Interactions of the Galactic bar and spiral arm in NGC 3627

Aims: To gain insight into the expected gas dynamics at the interface of the Galactic bar and spiral arms in our own Milky Way galaxy, we examine as an extragalactic counterpart the evidence of multiple distinct velocity components in the cold dense molecular gas that populates a similar region at the end of the bar in the nearby galaxy NGC 3627. Methods: We assembled a high-resolution view of molecular gas kinematics traced by CO(2-1) emission and extracted line-of-sight velocity profiles from regions of high and low gas velocity dispersion. Results: The high velocity dispersions arise with often double-peaked or multiple line-profiles. We compare the centroids of the different velocity components to expectations based on orbital dynamics in the presence of bar and spiral potential perturbations. A model of the region as the interface of two gas-populated orbits families supporting the bar and the independently rotating spiral arms provides an overall good match to the data. An extent of the bar to the corotation radius of the galaxy is favored. Conclusions: Using NGC 3627 as an extragalactic example, we expect situations like this to favor strong star formation events such as are observed in our own Milky Way since gas can pile up where the orbit families cross. The relative motions of the material following these orbits is most likely even more important for the build-up of high density in the region. The surface densities in NGC 3627 are also so high that shear at the bar end is unlikely to significantly weaken the star formation activity. We speculate that scenarios in which the bar and spiral rotate at two different pattern speeds may be the most favorable for intense star formation at such interfaces

Interactions of the Galactic bar and spiral arm in NGC 3627

Aims: To gain insight into the expected gas dynamics at the interface of the Galactic bar and spiral arms in our own Milky Way galaxy, we examine as an extragalactic counterpart the evidence of multiple distinct velocity components in the cold dense molecular gas that populates a similar region at the end of the bar in the nearby galaxy NGC 3627. Methods: We assembled a high-resolution view of molecular gas kinematics traced by CO(2-1) emission and extracted line-of-sight velocity profiles from regions of high and low gas velocity dispersion. Results: The high velocity dispersions arise with often double-peaked or multiple line-profiles. We compare the centroids of the different velocity components to expectations based on orbital dynamics in the presence of bar and spiral potential perturbations. A model of the region as the interface of two gas-populated orbits families supporting the bar and the independently rotating spiral arms provides an overall good match to the data. An extent of the bar to the corotation radius of the galaxy is favored. Conclusions: Using NGC 3627 as an extragalactic example, we expect situations like this to favor strong star formation events such as are observed in our own Milky Way since gas can pile up where the orbit families cross. The relative motions of the material following these orbits is most likely even more important for the build-up of high density in the region. The surface densities in NGC 3627 are also so high that shear at the bar end is unlikely to significantly weaken the star formation activity. We speculate that scenarios in which the bar and spiral rotate at two different pattern speeds may be the most favorable for intense star formation at such interfaces

Setting the scale: Photometric and dynamical properties of high-redshift early-type galaxies

Sterrewacht Leiden - OU

M/L and Color Evolution for A Deep Sample of M* Cluster Galaxies at z~1: The Formation Epoch and the Tilt of the Fundamental Plane

We have measured velocity dispersions for a sample of 36 galaxies with J < 21.2 or Mr < -20.6 mag in MS1054-03, a massive cluster of galaxies at z = 0.83. Our data are of uniformly high quality down to our selection limit, our 16-hour exposures typically yielding errors of only \delta(dispersion)~10% for L* and fainter galaxies. By combining our measurements with data from the literature, we have 53 cluster galaxies with measured dispersions, and HST/ACS-derived sizes, colors and surface brightnesses. This sample is complete for the typical L* galaxy at z~1, unlike most previous z~1 cluster samples which are complete only for the massive cluster members (>1e11 M_sun). We find no evidence for a change in the tilt of the fundamental plane (FP). Nor do we find evidence for evolution in the slope of the color-dispersion relation and M/L_B-dispersion relations; measuring evolution at a fixed dispersion should minimize the impact of size evolution found in other work. The M/L_B at fixed dispersion evolves by \Delta log10 M/L_B=-0.50 +/- 0.03 between z=0.83 and z=0.02 or d(log10 M/L_B)=-0.60 +/- 0.04 dz, and we find \Delta (U-V)_z=-0.24 +/- 0.02 mag at fixed dispersion in the rest-frame, matching the expected evolution in M/L_B within 2.25 standard deviations. The implied formation redshift from both the color and M/L_B evolution is z*=2.0 +/- 0.2 +/- 0.3 (sys), during the epoch in which the cosmic star-formation activity peaked, with the systematic uncertainty showing the dependence of z* on the assumptions we make about the stellar populations. The lack of evolution in either the tilt of the FP or in the M/L- and color-dispersion relations imply that the formation epoch depends weakly on mass, ranging from z*=2.3 +1.3 -0.3 at 300 km/s to z*=1.7 +0.3 -0.2 at 160 km/s and implies that the IMF similarly varies slowly with galaxy mass.Comment: revised; typos corrected, references updated, and other cosmetic changes to meet ApJ format ApJ accepted, 22 pages in emulate ApJ format, 8 color figures, 1 b/w figur

Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s disease

Huntington’s disease, like other neurodegenerative diseases, continues to lack an effective cure. Current treatments that address early symptoms ultimately fail Huntington’s disease patients and their families, with the disease typically being fatal within 10–15 years from onset. Huntington’s disease is an inherited disorder with motor and mental impairment, and is associated with the genetic expansion of a CAG codon repeat encoding a polyglutamine-segment-containing protein called huntingtin. These Huntington’s disease mutations cause misfolding and aggregation of fragments of the mutant huntingtin protein, thereby likely contributing to disease toxicity through a combination of gain-of-toxic-function for the misfolded aggregates and a loss of function from sequestration of huntingtin and other proteins. As with other amyloid diseases, the mutant protein forms non-native fibrillar structures, which in Huntington’s disease are found within patients’ neurons. The intracellular deposits are associated with dysregulation of vital processes, and inter-neuronal transport of aggregates may contribute to disease progression. However, a molecular understanding of these aggregates and their detrimental effects has been frustrated by insufficient structural data on the misfolded protein state. In this review, we examine recent developments in the structural biology of polyglutamine-expanded huntingtin fragments, and especially the contributions enabled by advances in solid-state nuclear magnetic resonance spectroscopy. We summarize and discuss our current structural understanding of the huntingtin deposits and how this information furthers our understanding of the misfolding mechanism and disease toxicity mechanisms

The Dependence of Galaxy Morphology and Structure on Environment and Stellar Mass

From the Sloan Digital Sky Survey (SDSS) Data Release 5 (DR5), we extract a sample of 4594 galaxies at redshifts 0.02<z<0.03, complete down to a stellar mass of M=10^10 Msol. We quantify their structure (Sersic index), morphology (Sersic index + ``Bumpiness''), and local environment. We show that morphology and structure are intrinsically different galaxy properties, and we demonstrate that this is a physically relevant distinction by showing that these properties depend differently on galaxy mass and environment. Structure mainly depends on galaxy mass whereas morphology mainly depends on environment. This is driven by variations in star formation activity, as traced by color, which only weakly affects the structure of a galaxy but strongly affects its morphological appearance. The implication of our results is that the existence of the morphology-density relation is intrinsic and not just due to a combination of more fundamental, underlying relations. Our findings have consequences for high-redshift studies, which often use some measure of structure as a proxy for morphology. A direct comparison with local samples selected through visually classified morphologies may lead to biases in the inferred evolution of the morphological mix of the galaxy population, and misinterpretations in terms of how galaxy evolution depends on mass and environment.Comment: Accepted for publication in ApJ Letters, 5 pages, 5 figures. Minor changes made to match published versio

The Physical Origins of The Morphology-Density Relation: Evidence for Gas Stripping from the SDSS

We provide a physical interpretation and explanation of the morphology-density relation for galaxies, drawing on stellar masses, star formation rates, axis ratios and group halo masses from the Sloan Digital Sky Survey. We first re-cast the classical morphology-density relation in more quantitative terms, using low star formation rate (quiescence) as a proxy for early-type morphology and dark matter halo mass from a group catalog as a proxy for environmental density: for galaxies of a given stellar mass the quiescent fraction is found to increase with increasing dark matter halo mass. Our novel result is that - at a given stellar mass - quiescent galaxies are significantly flatter in dense environments, implying a higher fraction of disk galaxies. Supposing that the denser environments differ simply by a higher incidence of quiescent disk galaxies that are structurally similar to star-forming disk galaxies of similar mass, explains simultaneously and quantitatively these quiescence -nvironment and shape-environment relations. Our findings add considerable weight to the slow removal of gas as the main physical driver of the morphology-density relation, at the expense of other explanations.Comment: published in ApJ: http://adsabs.harvard.edu/abs/2010ApJ...714.1779

Low Star Formation Rates for z=1 Early-Type Galaxies in the Very Deep GOODS-MIPS Imaging: Implications for their Optical/Near-Infrared Spectral Energy Distributions

We measure the obscured star formation in z~1 early-type galaxies. This constrains the influence of star formation on their optical/near-IR colors, which, we found, are redder than predicted by the model by Bruzual & Charlot (2003). From deep ACS imaging we construct a sample of 95 morphologically selected early-type galaxies in the HDF-N and CDF-S with spectroscopic redshifts in the range 0.85<z<1.15. We measure their 24 micron fluxes from the deep GOODS-MIPS imaging and derive the IR luminosities and star formation rates. The fraction of galaxies with >2 sigma detections (~25 muJy} is 17(-4,+9)%. Of the 15 galaxies with significant detections at least six have an AGN. Stacking the MIPS images of the galaxies without significant detections and adding the detected galaxies without AGN we find an upper limit on the mean star formation rate (SFR) of 5.2+/-3.0 Msol yr^-1, and on the mean specific SFR of 4.6+/-2.2 * 10^-11 yr^-1. Under the assumption that the average SFR will decline at the same rate as the cosmic average, the in situ growth in stellar mass of the early-type galaxy population is less than 14+/-7% between z=1 and the present. We show that the typically low IR luminosity and SFR imply that the effect of obscured star formation (or AGN) on their rest-frame optical/near-IR SEDs is negligible for ~90% of the galaxies in our sample. Hence, their optical/near-IR colors are most likely dominated by evolved stellar populations. This implies that the colors predicted by the Bruzual & Charlot (2003) model for stellar populations with ages similar to those of z~1 early-type galaxies (~1-3 Gyr) are most likely too blue, and that stellar masses of evolved, high-redshift galaxies can be overestimated by up to a factor of ~2.Comment: Accepted for publication in ApJ, 8 pages, 4 figures, 1 tabl

Mental Health and Access to Active Labor Market Programs

This paper examines the often-overlooked precondition for successful implementation of active labor market policy, namely equal access to labor market programs. Focusing on a cohort of social assistance recipients, we compare program participation between individuals who were eligible for vocational training and had reported psychological distress, to possible participants with other health or social challenges. The study covers a period of six years. The results indicate that social services prioritize training for those without mental health problems. This is true independently of observed differences between the two groups in terms of demographic and human capital characteristics, work motivation and self-efficacy. Hence, the study concludes that there seems to be a mental health access bias in program participation among disadvantaged groups. Policy makers and future research should address possible organizational barriers to equal program acces

On the use of ultracentrifugal devices for routine sample preparation in biomolecular magic-angle-spinning NMR

A number of recent advances in the field of magic-angle-spinning (MAS) solid-state NMR have enabled its application to a range of biological systems of ever increasing complexity. To retain biological relevance, these samples are increasingly studied in a hydrated state. At the same time, experimental feasibility requires the sample preparation process to attain a high sample concentration within the final MAS rotor. We discuss these considerations, and how they have led to a number of different approaches to MAS NMR sample preparation. We describe our experience of how custom-made (or commercially available) ultracentrifugal devices can facilitate a simple, fast and reliable sample preparation process. A number of groups have since adopted such tools, in some cases to prepare samples for sedimentation-style MAS NMR experiments. Here we argue for a more widespread adoption of their use for routine MAS NMR sample preparation