Near-Infrared Imaging Polarimetry of Young Stellar Objects in rho-Ophiuchi

The results of a near-infrared (J H K LP) imaging linear polarimetry survey of 20 young stellar objects (YSOs) in rho Ophiuchi are presented. The majority of the sources are unresolved, with K-band polarizations, P_K < 6 per cent. Several objects are associated with extended reflection nebulae. These objects have centrosymmetric vector patterns with polarization discs over their cores; maximum polarizations of P_K > 20 per cent are seen over their envelopes. Correlations are observed between the degree of core polarization and the evolutionary status inferred from the spectral energy distribution. K-band core polarizations >6 per cent are only observed in Class I YSOs. A 3D Monte Carlo model with oblate grains aligned with a magnetic field is used to investigate the flux distributions and polarization structures of three of the rho Oph YSOs with extended nebulae. A rho proportional to r^(-1.5) power law for the density is applied throughout the envelopes. The large-scale centrosymmetric polarization structures are due to scattering. However, the polarization structure in the bright core of the nebula appears to require dichroic extinction by aligned non-spherical dust grains. The position angle indicates a toroidal magnetic field in the inner part of the envelope. Since the measured polarizations attributed to dichroic extinction are usually <10 per cent, the grains must either be nearly spherical or very weakly aligned. The higher polarizations observed in the outer parts of the reflection nebulae require that the dust grains responsible for scattering have maximum grain sizes <=1.05 microns.Comment: 26 pages. Accepted by MNRAS. Available as online early versio

Near Infrared polarimetry of a sample of YSOs

Our goal is to study the physical properties of the circumstellar environment of young stellar objetcs (YSOs). In particular, the determination of the scattering mechanism can help to constrain the optical depth of the disk and/or envelope in the near infrared. We used the IAGPOL imaging polarimeter along with the CamIV infrared camera at the LNA observatory to obtain near infrared polarimetry measurements at the H band of a sample of optically visible YSOs, namely, eleven T Tauri stars and eight Herbig Ae/Be stars. An independent determination of the disk (or jet) orientation was obtained for twelve objects from the literature. The circumstellar optical depth could be then estimated comparing the integrated polarization position angle (PA) with the direction of the major axis of the disk projected in the plane of the sky. In general, optically thin disks have polarization PA perpendicular to the disk plane. In contrast, optically thick disks produce polarization PA parallel to the disks. Among the T Tauri stars, three are consistent with optically thin disks (AS 353A, RY Tau and UY Aur) and five with optically thick disks (V536 Aql, DG Tau, DO Tau, HL Tau and LkHalpha 358). Among the Herbig Ae/Be stars, two stars show evidence of optically thin disk (Hen 3-1191 and VV Ser) and two of optically thick disks (PDS 453 and MWC 297). Our results seem consistent with the fact that optically thick disks at near infrared bands are associated more likely with younger YSOs. Marginal evidence of polarization reversal is found in RY Tau, RY Ori, WW Vul, and UY Aur. On the first three cases this feature can be associated to the UXOR phenomenon. Correlations with the IRAS colours and the spectral index yielded evidence of an evolutionary segregation with the disks tend to be optically thin when they are older.Comment: 15 pages, 15 figures, accepted in Astronomy and Astrophysic

High resolution imaging polarimetry of HL Tau and magnetic field structure

We present high quality near infrared imaging polarimetry of HL Tau at 0.4 to 0.6 arcsec resolution, obtained with Subaru/CIAO and UKIRT/IRCAM. 3-D Monte Carlo modelling with aligned oblate grains is used to probe the structure of the circumstellar envelope and the magnetic field, as well as the dust properties. At J band the source shows a centrosymmetric pattern dominated by scattered light. In the H and K bands the central source becomes visible and its polarisation appears to be dominated by dichroic extinction, with a position angle inclined by ~40 degrees to the disc axis. The polarisation pattern of the environs on scales up to 200 AU is consistent with the same dichroic extinction signature superimposed on the centrosymmetric scattering pattern. These data can be modelled with a magnetic field which is twisted on scales from tens to hundreds of AU, or alternatively by a field which is globally misaligned with the disc axis. A unique solution to the field structure will require spatially resolved circular polarisation data. The best fit Monte Carlo model indicates a shallow near infrared extinction law. When combined with the observed high polarisation and non-negligible albedo these constraints can be fitted with a grain model involving dirty water ice mantles in which the largest particles have radii slightly in excess of 1 um. The best fit model has an envelope structure which is slightly flattened on scales up to several hundred AU. Both lobes of the bipolar outflow cavity contain a substantial optical depth of dust (not just within the cavity walls). Curved, approximately parabolic, cavity walls fit the data better than a conical cavity. The small inner accretion disc observed at millimetre wavelengths is not seen at this spatial resolution.Comment: Accepted by MNRAS, 21 pages, 10 figure

The new enclosures: critical perspectives on corporate land deals

The contributions to this collection use the tools of agrarian political economy to explore the rapid growth and complex dynamics of large-scale land deals in recent years, with a special focus on the implications of big land deals for property and labour regimes, labour processes and structures of accumulation. The first part of this introductory essay examines the implications of this agrarian political economy perspective. First we explore the continuities and contrasts between historical and contemporary land grabs, before examining the core underlying debate around large- versus small-scale farming futures. Next, we unpack the diverse contexts and causes of land grabbing today, highlighting six overlapping mechanisms. The following section turns to assessing the crisis narratives that frame the justifications for land deals, and the flaws in the argument around there being excess, empty or idle land available. Next the paper turns to an examination of the impacts of land deals, and the processes of inclusion and exclusion at play, before looking at patterns of resistance and constructions of alternatives. The final section introduces the papers in the collection.ESR

Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

Clostridioides (formerly Clostridium) difficile is a leading cause of healthcare-associated infections. Although considerable progress has been made in the understanding of its genome, the epigenome of C. difficile and its functional impact has not been systematically explored. Here, we perform a comprehensive DNA methylome analysis of C. difficile using 36 human isolates and observe a high level of epigenomic diversity. We discovered an orphan DNA methyltransferase with a well-defined specificity, the corresponding gene of which is highly conserved across our dataset and in all of the approximately 300 global C. difficile genomes examined. Inactivation of the methyltransferase gene negatively impacts sporulation, a key step in C. difficile disease transmission, and these results are consistently supported by multiomics data, genetic experiments and a mouse colonization model. Further experimental and transcriptomic analyses suggest that epigenetic regulation is associated with cell length, biofilm formation and host colonization. These findings provide a unique epigenetic dimension to characterize medically relevant biological processes in this important pathogen. This study also provides a set of methods for comparative epigenomics and integrative analysis, which we expect to be broadly applicable to bacterial epigenomic studies

Addressing food and nutrition insecurity in the Caribbean through domestic smallholder farming system innovation

Structural conditions underlying the development of CARICOM’s two-tiered agricultural innovation system depict diverse drivers of change over time, versus institutional inertia of export-oriented formal institutions and the neglect of informal domestic markets. Key principles of taking an agroecological approach would include: supporting diversity and redundancy, building connectivity, managing slow variables and feedbacks, improving understanding of socioecological systems as complex adaptive systems, and encouraging polycentric governance systems. In this paper, we review the conditions that have been undermining sustainable food and nutrition security in the Caribbean, focusing on issues of history, economy, and innovation

Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria

Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component markedly increased potency (IC50 values for such derivatives ranged from 0.81 to 2.27 mu M). Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate derivatives; both classes provided inhibitors with nanomolar-range potencies (e.g., the K-i of compound 67 is 0.10 mu M). During BoNT/A challenge using primary neurons, select derivatives protected SNAP-25 by up to 89%. Docking simulations were performed to rationalize the compounds' in vitro potencies. In addition to specific residue contacts, coordination of the enzyme's catalytic zinc and expulsion of the enzyme's catalytic water were a consistent theme. With respect to antimalarial activity, the compounds provided better IC90 activities against chloroquine resistant (CQR) malaria than CQ, and seven compounds were more active than mefloquine against CQR strain W2