SOX genes are developmental regulators with functions in the instruction of cell fate and maintenance of
progenitor’s identity during embryogenesis. They play additional roles during tissue homeostasis and regeneration
in adults particularly in the Central Nervous System (CNS). In the last years a growing number of evidences has
shown that mutations and dysfunction of SOX factors are implicated in several human diseases, including a variety
of cancers. In this review, we will summarize the current knowledge about SOX family in CNS tumors and their role
in the origin and maintenance of the subpopulation of cancer stem cells in these tumors
