Latency and Availability Driven VNF Placement in a MEC-NFV Environment

Multi-access Edge Computing (MEC) is gaining momentum as it is considered as one of the enablers of 5G ultra-Reliable Low-Latency Communications (uRLLC) services. MEC deploys computation resources close to the end user, enabling to reduce drastically the end-to-end latency. ETSI has recently leveraged the MEC architecture to run all MEC entities, including MEC applications, as Virtual Network Functions (VNF) in a Network Functions Virtualization (NFV) environment. This evolution allows taking advantage of the mature architecture and the enabling tools of NFV, including the potential to apply a variety of service-tailored function placement algorithms. However, the latter need to be carefully designed in case of MEC applications such as uRLLC, where service access latency is critical. In this paper, we propose a novel placement scheme applicable to a MEC in NFV environment. In particular, we propose a formulation of the problem of VNF placement tailored to uRLLC as an optimization problem of two conflicting objectives, namely minimizing access latency and maximizing service availability. To deal with the complexity of the problem, we propose a Genetic Algorithm to solve it, which we compare with a CPLEX implementation of our model. Our numerical results show that our heuristic algorithm runs efficiently and produces solutions that approximate well the optimal, reducing latency and providing a highly-available service.This work has been partially supported by the European Union’s H2020 5G-Transformer Project (grant no. 761536

Cost and availability aware resource allocation and virtual function placement for CDNaaS provision

We address the fundamental tradeoff between deployment cost and service availability in the context of on-demand content delivery service provision over a telecom operator's network functions virtualization infrastructure. In particular, given a specific set of preferences and constraints with respect to deployment cost, availability and computing resource capacity, we provide polynomial-time heuristics for the problem of jointly deriving an appropriate assignment of computing resources to a set of virtual instances and the placement of the latter in a subset of the available physical hosts. We capture the conflicting criteria of service availability and deployment cost by proposing a multi-objective optimization problem formulation. Our algorithms are experimentally shown to outperform state-of-the-art solutions in terms of both execution time and optimality, while providing the system operator with the necessary flexibility to balance between conflicting objectives and reflect the relevant preferences of the customer in the produced solutions.This work was supported in part by the French FUI-18 DVD2C project and by the European Union’s Horizon 2020 research and innovation program under the 5G-Transformer project (grant no. 761536)

Electron correlations for ground state properties of group IV semiconductors

Valence energies for crystalline C, Si, Ge, and Sn with diamond structure have been determined using an ab-initio approach based on information from cluster calculations. Correlation contributions, in particular, have been evaluated in the coupled electron pair approximation (CEPA), by means of increments obtained for localized bond orbitals and for pairs and triples of such bonds. Combining these results with corresponding Hartree-Fock (HF) data, we recover about 95 % of the experimental cohesive energies. Lattice constants are overestimated at the HF level by about 1.5 %; correlation effects reduce these deviations to values which are within the error bounds of this method. A similar behavior is found for the bulk modulus: the HF values which are significantly too high are reduced by correlation effects to about 97 % of the experimental values.Comment: 22 pages, latex, 2 figure

CeLAND: search for a 4th light neutrino state with a 3 PBq 144Ce-144Pr electron antineutrino generator in KamLAND

The reactor neutrino and gallium anomalies can be tested with a 3-4 PBq (75-100 kCi scale) 144Ce-144Pr antineutrino beta-source deployed at the center or next to a large low-background liquid scintillator detector. The antineutrino generator will be produced by the Russian reprocessing plant PA Mayak as early as 2014, transported to Japan, and deployed in the Kamioka Liquid Scintillator Anti-Neutrino Detector (KamLAND) as early as 2015. KamLAND's 13 m diameter target volume provides a suitable environment to measure the energy and position dependence of the detected neutrino flux. A characteristic oscillation pattern would be visible for a baseline of about 10 m or less, providing a very clean signal of neutrino disappearance into a yet-unknown, sterile neutrino state. This will provide a comprehensive test of the electron dissaperance neutrino anomalies and could lead to the discovery of a 4th neutrino state for Delta_m^2 > 0.1 eV^2 and sin^2(2theta) > 0.05.Comment: 67 pages, 50 figures. Th. Lasserre thanks the European Research Council for support under the Starting Grant StG-30718

Criopreservação de protozoários dos gêneros trichomonas donne, 1837 e tritrichomonas kafoid, 1920

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The fingerprint of the summer 2018 drought in Europe on ground-based atmospheric CO2 measurements

During the summer of 2018, a widespread drought developed over Northern and Central Europe. The increase in temperature and the reduction of soil moisture have influenced carbon dioxide (CO2) exchange between the atmosphere and terrestrial ecosystems in various ways, such as a reduction of photosynthesis, changes in ecosystem respiration, or allowing more frequent fires. In this study, we characterize the resulting perturbation of the atmospheric CO2 seasonal cycles. 2018 has a good coverage of European regions affected by drought, allowing the investigation of how ecosystem flux anomalies impacted spatial CO2 gradients between stations. This density of stations is unprecedented compared to previous drought events in 2003 and 2015, particularly thanks to the deployment of the Integrated Carbon Observation System (ICOS) network of atmospheric greenhouse gas monitoring stations in recent years. Seasonal CO2 cycles from 48 European stations were available for 2017 and 2018.The UK sites were funded by the UK Department of Business, Energy and Industrial Strategy (formerly the Department of Energy and Climate Change) through contracts TRN1028/06/2015 and TRN1537/06/2018. The stations at the ClimaDat Network in Spain have received funding from the ‘la Caixa’ Foundation, under agreement 2010-002624

Hydroxyapatite-TiO2-SiO2-Coated 316L Stainless Steel for Biomedical Application

This study investigated the effectiveness of titania (TiO2) as a reinforcing phase in the hydroxyapatite (HAP) coating and silica (SiO2) single-layer as a bond coat between the TiO2-reinforced hydroxyapatite (TiO2/HAP) top layer and 316L stainless steel (316L SS) substrate on the corrosion resistance and mechanical properties of the underlying 316L SS metallic implant. Single-layer of SiO2 film was first deposited on 316L SS substrate and studied separately. Water contact angle measurements, X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectrophotometer analysis were used to evaluate the hydroxyl group reactivity at the SiO2 outer surface. The microstructural and morphological results showed that the reinforcement of HAP coating with TiO2 and SiO2 reduced the crystallite size and the roughness surface. Indeed, the deposition of 50 vol. % TiO2-reinforced hydroxyapatite layer enhanced the hardness and the elastic modulus of the HAP coating, the introduction of SiO2 inner-layer on the surface of the 316L SS allowed the improvement of the bonding strength and the corrosion resistance as confirmed by scratch studies, nanoindentation and cyclic voltammetry tests

Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

OBJECTIVE: Sex-specific research in adult bipolar disorder (BD) is sparse and even more so among those with older age bipolar disorder (OABD). Knowledge about sex differences across the bipolar lifespan is urgently needed to target and improve treatment. To address this gap, the current study examined sex differences in the domains of clinical presentation, general functioning, and mood symptoms among individuals with OABD. METHODS: This Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) study used data from 19 international studies including BD patients aged ≥50 years (N = 1,185: 645 women, 540 men).A comparison of mood symptoms between women and men was conducted initially using two-tailed t tests and then accounting for systematic differences between the contributing cohorts by performing generalized linear mixed models (GLMMs). Associations between sex and other clinical characteristics were examined using GLMM including: age, BD subtype, rapid cycling, psychiatric hospitalization, lifetime psychiatric comorbidity, and physical health comorbidity, with study cohort as a random intercept. RESULTS: Regarding depressive mood symptoms, women had higher scores on anxiety and hypochondriasis items. Female sex was associated with more psychiatric hospitalizations and male sex with lifetime substance abuse disorders. CONCLUSION: Our findings show important clinical sex differences and provide support that older age women experience a more severe course of BD, with higher rates of psychiatric hospitalization. The reasons for this may be biological, psychological, or social. These differences as well as underlying mechanisms should be a focus for healthcare professionals and need to be studied further

Personalized early detection and prevention of breast cancer: ENVISION consensus statement

Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness–implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas

Les plans d'expérience appliqués à l'optimisation des patchs composites

Les patchs en matériaux composite sont reconnus comme étant un des moyens les plus judicieux et efficaces pour la réparation des fissures et défauts. Leur utilisation se traduit par une réduction du facteur d'intensité des contraintes. Ce dernier dépend de plusieurs paramètres, tels que les dimensions et les propriétés intrinsèques du patch, de l'adhésif et du matériau. Dans ce travail, nous appliquons la méthode des plans d'expériences pour étudier les effets de ces paramètres pour aboutir à une optimisation du patch. Le calcul du facteur d'intensité de contrainte se fait par la méthode des éléments finis