679 research outputs found
Normal and Pathological NCAT Image and Phantom Data Based on Physiologically Realistic Left Ventricle Finite-Element Models
The redshift distribution of dusty star forming galaxies from the SPT survey
We use the Atacama Large Millimeter/submillimeter Array (ALMA) in Cycle 1 to
determine spectroscopic redshifts of high-redshift dusty star-forming galaxies
(DSFGs) selected by their 1.4mm continuum emission in the South Pole Telescope
(SPT) survey. We present ALMA 3mm spectral scans between 84-114GHz for 15
galaxies and targeted ALMA 1mm observations for an additional eight sources.
Our observations yield 30 new line detections from CO, [CI] , [NII] , H_2O and
NH_3. We further present APEX [CII] and CO mid-J observations for seven sources
for which only a single line was detected in spectral-scan data from ALMA Cycle
0 or Cycle 1. We combine the new observations with previously published and new
mm/submm line and photometric data of the SPT-selected DSFGs to study their
redshift distribution. The combined data yield 39 spectroscopic redshifts from
molecular lines, a success rate of >85%. Our sample represents the largest data
set of its kind today and has the highest spectroscopic completeness among all
redshift surveys of high-z DSFGs. The median of the redshift distribution is
z=3.9+/-0.4, and the highest-redshift source in our sample is at z=5.8. We
discuss how the selection of our sources affects the redshift distribution,
focusing on source brightness, selection wavelength, and strong gravitational
lensing. We correct for the effect of gravitational lensing and find the
redshift distribution for 1.4mm-selected sources with a median redshift of
z=3.1+/-0.3. Comparing to redshift distributions selected at shorter
wavelengths from the literature, we show that selection wavelength affects the
shape of the redshift distribution
The Role of Repeated Exposure to Multimodal Input in Incidental Acquisition of Foreign Language Vocabulary
Prior research has reported incidental vocabulary acquisition with complete beginners in a foreign language (FL), within 8 exposures to auditory and written FL word forms presented with a picture depicting their meaning. However, important questions remain about whether acquisition occurs with fewer exposures to FL words in a multimodal situation and whether there is a repeated exposure effect. Here we report a study where the number of exposures to FL words in an incidental learning phase varied between 2, 4, 6, and 8 exposures. Following the incidental learning phase, participants completed an explicit learning task where they learned to recognize written translation equivalents of auditory FL word forms, half of which had occurred in the incidental learning phase. The results showed that participants performed better on the words they had previously been exposed to, and that this incidental learning effect occurred from as little as 2 exposures to the multimodal stimuli. In addition, repeated exposure to the stimuli was found to have a larger impact on learning during the first few exposures and decrease thereafter, suggesting that the effects of repeated exposure on vocabulary acquisition are not necessarily constant
Measuring Regional Changes in the Diastolic Deformation of the Left Ventricle of SHR Rats Using microPET Technology and Hyperelastic Warping
The objective of this research was to assess applicability of a technique known as hyperelastic warping for the measurement of local strains in the left ventricle (LV) directly from microPET image data sets. The technique uses differences in image intensities between template (reference) and target (loaded) image data sets to generate a body force that deforms a finite element (FE) representation of the template so that it registers with the target images. For validation, the template image was defined as the end-systolic microPET image data set from a Wistar Kyoto (WKY) rat. The target image was created by mapping the template image using the deformation results obtained from a FE model of diastolic filling. Regression analysis revealed highly significant correlations between the simulated forward FE solution and image derived warping predictions for fiber stretch (R2 = 0.96), circumferential strain (R2 = 0.96), radial strain (R2 = 0.93), and longitudinal strain (R2 = 0.76) (p<0.001for all cases). The technology was applied to microPET image data of two spontaneously hypertensive rats (SHR) and a WKY control. Regional analysis revealed that, the lateral freewall in the SHR subjects showed the greatest deformation compared with the other wall segments. This work indicates that warping can accurately predict the strain distributions during diastole from the analysis of microPET data sets
The Rest-Frame Submillimeter Spectrum of High-Redshift, Dusty, Star-Forming Galaxies
We present the average rest-frame spectrum of high-redshift dusty,
star-forming galaxies from 250-770GHz. This spectrum was constructed by
stacking ALMA 3mm spectra of 22 such sources discovered by the South Pole
Telescope and spanning z=2.0-5.7. In addition to multiple bright spectral
features of 12CO, [CI], and H2O, we also detect several faint transitions of
13CO, HCN, HNC, HCO+, and CN, and use the observed line strengths to
characterize the typical properties of the interstellar medium of these
high-redshift starburst galaxies. We find that the 13CO brightness in these
objects is comparable to that of the only other z>2 star-forming galaxy in
which 13CO has been observed. We show that the emission from the high-critical
density molecules HCN, HNC, HCO+, and CN is consistent with a warm, dense
medium with T_kin ~ 55K and n_H2 >~ 10^5.5 cm^-3. High molecular hydrogen
densities are required to reproduce the observed line ratios, and we
demonstrate that alternatives to purely collisional excitation are unlikely to
be significant for the bulk of these systems. We quantify the average emission
from several species with no individually detected transitions, and find
emission from the hydride CH and the linear molecule CCH for the first time at
high redshift, indicating that these molecules may be powerful probes of
interstellar chemistry in high-redshift systems. These observations represent
the first constraints on many molecular species with rest-frame transitions
from 0.4-1.2mm in star-forming systems at high redshift, and will be invaluable
in making effective use of ALMA in full science operations.Comment: 19 pages, 10 figures (2 in appendices); accepted for publication in
Ap
SPT 0538-50: Physical conditions in the ISM of a strongly lensed dusty star-forming galaxy at z=2.8
We present observations of SPT-S J053816-5030.8, a gravitationally-lensed
dusty star forming galaxy (DSFG) at z = 2.7817, first discovered at millimeter
wavelengths by the South Pole Telescope. SPT 0538-50 is typical of the
brightest sources found by wide-field millimeter-wavelength surveys, being
lensed by an intervening galaxy at moderate redshift (in this instance, at z =
0.441). We present a wide array of multi-wavelength spectroscopic and
photometric data on SPT 0538-50, including data from ALMA, Herschel PACS and
SPIRE, Hubble, Spitzer, VLT, ATCA, APEX, and the SMA. We use high resolution
imaging from HST to de-blend SPT 0538-50, separating DSFG emission from that of
the foreground lens. Combined with a source model derived from ALMA imaging
(which suggests a magnification factor of 21 +/- 4), we derive the intrinsic
properties of SPT 0538-50, including the stellar mass, far-IR luminosity, star
formation rate, molecular gas mass, and - using molecular line fluxes - the
excitation conditions within the ISM. The derived physical properties argue
that we are witnessing compact, merger-driven star formation in SPT 0538-50,
similar to local starburst galaxies, and unlike that seen in some other DSFGs
at this epoch.Comment: 16 pages, 11 figures. Accepted for publication in Ap
Explanation in mathematics: Proofs and practice
Mathematicians distinguish between proofs that explain their results and those that merely prove. This paper explores the nature of explanatory proofs, their role in mathematical practice, and some of the reasons why philosophers should care about them. Among the questions addressed are the following: what kinds of proofs are generally explanatory (or not)? What makes a proof explanatory? Do all mathematical explanations involve proof in an essential way? Are there really such things as explanatory proofs, and if so, how do they relate to the sorts of explanation encountered in philosophy of science and metaphysics
Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression
Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ–positive CAF subset displaying tumor-promoting features in BC. In the preclinical MMTV-PyMT mouse model, integrin α11 deficiency led to a drastic reduction of tumor progression and metastasis. A clear association between integrin α11 and PDGFRβ was found at both transcriptional and histological levels in BC specimens. High stromal integrin α11/PDGFRβ expression was associated with high grades and poorer clinical outcome in human BC patients. Functional assays using 5 CAF subpopulations (1 murine, 4 human) revealed that integrin α11 promotes CAF invasion and CAF-induced tumor cell invasion upon PDGF-BB stimulation. Mechanistically, the proinvasive activity of integrin α11 relies on its ability to interact with PDGFRβ in a ligand-dependent manner and to promote its downstream JNK activation, leading to the production of tenascin C, a proinvasive matricellular protein. Pharmacological inhibition of PDGFRβ and JNK impaired tumor cell invasion induced by integrin α11+ CAFs. Collectively, our study uncovers an integrin α11+ subset of protumoral CAFs that exploits the PDGFRβ/JNK signaling axis to promote tumor invasiveness in BC.publishedVersio
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