Effects of nuclear structure on average angular momentum in subbarrier fusion

We investigate the effects of nuclear quadrupole and hexadecapole couplings on the average angular momentum in sub-barrier fusion reactions. This quantity could provide a probe for nuclear shapes, distinguishing between prolate vs. oblate quadrupole and positive vs. negative hexadecapole couplings. We describe the data in the O + Sm system and discuss heavier systems where shape effects become more pronounced.Comment: Latex (uses the epsf macro), 10 pages of text, 3 postscript figures included. Full postscript version available by anonymous ftp from wisnuf.physics.wisc.edu:/pub/preprints. MAD-NT-94-0

Quantifying distortions in two-photon remote focussing microscope images using a volumetric calibration specimen

This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.Remote focussing microscopy allows sharp, in-focus images to be acquired at high speed from outside of the focal plane of an objective lens without any agitation of the specimen. However, without careful optical alignment, the advantages of remote focussing microscopy could be compromised by the introduction of depth-dependent scaling artifacts. To achieve an ideal alignment in a point-scanning remote focussing microscope, the lateral (XY) scan mirror pair must be imaged onto the back focal plane of both the reference and imaging objectives, in a telecentric arrangement. However, for many commercial objective lenses, it can be difficult to accurately locate the position of the back focal plane. This paper investigates the impact of this limitation on the fidelity of three-dimensional data sets of living cardiac tissue, specifically the introduction of distortions. These distortions limit the accuracy of sarcomere measurements taken directly from raw volumetric data. The origin of the distortion is first identified through simulation of a remote focussing microscope. Using a novel three-dimensional calibration specimen it was then possible to quantify experimentally the size of the distortion as a function of objective misalignment. Finally, by first approximating and then compensating the distortion in imaging data from whole heart rodent studies, the variance of sarcomere length (SL) measurements was reduced by almost 50%.Medical Research Council (MRC)Engineering and Physical Sciences Research Council (EPSRC)Biotechnology and Biological Sciences Research Council (BBSRC)British Heart Foundation Centre of Research Excellence, Oxfor

Enhancement of quality of rainbow trout (Oncorhynchus mykiss) flesh incorporating barley on diet without negative effect on rearing parameters

[EN] Barley concentrations ranging from 0 to 32% (0B, 40B, 80B, 160B, and 319B) were incorporated into rainbow trout, Oncorhynchus mykiss (Walbaum) diets. The experiment started with an initial average fish weight of 127.72 +/- 5.65 g and finished when they reached commercial weight (final weight between 312 and 330 g) after 84 days. The inclusion of barley in the diets did not show a significant effect on growth and biometric parameters, fat and carbohydrate digestibilities; however, protein digestibility decreased significantly with the incorporation of barley on diets. Glucose levels increased significantly with barley concentration in the diet, and lactate and cortisol levels were also significantly affected after a stress period regardless of the diet. Meat quality was influenced as well by barley concentration. Lower water activity values and an enhancement in textural and color properties were observed in fish fed with the diet containing the highest barley concentration. Trout fed feed with higher concentrations of barley (160B) showed lower lipid oxidation levels than those fed with lower concentrations (control and 40B). The sensory panel found that fish fed with diets higher than 8% in barley content (80B) exhibited a brighter red color in the gills and a better texture; also, meat color became redder with a higher barley inclusion (160B and 319B), being all these sensory parameters correlated with fish freshness. Thus, results indicate that barley can be substituted for wheat fraction without any detrimental effect on production efficiency and enhancing fish quality.This work has been co-funded with FEDER and INIA funds. The authors thanks Dr. Francisco Ciudad Bautista for providing barley variety obtained in ITACyL, IRTA, EEDF-CSIC, ITAP, and INIA (1FD97-0792 and RTA2006-00020-C04). Julia Pinedo has been granted with the FPI-INIA grant number 21 (call 2012, BOE-2012-13337).Pinedo-Gil, J.; Tomas-Vidal, A.; Larrán-García, AM.; Tomas-Almenar, C.; Jover Cerda, M.; Sanz-Calvo, M.; Martín-Diana, A. (2017). Enhancement of quality of rainbow trout (Oncorhynchus mykiss) flesh incorporating barley on diet without negative effect on rearing parameters. Aquaculture International. 25(3):1005-1023. https://doi.org/10.1007/s10499-016-0091-010051023253A.O.A.C., Association of Official Analytical Chemists (1990) Official methods of analysis, 15th edn. Association of Official Analytical Chemists, Arlington 1298 ppAi Q, Mai K, Zhang L, Tan B, Zhang W, Xu W, Li H (2007) Effects of dietary β-1,3- glucan on innate immune response on large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immun 22:394–402APROMAR 2014 La acuicultura en España 2013. Report by the Spanish Association of marine Aquaculture (APROMAR) and the Spanish Association of Freshwater Aquaculture (ESCUA). 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Aquac Res 38:551–579Gaylord TG, Barrows FT, Rawles SD, Liu K, Bregitzer P, Hang A, Obert DE, Morris C (2009) Apparent digestibility of nutrients and energy in extruded diets from cultivars of barley and wheat selected for nutritional quality in rainbow trout Oncorhynchus mykiss. Aquac Nutr 15:306–312Ghaedi G, Keyvanshokooh S, Azarm HM, Akhlaghi M (2015) Effects of dietary β-glucan on maternal immunity and fry quality of rainbow trout (Oncorhynchus mykiss). Aquaculture 441:78–83Grisdale-Helland B, Helland SJ (1997) Replacemente of protein by fat and carbohydrate in diets for Atlantic salmon (Salmo salar) at the end of the freshwater stage. Aquaculture 152:167–180Gu M, Ma H, Mai K, Zhang W, Bai N, Wang X (2011) Effects of dietary β-glucan, mannan oligosaccharide and their combinations on growth performance, immunity and resistance against Vibrio splendidus of sea cucumber, Apostichopus japonicus. 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On exact solutions for quintessential (inflationary) cosmological models with exponential potentials

We first study dark energy models with a minimally-coupled scalar field and exponential potentials, admitting exact solutions for the cosmological equations: actually, it turns out that for this class of potentials the Einstein field equations exhibit alternative Lagrangians, and are completely integrable and separable (i.e. it is possible to integrate the system analytically, at least by quadratures). We analyze such solutions, especially discussing when they are compatible with a late time quintessential expansion of the universe. As a further issue, we discuss how such quintessential scalar fields can be connected to the inflationary phase, building up, for this class of potentials, a quintessential inflationary scenario: actually, it turns out that the transition from inflation toward late-time exponential quintessential tail admits a kination period, which is an indispensable ingredient of this kind of theoretical models. All such considerations have also been done by including radiation into the model.Comment: Revtex4, 10 figure

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards human-based methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and overcome in each specific setting

Teaching of Energy Issues: A debate proposal for a GLobal Reorientation

The growing awareness of serious difficulties in the learning of energy issues has produced a great deal of research, most of which is focused on specific conceptual aspects. In our opinion, the difficulties pointed out in the literature are interrelated and connected to other aspects (conceptual as well as procedural and axiological), which are not sufficiently taken into account in previous research. This paper aims to carry out a global analysis in order to avoid the more limited approaches that deal only with individual aspects. From this global analysis we have outlined 24 propositions that are put forward for debate to lay the foundations for a profound reorientation of the teaching of energy topics in upper high school courses, in order to facilitate a better scientific understanding of these topics, avoid many students' misconceptions and enhance awareness of the current situation of planetary emergency

Learning Object Repositories with Federated Searcher over the Cloud

The education sector is a significant generator, consumer and depository for educational content. Educators and Learners have access to technologies that allow them to obtain information ubiquitously on demand. The problems arising from the integration of educational content are usually caused by the vast amount of educational content distributed among several repositories. This work presents a proposal for an architecture based on a cloud computing paradigm that will permit the evolution of current learning resource repositories by means of cloud computing paradigm and the integration of federated search system

Higgs Scalars in the Minimal Non-minimal Supersymmetric Standard Model

We consider the simplest and most economic version among the proposed non-minimal supersymmetric models, in which the $\mu$-parameter is promoted to a singlet superfield, whose all self-couplings are absent from the renormalizable superpotential. Such a particularly simple form of the renormalizable superpotential may be enforced by discrete $R$-symmetries which are extended to the gravity-induced non-renormalizable operators as well. We show explicitly that within the supergravity-mediated supersymmetry-breaking scenario, the potentially dangerous divergent tadpoles associated with the presence of the gauge singlet first appear at loop levels higher than 5 and therefore do not destabilize the gauge hierarchy. The model provides a natural explanation for the origin of the $\mu$-term, without suffering from the visible axion or the cosmological domain-wall problem. Focusing on the Higgs sector of this minimal non-minimal supersymmetric standard model, we calculate its effective Higgs potential by integrating out the dominant quantum effects due to stop squarks. We then discuss the phenomenological implications of the Higgs scalars predicted by the theory for the present and future high-energy colliders. In particular, we find that our new minimal non-minimal supersymmetric model can naturally accommodate a relatively light charged Higgs boson, with a mass close to the present experimental lower bound.Comment: 63 pages (12 figures), extended versio

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.

Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards human-based methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and overcome in each specific setting

Association between Use of Enhanced Recovery after Surgery Protocol and Postoperative Complications in Total Hip and Knee Arthroplasty in the Postoperative Outcomes Within Enhanced Recovery after Surgery Protocol in Elective Total Hip and Knee Arthroplasty Study (POWER2)

Importance: The Enhanced Recovery After Surgery (ERAS) care protocol has been shown to improve outcomes compared with traditional care in certain types of surgery. Objective: To assess the association of use of the ERAS protocols with complications in patients undergoing elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). Design, Setting, and Participants: This multicenter, prospective cohort study included patients recruited from 131 centers in Spain from October 22 through December 22, 2018. All consecutive adults scheduled for elective THA or TKA were eligible for inclusion. Patients were stratified between those treated in a self-designated ERAS center (ERAS group) and those treated in a non-ERAS center (non-ERAS group). Data were analyzed from June 15 through September 15, 2019. Exposures: Total hip or knee arthroplasty and perioperative management. Sixteen individual ERAS items were assessed in all included patients, whether they were treated at a center that was part of an established ERAS protocol or not. Main Outcomes and Measures: The primary outcome was postoperative complications within 30 days after surgery. Secondary outcomes included length of stay and mortality. Results: During the 2-month recruitment period, 6146 patients were included (3580 women [58.2%]; median age, 71 [interquartile range (IQR), 63-76] years). Of these, 680 patients (11.1%) presented with postoperative complications. No differences were found in the number of patients with overall postoperative complications between ERAS and non-ERAS groups (163 [10.2%] vs 517 [11.4%]; odds ratio [OR], 0.89; 95% CI, 0.74-1.07; P =.22). Fewer patients in the ERAS group had moderate to severe complications (73 [4.6%] vs 279 [6.1%]; OR, 0.74; 95% CI, 0.56-0.96; P =.02). The median overall adherence rate with the ERAS protocol was 50.0% (IQR, 43.8%-62.5%), with the rate for ERAS facilities being 68.8% (IQR, 56.2%-81.2%) vs 50.0% (IQR, 37.5%-56.2%) at non-ERAS centers (P <.001). Among the patients with the highest and lowest quartiles of adherence to ERAS components, the patients with the highest adherence had fewer overall postoperative complications (144 [10.6%] vs 270 [13.0%]; OR, 0.80; 95% CI, 0.64-0.99; P <.001) and moderate to severe postoperative complications (59 [4.4%] vs 143 [6.9%]; OR, 0.62; 95% CI, 0.45-0.84; P <.001) and shorter median length of hospital stay (4 [IQR, 3-5] vs 5 [IQR, 4-6] days; OR, 0.97; 95% CI, 0.96-0.99; P <.001). Conclusions and Relevance: An increase in adherence to the ERAS program was associated with a decrease in postoperative complications, although only a few ERAS items were individually associated with improved outcomes