124 research outputs found
Coherent and Non-Coherent Double Diffractive Production of - pairs in Collisions of Heavy Ions at High Energies
The double coherent and non-coherent diffractive production of heavy quark -
antiquark pairs () in heavy ion scattering at high energies (LHC) is
considered. The total and differential cross sections of these processes with
the formation of and pairs in , and
collisions are evaluated. The contribution of the considered mechanisms is a
few per cent of the number of heavy quark - antiquark pairs obtained in the
processes of hard (QCD) scattering, and it will be taken into account in the
registration of , quarks or, for instance, in the study of the heavy
quarkonia suppression effects in Quark - Gluon Plasma, in the search for
intermediate mass Higgs bosons and so on. It is shown that the cross section of
the coherent scattering process is great enough. This makes it suitable for
studying collective effects in nuclear interactions at high energies. An
example of such effects is given: large values of the invariant mass of a pair, M_{Q \bar{Q}} \gsim 100 GeV, in association with a large
rapidity gap between diffractive jets .Comment: 22 pages, 5(.eps) figures, 3 tables, LaTe
Simulation of Light Antinucleus-Nucleus Interactions
Creations of light anti-nuclei (anti-deuterium, anti-tritium, anti-He3 and
anti-He4) are observed by collaborations at the LHC and RHIC accelerators. Some
cosmic ray experiments are aimed to find the anti-nuclei in cosmic rays. To
support the experimental studies of the anti-nuclei a Monte Carlo simulation of
anti-nuclei interactions with matter is implemented in the Geant4 toolkit. The
implementation combines practically all known theoretical approaches to the
problem of antinucleon-nucleon interactions.Comment: 8 pages, 5 figure
Analysis of hadron production in nucleus-nucleus interactions up to and out of kinematical limit of free NN-collisions in the frame of FRITIOF model
In the framework of the modified FRITIOF model, the inclusive spectra of the
cumulative -, -mesons and protons produced in the
nucleus-nucleus interactions at 4.5 GeV/c/nucleon and 4.2 GeV/c/nucleon are
calculated. It is shown that the model reproduces qualitatively, and in some
cases quantitatively the main experimental regularities of -mesons
production, and "soft" part of the proton spectra. According to the model the
production of the cumulative particles is connected with the mechanism of the
"soft" nucleon-nucleon interaction.Comment: 12 pages, 11 figure
Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets
This document is the Technical Design Report covering the two large
spectrometer magnets of the PANDA detector set-up. It shows the conceptual
design of the magnets and their anticipated performance. It precedes the tender
and procurement of the magnets and, hence, is subject to possible modifications
arising during this process.Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti
Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski,
Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy),
Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy
Feasibility studies of time-like proton electromagnetic form factors at PANDA at FAIR
Simulation results for future measurements of electromagnetic proton form
factors at \PANDA (FAIR) within the PandaRoot software framework are reported.
The statistical precision with which the proton form factors can be determined
is estimated. The signal channel is studied on the basis
of two different but consistent procedures. The suppression of the main
background channel, , is studied.
Furthermore, the background versus signal efficiency, statistical and
systematical uncertainties on the extracted proton form factors are evaluated
using two different procedures. The results are consistent with those of a
previous simulation study using an older, simplified framework. However, a
slightly better precision is achieved in the PandaRoot study in a large range
of momentum transfer, assuming the nominal beam conditions and detector
performance
Feasibility studies of the time-like proton electromagnetic form factor measurements with PANDA at FAIR
The possibility of measuring the proton electromagnetic form factors in the
time-like region at FAIR with the \PANDA detector is discussed. Detailed
simulations on signal efficiency for the annihilation of into a
lepton pair as well as for the most important background channels have been
performed. It is shown that precision measurements of the differential cross
section of the reaction can be obtained in a wide
angular and kinematical range. The individual determination of the moduli of
the electric and magnetic proton form factors will be possible up to a value of
momentum transfer squared of (GeV/c). The total cross section will be measured up to (GeV/c).
The results obtained from simulated events are compared to the existing data.
Sensitivity to the two photons exchange mechanism is also investigated.Comment: 12 pages, 4 tables, 8 figures Revised, added details on simulations,
4 tables, 9 figure
A FRET-Based High Throughput Screening Assay to Identify Inhibitors of Anthrax Protective Antigen Binding to Capillary Morphogenesis Gene 2 Protein
Anti-angiogenic therapies are effective for the treatment of cancer, a variety of ocular diseases, and have potential benefits in cardiovascular disease, arthritis, and psoriasis. We have previously shown that anthrax protective antigen (PA), a non-pathogenic component of anthrax toxin, is an inhibitor of angiogenesis, apparently as a result of interaction with the cell surface receptors capillary morphogenesis gene 2 (CMG2) protein and tumor endothelial marker 8 (TEM8). Hence, molecules that bind the anthrax toxin receptors may be effective to slow or halt pathological vascular growth. Here we describe development and testing of an effective homogeneous steady-state fluorescence resonance energy transfer (FRET) high throughput screening assay designed to identify molecules that inhibit binding of PA to CMG2. Molecules identified in the screen can serve as potential lead compounds for the development of anti-angiogenic and anti-anthrax therapies. The assay to screen for inhibitors of this protein–protein interaction is sensitive and robust, with observed Z' values as high as 0.92. Preliminary screens conducted with a library of known bioactive compounds identified tannic acid and cisplatin as inhibitors of the PA-CMG2 interaction. We have confirmed that tannic acid both binds CMG2 and has anti-endothelial properties. In contrast, cisplatin appears to inhibit PA-CMG2 interaction by binding both PA and CMG2, and observed cisplatin anti-angiogenic effects are not mediated by interaction with CMG2. This work represents the first reported high throughput screening assay targeting CMG2 to identify possible inhibitors of both angiogenesis and anthrax intoxication
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