The chaetognatha of the Eastropic Expedition, with notes as to their possible value as indicators of hydrographic conditions

ENGLISH: The purpose of this study was to investigate the possibility that certain species of Chaetognatha found in Eastern Tropical Pacific waters can serve as biological indicators of oceanographic features. "Indicator" organisms have been found useful in identifying water types, in tracing the pattern of current systems, and in tracing the origin of moving water masses. To be of use in this type of study, the organisms must be sufficiently abundant to be readily sampled, and easily identified to species; they must also, at least partially, fulfill the additional requisites listed and discussed by Sverdrup, Johnson, and Fleming (1942, pp. 866-867). Among several groups of organisms fulfilling these requirements are the Chaetognatha. Specimens of this group of animals occurred in large numbers in the plankton samples used for this study. The works of Thomson (1947), Fraser (1942), Ritter-Zahony (1911), and Sund (1959) were used for identification. SPANISH: El objetivo de este estudio ha sido el de investigar la posibilidad de utilizar ciertas especies de quetognatos encontrados en el Pacífico Oriental Tropical como indicadoras biológicas de características oceanográficas. Organismos "indicadores" fueron encontrados útiles para la identificación de tipos de agua, el trazado del régimen de los sistemas de corrientes y la determinación del origen de masas de agua en movimiento. Para servir a este tipo de estudios, los organismos deben ser lo suficientemente abundantes como para ser fácilmente muestreados e identificados hasta la especie; también deben satisfacer, por lo menos parcialmente, los requerimientos indicados y discutidos par Sverdrup, Johnson y Fleming (1942, pags. 866-867)

Individual-Level Responses to Rapid Climate Change in Common Terns (Sterna hirundo) and Arctic Terns (Sterna paradisaea)

This study examines fine-scale environmental changes and intraspecific variation in the diet and foraging behavior of two seabirds in the Gulf of Maine, one of the fastest-warming regions of the ocean. This variation on the individual level, or behavioral plasticity, may help long-lived species to persist in rapidly changing environments. As the water warms, seabirds’ preferred prey (hake and herring) follow cooler waters deeper and farther offshore. It is unlikely that all individuals respond to changing food availability in the same way. For common terns (Sterna hirundo) and Arctic terns (Sterna paradisaea) breeding on Petit Manan Island, I hypothesized that: H1: Preferred prey decline in the diet as sea surface temperature (SST) increases; H2: Individuals vary in their response to increasing SST; H3: Individual-level diet influences fitness. In June and July of 2022, we conducted daily chick provisioning watches and recorded prey size and species. While SST did not influence average feeding rate, increased SST drove declines in the average prey size and the proportion of hake and herring in the diet at the colony level (H1 supported). Slopes were similar across nests, suggesting no individual variation in diet plasticity with increasing SST (H2 not supported). At the nest level, a higher average proportion of herring and hake was associated with higher chick mortality and a declining growth rate. A higher average feeding rate was associated with an increase in growth rate while prey size did not impact chick growth rate (H3 not supported). Our findings suggest that individuals that try to maintain a diet of preferred prey may have lower fitness in a changing climate. However, individuals that decrease their foraging distance and prey switch to maintain a sufficient feeding rate are successful in raising chicks that reach fledging age

BAT: A Benchmark suite for AutoTuners

the code by ?nding the best possible values for a given architecture. To our knowledge, there are currently no standardized benchmark suites for comparing and testing autotuners. Developers of autotuners thus make their own when presenting and comparing autotuners. We thus present BAT, a Benchmark suite for AutoTuners with HPC-based parameterized GPU programs. CUDA programs and kernels from "The Scalable Heterogeneous Computing (SHOC) Benchmark" are parameterized. BAT contains a varied selection of benchmarks of different complexity that can utilize multiple GPUs on one system, either by running the same program and computations on multiple nodes, or by splitting the work between nodes. BAT contains 9 di?erent HPC benchmarks that provide a large search space of autotuning parameters, and are modified to suite many di?erent autotuners. BAT also includes a CLI that facilitates autotuning with the benchmarks. Our benchmark suite is tested with four di?erent autotuners, OpenTuner, Kernel Tuner, CLTune and KTT. They di?er in setup and how they tune. The impact of the di?erent benchmark parameters on the running time across architectures is analyzed. Test systems used include a DGX-2, IBM Power System AC922 with Tesla V100-SXM2 32 GB GPUs, an RTX Titan, a GeForce GTX 980 and a server with 20 Tesla T4 GPUs

Prevalence of multimorbidity with frailty and associations with socioeconomic position in an adult population : findings from the cross-sectional HUNT Study in Norway

ObjectivesTo explore prevalences and occupational group inequalities of two measures of multimorbidity with frailty.DesignCross-sectional study.SettingThe Nord-TrOndelag Health Study (HUNT), Norway, a total county population health survey, 2006-2008.ParticipantsParticipants older than 25 years, with complete questionnaires, measurements and occupation data were included.Outcomes >= 2 of 51 multimorbid conditions with >= 1 of 4 frailty measures (poor health, mental illness, physical impairment or social impairment) and >= 3 of 51 multimorbid conditions with >= 2 of 4 frailty measures.AnalysisLogistic regression models with age and occupational group were specified for each sex separately.ResultsOf 41 193 adults, 38 027 (55% female; 25-100 years old) were included. Of them, 39% had >= 2 multimorbid conditions with >= 1 frailty measure, and 17% had >= 3 multimorbid conditions with >= 2 frailty measures. Prevalence differences in percentage points (pp) with 95% confidence intervals of those in high versus low occupational group with >= 2 multimorbid conditions and >= 1 frailty measure were largest in women age 30 years, 17 (14 to 20) pp and 55 years, 15 (13 to 17) pp and in men age 55 years, 15 (13 to 17) pp and 80 years, 14 (9 to 18) pp. In those with >= 3 multimorbid conditions and >= 2 frailty measures, prevalence differences were largest in women age 30 years, 8 (6 to 10) pp and 55 years, 10 (8 to 11) ppand in men age 55 years, 9 (8 to 11) pp and 80 years, 6 (95% CI 1 to 10) pp.ConclusionMultimorbidity with frailty is common, and social inequalities persist until age 80 years in women and throughout the lifespan in men. To manage complex multimorbidity, strategies for proportionate universalism in medical education, healthcare, public health prevention and promotion seem necessary

Cell kinetic analysis of murine squamous cell carcinomas: a comparison of single versus double labelling using flow cytometry and immunohistochemistry.

The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, several comparisons of techniques were made in two different centres. This paper reports on the results of those comparisons involving two different detection methods (flow cytometry and immunohistochemistry), single vs double labelling, and in vivo and in vitro labelling, the latter using tissue slices incubated under high pressure oxygen. Pulse labelling studies with bromodeoxyuridine (BrdUrd) showed that the labelling indices (LI) were not significantly different after in vitro or in vivo labelling. In addition, the flow cytometry (FCM) and immunohistochemistry (IHC) methods also gave labelling indices which were not significantly different. Only tumour cells were analysed in these studies by selecting cells on the basis of aneuploidy (FCM) or morphology (IHC). The DNA synthesis time of the tumour cells were analysed by both techniques. For FCM, the Relative Movement method was used (Begg et al., 1985). For IHC, a double labelling method was used, employing BrdUrd and triated thymidine (3H-TdR) administered several hours apart, detected simultaneously using immunoperoxidase and autoradiography, respectively. When both labels were administered in vivo, there was good agreement for Ts between the FCM and IHC methods. Attempts were also made to measure Ts in vitro using both techniques. With double labelling, it was found that cells did not take up the second label, implying a failure of cycle progression. This was confirmed by FCM results, showing no movement of labelled cells through the S-phase, despite an initially high uptake. This could not be influenced by lowering the DNA precursor concentration or by adding foetal calf serum. This indicates that DNA synthesis times are difficult or impossible to measure in vitro in fresh tumour explants. Finally, the double labelling IHC method allowed intratumoural variations of both LI and Ts to be studied. Both parameters were found to vary markedly throughout the tumour volume, particularly for larger tumours (600 mg), giving calculated local potential doubling time values (Tpot) ranging from 1-7 days

Socioeconomic position, multimorbidity and mortality in a population cohort, the HUNT Study

Multimorbidity and socioeconomic position are independently associated with mortality. We investigated the association of occupational position and several multimorbidity measures with all-cause mortality. A cohort of people aged 35 to 75 years who participated in the Trøndelag Health Study in 2006–2008 and had occupational data was linked to the Norwegian National Population Registry for all-cause mortality from study entry until 1 February 2019. Logistic regression models for each occupational group were used to analyze associations between the number of conditions and 10-year risk of death. Cox regression models were used to examine associations between combinations of multimorbidity, occupational position, and mortality. Analyses were conducted for men and women. Included were 31,132 adults (16,950 women (54.4%)); occupational groups: high, 7501 (24.1%); low, 15,261 (49.0%)). Increased mortality was associated with lower occupational group, more chronic conditions, and all multimorbidity measures. The joint impact of occupational group and multimorbidity on mortality was greater in men than women. All multimorbidity measures are strongly associated with mortality, with varying occupational gradients. Social differences in multimorbidity are a public health challenge and necessitate consideration in health care. Men in lower occupational groups seem to be a particularly vulnerable grouppublishedVersio

Socioeconomic inequalities in the prevalence of complex multimorbidity in a Norwegian population: findings from the cross-sectional HUNT Study

Objectives: Multimorbidity, the co-occurrence of multiple long-term conditions, is common and increasing. Definitions and assessment methods vary, yielding differences in estimates of prevalence and multimorbidity severity. Sociodemographic characteristics are associated with complicating factors of multimorbidity. We aimed to investigate the prevalence of complex multimorbidity by sex and occupational groups throughout adulthood. Design: Cross-sectional study. Setting: The third total county survey of The Nord-Trøndelag Health Study (HUNT), 2006–2008, Norway. Participants: Individuals aged 25–100 years with classifiable occupational data and complete questionnaires and measurements. Outcome measure: Complex multimorbidity defined as ‘the co-occurrence of three or more chronic conditions affecting three or more different body (organ) systems within one person without defining an index chronic condition’. Analysis: Logistic regression models with age and occupational group were specified for each sex separately. Results: 38 027 of 41 193 adults (55% women) were included in our analyses. 54% of the participants were identified as having complex multimorbidity. Prevalence differences in percentage points (pp) of those in the low occupational group (vs the high occupational group (reference)) were 19 (95% CI, 16 to 21) pp in women and 10 (8 to 13) pp in men at 30 years; 12 (10 to 14) pp in women and 13 (11 to 15) pp in men at 55 years; and 2 (−1 to 4) pp in women and 7 (4 to 10) pp in men at 75 years. Conclusion: Complex multimorbidity is common from early adulthood, and social inequalities persist until 75 years in women and 90 years in men in the general population. These findings have policy implications for public health as well as healthcare, organisation, treatment, education and research, as complex multimorbidity breaks with the specialised, fragmented paradigm dominating medicine today.publishedVersio

Global variation in postoperative mortality and complications after cancer surgery : a multicentre, prospective cohort study in 82 countries

Background 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings Between April 1, 2018, and jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3.72, 95% CI 1.70-8.16) and for colorectal cancer in low-income or lower-middle-income countries (4.59, 2.39-8.80) and upper-middle-income countries (2.06,1.11-3.83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6.15, 3.26-11.59) and upper-middle-income countries (3.89, 2- 08-7- 29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

New Advances in the Treatment of Metastatic Pancreatic Cancer

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an extremely poor overall survival (OS) compared to other solid tumours. As the incidence of the disease is rising and the treatment options are limited, PDAC is projected to be the 2nd leading cause of cancer-related deaths in the United States by 2030. A majority of patients are not eligible for curative resection at the time of diagnosis, and those that are resected will often relapse within the first few years after surgery. Summary: Until recently, the nucleoside analogue gemcitabine has been the standard of care for patients with non-resectable PDAC with only marginal effects on OS. In 2011, the gemcitabine-free FOLFIRINOX regimen (folinic acid, fluorouracil, irinotecan and oxaliplatin) showed a significant survival advantage for patients with metastatic PDAC in a phase III trial. In 2013, the Metastatic Pancreatic Adenocarcinoma Trial phase III trial with nano-formulated albumin-bound paclitaxel (nab-paclitaxel) in combination with gemcitabine also resulted in a significant survival extension compared to gemcitabine monotherapy. However, both intensified therapy regimens show a broad spectrum of side effects and patients need to be carefully selected for the most appropriate protocol. Key Message: In this study, recent advances in the chemotherapeutic options available to treat metastatic PDAC and their implications for today's treatment choices are reviewed