INTESTINAL SEGMENTS AT RECONSTRUCTIVE PLASTIC SURGERY IN URINARY TRACT

Objective: this article presents the analysis of treatment’s results, life’s quality and long-term postoperative period’s complications at using intestine segments for replacement plastic of bladder and ureter.Material and methods: this study included 122 patients with plactic by intestine segments at urology department of Pirogov National Medical & Surgical Center. At bladder’s reconstructive plastic we used Hautmann’s method (59 operations) and Reddy’s method (36 operations). At ureter’s reconstructive plastic we used method of ileoureteroplastic (all 27 operations). After operation, patients underwent urography with intravenous contrast, cystography for impermeability, anastomotic integrity and the lack of reflux. Evaluation of oncological and functional outcomes included clinical, laboratory and radiological diagnostic methods.Results: long-term results of intestinal grafts showed the highest level of life’s quality after ileoureteroplastic, the lowest level – after Reddy’s method of bladder’s plastic.Conclusion: postoperative results of intestinal segments at reconstructive plastic operations on the urinary tract analyzed and assessed

Up-to-date opportunities of cervical lymph nodes ultrasound investigation in patients, suffering from oral cavity cancer

Background. Incidence of oral cancer in Russia is 4.52 and mortality – 2.44. Head and neck cancer is characterized by the high risk of development of metastases in regional lymph nodes. Lymph nodes status exerts influence on the treatment plan and appears to be the major predictive factor. Regional metastases result into two-fold decrease of five-year survival. Therefore, evaluation and treatment of metastatic lymph nodes is of prime importance. Objective. The aim of this manuscript was to illustrate and summarize publications devoted to modern methods of ultrasound evaluation of cervical lymph node status in patients with squamous cell carcinoma of the oral cavity. Results. Numerous studies have demonstrated, that standard ultrasound investigation (in B-mode) is characterized by high sensitivity and specificity (specificity varies from 71.0 to 96.4 %, and specificity – from 46.6 to 91.0 %, according to different studies). In addition, ultrasound efficiency exceeds that of CT. Accuracy of ultrasound as the method of cervical lymph node investigation has increased after implementation of such methods, as elastography and elastometry (this techniques allow to achieve sensitivity of 98.1 % and specificity of 100 %)

Features of the lymphocytic microenvironment in metastatic uveal melanoma

Aim of the study. Compare the lymphocytic microenvironment of primary uveal melanomas and distant metastases (to the liver).Цель исследования — сравнить лимфоцитарное микроокружение первичных увеальных меланом и отдаленных метастазов (в печень)

The Concept of the "Field" in Early Soviet Ethnography : A Northern Perspective

Peer reviewedPublisher PD

Mammary analogue secretory carcinoma of the salivary gland with NTRK fusions: new approaches for diagnostics and targeted therapy (review)

Mammary analogue secretory carcinoma (MASC) of the salivary gland is a rare salivary cancer, histologically resembling to secretory carcinoma of the breast. In 2017 World Health Organization reported MASC is a new salivary cancer subtype. The aim of this article is to collect and analyze data about MASC, particularly clinical, histological and molecular profile, to evaluate targeted therapy effects. We discuss a case report of dramatic and durable response with entrectinib and the development of acquired resistance in an NTRK3-fusion positive salivary cancer, detected by next-generation sequencing. Next-generation sequencing as a comprehensive molecular profiling, that helps to investigate molecular profile of rare tumors and gives an opportunity to use an effective therapeutic options. Identifying ETV6-NTRK3 positive MASC provides a better prognosis for metastatic disease by using a novel effective targeted therapy with tyrosine kinase inhibitors (entrectinib, larotrectinib). Despite a durable and dramatic response, we showed an interesting case of the development of acquired resistance to tyrosine kinase inhibitors mediated by the appearance of a novel NTRK3 G623R mutation. Finally, we believe in great perspectives of comprehensive molecular profiling and targeted therapy for rare malignancies with NTRK gene fusions, including second-generation tyrosine kinase inhibitors