An Evaluation of the Sensitivity of Subjects with Peanut Allergy to Very Low Doses of Peanut Protein: A Randomized, Double-Blind, Placebo-Controlled Food Challenge Study

The minimum dose of food protein to which subjects with food allergy have reacted in double-blind, placebo-controlled food challenges is between 50 and 100 mg. However, subjects with peanut allergy often report severe reactions after minimal contact with peanuts, even through intact skin. Objective: We sought to determine whether adults previously proven by challenge to be allergic to peanut react to very low doses of peanut protein. Methods: We used a randomized, double-blind, placebo-controlled food challenge of 14 subjects allergic to peanuts with doses of peanut ranging from 10 μg to 50 mg, administered in the form of a commercially available peanut flour. Results: One subject had a systemic reaction to 5 mg of peanut protein, and two subjects had mild objective reactions to 2 mg and 50 mg of peanut protein, respectively. Five subjects had mild subjective reactions (1 to 5 mg and 4 to 50 mg). All subjects with convincing objective reactions had short-lived subjective reactions to preceding doses, as low as 100 μg in two cases. Five subjects did not react to any dose up to 50 mg. Conclusion: Even in a group of well-characterized, highly sensitive subjects with peanut allergy, the threshold dose of peanut protein varies. As little as 100 μg of peanut protein provokes symptoms in some subjects with peanut allergy

The Gaia-ESO Survey: Tracing interstellar extinction

Large spectroscopic surveys have enabled in the recent years the computation of three-dimensional interstellar extinction maps thanks to accurate stellar atmospheric parameters and line-of-sight distances. Such maps are complementary to 3D maps extracted from photometry, allowing a more thorough study of the dust properties. Our goal is to use the high-resolution spectroscopic survey Gaia-ESO in order to obtain with a good distance resolution the interstellar extinction and its dependency as a function of the environment and the Galactocentric position. We use the stellar atmospheric parameters of more than 5000 stars, obtained from the Gaia-ESO survey second internal data release, and combine them with optical (SDSS) and near-infrared (VISTA) photometry as well as different sets of theoretical stellar isochrones, in order to calculate line-of-sight extinction and distances. The extinction coefficients are then compared with the literature to discuss their dependancy on the stellar parameters and position in the Galaxy. Within the errors of our method, our work does not show that there is any dependence of the interstellar extinction coefficient on the atmospheric parameters of the stars. We do not find any evidence of the variation of E(J-H)/E(J-K) with the angle from the Galactic centre nor with Galactocentric distance. This suggests that we are dealing with a uniform extinction law in the SDSS ugriz bands and the near-IR JHKs bands. Therefore, extinction maps using mean colour-excesses and assuming a constant extinction coefficient can be used without introducing any systematic errors.Comment: 13 pages, 14 figures, 1 Appendix accepted for publication in Astronomy&Astrophysic

The Gaia-ESO Survey: a quiescent Milky Way with no significant dark/stellar accreted disc

According to our current cosmological model, galaxies like the Milky Way are expected to experience many mergers over their lifetimes. The most massive of the merging galaxies will be dragged towards the disc-plane, depositing stars and dark matter into an accreted disc structure. In this work, we utilize the chemo-dynamical template developed in Ruchti et al. to hunt for accreted stars. We apply the template to a sample of 4,675 stars in the third internal data release from the Gaia-ESO Spectroscopic Survey. We find a significant component of accreted halo stars, but find no evidence of an accreted disc component. This suggests that the Milky Way has had a rather quiescent merger history since its disc formed some 8-10 billion years ago and therefore possesses no significant dark matter disc.Comment: 15 pages, 11 figures, accepted for publication in MNRA

The Gaia-ESO Survey: N-body modelling of the Gamma Velorum cluster

The Gaia-ESO Survey has recently unveiled the complex kinematic signature of the Gamma Velorum cluster: this cluster is composed of two kinematically distinct populations (hereafter, population A and B), showing two different velocity dispersions and a relative ~2 km s^-1 radial velocity (RV) shift. In this paper, we propose that the two populations of the Gamma Velorum cluster originate from two different sub-clusters, born from the same parent molecular cloud. We investigate this possibility by means of direct-summation N-body simulations. Our scenario is able to reproduce not only the RV shift and the different velocity dispersions, but also the different centroid (~0.5 pc), the different spatial concentration and the different line-of-sight distance (~5 pc) of the two populations. The observed 1-2 Myr age difference between the two populations is also naturally explained by our scenario, in which the two sub-clusters formed in two slightly different star formation episodes. Our simulations suggest that population B is strongly supervirial, while population A is close to virial equilibrium. We discuss the implications of our models for the formation of young star clusters and OB associations in the Milky Way.Comment: 12 pages, 7 figures, 2 tables, Astronomy and Astrophysics, in pres

The Gaia-ESO Survey: the selection function of the Milky Way field stars

The Gaia-ESO Survey was designed to target all major Galactic components (i.e., bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of the survey construction, specifically the influence of target selection criteria on observed Milky Way field stars is required in order to analyse and interpret the survey data correctly. We present the target selection process for the Milky Way field stars observed with VLT/FLAMES and provide the weights that characterise the survey target selection. The weights can be used to account for the selection effects in the Gaia-ESO Survey data for scientific studies. We provide a couple of simple examples to highlight the necessity of including such information in studies of the stellar populations in the Milky Way.Comment: 18 pages, 19 figures, Accepted for publication in MNRAS (April 25, 2016

The Gaia-ESO Survey: Detailed Abundances in the Metal-poor Globular Cluster NGC 4372

We present the abundance analysis for a sample of 7 red giant branch stars in the metal-poor globular cluster NGC 4372 based on UVES spectra acquired as part of the Gaia-ESO Survey. This is the first extensive study of this cluster from high resolution spectroscopy. We derive abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, Fe, Cr, Ni, Y, Ba, and La. We find a metallicity of [Fe/H] = -2.19 $\pm$ 0.03 and find no evidence for a metallicity spread. This metallicity makes NGC 4372 one of the most metal-poor galactic globular clusters. We also find an {\alpha}-enhancement typical of halo globular clusters at this metallicity. Significant spreads are observed in the abundances of light elements. In particular we find a Na-O anti-correlation. Abundances of O are relatively high compared with other globular clusters. This could indicate that NGC 4372 was formed in an environment with high O for its metallicity. A Mg-Al spread is also present which spans a range of more than 0.5 dex in Al abundances. Na is correlated with Al and Mg abundances at a lower significance level. This pattern suggests that the Mg-Al burning cycle is active. This behavior can also be seen in giant stars of other massive, metal-poor clusters. A relation between light and heavy s-process elements has been identified.Comment: 14 pages, 14 figures, accepted for publication in A&

The Gaia-ESO Survey: Separating disk chemical substructures with cluster models

(Abridged) Recent spectroscopic surveys have begun to explore the Galactic disk system outside the solar neighborhood on the basis of large data samples. In this way, they provide valuable information for testing spatial and temporal variations of disk structure kinematics and chemical evolution. We used a Gaussian mixture model algorithm, as a rigurous mathematical approach, to separate in the [Mg/Fe] vs. [Fe/H] plane a clean disk star subsample from the Gaia-ESO survey internal data release 2. We find that the sample is separated into five groups associated with major Galactic components; the metal-rich end of the halo, the thick disk, and three subgroups for the thin disk sequence. This is confirmed with a sample of red clump stars from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. The two metal-intermediate and metal-rich groups of the thin disk decomposition ([Fe/H]>-0.25 dex) highlight a change in the slope at solar metallicity. This holds true at different radial regions. The distribution of Galactocentric radial distances of the metal-poor part of the thin disk ([Fe/H]<-0.25 dex) is shifted to larger distances than those of the more metal-rich parts. Moreover, the metal-poor part of the thin disk presents indications of a scale height intermediate between those of the thick and the rest of the thin disk, and it displays higher azimuthal velocities than the latter. These stars might have formed and evolved in parallel and/or dissociated from the inside-out formation taking place in the internal thin disk. Their enhancement levels might be due to their origin from gas pre-enriched by outflows from the thick disk or the inner halo. The smooth trends of their properties (their spatial distribution with respect to the plane, in particular) with [Fe/H] and [Mg/Fe] suggested by the data indicates a quiet dynamical evolution, with no relevant merger events

Activation and Inactivation Kinetics of Torpedo californica Acetylcholine Receptor in Reconstituted Membranes

P>Background: To date no studies have compared generic health-related quality of life (HRQL) of food allergic patients from childhood to adulthood with that of the general population or patients with other chronic diseases. The aim of this study was to compare generic HRQL of food allergic patients with the general population and other diseases. Methods: Generic HRQL questionnaires (CHQ-CF87 and RAND-36) were completed by 79 children, 74 adolescents and 72 adults with food allergy. The generic HRQL scores were compared with scores from published studies on the general population and patients with asthma, irritable bowel syndrome (IBS), diabetes mellitus (DM) and rheumatoid arthritis (RA). Results: Food allergic children and adolescents reported fewer limitations in school work due to behavioural problems (P <0.013), but food allergic adolescents and adults reported more pain (P = 0.020), poorer overall health (P <0.001), more limitations in social activities (P <0.001) and less vitality (P = 0.002) than individuals from the general population. Food allergic patients reported poorer generic HRQL than patients with DM, but better generic HRQL than patients with RA, asthma and IBS. Conclusion: HRQL is impaired in food allergic adolescents and adults, compared to the general population, and it is intermediate in magnitude between DM and RA, asthma and IBS. Children show the least impact on generic HRQL from food allergy

The Gaia-ESO Survey: Chromospheric Emission, Accretion Properties, and Rotation in γ\gamma Velorum and Chamaeleon I

We use the fundamental parameters delivered by the GES consortium in the first internal data release to select the members of $\gamma$ Vel and Cha I among the UVES and GIRAFFE spectroscopic observations. A total of 140 $\gamma$ Vel members and 74 Cha I members were studied. We calculated stellar luminosities through spectral energy distributions, while stellar masses were derived by comparison with evolutionary tracks. The spectral subtraction of low-activity and slowly rotating templates, which are rotationally broadened to match the $v\sin i$ of the targets, enabled us to measure the equivalent widths (EWs) and the fluxes in the H$\alpha$ and H$\beta$ lines. The H$\alpha$ line was also used for identifying accreting objects and for evaluating the mass accretion rate ($\dot M_{\rm acc}$). The distribution of $v\sin i$ for the members of $\gamma$ Vel displays a peak at about 10 km s$^{-1}$ with a tail toward faster rotators. There is also some indication of a different $v\sin i$ distribution for the members of its two kinematical populations. Only a handful of stars in $\gamma$ Vel display signatures of accretion, while many more accretors were detected in the younger Cha~I. Accreting and active stars occupy two different regions in a $T_{\rm eff}$-flux diagram and we propose a criterion for distinguishing them. We derive $\dot M_{\rm acc}$ in the ranges $10^{-11}$-$10^{-9} M_\odot$yr$^{-1}$ and $10^{-10}$-$10^{-7} M_\odot$yr$^{-1}$ for $\gamma$ Vel and Cha I accretors, respectively. We find less scatter in the $\dot M_{\rm acc}-M_\star$ relation derived through the H$\alpha$ EWs, when compared to the H$\alpha$ $10\%W$ diagnostics, in agreement with other authors