5,946 research outputs found
Search for the standard model Higgs boson in the \hzzlepjet channel with the CMS experiment at LHC
A search for the standard model (SM) Higgs boson decaying
into two Z bosons with a subsequent decay into two leptons and two quark jets,
H â ZZ â
+
âq+qâ, is presented. The data sample, corresponding to an integrated luminosity of 4.6 fbâ1, is collected from proton proton collisions at the
centre-of-mass energy of 7 TeV, with the CMS detector at the LHC at CERN, in
proton-proton collisions at the centre-of-mass energy of 7 TeV. Discrimination of
signal from background events is based on a kinematic selection and exploiting the
different angular distribution of signal and background. No evidence for the Higgs
boson is found, and upper limits on the Higgs boson production cross section are
set between 130 and 600 GeV mass
[18F]-Fluorodeoxyglucose-positron emission tomography in rats with prolonged cocaine self-administration suggests potential brain biomarkers for addictive behavior
The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges. Compared to cocaine-naĂŻve control rats, 0crit animals showed higher glucose uptake in the caudate putamen (CPu) and medial prefrontal cortex (mPFC) respect to naĂŻve controls. 3crit animals did not show this adaptive higher glucose utilization, but had lower uptake in several cortical areas. Both cocaine and yohimbine challenges affected glucose uptake in control rats in several brain sites, but not in 0crit and 3crit rats, indicating that impaired glucose mobilization in response to these challenges is not specifically associated with addictive behavior. Compared to 0crit, 3crit rats showed higher reinstatement responses, which were negatively associated with glucose uptake in the ventral tegmental area. Data indicate that cocaine non-addict- and addict-like phenotypes are associated with several potential biomarkers. Specifically, we propose that increased glucose uptake in the CPu and mPFC is a function of controlled drug use, whereas a loss of striatal and prefrontal metabolic activity and reduced uptake in cortical areas are indicative of addictive behavior
Laparoscopy for management of nontraumatic acute abdomen
SecĹŁia Chirurgie, Spitalul Municipal de UrgenĹŁÄ, MoineĹti, România, Al XII-lea Congres al AsociaČiei Chirurgilor âNicolae Anestiadiâ din Republica Moldova cu participare internaČionalÄ 23-25 septembrie 2015Introducere: Laparoscopia ĂŽn abdomenul acut are atât rol ĂŽn stabilirea diagnosticului, confirmându-l ĂŽn situaĹŁiile echivoce, cât Ĺi
ĂŽn orientarea strategiei terapeutice cu avantajele chirurgiei mini-invazive.
Material Ĺi metode: Studiul nostru evalueazÄ 873 de cazuri de abdomen acut nontraumatic (exceptând colecistita acutÄ)
abordate laparoscopic ĂŽn perioada 2010-2014, urmarindu-se concordanĹŁa diagnosticului pre- Ĺi postoperator, stabilirea unui
diagnostic intraoperator cert, incidenĹŁa intervenĹŁiilor laparoscopice cât Ĺi complicaĹŁiile acestora.
Rezultate: Diagnosticul intraoperator a fost de apendicitÄ acutÄ ĂŽn 653 (75%) de cazuri, urgenĹŁele ginecologice au fost
certificate la 146 (17%) de pacienĹŁi (chist ovarian eclatat, sarcina extrauterinÄ, boala inflamatorie pelvinÄ), 52 (6%) de pacienĹŁi
au fost diagnosticaĹŁi cu ulcer perforat, 22 de cazuri fiind ĂŽnregistrate cu alte patologii (pancreatite acute, perforaĹŁii intestinale cu
peritonite, diverticul Meckel perforat, infarcte enteromezenterice, peritonita TBC). Incidente Ĺi accidente au fost ĂŽntâlnite la 56
(6,5%) de pacienĹŁi, au fost ĂŽnregistrate 33 (3,7%) de conversii, complicaĹŁii postoperatorii fiind ĂŽnregistrate ĂŽn 37 (4,2%) de cazuri.
Concluzii: Laparoscopia diagnosticÄ este o modalitate optimÄ diagnosticÄ ĂŽn cazurile de abdomen acut non-traumatic, fiind
salutarÄ ĂŽn cazurile de apendicitÄ acutÄ, urgenĹŁe ginecologice Ĺi peritonita de etiologie neprecizatÄ cu posibilitatea rezolvÄrii pe
aceastÄ cale a patologiei identificate, ĂŽn abdomenul acut laparoscopia fiind ultimul mijloc diagnostic Ĺi primul mijloc terapeutic.Aims: Laparoscopy for acute abdomen is important either for diagnostic, when there is uncertainty in establishing the etiology,
and also has a therapeutic role with the well known advantages of mini-invasive surgery.
Material and methods: Our study evaluates 873 patients of nontraumatic acute abdomen (excepting acute cholecystitis),
approached laparoscopically during 2010-2014. The following factors were pursued: the concordance between pre- and
postoperative diagnostic, the establishment of a certain intraoperative diagnostic, incidence of laparoscopic interventions and
their complications.
Results: There were 653 (75%) cases of acute appendicitis, 146 patients with gynecological (ruptured ovarian cyst, ectopic
pregnancy, inflammatory pelvic disease), 52 (6%) patients with perforated ulcer, 22 cases with other pathologies (acute
pancreatitis, enteral perforations, perforations of Meckel diverticulum, entero-mesenteric infarction, tuberculous peritonitis),
confirmed laparoscopically. Incidents and accidents were encountered in 56 (6.5%) cases, there were 33 (3.7%) conversions to
open technique and for 37 (4.2%) patients were recorded postoperative complications.
Conclusions: Diagnostic laparoscopy is an optimal method of diagnostic confirmation for cases of non-traumatic acute
abdomen especially for acute appendicitis, gynecological emergencies and peritonitis of unknown etiology with the possibility of
laparoscopic treatment of these pathologies, being also the last option for diagnostic and the first solution for treatment
Caracteres histolĂłgicos de frutos definen sinapomorfĂas y plesiomorfĂas en la familia Solanaceae
Fil: Machado, A.S. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Solananceae es una familia cosmopolita con especies de importancia econĂłmica y medicinal.
Los frutos representan la unidad de dispersiĂłn de las semillas y estĂĄn sometidos a presiones
selectivas; por lo que son altamente homoplĂĄsicos (Knapp, 2002).Fil: Machado, A.S. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Ciencias de las Plantas, BotĂĄnic
Conversion in laparoscopic cholecystectomy for acute cholecystitis
Scopul lucrÄrii. Colecistectomia laparoscopicÄ a devenit o operaČie curentÄ ĂŽn practica chirurgicalÄ zilnicÄ Či este consideratÄ ĂŽn prezent un standard de aur, oferind posibilitatea de a rezolva aproape toate litiazele veziculare simptomatice. Ăn anumite cazuri totuČi, condiČiile tehnice particulare creeazÄ riscuri specifice, ce impun conversia la tehnica deschisÄ.Materiale Či metodÄ. Studiul nostru se ĂŽntinde pe o perioada de 5 ani, fiind incluČi urmÄtorii factori: forma anatomopatologicÄ, motivele Či rata conversiei, complicaČiile postoperatorii Či durata medie de spitalizare.Rezultate. Ăn perioada decembrie 2018- decembrie 2022 au fost efectuate 3576 de colecistectomii laparoscopice din care 2848 au fost realizate pentru colecistita acutÄ (79,6%). Din punct de vedere al formelor anatomopatologice au predominat colecistitele acute catarale (52%), urmate de cele flegmonoase (37%) Či gangrenoase (11%). Rata conversiei a fost de 5,4% (156 cazuri), cu o tendinČÄ constantÄ la descreČtere corelatÄ cu ĂŽmbunÄtÄČirea experienČei echipei chirurgicale. Printre cele mai ĂŽntâlnite cauze ce au dus la conversie putem enumera: anatomie incertÄ datoritÄ proceselor inflamatorii importante (62 de pacienČi), fibroza la nivelul triunghiului Calot (43 de cazuri), dar Či alte cauze (hemoragie, cirozÄ hepaticÄ, sindrom aderenČial â 51 de cazuri ). La pacienČii la care s-a realizat conversia, complicaČiile postoperatorii au fost ĂŽntâlnite ĂŽn 18% din cazuri, durata medie de spitalizare a fost de 13 zile, cu o mortalitate de 1,28%.Concluzii. Conversia ĂŽn colecistectomia laparoscopicÄ pentru colecistita acutÄ reprezintÄ o dovadÄ a maturitÄČii chirurgicale Ĺi nu trebuie consideratÄ un eČec al tehnicii laparoscopice, fiind salutatÄ ĂŽn situaČii ĂŽn care avantajul abordului laparoscopic este depÄsit de riscurile unor situaČii ĂŽntâlnite ĂŽn practicÄ.Aim of study. Laparoscopic cholecystectomy is now the âgold standardâ operation for patients with gallstones disease. However, a number of patients require conversion to open cholecystectomy for the safe completion of the procedure, generally being certified that untransparency in operative field, unclear anatomical proportion , are the most frequent causes of conversion and postoperative complications.Materials and methods. From 3576 patients who underwent laparoscopic cholecystectomy between 2018-2022, we selected a lot of 2848 cases of acute cholecystitis and evaluated the conversion rate encountered. The patients were selected according to the morphopatological form of cholecystitis as: catarrhal cholecystitis â 52% (1436 cases), phlegmonous cholecystitis - 37% (1275 cases) and gangrenous cholecystitis â 11% (896 cases). The conversion rate was 5,4% (156 cases) Results. In this paper the modalities, the technical particularities and the causes that can lead to conversion in laparoscopic cholecystectomy for acute cholecystitis are discussed.Conclusions. Laparoscopic cholecystectomies can be safely performed for almost all patients with acute cholecystitis by an experienced surgical team, although unclear anatomy secondary to inflammation remains the most common reason for conversion leading to higher rate of postoperative complications and a longer hospital stay, the overall impact of acute cholecystitis on the operative outcome has decreased with time
AnatomĂa vegetativa e histoquĂmica en Cynanchum bonariense (Apocynaceae)
Fil: Bravi, V. S. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂsicas y Naturales. CĂĄtedra de MorfologĂa Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂsicas y Naturales. CĂĄtedra de MorfologĂa Vegetal; Argentina.Fil: Pacciaroni, A. del V. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Fil: Pacciaroni, A. del V. Universidad Nacional de CĂłrdoba. Facultad de Ciencias QuĂmicas; Argentina.Fil: Wiemer, A. P. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂsicas y Naturales. CĂĄtedra de MorfologĂa Vegetal; Argentina.Cynanchum bonariense (Decne.) T. Mey es una enredaderanativa que habita en los bordes de
caminos, sobre arbustos, ĂĄrboles bajos y estĂĄ ampliamente distribuida en la zona centro y
norte de Argentina. Presenta abundante lĂĄtex de color blanco.El objetivo del presente trabajo
fue realizarun anĂĄlisis anatĂłmico comparativo de los Ăłrganos vegetativos con especial
atenciĂłn en los laticĂferos.Fil: Bravi, V. S. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂsicas y Naturales. CĂĄtedra de MorfologĂa Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂsicas y Naturales. CĂĄtedra de MorfologĂa Vegetal; Argentina.Fil: Pacciaroni, A. del V. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂa Vegetal; Argentina.Fil: Pacciaroni, A. del V. Universidad Nacional de CĂłrdoba. Facultad de Ciencias QuĂmicas; Argentina.Fil: Wiemer, A. P. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂsicas y Naturales. CĂĄtedra de MorfologĂa Vegetal; Argentina.Ciencias de las Plantas, BotĂĄnic
Microstructural White Matter Alterations in Men with Alcohol Use Disorder and Rats with Excessive Alcohol Consumption during Early Abstinence
Importance: Although the detrimental effects of alcohol on the brain are widely acknowledged, observed structural changes are highly heterogeneous, and diagnostic markers for characterizing alcohol-induced brain damage, especially in early abstinence, are lacking. This heterogeneity, likely contributed to by comorbidity factors in patients with alcohol use disorder (AUD), challenges a direct link of brain alterations to the pathophysiology of alcohol misuse. Translational studies in animal models may help bridge this causal gap. Objective: To compare microstructural properties extracted using advanced diffusion tensor imaging (DTI) in the brains of patients with AUD and a well-controlled rat model of excessive alcohol consumption and monitor the progression of these properties during early abstinence. Design, Setting, and Participants: This prospective observational study included 2 cohorts of hospitalized patients with AUD (n = 91) and Marchigian Sardinian alcohol-preferring (msP) rats (n = 27). In humans cross-sectional comparison were performed with control participants (healthy men [n = 36]) and longitudinal comparisons between different points after alcohol withdrawal. In rats, longitudinal comparisons were performed in alcohol-exposed (n = 27) and alcohol-naive msP rats (n = 9). Human data were collected from March 7, 2013, to August 3, 2016, and analyzed from June 14, 2017, to May 31, 2018; rat data were collected from January 15, 2017, to May 12, 2017, and analyzed from October 11, 2017, to May 28, 2018. Main Outcomes and Measures: Fractional anisotropy and other DTI measures of white matter properties after long-term alcohol exposure and during early abstinence in both species and clinical and demographic variables and time of abstinence after discharge from hospital in patients. Results: The analysis included 91 men with AUD (mean [SD] age, 46.1 [9.6] years) and 27 male rats in the AUD groups and 36 male controls (mean [SD] age, 41.7 [9.3] years) and 9 male control rats. Comparable DTI alterations were found between alcohol and control groups in both species, with a preferential involvement of the corpus callosum (fractional anisotropy Cohen d = -0.84 [P <.01] corrected in humans and Cohen d = -1.17 [P <.001] corrected in rats) and the fornix/fimbria (fractional anisotropy Cohen d = -0.92 [P <.001] corrected in humans and d = -1.24 [P <.001] corrected in rats). Changes in DTI were associated with preadmission consumption patterns in patients and progress in humans and rats during 6 weeks of abstinence. Mathematical modeling shows this process to be compatible with a sustained demyelination and/or a glial reaction. Conclusions and Relevance: Using a translational DTI approach, comparable white matter alterations were found in patients with AUD and rats with long-term alcohol consumption. In humans and rats, a progression of DTI alterations into early abstinence (2-6 weeks) suggests an underlying process that evolves soon after cessation of alcohol use
Measurement of diffraction dissociation cross sections in pp collisions at = 7 TeV
Measurements of diffractive dissociation cross sections in pp collisions at sâ=7ââTeV are presented in kinematic regions defined by the masses MX and MY of the two final-state hadronic systems separated by the largest rapidity gap in the event. Differential cross sections are measured as a function of ΞX=M2X/s in the region â5.53, log10MX>1.1, and log10MY>1.1, a region dominated by DD. The cross sections integrated over these regions are found to be, respectively, 2.99Âą0.02(stat)+0.32â0.29(syst)ââmb, 1.18Âą0.02(stat)Âą0.13(syst)ââmb, and 0.58Âą0.01(stat)+0.13â0.11(syst)ââmb, and are used to extract extrapolated total SD and DD cross sections. In addition, the inclusive differential cross section, dĎ/dÎΡF, for events with a pseudorapidity gap adjacent to the edge of the detector, is measured over ÎΡF=8.4 units of pseudorapidity. The results are compared to those of other experiments and to theoretical predictions and found compatible with slowly rising diffractive cross sections as a function of center-of-mass energy
Search for a pseudoscalar boson decaying into a boson and the 125 GeV Higgs boson in â+ââ final states
Results are reported on a search for decays of a pseudoscalar A boson into a boson and a light scalar h boson, where the Z boson decays into a pair of oppositely-charged electrons or muons, and the h boson decays into . The search is based on data from protonâproton collisions at a center-of-mass energy =8 TeV collected with the CMS detector, corresponding to an integrated luminosity of 19.7 . The h boson is assumed to be the standard model-like Higgs boson with a mass of 125 GeV. With no evidence for signal, upper limits are obtained on the product of the production cross section and the branching fraction of the A boson in the Zh channel. Results are also interpreted in the context of two Higgs doublet models
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
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