8,196 research outputs found
Detection of Sugar-Lectin Interactions by Multivalent Dendritic Sugar Functionalized Single-Walled Carbon Nanotubes
We show that single walled carbon nanotubes (SWNT) decorated with sugar
functionalized poly (propyl ether imine) (PETIM) dendrimer is a very sensitive
platform to quantitatively detect carbohydrate recognizing proteins, namely,
lectins. The changes in electrical conductivity of SWNT in field effect
transistor device due to carbohydrate - protein interactions form the basis of
present study. The mannose sugar attached PETIM dendrimers undergo charge -
transfer interactions with the SWNT. The changes in the conductance of the
dendritic sugar functionalized SWNT after addition of lectins in varying
concentrations were found to follow the Langmuir type isotherm, giving the
concanavalin A (Con A) - mannose affinity constant to be 8.5 x 106 M-1. The
increase in the device conductance observed after adding 10 nM of Con A is same
as after adding 20 \muM of a non - specific lectin peanut agglutinin, showing
the high specificity of the Con A - mannose interactions. The specificity of
sugar-lectin interactions was characterized further by observing significant
shifts in Raman modes of the SWNT.Comment: 12 pages, 3 figure
Kaplan-Narayanan-Neuberger lattice fermions pass a perturbative test
We test perturbatively a recent scheme for implementing chiral fermions on
the lattice, proposed by Kaplan and modified by Narayanan and Neuberger, using
as our testing ground the chiral Schwinger model. The scheme is found to
reproduce the desired form of the effective action, whose real part is gauge
invariant and whose imaginary part gives the correct anomaly in the continuum
limit, once technical problems relating to the necessary infinite extent of the
extra dimension are properly addressed. The indications from this study are
that the Kaplan--Narayanan--Neuberger (KNN) scheme has a good chance at being a
correct lattice regularization of chiral gauge theories.Comment: LaTeX 18 pages, 3 figure
A formal framework for a nonlocal generalization of Einstein's theory of gravitation
The analogy between electrodynamics and the translational gauge theory of
gravity is employed in this paper to develop an ansatz for a nonlocal
generalization of Einstein's theory of gravitation. Working in the linear
approximation, we show that the resulting nonlocal theory is equivalent to
general relativity with "dark matter". The nature of the predicted "dark
matter", which is the manifestation of the nonlocal character of gravity in our
model, is briefly discussed. It is demonstrated that this approach can provide
a basis for the Tohline-Kuhn treatment of the astrophysical evidence for dark
matter.Comment: 13 pages RevTex, no figures; v2: minor corrections, reference added,
matches published versio
Magnetoresistance of a 2-dimensional electron gas in a random magnetic field
We report magnetoresistance measurements on a two-dimensional electron gas
(2DEG) made from a high mobility GaAs/AlGaAs heterostructure, where the
externally applied magnetic field was expelled from regions of the
semiconductor by means of superconducting lead grains randomly distributed on
the surface of the sample. A theoretical explanation in excellent agreement
with the experiment is given within the framework of the semiclassical
Boltzmann equation.Comment: REVTEX 3.0, 11 pages, 3 Postscript figures appended. The manuscript
can also be obtained from our World Wide Web server:
http://roemer.fys.ku.dk/randmag.ht
Thermally driven spin injection from a ferromagnet into a non-magnetic metal
Creating, manipulating and detecting spin polarized carriers are the key
elements of spin based electronics. Most practical devices use a perpendicular
geometry in which the spin currents, describing the transport of spin angular
momentum, are accompanied by charge currents. In recent years, new sources of
pure spin currents, i.e., without charge currents, have been demonstrated and
applied. In this paper, we demonstrate a conceptually new source of pure spin
current driven by the flow of heat across a ferromagnetic/non-magnetic metal
(FM/NM) interface. This spin current is generated because the Seebeck
coefficient, which describes the generation of a voltage as a result of a
temperature gradient, is spin dependent in a ferromagnet. For a detailed study
of this new source of spins, it is measured in a non-local lateral geometry. We
developed a 3D model that describes the heat, charge and spin transport in this
geometry which allows us to quantify this process. We obtain a spin Seebeck
coefficient for Permalloy of -3.8 microvolt/Kelvin demonstrating that thermally
driven spin injection is a feasible alternative for electrical spin injection
in, for example, spin transfer torque experiments
Flux lattice melting and depinning in the weakly frustrated 2D XY model
Monte Carlo simulations of the frustrated 2D XY model were carried out at
small commensurate values of the frustration . For a single
transition was observed at which phase coherence (finite helicity modulus) and
vortex lattice orientational order vanish together. For a new phase in
which phase coherence is absent but orientational order persists was observed.
Where comparison is possible, the results are in detailed agreement with the
behavior of the lattice Coulomb gas model of vortices. It is argued that the
helicity modulus of the frustrated 2D XY model vanishes for any finite
temperature in the limit of weak frustration .Comment: 4 pages, RevTeX, 3 figures in separate uuencoded file The manuscript
will appear in Phys. Rev.
Strongly anisotropic spin relaxation in graphene/transition metal dichalcogenide heterostructures at room temperature
Graphene has emerged as the foremost material for future two-dimensional
spintronics due to its tuneable electronic properties. In graphene, spin
information can be transported over long distances and, in principle, be
manipulated by using magnetic correlations or large spin-orbit coupling (SOC)
induced by proximity effects. In particular, a dramatic SOC enhancement has
been predicted when interfacing graphene with a semiconducting transition metal
dechalcogenide, such as tungsten disulphide (WS). Signatures of such an
enhancement have recently been reported but the nature of the spin relaxation
in these systems remains unknown. Here, we unambiguously demonstrate
anisotropic spin dynamics in bilayer heterostructures comprising graphene and
WS. By using out-of-plane spin precession, we show that the spin lifetime
is largest when the spins point out of the graphene plane. Moreover, we observe
that the spin lifetime varies over one order of magnitude depending on the spin
orientation, indicating that the strong spin-valley coupling in WS is
imprinted in the bilayer and felt by the propagating spins. These findings
provide a rich platform to explore coupled spin-valley phenomena and offer
novel spin manipulation strategies based on spin relaxation anisotropy in
two-dimensional materials
Cover to Volume 3
The fibroblast mitogen platelet-derived growth factor -BB (PDGF-BB) induces a transient expression of the orphan nuclear receptor NR4A1 (also named Nur77, TR3 or NGFIB). The aim of the present study was to investigate the pathways through which NR4A1 is induced by PDGF-BB and its functional role. We demonstrate that in PDGF-BB stimulated NIH3T3 cells, the MEK1/2 inhibitor CI-1040 strongly represses NR4A1 expression, whereas Erk5 downregulation delays the expression, but does not block it. Moreover, we report that treatment with the NF-κB inhibitor BAY11-7082 suppresses NR4A1 mRNA and protein expression. The majority of NR4A1 in NIH3T3 was found to be localized in the cytoplasm and only a fraction was translocated to the nucleus after continued PDGF-BB treatment. Silencing NR4A1 slightly increased the proliferation rate of NIH3T3 cells; however, it did not affect the chemotactic or survival abilities conferred by PDGF-BB. Moreover, overexpression of NR4A1 promoted anchorage-independent growth of NIH3T3 cells and the glioblastoma cell lines U-105MG and U-251MG. Thus, whereas NR4A1, induced by PDGF-BB, suppresses cell growth on a solid surface, it increases anchorage-independent growth
Ageing memory and glassiness of a driven vortex system
Many systems in nature, glasses, interfaces and fractures being some
examples, cannot equilibrate with their environment, which gives rise to novel
and surprising behaviour such as memory effects, ageing and nonlinear dynamics.
Unlike their equilibrated counterparts, the dynamics of out-of- equilibrium
systems is generally too complex to be captured by simple macroscopic laws.
Here we investigate a system that straddles the boundary between glass and
crystal: a Bragg glass formed by vortices in a superconductor. We find that the
response to an applied force evolves according to a stretched exponential, with
the exponent reflecting the deviation from equilibrium. After the force is
removed, the system ages with time and its subsequent response time scales
linearly with its age (simple ageing), meaning that older systems are slower
than younger ones. We show that simple ageing can occur naturally in the
presence of sufficient quenched disorder. Moreover, the hierarchical
distribution of timescales, arising when chunks of loose vortices cannot move
before trapped ones become dislodged, leads to a stretched-exponential
response.Comment: 16 pages, 5 figure
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