted and published by Phys. Rev. Let
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