Greater Eccentric Exercise-induced Muscle Damage By Large Versus Small Range Of Motion With The Same End-point

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Several factors can affect the magnitude of eccentric exercise (ECC)-induced muscle damage, but little is known regarding the effect of the range of motion (ROM) in ECC-induced muscle damage. The purpose of this study was to investigate whether elbow flexor ECC with 120 degrees of ROM (from 60 degrees of elbow flexion until elbow full extension - 180 degrees [120ROM]) induces a greater magnitude of muscle damage compared with a protocol with 60 degrees of ROM (120-180 degrees of elbow flexion [60ROM]). Twelve healthy young men (age: 22 +/- 3.1 years; height: 1.75 +/- 0.05 m; body mass: 75.6 +/- 13.6 kg) performed the ECC with 120ROM and 60ROM using different arms in a random order separated by 2 weeks and were tested before and 24, 48, 72 and 96 h after ECC for maximal voluntary isometric contraction torque (MVC-ISO), ROM and muscle soreness. The 120ROM protocol showed greater changes and effect sizes (ES) for MVC-ISO (-35%, ES: 1.97), ROM (-11.5 degrees, ES: 1.27) and muscle soreness (19 mm, ES: 1.18) compared with the 60ROM protocol (-23%, ES: 0.93; -12%, ES: 0.56; 17 degrees, ES: 0.63; 8 mm, ES: 1.07, respectively). In conclusion, ECC of the elbow flexors with 120 degrees of ROM promotes a greater magnitude of muscle damage compared with a protocol with 60 degrees of ROM, even when both protocols are performed at long muscle lengths.333285289Sao Paulo Research Foundation (FAPESP) [2013/21218-4, 2012/24499-1, 2014/19594-0, 2011/22122-5]National Council for Scientific and Technological Development (CNPq) grantFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Prediction of positron emitter distributions for range monitoring in carbon ion therapy: an analytical approach

Range verification is one of the most relevant tasks in ion beam therapy. In the case of carbon ion therapy, positron emission tomography (PET) is the most widely used method for this purpose, which images the -activation following nuclear interactions of the ions with the tissue nuclei. Since the positron emitter activity profile is not directly proportional to the dose distribution, until today only its comparison to a prediction of the PET profile allows for treatment verification. Usually, this prediction is obtained from time-consuming Monte Carlo simulations of high computational effort, which impacts the clinical workflow. To solve this issue in proton therapy, a convolution approach was suggested to predict positron emitter activity profiles from depth dose distributions analytically. In this work, we introduce an approach to predict positron emitter distributions from depth dose profiles in carbon ion therapy. While the distal fall-off position of the positron emitter profile is predicted from a convolution approach similar to the one suggested for protons, additional analytical functions are introduced to describe the characteristics of the positron emitter distribution in tissue. The feasibility of this approach is demonstrated with monoenergetic depth dose profiles and spread out Bragg peaks in homogeneous and heterogeneous phantoms. In all cases, the positron emitter profile is predicted with high precision and the distal fall-off position is reproduced with millimeter accuracy

Diastereoselective additions of organometallic reagents to (SFc)-2-p-tolylsulfanylferrocene carboxyaldehyde and to (SFc)-2-p-tolylsulfanyl ferrocenyl imines. Synthesis of new central and planar chiral ferrocenyl alcohols and amines

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Investigation of Squaramide Catalysts in the Aldol Reaction En Route to Funapide

Funapide is a 3,3’-spirocyclic oxindole with promising analgesic activity. A reported pilot-plant scale synthesis of this chiral compound involves an asymmetric aldol reaction, catalyzed by a common bifunctional thiourea structure. In this work, we show that the swapping of the thiourea unit of the catalyst for a tailored squaramide group provides an equally active, but rewardingly more selective, catalyst for this aldol reaction (from 70.5 to 85 % ee). The reaction was studied first on a model oxindole compound. Then, the set of optimal conditions was applied to the target funapide intermediate. The applicability of these conditions seems limited to oxindoles bearing the 3-substituent of funapide. Exemplifying the characteristics of target-focused methodological development, this study highlights how a wide-range screening of catalysts and reaction conditions can provide non-negligible improvements in an industrially viable asymmetric transformation

The AU free movement protocol: Challenges in its implementation

One of the major pillars of the African Union is the integration of peoples and the ability for them to move freely from one member country to another, with the right to reside and practise their trade or profession. This aspect of integration found full expression in the Protocol to the Treaty Establishing the African Economic Community Relating to the Free Movement of Persons, Right of Residence andRight of Establishment, adopted in 2018. Upon operationalization, it will remove obstacles to the movement of people, capital and resources in the region and give expression to aspiration 2 of the African Union Agenda 2063. However, significant challenges lie on the path of its implementation. This article doctrinally reviews the protocol, looking at its prospects for promoting African integration and development, anticipates some of the problems that the protocol will face. It concludes with recommendations for achieving its lofty but desirable ends

Orthogonalities and functional equations

In this survey we show how various notions of orthogonality appear in the theory of functional equations. After introducing some orthogonality relations, we give examples of functional equations postulated for orthogonal vectors only. We show their solutions as well as some applications. Then we discuss the problem of stability of some of them considering various aspects of the problem. In the sequel, we mention the orthogonality equation and the problem of preserving orthogonality. Last, but not least, in addition to presenting results, we state some open problems concerning these topics. Taking into account the big amount of results concerning functional equations postulated for orthogonal vectors which have appeared in the literature during the last decades, we restrict ourselves to the most classical equations

Mathematics, capitalism and biosocial research

In my previous work, I criticised studies within the sociopolitical turn for disavowing a comprehension of schools as places of capitalist production. Here, I extend this critique to what is being flagged as a new turn in educational research. I am referring to biosocial research, particularly in the way it is coupled with new materialist and more than human philosophies in the work of Elizabeth de Freitas. I use elements from Marxian theory and Lacanian psychoanalysis to explore the concomitances between mathematics and capitalism, showing how both mathematics and capital need to suture the subject in order to thrive. Biosocial research epitomises this drive towards automation and totality, and, notwithstanding de Freitas’ attempts to rescue it from the logic of control, I will argue that agent-centred intentions dismiss the underlying workings of capital as a real abstraction. I do so by engaging with elements of Deleuze’s philosophy, showing how the more than human frame in which de Freitas’ biosocial research rests contradicts her own perception of how biosocial research can be rescued for inclusive purposes