383 research outputs found

    Lattice WW algebras and quantum groups

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    We represent Feigin's construction [22] of lattice W algebras and give some simple results: lattice Virasoro and W3W_3 algebras. For simplest case g=sl(2)g=sl(2) we introduce whole Uq(sl(2))U_q(sl(2)) quantum group on this lattice. We find simplest two-dimensional module as well as exchange relations and define lattice Virasoro algebra as algebra of invariants of Uq(sl(2))U_q(sl(2)). Another generalization is connected with lattice integrals of motion as the invariants of quantum affine group Uq(n^+)U_q(\hat{n}_{+}). We show that Volkov's scheme leads to the system of difference equations for the function from non-commutative variables.Comment: 13 pages, misprints have been correcte

    Defining the Behavior of IoT Devices through the MUD Standard: Review, Challenges, and Research Directions

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    With the strong development of the Internet of Things (IoT), the definition of IoT devices' intended behavior is key for an effective detection of potential cybersecurity attacks and threats in an increasingly connected environment. In 2019, the Manufacturer Usage Description (MUD) was standardized within the IETF as a data model and architecture for defining, obtaining and deploying MUD files, which describe the network behavioral profiles of IoT devices. While it has attracted a strong interest from academia, industry, and Standards Developing Organizations (SDOs), MUD is not yet widely deployed in real-world scenarios. In this work, we analyze the current research landscape around this standard, and describe some of the main challenges to be considered in the coming years to foster its adoption and deployment. Based on the literature analysis and our own experience in this area, we further describe potential research directions exploiting the MUD standard to encourage the development of secure IoT-enabled scenarios

    Role of SOX family of transcription factors in central nervous system tumors

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    SOX genes are developmental regulators with functions in the instruction of cell fate and maintenance of progenitor’s identity during embryogenesis. They play additional roles during tissue homeostasis and regeneration in adults particularly in the Central Nervous System (CNS). In the last years a growing number of evidences has shown that mutations and dysfunction of SOX factors are implicated in several human diseases, including a variety of cancers. In this review, we will summarize the current knowledge about SOX family in CNS tumors and their role in the origin and maintenance of the subpopulation of cancer stem cells in these tumors

    Photoelectrochemical Behavior of a Molecular Ru-Based Water-Oxidation Catalyst Bound to TiO_2-Protected Si Photoanodes

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    A hybrid photoanode based on a molecular water oxidation precatalyst was prepared from TiO_2-protected n- or p+-Si coated with multiwalled carbon nanotubes (CNT) and the ruthenium-based water oxidation precatalyst [Ru^(IV)(tda)(py-pyr)_2(O)], 1(O) (tda^(2–) is [2,2′:6′,2″-terpyridine]-6,6″-dicarboxylato and py-pir is 4-(pyren-1-yl)-N-(pyridin-4-ylmethyl)butanamide). The Ru complex was immobilized by π–π stacking onto CNTs that had been deposited by drop casting onto Si electrodes coated with 60 nm of amorphous TiO_2 and 20 nm of a layer of sputtered C. At pH = 7 with 3 Sun illumination, the n-Si/TiO_2/C/CNT/[1+1(O)] electrodes exhibited current densities of 1 mA cm^(–2) at 1.07 V vs NHE. The current density was maintained for >200 min at a constant potential while intermittently collecting voltammograms that indicated that over half of the Ru was still in molecular form after O_2 evolution

    Sox9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin

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    The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance and commonly overexpressed in solid cancers including colorectal cancer. In this study, we show that SOX9 levels are higher in metastatic (SW620) than in primary colorectal cancer cells (SW480) derived from the same patient. This elevated expression correlated with enhanced self-renewal activity. By gain and loss-of-function studies in SW480 and SW620 cells respectively, we reveal that SOX9 levels modulate tumorsphere formation and self-renewal ability in vitro and tumor initiation in vivo. Moreover, SOX9 regulates migration and invasion and triggers the transition between epithelial and mesenchymal states. These activities are partially dependent on SOX9 post-transcriptional modifications. Importantly, treatment with rapamycin inhibits self-renewal and tumor growth in a SOX9- dependent manner. These results identify a functional role for SOX9 in regulating colorectal cancer cell plasticity and metastasis, and provide a strong rationale for a rapamycin-based therapeutic strategy.published_or_final_versio

    Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production.

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    Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38α to neuroinflammation, neuronal death and synaptic dysfunction. To explore the specific role of neuronal p38α signalling in the appearance of pathological symptoms, we have generated mice that combine expression of the 5XFAD transgenes to induce AD symptoms with the downregulation of p38α only in neurons (5XFAD/p38α∆-N). We found that the neuronal-specific deletion of p38α improves the memory loss and long-term potentiation impairment induced by 5XFAD transgenes. Furthermore, 5XFAD/p38α∆-N mice display reduced amyloid-β accumulation, improved neurogenesis, and important changes in brain cytokine expression compared with 5XFAD mice. Our results implicate neuronal p38α signalling in the synaptic plasticity dysfunction and memory impairment observed in 5XFAD mice, by regulating both amyloid-β deposition in the brain and the relay of this accumulation to mount an inflammatory response, which leads to the cognitive deficits.post-print1848 K
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