Origin and standing of Canary Black Pig

We summarize the historical information about origin of Canary Black Pig and standing in the Canary Islands. The presence of pig in Canary Islands is from 500 year b.C., where aborigines used its meat as food, its fat to preserve foods, its skin as clothing and its bones to produce tools and adornments. The census is constituted for 283 animals, 182 females and 101 males, with a major representation in Tenerife and Gran Canaria islands, 173 and 71 animals respectively.A través de la documentación histórica del Archipiélago Canario, se ha esbozado el origen del Cerdo Negro Canario, a la vez que se expone su estado actual en las diferentes islas del archipiélago. La presencia del cerdo data desde hace 2500 años en el Archipiélago Canario, donde los aborígenes utilizaron su carne como alimento, su manteca para conservas, su piel para vestimenta y sus huesos para fabricación de útiles y adornos. El censo lo constituyen unos 283 ejemplares, 182 hembras y 101 machos, y su mayor representación está en las islas de Tenerife y de Gran Canaria con 173 y 71 animales respectivamente

Antiangiogenic Therapy in Epithelial Ovarian Cancer

Approximately 75% of women with ovarian cancer are diagnosed at advanced stages (FIGO stage III/IV), with 15-23 months median global survival and 20% 5-year survival. Angiogenesis plays an important role in tumour development and proliferation. Increased angiogenesis is associated with worse clinical outcome in ovarian cancer. Here we review the play of bevacizumab in the treatment of ovarian cancer and also other antiangiogenic drugs. In total, to date there are no promising results for most of the reviewed antiangiogenic agents, except those already known for bevacizumab, trebananib, pazopanib, cediranib and nintedanib. Ongoing research will shed more light on this fascinating tumour process and its control

Caracterización de las estructuras de las series de heladas, Valdecaballeros (Badajoz)

[ES]La metodología de caracterización de las estructuras y dinámicas de las heladas, a partir de los datos de temperaturas mínimas diarias, no está sistematizada, siendo necesario para su aplicación recurrir a procedimientos que contemplan aspectos parciales y que se encuentran dispersos en numerosas citas bibliográficas. La conjugación y complementación de estos aspectos da lugar a una sistemática de trabajo capaz de poner en evidencia los aspectos estructurales y de dinámica perseguidos a la par que constituir una herramienta útil para comparar resultados, aunque se trate de localidades de climatología distinta.[EN]The methodology used to characterize frost structures and dynamics from daily mínimum temperature data is not systematized. In order for this to be applied, it is necessary to resort to procedures that take into account partía! aspects which are to be found amoug numerous bibliographic references. The combining of these aspects gives rise to a methodology of work, capable of showing the structural and dynamic aspects pursued, while providing a useful tool for comparing results, however different the climatological characteristics of each area may be

Production of small peptides and low molecular weight amino acids by subcritical water from fish meal: Effect of pressurization agent and temperature

Trabajo presentado en: 19th European meeting on Supercritical Fluids (EMSF 2023), organized by the International Society for the Advancement of Supercritical Fluids, Budapest, 21-24 may, 2023Fish meal is a by-product obtained in the marine food industry that is actually used in aquaculture and pet-food industry. It presents a high protein content as well as a valuable lipid fraction composition. The protein fraction from marine origin has a high nutritional value and a great amino acid profile. In order to improve the use of this by-product, more sustainable forms of exploiting it must be considered and the products obtained more useful.This work was supported by the AEI [grant numbers PID2019-104950RB-I00, PID2020-116716RJ-I00, TED2021-129311B-I00, PDC2022-133443-I00] and the JCyL and the ERDF [grant number BU050P20]. P. Barea predoctoral contract was funded by JCyL and the European Social Fund (ESF) by ORDEN EDU/1868/2022, de 19 de diciembre. P. Alonso-Riaño predoctoral contract was funded by JCyL and the European Social Fund (ESF) by ORDEN EDU/556/2019, de 5 de junio. R. Melgosa contract was funded by a Beatriz Galindo Research Fellowship [BG20/00182]. A. Bermejo López acknowledges the Margarita Salas grant (MARSA22/03)

Volatile compounds emitted by diverse phytopathogenic microorganisms promote plant growth and flowering through cytokinin action

Sánchez-López, Ángela María et al.It is known that volatile emissions from some beneficial rhizosphere microorganisms promote plant growth. Here we show that volatile compounds (VCs) emitted by phylogenetically diverse rhizosphere and non-rhizhosphere bacteria and fungi (including plant pathogens and microbes that do not normally interact mutualistically with plants) promote growth and flowering of various plant species, including crops. In Arabidopsis plants exposed to VCs emitted by the phytopathogen Alternaria alternata, changes included enhancement of photosynthesis and accumulation of high levels of cytokinins (CKs) and sugars. Evidence obtained using transgenic Arabidopsis plants with altered CK status show that CKs play essential roles in this phenomenon, because growth and flowering responses to the VCs were reduced in mutants with CK-deficiency (35S:AtCKX1) or low receptor sensitivity (ahk2/3). Further, we demonstrate that the plant responses to fungal VCs are light-dependent. Transcriptomic analyses of Arabidopsis leaves exposed to A. alternata VCs revealed changes in the expression of light- and CK-responsive genes involved in photosynthesis, growth and flowering. Notably, many genes differentially expressed in plants treated with fungal VCs were also differentially expressed in plants exposed to VCs emitted by the plant growth promoting rhizobacterium Bacillus subtilis GB03, suggesting that plants react to microbial VCs through highly conserved regulatory mechanisms.This work was partially supported by the Comisión Interministerial de Ciencia y Tecnología and Fondo Europeo de Desarrollo Regional (Spain) (grant numbers BIO2010-18239 and BIO2013- 49125-C2-1-P), the Government of Navarra (grant number IIM010491.RI1), the I-Link0939 project from the Ministerio de Economía y Competitividad, the Ministry of Education, Youth and Sports of the Czech Republic (Grant L01204 from the National Program of Sustainability) and Palacky University institutional support. AM S-L and P G-G gratefully acknowledge predoctoral fellowships from the Spanish Ministry of Science and Innovation. M B and G A acknowledge post-doctoral fellowships awarded by the Public University of Navarra.Peer reviewe

Prevalence and Penetrance of BRCA1 and BRCA2 Germline Mutations in Colombian Breast Cancer Patients

9 páginasPathogenic BRCA1/2 germline mutations confer high risks of breast and ovarian cancer to women of European ancestry. Characterization of BRCA1/2 mutations in other ethnic groups is also medically important. We comprehensively screened 68 Colombian breast/ovarian cancer families for small-range mutations, 221 families for large-genomic rearrangements, and 1,022 unselected breast cancer cases for Colombian founder mutations in BRCA1/2. The risk of cancer among relatives of mutation carriers and the mutation penetrance were estimated by survival analysis. Identified BRCA2 mutations included 6310delGA and the recurrent 1991del4 mutations. A novel large BRCA2 deletion was found in 0.9% of the screened families. Among unselected breast cancer cases, 3.3% tested positive for BRCA1/3450del4, 2.2% for BRCA1/A1708E, 1.1% for BRCA2/3034del4, and 0.4% for BRCA2/1991del4. Female relatives of carriers of BRCA1/2 founder mutations showed a 5.90 times higher risk of breast cancer, when the woman herself carried a BRCA1 mutation compared to a non-carrier (95% CI 2.01–17.3). The estimated cumulative risk of breast cancer by age 70 years for BRCA1 mutations carriers was 14% (95% CI 5–38) compared to 3% for the general Colombian population (relative risk of breast cancer 4.05). Together with known founder mutations, reported novel variants may ease a cost-effective BRCA1/2 screening in women with Colombian ancestry

Lactic acid production from biomass-derived sugars using acid or base catalysts

Póster presentado en: 19th European meeting on Supercritical Fluids (EMSF 2023), organized by the International Society for the Advancement of Supercritical Fluids, Budapest, 21-24 may, 2023Lactic acid can be produced from biomass-derived sugars, both with basic and acid catalysts, and is a stable system, as no degradation of the produced lactic acid is observed over timeThis work was supported by AEI [PID2019-104950RB-I00, PID2020-116716RJ-I00, TED2021-129311B-I00, PDC2022-133443-I00] and JCyL-ERDF [BU050P20]. ABL wants to acknowledge the Margarita Salas grant [MARSA22/03], PAR to JCyL and ESF [ORDEN EDU/556/2019] and RM the Beatriz Galindo Research Fellowship [BG20/00182]

Catch-up growth in juvenile rats, fat expansion, and dysregulation of visceral adipose tissue

BACKGROUND: Accelerated catch-up growth following intrauterine restriction increases the risk of developing visceral adiposity and metabolic abnormalities. However, the underlying molecular mechanisms of such metabolic programming are still poorly understood. METHODS: A Wistar rat model of catch-up growth following intrauterine restriction was used. A gene expression array was performed in the retroperitoneal adipose tissue sampled at postnatal day (PD) 42. RESULTS: Five hundred and forty-six differentially expressed genes (DEGs) were identified (adjusted p value < 0.05). Gene ontology enrichment analysis identified pathways related to immune and lipid metabolic processes, brown fat cell differentiation, and regulation of PI3K. Ccl21, Npr3, Serpina3n, Pnpla3, Slc2a4, and Serpina12 were validated to be upregulated in catch-up pups (all p < 0.01) and related to several fat expansion and metabolic parameters, including body weight at PD42, postnatal body weight gain, white and brown adipose tissue mass, plasma triglycerides, and insulin resistance index (all p < 0.05). CONCLUSIONS: Genes related to immune and metabolic processes were upregulated in retroperitoneal adipose tissue following catch-up growth in juvenile rats and were found to be associated with fat expansion and metabolic parameters. Our results provide evidence for several dysregulated genes in white adipose tissue that could help develop novel strategies to prevent the metabolic abnormalities associated with catch-up growth

Efecto de la adicción de extracto de vino tinto en la conservación de hamburguesas de cordero enriquecidas en ácidos grasos omega-3

Red wine is a great source of polyphenols compounds, which exert a high antioxidant capacity. The effect of red wine extract (EV) on the oxidative stability of lamb patties in terms of metmyoglobin (MetMb) formation, lipid oxidation, protein oxidation, and the stability of docosahexaenoic fatty acid (DHA) was investigated. Ground lamb meat enriched in ω3 fatty acids was divided into four treatments. Three treatments were supplemented with 3 doses of EV being 50 (EV1), 100 (EV2) and 200 (EV3) mg GAE/kg meat and, the last one, without antioxidant supplementation, was kept as control (C). The lamb patties were stored under MAP (70% O2/30% CO2) during 9 days. There was an interaction between treatment (L) and storage period (PC) for MetMb proportion (p&lt;0.001) and DHA content (p&lt;0.01). Groups EV2 and EV3 showed less MetMb proportion and higher DHA content at the end of storage period in comparison to groups EV1 and C. Lipid and protein oxidation was affected by storage period (p&lt;0.001), increasing in all treatments.El vino tinto es una gran fuente de compuestos polifenólicos que presentan una gran capacidad antioxidante. El objetivo de este estudio fue evaluar el efecto de la adición de extracto de vino (EV) en la estabilidad oxidativa de hamburguesas de cordero, estudiando la formación de metamioglobina (MetMb), la oxidación lipídica, la oxidación proteica y el contenido en ácido docosahexaenoico (DHA). Se realizaron 4 lotes de carne picada de cordero, todos enriquecidos en ácidos grasos ω3. A tres lotes se les adicionó EV para obtener una concentración final de 50 (EV1), 100 (EV2) y 200 (EV3) mg GAE/kg de carne y el último lote, sin antioxidantes, se mantuvo como control (C). Las hamburguesas se conservaron en MAP (70% O2/30% CO2) durante 9 días. Se observó una interacción entre el lote (L) y el periodo de conservación (PC) para la proporción de MetMb (p&lt;0,001) y el contenido en DHA (p&lt;0,01). Los lotes EV2 y EV3 presentaron menor proporción de MetMb y mayor contenido en DHA que los lotes EV1 y C. La oxidación lipídica y proteica estuvo afectada por el periodo de conservación (p&lt;0,001) aumentando en todos los tratamientos