Análisis del clima urbano a partir de imágenes de satélite en el centro peninsular español

In this paper, urban thermic island of some cities of central Spain (Madrid, Segovia, Ávila, Guadalajara and Toledo), with very different natural and social characteristics, has been analyzed. Field-city thermic contrasts have been drawn out through NOAA and Landsat images, as well as weather stations data. Diurnal temperatures are often lower inside the cities than on not urbanised areas of their surroundings. This urban thermical anomaly seems to be related to the different heating-cooling rate of the land cover, so «urban heat island» is only apparent by night, while, inversely, during day time these cities show an «urban cool island» in relation to their neighbouring areas. In this way, cities work as heat accumulators during day time and releasing the stored energy during night.Este trabajo analiza la isla térmica urbana de ciudades del centro de España (Madrid, Segovia, Ávila, Guadalajara y Toledo), con características físicas y humanas muy dispares. El contraste térmico campo-ciudad se analiza a partir de la información aportada por los satélites NOAA y Landsat y por las estaciones meteorológicas. Las temperaturas diurnas resultan con frecuencia más bajas en el interior de las ciudades que en las áreas no urbanizadas de su entorno. Esta anomalía térmica urbana diurna parece responder al distinto ritmo de caldeamiento-enfriamiento de los materiales, de modo que la «isla de calor urbana» sólo se manifiesta por la noche, mientras que durante el día las ciudades estudiadas muestran una «isla de frío» respecto a su entorno. Así, las ciudades estarían funcionando como acumuladores térmicos durante el día, y liberando la energía almacenada en todo el entramado urbano por la noche

Investigación y nuevas tecnologías en la educación artística.

Sin resume

Discriminación visual y digital de suelos de baja calidad agrícola a partir de imágenes Landsat

This study is based on multitemporal Landsat's images in order to identify low agricultural quality soils in Castilla-La Mancha Autonomous Community. This low class, within soil quality indices, includes, among others, saline soils and floodable areas. These soils can be discriminated through TM and ETM satellite images, with field-work and laboratory support. For saline soils identification, different physical and chemical properties of surface samples have been analysed, correlating these data with Normalised Difference Vegetation Index (NDVi). This Index, used for different dates, has been quite useful in order to discriminate halophytic vegetation, despite recording lesser digital values than in cultivated land, mainly irrigated areas.Este estudio se basa en el análisis de imágenes Landsat multitemporales con el objetivo de identificar suelos con baja calidad agrícola en la Comunidad Autónoma de Castilla-La Mancha. Esta categoría, dentro de los índices de calidad de suelo, incluye, entre otros, los suelos salinos y áreas con elevado riesgo de inundación. Todos ellos pueden discriminarse mediante imágenes TM y ETM, si bien es preciso el apoyo de trabajo de campo y laboratorio. Para la identificación de los suelos salinos se han analizado diferentes propiedades fisicas y químicas de nuestras superficiales y se han correlacionado estos datos con el Índice de Vegetación de Diferencia Normalizada (NDVI). Este Índice, escogido para fechas concretas, ha resultado de gran utilidad para detectar vegetación halófita, pese a mostrar valores digitales mucho menores a los suelos cultivados, principalmente los regadíos

Retention of three fissure sealants and a dentin bonding system used as fissure sealant in caries prevention: 12-month follow-up results

Background. Bonding agents could be used as fissure sealants. This study compares the retention three fissure sealants (Delton®, Delton Plus® and Concise®) and a filled dentin bonding system (Optibond Solo®). Methods. Fifty-six children aged 7-8 years received fissure sealants either in the four permanent first molars, in the four deciduous second molars, or in all eight of these teeth. Every child received a different sealing material in each quadrant on a random basis. Clinical evaluation at 12 months was performed by a single blind examiner, and the retention was classified as either a success (total retention) or a failure (partial retention or not present). Results: There were no statistically significant differences among the four materials in permanent maxillary molars or deciduous molars. In permanent mandibular molars, Optibond Solo® showed a lower percentage of retention (40.9%), significantly different (p=0.002) to that of Delton® (89.5%), Delton Plus® (87.5%) and Concise® (76.5%). Conclusion: One bottle dentin bonding system used as a sealant does not improve the retention of conventional fissure sealants. Clinical Implication: Because of the scarcity of studies on the use of dental adhesives as sealants, further studies are warranted for the final support of that conclusion

Approaches to the Synthesis of 2,3-Dihaloanilines. Useful Precursors of 4-Functionalized-1H-indoles§

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.Ministerio de Ciencia e Innovacion (MICINN) and FEDER (CTQ2010-15358) and Junta de Castilla y Leon (BU021A09 and GR-172) for financial support. V.G. thanks Ministerio de Educacion y Ciencia for a MEC-FPU predoctoral fellowship. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contracts.This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of organic chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher

Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer

Cetuximab; Metastatic colorectal cancer; KIR genesCetuximab; Càncer colorectal amb metàstasi; Gens KIRCetuximab; Cáncer colorrectal con metástasis; Genes KIRCetuximab is a standard-of-care treatment for RAS wild-type metastatic colorectal cancer (mCRC) but not for those harbor a KRAS mutation since MAPK pathway is constitutively activated. Nevertheless, cetuximab also exerts its effect by its immunomodulatory activity despite the presence of RAS mutation. The aim of this study was to determine the impact of polymorphism FcγRIIIa V158F and killer immunoglobulin-like receptor (KIR) genes on the outcome of mCRC patients with KRAS mutations treated with cetuximab. This multicenter Phase II clinical trial included 70 mCRC patients with KRAS mutated. We found KIR2DS4 gene was significantly associated with OS (HR 2.27; 95% CI, 1.08-4.77; P = 0.03). In non-functional receptor homozygotes the median OS was 2.6 months longer than in carriers of one copy of full receptor. Multivariate analysis confirmed KIR2DS4 as a favorable prognostic marker for OS (HR 6.71) in mCRC patients with KRAS mutation treated with cetuximab. These data support the potential therapeutic of cetuximab in KRAS mutated mCRC carrying non-functional receptor KIR2DS4 since these patients significantly prolong their OS even after heavily treatment. KIR2DS4 typing could be used as predictive marker for identifying RAS mutated patients that could benefit from combination approaches of anti-EGFR monoclonal antibodies and other immunotherapies to overcome the resistance mediated by mutation in RAS

Assessment of techno-functional and sensory attributes of tiger nut fresh egg tagliatelle

[EN] This work aims to evaluate the effect of tiger nut flour -TNF- (rich in insoluble fiber, minerals and lipids of healthy fatty acid profile) incorporation on the techno-functional and sensory attributes of durum wheat fresh egg tagliatelle. Durum wheat semolina was replaced by 10, 20 and 30% (w/w) of TNF and the resultant tiger nut tagliatelles were compared to traditional pasta (100% durum semolina). The maximum substitution level was chosen in order to obtain tagliatelle with fair techno-functional properties and acceptable sensory quality. In addition, the 30% substitution level assures a product with more than 3% of fiber content. The cooking properties, texture, colour attributes, sensory profile and water uptake kinetics of tagliatelle were evaluated. The proximate chemical composition and particle size distribution of raw materials was assessed as well. The higher cooking loss, water absorption ratios and swelling indexes associated with higher substitution levels of TNF resulted in a darker and stickier product, with a lower firmness, hardness and cohesive structure. The overall acceptability of tiger nut pasta depends more on visual and textural characteristics than on taste. No significant changes on the initial water absorption rate during cooking were observed between the control and tiger nut pasta. (C) 2016 Elsevier Ltd. All rights reserved.Authors would like to thank the Conselleria de Empresa, Universidad y Ciencia (Spain) for financial support throughout the project AICO/2016/056. Also, authors express sincere thanks to Harinas Villamayor S.A., Tigernuts Traders, S.L. and Avicola Llombai S.A. for providing raw materials for conducting this study.Albors, A.; Raigón Jiménez, MD.; García-Martínez, MD.; Martín-Esparza, M. (2016). Assessment of techno-functional and sensory attributes of tiger nut fresh egg tagliatelle. LWT - Food Science and Technology. 74:183-190. doi:10.1016/j.lwt.2016.07.047S1831907

Homocistinuria y Acidemia Metilmalónica (CbIC) de evolución fatal en un recién nacido

La forma CblC de la Acidemia Metilmalónica (AMMC CbIC) es un error congénito del metabolismo intracelular de la cobalamina. Los síntomas clínicos consisten en descompensación neurológica y síntomas sistémicos. Describimos la evolución clínica y bioquímica en una paciente con inicio neonatal del defecto CblC. Recién nacido a termino, mujer, con peso al nacer de 2290 g. A los pocos día de vida presentó hipotonía, hipoactividad y succión dificultosa. Alos 13 días de vida se ingresó en UCIN presentando letargia, hipotonía, hipotermia y signos de afectación neurológica de tronco encefálico, además hiperlactacidemia y alteraciones del recuento celular. La RNM junto con los síntomas clínicos nos surgirieron una patología mitocondrial. Los ácidos orgánicos mostraron un importante aumento del ácido metilmalónico con homocistinemia y homocistinuria, sospechándose un defecto del metabolismo de la cobalamina que se comprobó in vitro. En el estudio mutacional se confirmó el diagnostico de AMM CbIC. A pesar de una buena respuesta bioquímica al tratamiento con cobalamina la paciente mantuvo un deterioro neurológico progresivo con éxitus a los 2 meses de vida. Se concluye que la AMMC, variante CblC, se puede presentar con retraso en el desarollo, lactacidemia y alteración en los parámetros hematológicos. A pesar de la normalización de los parámetros bioquímicos presentó una progresión de la enfermedad que la condujo al éxitus. Se especula la posibilidad de que existan otros factores fisiopatológicos que influyen en una mala evolución.The CblC form of methylmalonic acidemia with homocistinuria (MMA CblC) is a rare condition which results from impaired biosynthesis of methylcobalamin and adenosylcobalamin. The clinical phenotype implies neurological decompensation and systemic symptoms. We describe the clinical course and biochemical evolution of a girl with neonatal onset of the CblC variant. The female patient was delivered at term and weighed 2290 gr. The mother noticed hypotonia, hypoactivity and lack of sucking from very early on. At the 13 th day of life the patient was admitted to our hospital at the NICU. Lethargy, hypotonia, hipothermia, central ataxic breathing were the main symptoms. Initial blood profile pointed moderate hyperlactacidemia and alterations of blood cell count. RMN and the clinical profile suggested a mitochondrial disease. The metabolic profile, showed methylmalonic aciduria, with homocystinemia and homocystinuria suggesting a intracellular defect of cobalamin metabolism. The diagnosis of a MMA CbIC variant was confirmed by the propionate test in vitro and the genetic study. After treatment with cobalamin, levels of methylmalonic acid and homocysteine normalized, but the patient suffered progressive neurological deterioration with secondary multiorgan failure and death at two months of age. We conclude that Methylmalonic Aciduria with combined homocystinuria, CblC variant, may present with developmental delay, minor dysmorphology, moderate hyperlactacidemia and alteration of hematologic parameters. In spite of a normalization of biochemical parameters the disease led to a fatal outcome. We therefore think that in presence of a dysfunction of intracellular cobalamin, other physiological alterations leading to a fatal evolution might be possible

Microwave-assisted solution synthesis, microwave sintering and magnetic properties of cobalt ferrite

[EN] A simple, soft, and fast microwave-assisted hydrothermal method was used for the preparation of nanocrystalline cobalt ferrite powders from commercially-available Fe(NO3)(3)center dot 9H(2)O, Co(NO3)(2)center dot 6H(2)O, ammonium hydroxide, and tetrapropylammonium hydroxide (TPAH). The synthesis was conducted in a sealed-vessel microwave reactor specifically designed for synthetic applications, and the resulting products were characterized by XRD, FE-SEM, TEM, and HR-TEM. After a systematic study of the influence of the microwave variables (temperature, reaction time and nature of the bases), highly crystalline CoFe2O4 nanoparticles with a high uniformity in morphology and size, were directly obtained by heating at 130 degrees C for 20 min using the base TPAH. Dense ceramics of cobalt ferrite were prepared by non-conventional, microwave sintering of synthesized nanopowders at temperatures of 850-900 degrees C. The magnetic properties of both the nanopowders and the sintered specimens were determined in order to establish their feasibility as a permanent magnet.This work has been carried out with financial support from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and CSIC through the Projects MAT2015-67586-C3-R and NANOMIND, respectively. A. Borrell acknowledges MINECO for a Juan de la Cierva contract (IJCI-2014-19839).Fariñas, JC.; Moreno, R.; Pérez, A.; García, MA.; García-Hernández, M.; Salvador Moya, MD.; Borrell Tomás, MA. (2018). Microwave-assisted solution synthesis, microwave sintering and magnetic properties of cobalt ferrite. Journal of the European Ceramic Society. 38(5):2360-2368. https://doi.org/10.1016/j.jeurceramsoc.2017.12.052S2360236838