The Megamaser Cosmology Project. VII. Investigating disk physics using spectral monitoring observations

We use single-dish radio spectra of known 22 GHz H$_2$O megamasers, primarily gathered from the large dataset observed by the Megamaser Cosmology Project, to identify Keplerian accretion disks and to investigate several aspects of the disk physics. We test a mechanism for maser excitation proposed by Maoz & McKee (1998), whereby population inversion arises in gas behind spiral shocks traveling through the disk. Though the flux of redshifted features is larger on average than that of blueshifted features, in support of the model, the high-velocity features show none of the predicted systematic velocity drifts. We find rapid intra-day variability in the maser spectrum of ESO 558-G009 that is likely the result of interstellar scintillation, for which we favor a nearby ($D \approx 70$ pc) scattering screen. In a search for reverberation in six well-sampled sources, we find that any radially-propagating signal must be contributing $\lesssim$10% of the total variability. We also set limits on the magnetic field strengths in seven sources, using strong flaring events to check for the presence of Zeeman splitting. These limits are typically 200--300 mG ($1\sigma$), but our most stringent limits reach down to 73 mG for the galaxy NGC 1194.Comment: Accepted for publication in Ap

Radio continuum of galaxies with H2_{2}O megamaser disks: 33 GHz VLA data

We investigate the nuclear environment of galaxies with observed 22 GHz water megamaser in their subparsec edge-on accretion disks, using 33 GHz (9mm) radio continuum data from VLA, with a resolution of ~ 0.2-0.5 arcsecs, and relate the maser and host galaxy properties to those of its radio continuum emission. Eighty-seven percent (21 out of 24) galaxies in our sample show 33 GHz radio continuum emission at levels of 4.5-240 $\sigma$. Five sources show extended emission, including one source with two main components and one with three main components. The remaining detected 16 sources exhibit compact cores within the sensitivity limits. Little evidence is found for extended jets (>300 pc) in most sources. Either they do not exist, or our chosen frequency of 33 GHz is too high for a detection of these supposedly steep spectrum features. In only one source among those with known maser disk orientation, NGC4388, we found an extended jet-like feature that appears to be oriented perpendicular to the water megamaser disk. Smaller 100-300 pc sized jets might also be present, as is suggested by the beam-deconvolved morphology of our sources. Whenever possible, central positions with accuracies of 20-280 mas are provided. A correlation analysis shows that the 33 GHz luminosity weakly correlates with the infrared luminosity. The 33 GHz luminosity is anticorrelated with the circular velocity of the galaxy. The black hole masses show stronger correlations with water maser luminosity than with 1.4 GHz, 33 GHz, or hard X-ray luminosities. Furthermore, the inner radii of the disks show stronger correlations with 1.4 GHz, 33 GHz, and hard X-ray luminosities than their outer radii, suggesting that the outer radii may be affected by disk warping, star formation, or peculiar density distributions.Comment: 18 pages, 10 figures, Accepted for publication in A&

The lean oxidation of iso-octane at elevated pressures

Both spark-ignition and compression-ignition engines burn large molecular-weight blended fuels, a class to which the primary reference fuels (PRF), n-heptane and iso-octane belong. In this study experiments were performed using iso-octane in a high pressure flow reactor at a temperature of 925 K, at 3, 6 and 9 atm pressure and with a fuel/air equivalence ratio of approximately 0.05. Many hydrocarbon and oxygenated hydrocarbon intermediates were identified and quantified as a function of time. These experimental results provide a strin- gent test of the low temperature chemistry portion of a kinetic model as they emphasise the importance of alkyl radical addition to molecular oxygen and internal H-atom isomerization reactions relative to alkyl radical decomposition reactions. A detailed chemical kinetic mechanism is used to simulate these experiments. We provide comparisons of model predictions with experimentally measured species profiles and describe how each species is formed as predicted by the detailed model

School-Based Prevention Of Depressive Symptoms: A Randomized Controlled Study Of The Effectiveness And Specificity Of The Penn Resiliency Program

The authors investigated the effectiveness and specificity of the Penn Resiliency Program (PRP; J. E. Gillham, L. H. Jaycox, K. J. Reivich, M. E. P. Seligman, & T. Silver, 1990), a cognitive-behavioral depression prevention program. Children (N = 697) from 3 middle schools were randomly assigned to PRP, Control (CON), or the Penn Enhancement Program (PEP; K. J. Reivich, 1996; A. J. Shatté, 1997), an alternate intervention that controls for nonspecific intervention ingredients. Children\u27s depressive symptoms were assessed through 3 years of follow-up. There was no intervention effect on average levels of depressive symptoms in the full sample. Findings varied by school. In 2 schools, PRP significantly reduced depressive symptoms across the follow-up relative to both CON and PEP. In the 3rd school, PRP did not prevent depressive symptoms. The authors discuss the findings in relation to previous research on PRP and the dissemination of prevention programs. (PsycINFO Database Record (c) 2013 APA, all rights reserved)(journal abstract

Enhancing students’ motivation to learn software engineering programming techniques: a collaborative and social interaction approach

To motivate students to study advanced programming techniques, including the use of architectural styles such as the model–view–controller pattern, we have con-ducted action research upon a project based-learning approach. In addition to collabo-ration, the approach includes students’ searching and analysis of scientific documents and their involvement in communities of practice outside academia. In this paper, we report the findings of second action research cycle, which took place throughout the fourth semester of a six-semester program. As with the previous cycle during the pre-vious academic year, students did not satisfactorily achieve expected learning out-comes. More groups completed the assigned activities, but results continue to reflect poor engagement in the communities of practice and very low performance in other learning tasks. From the collected data we have identified new approaches and recom-mendations for subsequent research.Fundação para a Ciência e Tecnologia (FCT), Portugal, for Ph.D. Grants SFRH/BD/91309/2012 and SFRH/BD/87815/201

A Peptidoglycan Fragment Triggers β-lactam Resistance in Bacillus licheniformis

To resist to β-lactam antibiotics Eubacteria either constitutively synthesize a β-lactamase or a low affinity penicillin-binding protein target, or induce its synthesis in response to the presence of antibiotic outside the cell. In Bacillus licheniformis and Staphylococcus aureus, a membrane-bound penicillin receptor (BlaR/MecR) detects the presence of β-lactam and launches a cytoplasmic signal leading to the inactivation of BlaI/MecI repressor, and the synthesis of a β-lactamase or a low affinity target. We identified a dipeptide, resulting from the peptidoglycan turnover and present in bacterial cytoplasm, which is able to directly bind to the BlaI/MecI repressor and to destabilize the BlaI/MecI-DNA complex. We propose a general model, in which the acylation of BlaR/MecR receptor and the cellular stress induced by the antibiotic, are both necessary to generate a cell wall-derived coactivator responsible for the expression of an inducible β-lactam-resistance factor. The new model proposed confirms and emphasizes the role of peptidoglycan degradation fragments in bacterial cell regulation

Shape coexistence in Hg-178

Lifetime measurements of excited states in Hg-178 have been performed using the Rh-103(Kr-78, p2n) reaction at a beam energy of 354 MeV. The recoil-decay tagging (RDT) technique was applied to select the Hg-178 nuclei and associate the prompt gamma rays with the correlated characteristic ground-state alpha decay. Lifetimes of the four lowest yrast states of Hg-178 have been determined using the recoil distance Doppler-shift (RDDS) method. The experimental data are compared to theoretical predictions with focus on shape coexistence. The results confirm the shift of the deformed prolate structures to higher lying states but also indicate their increasing deformation with decreasing neutron number.Peer reviewe

Lifetime measurements in the transitional nucleus Gd-138

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Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

<p>Abstract</p> <p>Background</p> <p>We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4⁺CD25^HIFoxp3⁺regulatory T cells and expanded melanoma-specific CD8⁺T cells. The goal of this study was to assess the clinical efficacy of DAB/IL2 in an expanded cohort of stage IV melanoma patients.</p> <p>Methods</p> <p>In a single-center, phase II trial, DAB/IL2 (12 μg/kg; 4 daily doses; 21 day cycles) was administered to 60 unresectable stage IV melanoma patients and response rates were assessed using a combination of 2-[¹⁸F]-fluoro-2-deoxy-glucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging.</p> <p>Results</p> <p>After DAB/IL2 administration, 16.7% of the 60 patients had partial responses, 5% stable disease and 15% mixed responses. Importantly, 45.5% of the chemo/immuno-naïve sub-population (11/60 patients) experienced partial responses. One year survival was markedly higher in partial responders (80 ± 11.9%) relative to patients with progressive disease (23.7 ± 6.5%; <it>p </it>value < 0.001) and 40 ± 6.2% of the total DAB/IL2-treated population were alive at 1 year.</p> <p>Conclusions</p> <p>These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma.</p> <p>Trial registration</p> <p><a href="http://www.clinicaltrials.gov/ct2/show/NCT00299689">NCT00299689</a></p