2,170 research outputs found
Standard versus personalized schedule of regorafenib in metastatic gastrointestinal stromal tumors: a retrospective, multicenter, real-world study
A Fast Quasi-Conformal Mapping Preconditioner for Electromagnetic Integral Equations
Boundary Element Methods (BEMs) are efficient strategies to numerically solve electromagnetic radiation and scattering problems. Unfortunately, however, classical BEM formulations suffer from ill-conditioning when the frequency is low, or the discretization density is high. In the past, several remedies have been presented for these ill-conditioning problems including preconditioners based on Calderón identities, hierarchical bases, and current decompositions. While effective, these strategies however require ad-hoc procedures including mesh-refinements, new basis function definitions, and adapted fast methods that, if not implemented properly, can become computationally cumbersome
Perancangan Sistem Informasi Administrasi Surat Berbasis Desktop pada Kantor Notaris Hoiril Masuli, Sh, M.Kn
Pada Kantor Notaris Hoiril Masuli, Sh, M.Kn dalam pengelolaan penerimaan berkas masih menggunakan cara manual dan belum terkomputerisasi. Hal ini meyulitkan pegawai dalam pengelolaan data klien, seperti halnya dalam penyimpanan data-data yang masih disimpan dalam bentuk berkas sehingga menyulitkan pegawai dalam mencari data berkas masuk dari klien ataupun berkas yang sudah selesai dibuat serta berkas yang sudah diambil klien. Untuk mengatasi masalah-masalah yang dihadapi, untuk mempercepat pekerjaan dan memudahkan pengelolahaan data perlu adanya sistem yang terkomputerisasi dalam pengelolaan berkas klien. Pada penelitian ini metode yang digunakan adalah berorientasi objek, model penelitian yang digunakan adalah Waterfall serta tools yang digunakan adalah UML (Unified Model Language)
On a Frequency-Stabilized Single Current Inverse Source Formulation
Several strategies are available for solving the inverse source problem in electromagnetics. Among them, many have been focusing in retrieving Love currents by solving, after regularization, for Love’s electric and magnetic currents. In this work we present a dual-element discretization, analysis, and stabilization of an inverse source formulation providing Love data by solving for only one current. This results in substantial savings and allows for an effective quasi-Helmholtz projector stabilization of the resulting operator. Theoretical considerations are complemented by numerical tests showing effectiveness and efficiency of the newly proposed method
On preconditioning electromagnetic integral equations in the high frequency regime via helmholtz operators and quasi-helmholtz projectors
Fast and accurate resolution of electromagnetic problems via the boundary element method (BEM) is oftentimes challenged by conditioning issues occurring in three distinct regimes: (i) when the frequency decreases and the discretization density remains constant, (ii) when the frequency is kept constant while the discretization is refined and (iii) when the frequency increases along with the discretization density. While satisfactory remedies to the problems arising in regimes (i) and (ii), respectively based on Helmholtz decompositions and Calderon-like techniques have been presented, the last regime is still challenging. In fact, this last regime is plagued by both spurious resonances and ill-conditioning, the former can be tackled via combined field strategies and is not the topic of this work. In this contribution new symmetric scalar and vectorial electric type formulations that remain well-conditioned in all of the aforementioned regimes and that do not require barycentric discretization of the dense electromagnetic potential operators are presented along with a spherical harmonics analysis illustrating their key properties
Complementary Riordan arrays
Abstract Recently, the concept of the complementary array of a Riordan array (or recursive matrix) has been introduced. Here we generalize the concept and distinguish between dual and complementary arrays. We show a number of properties of these arrays, how they are computed and their relation with inversion. Finally, we use them to find explicit formulas for the elements of many recursive matrices
On a Low-Frequency and Contrast Stabilized Full-Wave Volume Integral Equation Solver for Lossy Media
In this article, we present a new regularized electric flux volume integral equation (D-VIE) for modeling high-contrast conductive dielectric objects in a broad frequency range. This new formulation is particularly suitable for modeling biological tissues at low frequencies, as it is required by brain epileptogenic area imaging, but also at higher ones, as it is required by several applications, including, but not limited to, deep brain stimulation (DBS). When modeling inhomogeneous objects with high complex permittivities at low frequencies, the traditional D-VIE is ill-conditioned and suffers from numerical instabilities that result in slower convergence and less accurate solutions. In this work, we address these shortcomings by leveraging a new set of volume quasi-Helmholtz projectors. Their scaling by the material permittivity matrix allows for the rebalancing of the equation when applied to inhomogeneous scatterers and, thereby, makes the proposed method accurate and stable even for high complex permittivity objects until arbitrarily low frequencies. Numerical results, canonical and realistic, corroborate the theory and confirm the stability and the accuracy of this new method both in the quasi-static regime and at higher frequencies
Magnetic and Combined Field Integral Equations Based on the Quasi-Helmholtz Projectors
Boundary integral equation methods for analyzing electromagnetic scattering phenomena typically suffer from several of the following shortcomings: 1) ill-conditioning when the frequency is low; 2) ill-conditioning when the discretization density is high; 3) ill-conditioning when the structure contains global loops (which are computationally expensive to detect); 4) incorrect solution at low frequencies due to a loss of significant digits; and 5) the presence of spurious resonances. In this article, quasi-Helmholtz projectors are leveraged to obtain magnetic field integral equation (MFIE) that is immune to drawbacks 1)-4). Moreover, when this new MFIE is combined with a regularized electric field integral equation (EFIE), a new quasi-Helmholtz projector-combined field integral equation (CFIE) is obtained that also is immune to 5). The numerical results corroborate the theory and show the practical impact of the newly proposed formulations
Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance.
To ensure genome stability, sexually reproducing organisms require that mating brings together exactly 2 haploid gametes and that meiosis occurs only in diploid zygotes. In the fission yeast Schizosaccharomyces pombe, fertilization triggers the Mei3-Pat1-Mei2 signaling cascade, which represses subsequent mating and initiates meiosis. Here, we establish a degron system to specifically degrade proteins postfusion and demonstrate that mating blocks not only safeguard zygote ploidy but also prevent lysis caused by aberrant fusion attempts. Using long-term imaging and flow-cytometry approaches, we identify previously unrecognized and independent roles for Mei3 and Mei2 in zygotes. We show that Mei3 promotes premeiotic S-phase independently of Mei2 and that cell cycle progression is both necessary and sufficient to reduce zygotic mating behaviors. Mei2 not only imposes the meiotic program and promotes the meiotic cycle, but also blocks mating behaviors independently of Mei3 and cell cycle progression. Thus, we find that fungi preserve zygote ploidy and survival by at least 2 mechanisms where the zygotic fate imposed by Mei2 and the cell cycle reentry triggered by Mei3 synergize to prevent zygotic mating
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