Supervised Associative Learning in Spiking Neural Network

In this paper, we propose a simple supervised associative learning approach for spiking neural networks. In an excitatory-inhibitory network paradigm with Izhikevich spiking neurons, synaptic plasticity is implemented on excitatory to excitatory synapses dependent on both spike emission rates and spike timings. As results of learning, the network is able to associate not just familiar stimuli but also novel stimuli observed through synchronised activity within the same subpopulation and between two associated subpopulations

Development of an organ failure score in acute liver failure for transplant selection and identification of patients at high risk of futility.

INTRODUCTION: King's College Hospital criteria are currently used to select liver transplant candidates in acetaminophen-related acute liver failure (ALF). Although widely accepted, they show a poor sensitivity in predicting pre-transplant mortality and cannot predict the outcome after surgery. In this study we aimed to develop a new prognostic score that can allow patient selection for liver transplantation more appropriately and identify patients at high risk of futile transplantation. METHODS: We analysed consecutive patients admitted to the Royal Free and Beaujon Hospitals between 1990 and 2015. Clinical and laboratory data at admission were collected. Predictors of 3-month mortality in the non-transplanted patients admitted to the Royal Free Hospital were used to develop the new score, which was then validated against the Beaujon cohort. The Beaujon-transplanted group was also used to assess the ability of the new score in identifying patients at high risk of transplant futility. RESULTS: 152 patients were included of who 44 were transplanted. SOFA, CLIF-C OF and CLIF-ACLF scores were the best predictors of 3-month mortality among non-transplanted patients. CLIF-C OF score and high dosages of norepinephrine requirement were the only significant predictors of 3-month mortality in the non-transplanted patients, and therefore were included in the ALF-OFs score. In non-transplanted patients, ALF-OFs showed good performance in both exploratory (AUC = 0.89; sensitivity = 82.6%; specificity = 89.5%) and the validation cohort (AUC = 0.988; sensitivity = 100%; specificity = 92.3%). ALF-OFs score was also able to identify patients at high risk of transplant futility (AUC = 0.917; sensitivity = 100%; specificity = 79.2%). CONCLUSION: ALF-OFs is a new prognostic score in acetaminophen-related ALF that can predict both the need for liver transplant and high risk of transplant futility, improving candidate selection for liver transplantation

Open fires in Greenland in summer 2017: transport, deposition and radiative effects of BC, OC and BrC emissions

Highly unusual open fires burned in western Greenland between 31 July and 21 August 2017, after a period of warm, dry and sunny weather. The fires burned on peatlands that became vulnerable to fires by permafrost thawing. We used several satellite data sets to estimate that the total area burned was about 2345&thinsp;ha. Based on assumptions of typical burn depths and emission factors for peat fires, we estimate that the fires consumed a fuel amount of about 117&thinsp;kt&thinsp;C and emitted about 23.5&thinsp;t of black carbon (BC) and 731&thinsp;t of organic carbon (OC), including 141&thinsp;t of brown carbon (BrC). We used a Lagrangian particle dispersion model to simulate the atmospheric transport and deposition of these species. We find that the smoke plumes were often pushed towards the Greenland ice sheet by westerly winds, and thus a large fraction of the emissions (30&thinsp;%) was deposited on snow- or ice-covered surfaces. The calculated deposition was small compared to the deposition from global sources, but not entirely negligible. Analysis of aerosol optical depth data from three sites in western Greenland in August 2017 showed strong influence of forest fire plumes from Canada, but little impact of the Greenland fires. Nevertheless, CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization) lidar data showed that our model captured the presence and structure of the plume from the Greenland fires. The albedo changes and instantaneous surface radiative forcing in Greenland due to the fire emissions were estimated with the SNICAR model and the uvspec model from the libRadtran radiative transfer software package. We estimate that the maximum albedo change due to the BC and BrC deposition was about 0.007, too small to be measured. The average instantaneous surface radiative forcing over Greenland at noon on 31 August was 0.03–0.04&thinsp;W&thinsp;m−2, with locally occurring maxima of 0.63–0.77&thinsp;W&thinsp;m−2 (depending on the studied scenario). The average value is up to an order of magnitude smaller than the radiative forcing from other sources. Overall, the fires burning in Greenland in the summer of 2017 had little impact on the Greenland ice sheet, causing a small extra radiative forcing. This was due to the – in a global context – still rather small size of the fires. However, the very large fraction of the emissions deposited on the Greenland ice sheet from these fires could contribute to accelerated melting of the Greenland ice sheet if these fires become several orders of magnitude larger under future climate.</p

Use of Artificial Intelligence as an Innovative Method for Liver Graft Macrosteatosis Assessment

The worldwide implementation of a liver graft pool using marginal livers (ie, grafts with a high risk of technical complications and impaired function or with a risk of transmitting infection or malignancy to the recipient) has led to a growing interest in developing methods for accurate evaluation of graft quality. Liver steatosis is associated with a higher risk of primary nonfunction, early graft dysfunction, and poor graft survival rate. The present study aimed to analyze the value of artificial intelligence (AI) in the assessment of liver steatosis during procurement compared with liver biopsy evaluation. A total of 117 consecutive liver grafts from brain-dead donors were included and classified into 2 cohorts: ≥30 versus &lt;30% hepatic steatosis. AI analysis required the presence of an intraoperative smartphone liver picture as well as a graft biopsy and donor data. First, a new algorithm arising from current visual recognition methods was developed, trained, and validated to obtain automatic liver graft segmentation from smartphone images. Second, a fully automated texture analysis and classification of the liver graft was performed by machine-learning algorithms. Automatic liver graft segmentation from smartphone images achieved an accuracy (Acc) of 98%, whereas the analysis of the liver graft features (cropped picture and donor data) showed an Acc of 89% in graft classification (≥30 versus &lt;30%). This study demonstrates that AI has the potential to assess steatosis in a handy and noninvasive way to reliably identify potential nontransplantable liver grafts and to avoid improper graft utilization

Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial

PURPOSE: Shortening the duration of antibiotic therapy (ABT) is a key measure in antimicrobial stewardship. The optimal duration of ABT for treatment of postoperative intra-abdominal infections (PIAI) in critically ill patients is unknown. METHODS: A multicentre prospective randomised trial conducted in 21 French intensive care units (ICU) between May 2011 and February 2015 compared the efficacy and safety of 8-day versus 15-day antibiotic therapy in critically ill patients with PIAI. Among 410 eligible patients (adequate source control and ABT on day 0), 249 patients were randomly assigned on day 8 to either stop ABT immediately (n = 126) or to continue ABT until day 15 (n = 123). The primary endpoint was the number of antibiotic-free days between randomisation (day 8) and day 28. Secondary outcomes were death, ICU and hospital length of stay, emergence of multidrug-resistant (MDR) bacteria and reoperation rate, with 45-day follow-up. RESULTS: Patients treated for 8 days had a higher median number of antibiotic-free days than those treated for 15 days (15 [6-20] vs 12 [6-13] days, respectively; P &lt; 0.0001) (Wilcoxon rank difference 4.99 days [95% CI 2.99-6.00; P &lt; 0.0001). Equivalence was established in terms of 45-day mortality (rate difference 0.038, 95% CI - 0.013 to 0.061). Treatments did not differ in terms of ICU and hospital length of stay, emergence of MDR bacteria or reoperation rate, while subsequent drainages between day 8 and day 45 were observed following short-course ABT (P = 0.041). CONCLUSION: Short-course antibiotic therapy in critically ill ICU patients with PIAI reduces antibiotic exposure. Continuation of treatment until day 15 is not associated with any clinical benefit. CLINICALTRIALS. GOV IDENTIFIER: NCT01311765

Utilisation du MALDI-TOF-MS pour l’identification rapide et precise des especes cliniques de Scedosporium et de Pseudallescheria

National audienc

Statistics and State-istics : exclusion categories in the population census (Belgium, 1846-1930)

Peer reviewe

Productive restructuring and the reallocation of work and employment: a survey of the “new” forms of social inequality

O propósito do presente artigo consiste em questionar a inevitabilidade dos processos de segmentação e precarização das relações de trabalho e emprego, responsáveis pela inscrição de “novas” formas de desigualdade social que alicerçam o actual modelo de desenvolvimento das economias e sociedades. Visa-se criticar os limites da lógica econômica e financeira, de contornos globais, que configuram um “novo espírito do capitalismo”, ou seja, uma espécie de divinização da ordem natural das coisas. Impõe-se fazer, por isso, um périplo analítico pelas transformações em curso no mercado de trabalho, acompanhado pela vigilância epistemológica que permita enquadrar e relativizar as (di)visões neoliberais e teses tecnodeterministas dominantes. A perspectivação de cenários sobre o futuro do trabalho encerrará este périplo, permitindo-nos alertar para os condicionalismos histórico-temporais, para a urgência de se desocultar o que de ideológico e político existe nas actuais lógicas de racionalização e para os processos de ressimbolização do trabalho e emprego enquanto “experiência social central” na contemporaneidade.The scope of this paper is to question the inevitability of the processes of segmentation and increased precariousness of the relations of labor and employment, which are responsible for the introduction of “new” forms of social inequality that underpin the current model of development of economies and societies. It seeks to criticize the limits of global financial and economic logic, which constitute a “new spirit of capitalism,” namely a kind of reverence for the natural order of things. It is therefore necessary to conduct an analytical survey of the ongoing changes in the labor market, accompanied by epistemological vigilance which makes it possible to see neoliberal (di)visions and dominant technodeterministic theses in context. The enunciation of scenarios on the future of work will conclude this survey and will make it possible to draw attention to both the historical and temporal constraints and to the urgent need to unveil what is ideological and political in the prevailing logic of rationalization and processes to reinstate work and employment as a “central social experience” in contemporary times