5,946 research outputs found

    Search for the standard model Higgs boson in the \hzzlepjet channel with the CMS experiment at LHC

    Get PDF
    A search for the standard model (SM) Higgs boson decaying into two Z bosons with a subsequent decay into two leptons and two quark jets, H → ZZ → + −q+q−, is presented. The data sample, corresponding to an integrated luminosity of 4.6 fb−1, is collected from proton proton collisions at the centre-of-mass energy of 7 TeV, with the CMS detector at the LHC at CERN, in proton-proton collisions at the centre-of-mass energy of 7 TeV. Discrimination of signal from background events is based on a kinematic selection and exploiting the different angular distribution of signal and background. No evidence for the Higgs boson is found, and upper limits on the Higgs boson production cross section are set between 130 and 600 GeV mass

    [18F]-Fluorodeoxyglucose-positron emission tomography in rats with prolonged cocaine self-administration suggests potential brain biomarkers for addictive behavior

    Get PDF
    The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges. Compared to cocaine-naĂŻve control rats, 0crit animals showed higher glucose uptake in the caudate putamen (CPu) and medial prefrontal cortex (mPFC) respect to naĂŻve controls. 3crit animals did not show this adaptive higher glucose utilization, but had lower uptake in several cortical areas. Both cocaine and yohimbine challenges affected glucose uptake in control rats in several brain sites, but not in 0crit and 3crit rats, indicating that impaired glucose mobilization in response to these challenges is not specifically associated with addictive behavior. Compared to 0crit, 3crit rats showed higher reinstatement responses, which were negatively associated with glucose uptake in the ventral tegmental area. Data indicate that cocaine non-addict- and addict-like phenotypes are associated with several potential biomarkers. Specifically, we propose that increased glucose uptake in the CPu and mPFC is a function of controlled drug use, whereas a loss of striatal and prefrontal metabolic activity and reduced uptake in cortical areas are indicative of addictive behavior

    Laparoscopy for management of nontraumatic acute abdomen

    Get PDF
    Secţia Chirurgie, Spitalul Municipal de Urgenţă, Moineşti, România, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Laparoscopia în abdomenul acut are atât rol în stabilirea diagnosticului, confirmându-l în situaţiile echivoce, cât şi în orientarea strategiei terapeutice cu avantajele chirurgiei mini-invazive. Material şi metode: Studiul nostru evaluează 873 de cazuri de abdomen acut nontraumatic (exceptând colecistita acută) abordate laparoscopic în perioada 2010-2014, urmarindu-se concordanţa diagnosticului pre- şi postoperator, stabilirea unui diagnostic intraoperator cert, incidenţa intervenţiilor laparoscopice cât şi complicaţiile acestora. Rezultate: Diagnosticul intraoperator a fost de apendicită acută în 653 (75%) de cazuri, urgenţele ginecologice au fost certificate la 146 (17%) de pacienţi (chist ovarian eclatat, sarcina extrauterină, boala inflamatorie pelvină), 52 (6%) de pacienţi au fost diagnosticaţi cu ulcer perforat, 22 de cazuri fiind înregistrate cu alte patologii (pancreatite acute, perforaţii intestinale cu peritonite, diverticul Meckel perforat, infarcte enteromezenterice, peritonita TBC). Incidente şi accidente au fost întâlnite la 56 (6,5%) de pacienţi, au fost înregistrate 33 (3,7%) de conversii, complicaţii postoperatorii fiind înregistrate în 37 (4,2%) de cazuri. Concluzii: Laparoscopia diagnostică este o modalitate optimă diagnostică în cazurile de abdomen acut non-traumatic, fiind salutară în cazurile de apendicită acută, urgenţe ginecologice şi peritonita de etiologie neprecizată cu posibilitatea rezolvării pe această cale a patologiei identificate, în abdomenul acut laparoscopia fiind ultimul mijloc diagnostic şi primul mijloc terapeutic.Aims: Laparoscopy for acute abdomen is important either for diagnostic, when there is uncertainty in establishing the etiology, and also has a therapeutic role with the well known advantages of mini-invasive surgery. Material and methods: Our study evaluates 873 patients of nontraumatic acute abdomen (excepting acute cholecystitis), approached laparoscopically during 2010-2014. The following factors were pursued: the concordance between pre- and postoperative diagnostic, the establishment of a certain intraoperative diagnostic, incidence of laparoscopic interventions and their complications. Results: There were 653 (75%) cases of acute appendicitis, 146 patients with gynecological (ruptured ovarian cyst, ectopic pregnancy, inflammatory pelvic disease), 52 (6%) patients with perforated ulcer, 22 cases with other pathologies (acute pancreatitis, enteral perforations, perforations of Meckel diverticulum, entero-mesenteric infarction, tuberculous peritonitis), confirmed laparoscopically. Incidents and accidents were encountered in 56 (6.5%) cases, there were 33 (3.7%) conversions to open technique and for 37 (4.2%) patients were recorded postoperative complications. Conclusions: Diagnostic laparoscopy is an optimal method of diagnostic confirmation for cases of non-traumatic acute abdomen especially for acute appendicitis, gynecological emergencies and peritonitis of unknown etiology with the possibility of laparoscopic treatment of these pathologies, being also the last option for diagnostic and the first solution for treatment

    Caracteres histolĂłgicos de frutos definen sinapomorfĂ­as y plesiomorfĂ­as en la familia Solanaceae

    Get PDF
    Fil: Machado, A.S. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Solananceae es una familia cosmopolita con especies de importancia econĂłmica y medicinal. Los frutos representan la unidad de dispersiĂłn de las semillas y estĂĄn sometidos a presiones selectivas; por lo que son altamente homoplĂĄsicos (Knapp, 2002).Fil: Machado, A.S. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Fil: Cosa, M. T. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Fil: Barboza, G. E. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Ciencias de las Plantas, BotĂĄnic

    Conversion in laparoscopic cholecystectomy for acute cholecystitis

    Get PDF
    Scopul lucrării. Colecistectomia laparoscopică a devenit o operație curentă în practica chirurgicală zilnică și este considerată în prezent un standard de aur, oferind posibilitatea de a rezolva aproape toate litiazele veziculare simptomatice. În anumite cazuri totuși, condițiile tehnice particulare creează riscuri specifice, ce impun conversia la tehnica deschisă.Materiale și metodă. Studiul nostru se întinde pe o perioada de 5 ani, fiind incluși următorii factori: forma anatomopatologică, motivele și rata conversiei, complicațiile postoperatorii și durata medie de spitalizare.Rezultate. În perioada decembrie 2018- decembrie 2022 au fost efectuate 3576 de colecistectomii laparoscopice din care 2848 au fost realizate pentru colecistita acută (79,6%). Din punct de vedere al formelor anatomopatologice au predominat colecistitele acute catarale (52%), urmate de cele flegmonoase (37%) și gangrenoase (11%). Rata conversiei a fost de 5,4% (156 cazuri), cu o tendință constantă la descreștere corelată cu îmbunătățirea experienței echipei chirurgicale. Printre cele mai întâlnite cauze ce au dus la conversie putem enumera: anatomie incertă datorită proceselor inflamatorii importante (62 de pacienți), fibroza la nivelul triunghiului Calot (43 de cazuri), dar și alte cauze (hemoragie, ciroză hepatică, sindrom aderențial – 51 de cazuri ). La pacienții la care s-a realizat conversia, complicațiile postoperatorii au fost întâlnite în 18% din cazuri, durata medie de spitalizare a fost de 13 zile, cu o mortalitate de 1,28%.Concluzii. Conversia în colecistectomia laparoscopică pentru colecistita acută reprezintă o dovadă a maturității chirurgicale şi nu trebuie considerată un eșec al tehnicii laparoscopice, fiind salutată în situații în care avantajul abordului laparoscopic este depăsit de riscurile unor situații întâlnite în practică.Aim of study. Laparoscopic cholecystectomy is now the “gold standard” operation for patients with gallstones disease. However, a number of patients require conversion to open cholecystectomy for the safe completion of the procedure, generally being certified that untransparency in operative field, unclear anatomical proportion , are the most frequent causes of conversion and postoperative complications.Materials and methods. From 3576 patients who underwent laparoscopic cholecystectomy between 2018-2022, we selected a lot of 2848 cases of acute cholecystitis and evaluated the conversion rate encountered. The patients were selected according to the morphopatological form of cholecystitis as: catarrhal cholecystitis – 52% (1436 cases), phlegmonous cholecystitis - 37% (1275 cases) and gangrenous cholecystitis – 11% (896 cases). The conversion rate was 5,4% (156 cases) Results. In this paper the modalities, the technical particularities and the causes that can lead to conversion in laparoscopic cholecystectomy for acute cholecystitis are discussed.Conclusions. Laparoscopic cholecystectomies can be safely performed for almost all patients with acute cholecystitis by an experienced surgical team, although unclear anatomy secondary to inflammation remains the most common reason for conversion leading to higher rate of postoperative complications and a longer hospital stay, the overall impact of acute cholecystitis on the operative outcome has decreased with time

    AnatomĂ­a vegetativa e histoquĂ­mica en Cynanchum bonariense (Apocynaceae)

    Get PDF
    Fil: Bravi, V. S. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂ­sicas y Naturales. CĂĄtedra de MorfologĂ­a Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂ­sicas y Naturales. CĂĄtedra de MorfologĂ­a Vegetal; Argentina.Fil: Pacciaroni, A. del V. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Fil: Pacciaroni, A. del V. Universidad Nacional de CĂłrdoba. Facultad de Ciencias QuĂ­micas; Argentina.Fil: Wiemer, A. P. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂ­sicas y Naturales. CĂĄtedra de MorfologĂ­a Vegetal; Argentina.Cynanchum bonariense (Decne.) T. Mey es una enredaderanativa que habita en los bordes de caminos, sobre arbustos, ĂĄrboles bajos y estĂĄ ampliamente distribuida en la zona centro y norte de Argentina. Presenta abundante lĂĄtex de color blanco.El objetivo del presente trabajo fue realizarun anĂĄlisis anatĂłmico comparativo de los Ăłrganos vegetativos con especial atenciĂłn en los laticĂ­feros.Fil: Bravi, V. S. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂ­sicas y Naturales. CĂĄtedra de MorfologĂ­a Vegetal; Argentina.Fil: Cosa, M. T. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂ­sicas y Naturales. CĂĄtedra de MorfologĂ­a Vegetal; Argentina.Fil: Pacciaroni, A. del V. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto Multidisciplinario de BiologĂ­a Vegetal; Argentina.Fil: Pacciaroni, A. del V. Universidad Nacional de CĂłrdoba. Facultad de Ciencias QuĂ­micas; Argentina.Fil: Wiemer, A. P. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas, FĂ­sicas y Naturales. CĂĄtedra de MorfologĂ­a Vegetal; Argentina.Ciencias de las Plantas, BotĂĄnic

    Microstructural White Matter Alterations in Men with Alcohol Use Disorder and Rats with Excessive Alcohol Consumption during Early Abstinence

    Get PDF
    Importance: Although the detrimental effects of alcohol on the brain are widely acknowledged, observed structural changes are highly heterogeneous, and diagnostic markers for characterizing alcohol-induced brain damage, especially in early abstinence, are lacking. This heterogeneity, likely contributed to by comorbidity factors in patients with alcohol use disorder (AUD), challenges a direct link of brain alterations to the pathophysiology of alcohol misuse. Translational studies in animal models may help bridge this causal gap. Objective: To compare microstructural properties extracted using advanced diffusion tensor imaging (DTI) in the brains of patients with AUD and a well-controlled rat model of excessive alcohol consumption and monitor the progression of these properties during early abstinence. Design, Setting, and Participants: This prospective observational study included 2 cohorts of hospitalized patients with AUD (n = 91) and Marchigian Sardinian alcohol-preferring (msP) rats (n = 27). In humans cross-sectional comparison were performed with control participants (healthy men [n = 36]) and longitudinal comparisons between different points after alcohol withdrawal. In rats, longitudinal comparisons were performed in alcohol-exposed (n = 27) and alcohol-naive msP rats (n = 9). Human data were collected from March 7, 2013, to August 3, 2016, and analyzed from June 14, 2017, to May 31, 2018; rat data were collected from January 15, 2017, to May 12, 2017, and analyzed from October 11, 2017, to May 28, 2018. Main Outcomes and Measures: Fractional anisotropy and other DTI measures of white matter properties after long-term alcohol exposure and during early abstinence in both species and clinical and demographic variables and time of abstinence after discharge from hospital in patients. Results: The analysis included 91 men with AUD (mean [SD] age, 46.1 [9.6] years) and 27 male rats in the AUD groups and 36 male controls (mean [SD] age, 41.7 [9.3] years) and 9 male control rats. Comparable DTI alterations were found between alcohol and control groups in both species, with a preferential involvement of the corpus callosum (fractional anisotropy Cohen d = -0.84 [P <.01] corrected in humans and Cohen d = -1.17 [P <.001] corrected in rats) and the fornix/fimbria (fractional anisotropy Cohen d = -0.92 [P <.001] corrected in humans and d = -1.24 [P <.001] corrected in rats). Changes in DTI were associated with preadmission consumption patterns in patients and progress in humans and rats during 6 weeks of abstinence. Mathematical modeling shows this process to be compatible with a sustained demyelination and/or a glial reaction. Conclusions and Relevance: Using a translational DTI approach, comparable white matter alterations were found in patients with AUD and rats with long-term alcohol consumption. In humans and rats, a progression of DTI alterations into early abstinence (2-6 weeks) suggests an underlying process that evolves soon after cessation of alcohol use

    Measurement of diffraction dissociation cross sections in pp collisions at s\sqrt{s} = 7 TeV

    Full text link
    Measurements of diffractive dissociation cross sections in pp collisions at s√=7  TeV are presented in kinematic regions defined by the masses MX and MY of the two final-state hadronic systems separated by the largest rapidity gap in the event. Differential cross sections are measured as a function of ξX=M2X/s in the region −5.53, log10MX>1.1, and log10MY>1.1, a region dominated by DD. The cross sections integrated over these regions are found to be, respectively, 2.99±0.02(stat)+0.32−0.29(syst)  mb, 1.18±0.02(stat)±0.13(syst)  mb, and 0.58±0.01(stat)+0.13−0.11(syst)  mb, and are used to extract extrapolated total SD and DD cross sections. In addition, the inclusive differential cross section, dσ/dΔηF, for events with a pseudorapidity gap adjacent to the edge of the detector, is measured over ΔηF=8.4 units of pseudorapidity. The results are compared to those of other experiments and to theoretical predictions and found compatible with slowly rising diffractive cross sections as a function of center-of-mass energy

    Search for a pseudoscalar boson decaying into a ZZ boson and the 125 GeV Higgs boson in ℓ+ℓ−bbˉb\bar{b} final states

    Full text link
    Results are reported on a search for decays of a pseudoscalar A boson into a ZZ boson and a light scalar h boson, where the Z boson decays into a pair of oppositely-charged electrons or muons, and the h boson decays into bbˉb\bar{b}. The search is based on data from proton–proton collisions at a center-of-mass energy s\sqrt{s}=8 TeV collected with the CMS detector, corresponding to an integrated luminosity of 19.7 fb−1fb^{−1} . The h boson is assumed to be the standard model-like Higgs boson with a mass of 125 GeV. With no evidence for signal, upper limits are obtained on the product of the production cross section and the branching fraction of the A boson in the Zh channel. Results are also interpreted in the context of two Higgs doublet models

    Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

    Get PDF
    A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE
    • …
    corecore