Analisis karakteristik kinerja dan tingkat pelayanan pada ruas jalan dengan bukaan median

This study aims to analyze the effect of U-Turn facilities on traffic performance on Makassar Perintis Kemerdekaan Road, with a focus on three study points, namely KM 8+327 (in front of PO Bintang Marwah Bus), KM 10+467 (in front of Yonkav TNI Dormitory), and KM 10+910 (in front of Cokroaminoto Campus  Makassar). The method used in this research is quantitative analysis based on the Indonesian Road Capacity Manual (MKJI, 1997). Data were collected through traffic surveys for three days during  peak  hours  (07:00-09:00,  11:00-13:00,  and  15:00-18:00),  including  vehicle volume, travel time, vehicle speed, queue ratio, road capacity, and degree of saturation. The results showed that the presence of U-Turns on the Makassar Perintis Kemerdekaan Road  Section  has  a  significant  impact  on  increasing  traffic  delays  and  decreasing  the level  of  road  service.  High  vehicle  volumes,  especially  during  peak  hours,  cause  long queues  at  U-Turn  locations,  with  degree  of  saturation  (DS)  values  approaching  or exceeding the threshold suggested by MKJI. In addition, it was found that the presence of  "mr.  ogah"  who  regulates  traffic  unofficially  also  worsens  traffic  flow  conditions  by creating  conflicts  between  vehicles  by  causing  queues  characterized  by  the highest queue ratio of 1.34 at Km 8 + 327 then the queue ratio at km 10 + 467 of 1.16 and the queue ratio at km 10 + 910 of 1.067. The conclusion of this study is the need for evaluation and rearrangement of U-Turn facilities to improve the efficiency of  traffic  flow  on  the  Makassar  Independence  Pioneer  Road  Section.  Some  of  the recommendations proposed include the addition of special lanes for U-Turns, increasing road capacity, and installing clearer signs and road markings to reduce traffic conflicts.&nbsp

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk

Using the digital archive of pathological reports of stomach cancer as internal quality control of coding according to the ICD-O system

Purpose of the study. Demonstrate the possibilities of statistical analysis of the digital archive at pathological department (PD). To conduct internal quality control of the coding of malignant tumors according to the ICD-O-3 system of pathology reports using the example of gastric cancer (GC).Materials and methods. We retrospectively analyzed the digital archive of 368,157 pathology reports of the National Medical Research Centre for Oncology of the Ministry of Health of Russia from 2000 to 2019. For the study, 4,857 pathology reports of patients operated for gastric malignancies (ICD-X codes: C16.0 – C16.9) were selected for the period from 2000 to 2019.Results. The analysis of 368,157 protocols of the digital archive of PD revealed 4,614 malignant epithelial tumors of the stomach: tubular adenocarcinoma – 2,958, signet ring cell carcinoma – 791, undifferentiated cancer – 565, mucinous adenocarcinoma – 210, neuroendocrine neoplasia – 90. A significant increase in the ICD-O codes for "adenocarcinoma NOS" was found in 2018 and 2019. The pathology reports for these 2 years were reviewed by an independent pathologist and changes were made to the ICD-O codes according to the WHO classification digestive system tumors 2019. The adenocarcinoma NOS (8140/3) was replaced by the codes: tubular adenocarcinoma (ICD-O: 8211/3) – 41%, papillary adenocarcinoma (8260/3) – 9% and adenocarcinoma with mixed subtypes (8255/3) – 29%.Conclusion. The study, based on analysis of coding ICD-O stomach MN demonstrated the importance of digital archive at the PD, as a tool for rapid static analysis pathology reports and quality control of coding. The coding system can be the basis for large multicenter studies in oncology. Therefore, it is important to control the quality of coding of the pathology reports and to timely update the codes when new pathological classifications are released

Practical experience of a lung cancer primary cell culture collection creation at the National Medical Research Centre for Oncology

Purpose of the study. Testing of new chemotherapeutic agents in translational and biology medicine needs studies on immortalized cell lines. However, such models do not always have the biological properties of a tumor in situ, in contrast to primary cell cultures. Primary cultures of lung cancer cells have biological, morphological and molecular characteristics close or identical to tumor cells in vivo. Obtaining collections of primary lung cancer cell lines is an important task in creating various models for preclinical studies.Materials and methods. The materials are represented by postoperative tumor samples obtained from 25 patients with newly diagnosed lung cancer without prior treatment. The following methods were used to obtain primary cultures: enzymatic dissociation in Hanks' solution with the addition of 300 units/ml collagenase I (Thermo Fisher Scientific, USA), enzymatic dissociation using the Brain Tumor Dissoсiation Kit (Miltenyi Biotec, Germany) and 150 units/ml. ml of collagenase I, as well as the method of explants. The following methods were used to remove fibroblasts: the use of the FibrOut™ system (CHI Scientific, USA), magnetic separation of fibroblasts using Anti-Fibroblast MicroBeads (Miltenyi Biotec, Germany), and cold trypsinization.Results. We have obtained 15 primary lung cancer cell cultures that have passed the zero order passage. In this work, the method of enzymatic dissociation turned out to be the most effective. Incubation of lung tumor samples with collagenase for 1 hour preserves the viability and adhesiveness of the cells. The explant method did not show its effectiveness for long-term cultivation, there was no migration of tumor cells to plastic. Magnetic separation, as a method of removing stromal components of fibroblasts, showed the greatest efficiency, while maintaining the viability of tumor cells.Conclusion. The obtained primary cell cultures of lung cancer can be used for many tasks of experimental oncology: studies of the biological characteristics of lung cancer, development of preclinical models for the studies on new chemotherapeutic drugs

Analisis Kemampuan Pemahaman Konsep Matematis Siswa Kelas VIII SMP Negeri 17 Kendari

Tujuan penelitian ini adalah untuk menganalisis kemampuan pemahaman konsep matematis siswa. Penelitian ini adalah penelitian deskriptif eksploratif. Strategi yang digunakan adalah deskriptif kualitatif. Penelitian ini dilaksanakan di SMP Negeri 17 Kendari Tahun Ajaran 2017/2018 pada kelas VIII.7. Sumber data penelitian ini adalah hasil tes dan hasil wawancara. Hasil penelitian ini menunjukkan bahwa pemahaman konsep matematis siswa dengan kategori tingi sebanyak 3%, kategori sedang sebanyak 10%, dan kategori rendah sebanyak 87%. Hasil penelitian ini juga menunjukkan bahwa kinerja siswa dari masing-masing kategori adalah sebagai berikut: (a) siswa pada kategori tinggi dapat mengerjakan 6 butir soal atau menguasai 6 indikator kemampuan pemahaman konsep matematis; (b) siswa pada kategori sedang dapat mengerjakan 6 butir soal atau menguasai 6 indikator kemampuan pemahaman konsep matematis; dan (c) siswa pada kategori rendah dapat mengerjakan 4 butir soal atau menguasai 4 indikator kemampuan pemahaman konsep matemati

Pengaruh Pendekatan Saintifik terhadap Kemampuan Pemahaman Matematis Siswa Kelas VIII SMP Negeri 10

Penelitian ini merupakan penelitian eksperimen semu dengan rancangan posttest only control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 10 Kendari yang terdiri dari 7 kelas paralel berjumlah 210 siswa. Penentuan sampel dilakukan dengan teknik purposive sampling. Data diperoleh menggunakan instrumen berupa tes kemampuan pemahaman matematis siswa. Teknik analisis data menggunakan statistik deskriptif dan statistik inferensial. Hasil penelitian secara deskriptif dan secara inferensial menunjukkan bahwa: (1) Rata-rata kemampuan pemahaman matematis siswa yang diajar dengan pendekatan saintifik dengan cara berkelompok pada materi relasi dan fungsi adalah 76.38, (2) Rata-rata kemampuan pemahaman matematis siswa yang diajar dengan pendekatan saintifik dengan cara tidak berkelompok pada materi relasi dan fungsi adalah 69.00, dan (3) Peningkatan kemampuan pemahaman matematis siswa yang diajar dengan pendekatan saintifik dengan cara berkelompok lebih tinggi secara signifikan daripada peningkatan kemampuan pemahaman matematis siswa yang diajar dengan pendekatan saintifik tidak berkelompok